Prevalence, Antimicrobial Resistance Profile, and Genetic Characteristics of Methicillin-Resistant Isolated from Retail Raw Fish in South Korea.

Given the limited genetic characterization of methicillin-resistant (MRSA) in South Korea, we performed whole-genome sequencing (WGS) on eight MRSA strains isolated from raw fish products, including 327 sliced raw flatfish, 111 flatfish stew products, 85 sliced raw rockfish, and 11 rockfish stew products. Phylogenetic analysis revealed two distinct clusters-comprising five ST72-t324-SCCIVc strains and two novel sequence types-as well as a singleton strain (ST630-t4549-SCCV). A total of five antimicrobial resistance genes (ARGs), four plasmid replicon genes, three mobile genetic element genes, and seventy-three virulence factor genes were identified, with distinct genetic profiles observed between the clusters.

Impact of diabetes and ejection fraction on non-ST-Segment elevation myocardial infarction outcomes.

Given the limited published data, we examined three-year outcomes in patients with and without diabetes mellitus (DM) in non-ST-segment elevation myocardial infarction (NSTEMI), according to left ventricular ejection fraction (LVEF). A total of 4594 patients were classified into DM (n = 1608) and non-DM (n = 2986) groups. They were further classified into heart failure with reduced EF (HFrEF, LVEF ≤ 40%), HF with mildly reduced EF (HFmrEF, LVEF 41-49%), and HF with preserved EF (HFpEF, LVEF ≥ 50%) subgroups.

Enhanced gating efficiency in vertical mixed molecular transistors with deep orbital level.

The advancement of molecular junction transistors relies heavily on precise modulation of molecular orbitals, yet this is hindered by a limited transmission window and reduced bias stability, which typically restricts the range of active channel molecules adopted to those with orbital levels near Fermi level of the contacts. In this study, we demonstrate an effective orbital gating of prototypical alkanethiol-based molecules with deeper orbital levels in vertical large-area mixed self-assembled monolayers (SAMs) configuration that offers enhanced electrical bias stability and gating efficiency. By using ion gel gating in Au-molecule-graphene junction, the channel conductance could be modulated notably according to a clear transition from direct tunneling to Fowler-Nordheim tunneling regime.

The value of the monocyte to high-density lipoprotein cholesterol ratio in predicting the thrombosis burden and long-term prognosis of acute myocardial infarction patients: a retrospective cohort study.

Background: Percutaneous coronary intervention has an irreplaceable role in the treatment of patients with acute myocardial infarction (AMI), but it may exacerbate distal microthrombosis, lead to the further impairment of myocardial perfusion and microcirculation, and ultimately lead to a poor prognosis. Therefore, it is important to evaluate biomarkers that help estimate the thrombosis burden and long-term prognosis of AMI patients. Recent studies have found that the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) is closely related to the development of cardiovascular disease.

Janus Gold Nanodiscs with an Asymmetrically Positioned Polyaniline Nano-Urchin for Photothermal Therapy and Multimodal Imaging in the Second Near-Infrared Window.

The second near-infrared (NIR-II) window (1000-1700 nm) offers advantages in biomedical applications such as deeper tissue penetration and superior imaging contrast. Despite this potential, existing NIR-II probes are limited by biocompatibility concerns, photobleaching, and poor photostability, issues that constrain their clinical utility. This study introduces Janus-type gold nanodiscs having an asymmetrically integrated hierarchical polyaniline (PANI) structure, optimized for use as multifunctional agents for NIR-II photothermal therapy and multimodal imaging.

Hepatic estrogen-related receptor gamma is a key regulator of GDF15 production in acute and chronic liver injury.

Aims: Growth differentiation factor 15 (GDF15) is a stress-induced hepatokine with emerging roles in liver injury. Estrogen-related receptor γ (ERRγ), a nuclear receptor regulating mitochondrial function and metabolic stress, has also been implicated in various liver injury conditions. However, the regulatory interplay between ERRγ and GDF15 remains unclear.

Optimization of bile preparation for liquid biopsy in cholangiocarcinoma focusing on circulating tumor DNA and protein stability.

