Treatment Trends of Diabetic Macular Edema in Korea (TRACK) study: A Prospective Multicenter Study.

Purpose: To evaluate real-world functional and anatomical outcomes, treatment patterns, and ocular examination trends in diabetic macular edema (DME) in Korea.

Methods: A prospective, multicenter, observational study was conducted at 17 hospitals (2017-2022) involving adults with DME. Patients were categorized into center-involving (CI DME) and non-center-involving (non-CI DME) groups based on optical coherence tomography findings.

Clinical and Genetic Characteristics of Senior-Loken Syndrome Patients in Korea.

: Senior-Loken syndrome (SLS) is a rare autosomal recessive renal-retinal disease caused by mutations in 10 genes. This study aimed to review the ophthalmic findings, renal function, and genotypes of Korean SLS cases. : We retrospectively reviewed 17 genetically confirmed SLS patients in Korea, including 9 newly identified cases and 8 previously reported.

Clinical Features and Natural Progression of Unilateral High Myopia in Adults: A Comparison Study.

Purpose: To investigate and compare the clinical characteristics of patients with unilateral high myopia (UHM) and bilateral high myopia (BHM) based on axial length (AL).

Design: A retrospective cohort study.

Participants: Adult patients diagnosed with UHM or BHM between March 2011 and August 2021.

Morphological characteristics of high myopes complicated by serous retinal detachment with dome-shaped macula or inferior staphyloma.

Purpose: To investigate the morphological characteristics of dome-shaped macula (DSM) and inferior staphyloma complicated by serous retinal detachment (SRD).

Methods: Electronic medical records and multimodal images of patients diagnosed with DSM and inferior staphyloma were retrospectively reviewed. Morphological features, including axial length, curvature height, orientation of the dome, presence of retinal pigment epithelial detachment, choroidal vascular features such as subfoveal choroidal thickness, variations in choroidal thickness, presence of abrupt changes in choroidal thickness and presence of large choroidal vessels were analyzed.

Genome-wide association and multi-omics analyses provide insights into the disease mechanisms of central serous chorioretinopathy.

Central serous chorioretinopathy (CSC) is a major cause of vision loss, especially in middle-aged men, and its chronic subtype can lead to legal blindness. Despite its clinical importance, the underlying mechanisms of CSC need further clarification. In this study, we conducted a meta-analysis of three genome-wide association studies (GWASs) for CSC consisting of 8811 Asians and Caucasians, followed by replication in an additional 4338 Asians.

Incidence and risk factors of late-onset intraocular pressure elevation after vitrectomy with silicone oil tamponade.

Purpose: To evaluate the incidence and risk factors of late-onset intraocular pressure (IOP) elevation in patients who underwent pars plana vitrectomy with silicone oil (SO) injection for the management of various vitreoretinal pathologies.

Study Design: A retrospective observational study.

Methods: A single-center study involving 135 eyes of 129 patients who underwent vitrectomy with SO injections between January 2018 and May 2023 and maintained SO tamponade for ≥1 month.

Retinitis Pigmentosa GTPase Regulator-Associated X-Linked Retinitis Pigmentosa: Molecular Genetics and Clinical Characteristics.

Purpose: To describe in detail the genetic profile, clinical features, and genotype-phenotype correlation of retinitis pigmentosa GTPase regulator (RPGR)-associated X-linked retinitis pigmentosa (RP) in Koreans.

Design: A retrospective multicenter case series.

Methods: This study recruited genetically confirmed RPGR-associated X-linked RP patients from nine tertiary hospitals and clinics across Korea.

IMAGE QUALITY AND SAFETY OF 300 MG VERSUS 100 MG FLUORESCEIN IN ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY: A Randomized Clinical Trial.

Purpose: To compare the image quality and safety of ultra-widefield fluorescein angiography using 3 mL (300 mg) versus 1 mL (100 mg) of 10% fluorescein.

Methods: In this prospective, randomized clinical trial, a total of 144 patients who required ultra-widefield fluorescein angiography examination for various retinal diseases were randomized 1:1 to 300 mg or 100 mg of fluorescein. Images were qualitatively graded by three retinal specialists and quantitatively analyzed.

Clinical and Genetic Characteristics of Patients with Peripheral Retinal Flecks in Koreans.

