Publications by authors named "Chul-Ho Lee"
In Parkinson's disease (PD), long-term 3,4-dihydroxy-L-phenylalanine (L-dopa) therapy leads to the development of motor complications, including L-dopa-induced dyskinesia (LID). Increased numbers of reactive astrocytes in the brains of patients with PD are a key feature of this disease. Astrocytes are involved in the development of LID; however, whether the regulation of astrocytic activity influences LID development remains unclear.
View Article and Find Full Text PDFBackground: Stroke is a leading cause of mortality worldwide, with carotid stenosis contributing to approximately 20-25% of cases. Carotid endarterectomy (CEA) has been the standard surgical treatment for carotid stenosis since its implementation in 1953. Among the various CEA techniques, modified eversion CEA (meCEA) has been proposed as a promising alternative because of its potential to reduce operative time and avoid patch closure.
View Article and Find Full Text PDFHepatic estrogen-related receptor gamma is a key regulator of GDF15 production in acute and chronic liver injury.
Mol Cell Endocrinol
September 2025
Aims: Growth differentiation factor 15 (GDF15) is a stress-induced hepatokine with emerging roles in liver injury. Estrogen-related receptor γ (ERRγ), a nuclear receptor regulating mitochondrial function and metabolic stress, has also been implicated in various liver injury conditions. However, the regulatory interplay between ERRγ and GDF15 remains unclear.
View Article and Find Full Text PDFSuccessful treatment of gastropulmonary fistula in a patient with gastric diverticulum: A case report.
Medicine (Baltimore)
April 2025
Rationale: Gastropulmonary fistula (GPF) is defined as a communication pathway between the stomach and the lung. GPF is a rare condition, and there is no consensus regarding its treatment. GPF has been reported in only a small number of cases.
View Article and Find Full Text PDFThe aging process is associated with a decline in certain cognitive abilities, including learning and memory. This age‑related cognitive decline is associated with a reduction in neurogenesis and alterations in the cholinergic system. (HJ), an ornamental plant in the family , has been reported to exert beneficial effects against neurodegenerative pathophysiologies in mouse models of disorders such as Alzheimer's and Parkinson's disease.
View Article and Find Full Text PDFL-dopa-induced dyskinesia (LID) is an incapacitating complication of long-term administration of L-dopa therapy that commonly affects patients with Parkinson's disease (PD) due to the widespread use of the causative drug. Herein, we investigated the therapeutic potential of sitagliptin, a drug used to treat type 2 diabetes mellitus, to treat LID. 6-hydroxydopamine (6-OHDA) was unilaterally injected into the left side of the substantia nigra pas compacta to induce a mouse model of PD.
View Article and Find Full Text PDFSupplemental metaphyseal fixation of severe comminuted distal radius fracture with a mini plate.
BMC Musculoskelet Disord
February 2025
Backgrounds: The treatment of complex distal radius fractures, particularly those involving both intra-articular disruption and significant metaphyseal comminution, remains a considerable surgical challenge. While volar locking plates have become a widely accepted standard for stabilizing these fractures, alone they may not address all fracture patterns. This study presents a surgical approach that incorporates the use of a mini-plate to provide targeted support for the metaphyseal region.
View Article and Find Full Text PDFAnti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development.
Nat Commun
January 2025
Cancers with activating mutations of KRAS show a high prevalence but remain intractable, requiring innovative strategies to overcome the poor targetability of KRAS. Here, we report that KRAS expression is post-translationally up-regulated through deubiquitination when the scaffolding function of NDRG3 (N-Myc downstream-regulated gene 3) promotes specific interaction between KRAS and a deubiquitinating enzyme, USP9X. In KRAS-mutant cancer cells KRAS protein expression, downstream signaling, and cell growth are highly dependent on NDRG3.
View Article and Find Full Text PDFArticle Synopsis
- A new catalyst structure combining MoS and WS in a bilayer configuration has been developed to improve hydrogen production through photoelectrochemical (PEC) methods.