Liquid biopsy using bile offers a promising non-invasive approach for molecular analysis in cholangiocarcinoma (CCA). However, the stability of key biomarkers, such as proteins and circulating DNA (ctDNA), at room temperature has not been fully elucidated. This study investigates the temporal stability of proteins and ctDNA in bile samples under room temperature conditions to optimize pre-analytical handling for molecular diagnostics.

Short-Term DAPT After Complex PCI With Third-Generation DES: A Post Hoc Analysis of the HOST-IDEA Trial.

Background: The optimal duration of dual antiplatelet therapy (DAPT) after complex percutaneous coronary intervention (PCI) remains unclear. We aim to investigate the efficacy and safety of 3 to 6 months of DAPT over 12 months after complex PCI.

Methods: A post hoc analysis of the HOST-IDEA (Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis-Coronary Intervention With Next-Generation Drug-Eluting Stent Platforms and Abbreviated Dual Antiplatelet Therapy) randomized trial which enrolled patients undergoing PCI with third-generation drug-eluting stents was performed.

Design of Self-Assembled Monolayer in Tungsten Diselenide Bilayer for Exciton Dissociation.

Transition metal dichalcogenides (TMDs) have emerged as promising candidates for next-generation self-powered photodetectors due to their distinct optoelectronic properties, including strong light-matter interactions. However, their high exciton binding energies impede efficient exciton dissociation, hindering viable photodetector applications. This study, based on first-principles calculations, introduces a design approach featured by the asymmetrically enclosed structure of the TMD bilayer, i.

Effects of integrated takeover request warning with personal portable device on takeover time and post-takeover performance in level 3 driving automation.

Introduction: Level 3 driving automation defined by the Society of Automotive Engineers (SAE) requests human drivers to drive manually when the vehicle cannot perform the driving task. In this regard, researchers have studied the integrated takeover request (TOR) which provides visual and auditory TOR warning in both vehicle interface (e.g.

Flexible Synaptic Memristors With Controlled Rigidity in Zirconium-Oxo Clusters for High-Precision Neuromorphic Computing.

Flexible memristors are promising candidates for multifunctional neuromorphic computing applications, overcoming the limitations of conventional computing devices. However, unpredictable switching behavior and poor mechanical stability in conventional memristors present significant challenges to achieving device reliability. Here, a reliable and flexible memristor using zirconium-oxo cluster (ZrOOH(OMc)) as the resistive switching layer is demonstrated.

Drug-Coated Balloon-Based Treatment of Left Main True Bifurcation Lesion.

Background: There is a paucity of data regarding drug-coated balloon (DCB) treatment in the context of left main (LM) true bifurcation lesions.

Aims: The aim of this study was to evaluate the safety and efficacy of DCB-based treatment for unprotected LM true bifurcation lesions.

Methods: A total of 39 patients with LM true bifurcation lesion (Medina: 1,1,1/0,1,1/1,0,1) who were successfully treated with DCB alone or in combination with drug-eluting stent (DES) were retrospectively enrolled into the DCB-based group.

Contact-Engineered Oxide Memtransistors for Homeostasis-Based High-Linearity and Precision Neuromorphic Computing.

Homeostasis is essential in biological neural networks, optimizing information processing and experience-dependent learning by maintaining the balance of neuronal activity. However, conventional two-terminal memristors have limitations in implementing homeostatic functions due to the absence of global regulation ability. Here, three-terminal oxide memtransistor-based homeostatic synapses are demonstrated to perform highly linear synaptic weight update and enhanced accuracy in neuromorphic computing.

The influence between plaque rupture and non-plaque rupture on clinical outcomes in patients with ST-segment elevation myocardial infarction after primary percutaneous coronary intervention: a prospective cohort study.

Background: Coronary atherosclerosis can lead to acute clinical events upon atherosclerotic plaque rupture (PR) or erosion and arterial thrombus formation. Identifying the effect of distinct plaque characteristics on clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) is critical for clinical therapy. Our goal was to ascertain the correlation between clinical outcome, long-term prognosis, and morphological plaque characteristics in STEMI.

A 5-Year Mortality Prediction Model for Prostate Cancer Patients Based on the Korean Nationwide Health Insurance Claims Database.

Background: Prostate cancer is the fourth most common cancer and eighth leading cause of cancer-related mortality worldwide. Its incidence is increasing in South Korea. This study aimed to investigate a predictive model for the 5-year survival probability of prostate cancer patients in a Korean primary care setting.