Purpose: To describe the clinical and genetic features of Korean patients with peripheral retinal flecks unrelated to aging.

Methods: A retrospective analysis was conducted on the clinical characteristics of patients with symmetric peripheral retinal flecks. Age-related deposits such as reticular pseudodrusen were excluded, as well as secondary deposits related to intraocular inflammation, tumor, and drug toxicity.

INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR TREATMENT IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION AND POOR VISUAL ACUITY.

Purpose: To investigate the significance of intravitreal anti-vascular endothelial growth factor treatment in patients with neovascular age-related macular degeneration and poor visual acuity.

Methods: Retrospective study of patients with neovascular age-related macular degeneration with baseline best-corrected visual acuity of ≤20/200. Patients were divided into regular treatment and scarce treatment groups according to whether they underwent consecutive intravitreal anti-vascular endothelial growth factor treatments at intervals of ≤4 months or not.

Association between Pentosan Polysulfate and Subsequent Maculopathy: Insights from a Nationwide Population-Based Study in Korea.

Purpose: To determine the association between pentosan polysulfate (PPS) use and the subsequent development of maculopathy in an Asian population.

Design: A nationwide, population-based retrospective cohort study using the Health Insurance Review and Assessment Service database.

Participants: A total of 103 553 individuals in the PPS user group and 205 792 individuals in the PPS nonuser group, all newly diagnosed with cystitis between 2009 and 2020.

Late-Onset Slowly Progressing Cone/Macular Dystrophy in Patients With the Biallelic Hypomorphic Variant p.Arg1933Ter in RP1.

Purpose: Homozygous hypomorphic variants of the RP1 gene, including c.5797C>T, p.Arg1933Ter, have traditionally been considered non-pathogenic.

Two novel non-coding single nucleotide variants in the DNase1 hypersensitivity site of causing North Carolina macular dystrophy in Korea.

Purpose: Pathogenic variants in North Carolina macular dystrophy (NCMD) have rarely been reported in the East Asian population. Herein, we reported novel variants of NCMD in 2 Korean families.

Methods: The regions associated with NCMD were analyzed with genome sequencing, and variants were filtered based on the minor allele frequency (0.

Scleral buckling with adjuvant pneumatic retinopexy versus scleral buckling alone for rhegmatogenous retinal detachment.

To compare the efficacy of scleral buckling with adjuvant pneumatic retinopexy (SB with PR) and scleral buckling (SB) alone for primary rhegmatogenous retinal detachment (RRD). This retrospective and comparative study included patients who underwent SB with PR (n = 88) or SB alone (n = 161) for primary RRD. The primary anatomical success rate for SB with PR was 81.

Distinct Clinical Effects of Two RP1L1 Hotspots in East Asian Patients With Occult Macular Dystrophy (Miyake Disease): EAOMD Report 4.

Purpose: To characterize the clinical effects of two RP1L1 hotspots in patients with East Asian occult macular dystrophy (OMD).

Methods: Fifty-one patients diagnosed with OMD harboring monoallelic pathogenic RP1L1 variants (Miyake disease) from Japan, South Korea, and China were enrolled. Patients were classified into two genotype groups: group A, p.

ADDITIONAL PNEUMATIC RETINOPEXY IN PATIENTS WITH PERSISTENT RETINAL DETACHMENT AFTER SCLERAL BUCKLING.

Purpose: To investigate the efficacy, safety, and indications for additional pneumatic retinopexy (PR) in patients with persistent retinal detachment after scleral buckling.

Methods: This retrospective study included patients who underwent additional PR after scleral buckling for primary rhegmatogenous retinal detachment (n = 78). We defined "inadequate buckle" as retinal detachment persistence because of low buckle height despite accurate buckle placement and "buckle misplacement" as an uncovered tear because of incorrect buckle placement.

Phenotypic and Genetic Alterations in Adult-Onset Cone and Cone-Rod Dystrophy.

Introduction: The objective of this study was to investigate the clinical characteristics and genetic spectrum of adult-onset cone/cone-rod dystrophy (AOCD/AOCRD) in Korean individuals.

Methods: This is a single-center, retrospective cross-sectional study. We analyzed 22 individuals with genetically confirmed cone dystrophy, with symptoms beginning after 30 years of age.