- This catalyst is designed to be transparent, facilitate charge transfer, and protect the underlying semiconductor, addressing critical challenges in the field.
- The resulting structure shows excellent performance, achieving a photocurrent density of -25 mA/cm at 0 V, making it more stable and effective than previous single-layer designs.
Article Synopsis
- - The study focuses on making solid-state synthesis of quaternary cesium chlorides more efficient by targeting specific compositions based on predicted stabilities and available starting materials.
- - The team uses in situ synchrotron X-ray diffraction to monitor changes during heating, assessing the synthesizability of various target compounds before attempting laboratory synthesis.
- - Results reveal both successful and unsuccessful synthesis efforts, leading to the discovery of new polymorphs and a new compound, highlighting the importance of connecting computational predictions with experimental results.
Article Synopsis
- Gastritis and gastric ulcers are common conditions caused by factors like infection, drugs, alcohol, or stress, resulting in inflammation and damage to the stomach lining.
- The study explored the protective effects of SA, a plant with known anti-inflammatory properties, using mouse models and cell cultures, revealing that SA reduces gastric injury and inflammation.
- Key findings showed that SA and its key compound, kaempferol, significantly decreased gastric lesions and inflammatory responses by inhibiting specific cellular signaling pathways associated with inflammation.
Article Synopsis
- * The synthesis of compounds involved a Diels-Alder reaction guided by biomimetic studies, leading to the creation of various unnatural chalcone-monoterpene derivatives.
- * Some compounds demonstrated significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), suggesting their potential use as antidiabetic agents due to the enzyme inhibition.
Article Synopsis
- Current reports on the thermal expansion coefficients (TEC) of 2D materials show significant variation, largely due to the challenges in directly measuring these properties of ultra-thin and transparent samples.
- The study introduces a new methodology using four-dimensional scanning transmission electron microscopy (4D-STEM) to directly measure the TEC of monolayer WSe during controlled heating from 18-564 °C.
- The results indicate specific TEC values for WSe that align well with historical data for bulk crystals, providing improved clarity in understanding thermal properties of 2D materials.
Article Synopsis
- Type A aortic dissection and intramural hematoma are serious conditions that require emergency surgery typically involving cooled body temperatures and cardiopulmonary bypass.
- This study analyzed the outcomes of different arterial cannulation techniques used during surgery, comparing antegrade and retrograde methods regarding surgical time and ICU stay.
- Findings showed that while antegrade cannulation led to shorter surgical times and ICU stays, there was no significant difference in 30-day mortality or rates of cerebrovascular accidents between the two methods.
Article Synopsis
- A new device architecture called van der Waals Schottky gated metal-semiconductor FETs (vdW-SG MESFETs) uses molybdenum disulfide (MoS) channels with surface-oxidized metal gates to improve performance in field-effect transistors (FETs).
- These MESFETs operate at low gate voltages under 0.5 volts and demonstrate ideal switching behavior due to the strong coupling at the Schottky junction, achieving minimal energy loss during operation.
- The study shows that improving the interface between the metal gate and the MoS channel can enhance performance by eliminating unwanted states, leading to a new approach for developing efficient 2D electronic devices.
Article Synopsis
- * The study investigated the effects of combining angiotensin-converting enzyme inhibitors (ACEIs) with L-dopa in a mouse model of PD to see if it could reduce these negative side effects.
- * Results showed that using ACEIs like perindopril, captopril, and enalapril alongside L-dopa significantly reduced the development of L-dopa-induced dyskinesia (LID) and decreased certain inflammatory markers in the brain of PD-affected mice.
Article Synopsis
- Akkermansia muciniphila is important for gut health as it aids in gut immunity, intestinal development, and barrier integrity.
- The study focuses on a newly discovered protein, Amuc_1409, secreted by A. muciniphila, which enhances intestinal stem cell (ISC) growth and recovery in both lab models and aging male mice.