Long-term impact of socioeconomic status after acute myocardial infarction in Korea.

Background And Aims: Socioeconomic status (SES) is known to impact the prognosis of acute myocardial infarction (AMI). However, due to the limited scope of previous studies, this study aimed to investigate the impact of SES on the prognosis of AMI patients within the Korean national healthcare insurance system.

Methods And Results: A retrospective cohort study included patients who were diagnosed with AMI between 2007 and 2008 from the Korean National Health Insurance Service and underwent a national health check-up program.

Impact of symptom-to-balloon time in patients with non-ST-segment elevation myocardial infarction and complex lesions.

Aims: Considering the limited data regarding clinical outcomes of patients with non-ST-segment on the ECG elevation myocardial infarction (NSTEMI), this study compared the outcomes of patients undergoing percutaneous coronary intervention with newer-generation drug-eluting stents stratified by the presence/absence of complex lesions and symptom-to-balloon time (SBT; <48 h or ≥48 h).

Methods: We enrolled 4373 patients with NSTEMI from the Korea Acute Myocardial Infarction Registry-National Institute of Health dataset and stratified them into the complex group (2106 patients; SBT < 48 h, n  = 1365; SBT ≥48 h, n  = 741) and the noncomplex group (2267 patients; SBT < 48 h, n  = 1573; SBT ≥48 h, n  = 694). The primary outcome was the 3-year all-cause mortality rate.

Monolithically integrated neuromorphic electronic skin for biomimetic radiation shielding.

Melanogenesis, a natural responsive mechanism of human skin to harmful radiation, is a self-triggered defensive neural activity safeguarding the body from radiation exposure in advance. With the increasing significance of radiation shielding in diverse medical health care and wearable applications, a biomimetic neuromorphic optoelectronic system with adaptive radiation shielding capability is often needed. Here, we demonstrate a transparent and flexible metal oxide-based photovoltaic neuromorphic defensive system.

Characterizing Defects Inside Hexagonal Boron Nitride Using Random Telegraph Signals in van der Waals 2D Transistors.

Single-crystal hexagonal boron nitride (hBN) is used extensively in many two-dimensional electronic and quantum devices, where defects significantly impact performance. Therefore, characterizing and engineering hBN defects are crucial for advancing these technologies. Here, we examine the capture and emission dynamics of defects in hBN by utilizing low-frequency noise (LFN) spectroscopy in hBN-encapsulated and graphene-contacted MoS field-effect transistors (FETs).

Three-year outcomes following non-ST-segment elevation myocardial infarction and new-generation drug-eluting stent implantation, stratified by patient age (under and over 75 years) and left ventricular ejection fraction: A prospective cohort study.

Due to limited published data, we investigated 3-year outcomes according to left ventricular ejection fraction (LVEF) in patients older and younger than 75 years with non-ST-segment elevation myocardial infarction (NSTEMI) who underwent successful newer-generation drug-eluting stent (DES) implantation. This research analyzed the data of 4558 patients (1032 older adults [≥75 years] and 3526 younger adults [<75 years]) from the Korea Acute MI Registry-NIH. We further divided the older group based on LVEF: heart failure (HF) with reduced EF (HFrEF, ≤40%, n = 196; group A), HF with mildly reduced EF (HFmrEF, 41-49%, n = 228; group B), and HF with preserved EF (HFpEF, ≥50%, n = 608; group C).

Drug-coated balloon versus drug-eluting stent for femoropopliteal total occlusions: intraluminal versus subintimal approaches.

Because there is a lack of comparative studies assessing drug-coated balloon (DCB) and drug-eluting stent (DES) outcomes with respect to intraluminal (IL) and subintimal (SI) approaches in femoropopliteal (FP) total occlusive lesions, we compared the outcomes between DCB (including bailout stenting) and DES treatments for this lesion. A total of 487 limbs (434 patients) were divided into the IL (n = 344, DCB: n = 268, DES: n = 76) and SI (n = 143, DCB: n = 83, DES: n = 60) approach groups. The primary outcome was a major adverse limb event (MALE), defined as above-ankle amputation or repeat revascularization of the index limb.