- Amuc_1409 works by interacting with E-cadherin, activating Wnt/β-catenin signaling, and is suggested as a potential biological agent for promoting gut health.
Fibroblast growth factor 23 (FGF23) is a member of endocrine FGF family, along with FGF15/19 and FGF21. Recent reports showed that under pathological conditions, liver produces FGF23, although the role of hepatic FGF23 remains nebulous. Here, we investigated the role of hepatic FGF23 in alcoholic liver disease (ALD) and delineated the underlying molecular mechanism.
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- Venoarterial extracorporeal membrane oxygenation (ECMO) is used for patients in cardiac arrest, with peripheral cannulation methods being preferable for extracorporeal cardiopulmonary resuscitation (ECPR).
- A study at Daegu Catholic University Medical Center analyzed 99 ECPR patients, comparing surgical cutdown and percutaneous cannulation methods in terms of survival rates and insertion times.
- Both methods showed similar in-hospital survival rates (36.4% for surgical and 30.3% for percutaneous), but quicker ECMO insertion times were linked to better survival outcomes due to reduced low-flow times during resuscitation.
Article Synopsis
- The study explores a method to synthesize nitrogen-rich nitrides like γ-MoN at ambient pressure and temperature, which is typically difficult due to the strong triple bond in nitrogen.
- Using precursors such as NaMoO and dicyandiamide, the researchers heated the mixture in an alumina crucible to create MoN with a rock salt structure, avoiding oxygen incorporation, and producing wash-off byproducts.
- The work highlights dicyandiamide's effectiveness as a metathesis precursor for creating nitrogen-rich compounds under standard conditions, opening new avenues in nitride chemistry.
Characteristics and functional outcomes of varus displaced proximal humerus fractures.
J Orthop Sci
January 2025
Article Synopsis
- The study aimed to analyze the differences in fracture characteristics and recovery outcomes between patients with proximal humerus fractures who had initial varus displacement versus those who did not.
- A total of 325 patients were reviewed, with 60 in the varus cohort and 60 in the fracture cohort, revealing significant statistical differences in various angles and offsets, as well as complications and revision rates.
- Despite both groups achieving satisfactory outcomes, patients in the varus cohort had worse functional scores and a specific postoperative head shaft angle was identified as crucial for good outcomes.
Article Synopsis
- Macrophage stimulating protein (MSP) is a liver-produced protein that activates the RON receptor and plays an essential role in immune functions like cell survival and phagocytosis.
- The study reveals that alcohol exposure specifically increases MSP expression in the liver through the upregulation of the ERRγ protein.
- Inhibition of the cannabinoid receptor CB1R prevents this increase, and experiments show that ERRγ directly binds to the MSP gene promoter, regulating its expression, thus providing insights into alcohol's effects on gene regulation in the liver.
Novel Signal Peptides and Episomal Plasmid System for Enhanced Protein Secretion in Engineered Species.
ACS Synth Biol
February 2024
Article Synopsis
- The study focuses on a key group of bacteria in the human gut microbiome that has potential for creating treatments for gut diseases through microbiome engineering and live biotherapeutics.
- Researchers identified new signal peptides that improve protein transport within these bacteria, which is crucial for developing therapeutics.
- They also created an improved episomal plasmid system that enhances protein delivery and stability, while addressing the demand for antibiotic-free selection methods in clinical applications.
Article Synopsis
- The gut microbiota plays a significant role in maintaining immune health and brain function, with emerging research linking it to cognitive decline and dementia in older adults.
- The study explored the effects of a specific gut bacterium, Agathobaculum butyriciproducens SR79, on cognitive impairment in aged mice, using various behavioral tests to assess changes in cognitive performance.
- Results indicated that SR79 improved cognitive function in aged mice without affecting other behaviors, and it influenced brain health by altering dendritic spines and reducing astrocyte activation, suggesting it could be a promising treatment for age-related cognitive decline.