Amygdalin alleviates atopic dermatitis-like skin inflammation via inhibition of Th2 immune responses.

Atopic dermatitis (AD) is a chronic skin disease marked by immune dysregulation such as upregulated T helper (Th) 2 responses. While Th2-targeted therapies for AD are under development, their application is limited by side effects such as hypereosinophilia and arthritis. Amygdalin is a glucoside known for its anti-inflammatory and antioxidant effects.

Combination of intermittent fasting and endurance exercise impedes the development of the musculoskeletal system in non-obese growing rats.

Background/objectives: The proliferation of appearance-centered values on social media has driven non-obese adolescents towards increasingly extreme diets and exercise programs to achieve weight loss. Despite this, the effects of concurrent diets and exercise on musculoskeletal development during adolescence are unclear. This study examined whether prolonged endurance exercise (EX) with intermittent fasting during adolescence adversely affects musculoskeletal growth.

Real-World Effectiveness of Rosuvastatin-Ezetimibe Single Pill (Rovazet) in Korean Dyslipidemia Patients.

Fixed-dose combinations of rosuvastatin and ezetimibe are increasingly used in clinical practice, but real-world data on their effectiveness and safety in large populations remain limited. This prospective, single-group, open-label, non-interventional observational study was conducted in the Republic of Korea to evaluate the effectiveness and safety of Rovazet (a fixed-dose combination of rosuvastatin and ezetimibe). Patients were prospectively enrolled from 235 institutions (50 general hospitals and 185 private clinics) as part of routine clinical practice over a five-year period.

Ligand-orchestrated transition metal aerogels: a tailored sulfur coordination strategy for superior oxygen evolution catalysis.

A novel strategy was developed to enhance oxygen evolution reaction (OER) performance using a tailored sulfur coordination strategy in ternary transition metal sulfide-oxide aerogels (TMSO). The structural and electronic properties of the aerogels synthesized by a metal coordination-initiated sol-gel method were precisely engineered by tuning Co content and controlling sulfur coordination sites. With increasing cobalt content, enhanced sulfur coordination around nickel facilitated the formation of spike-shaped nanostructures, resulting in superior catalytic performance.

The association between multi-inflammatory index and long-term mortality in post-myocardial infarction patients treated with percutaneous coronary intervention.

Background: Inflammation plays a crucial role in the pathophysiology of acute myocardial infarction (AMI), and various inflammatory markers have been associated with patient outcomes. The multi-inflammatory index (MII) has emerged as a potential prognostic indicator, but its relationship with AMI mortality remains unclear.

Methods: We analyzed 8,414 patients with successfully revascularized AMI.

Incremental prognostic value of combined information of arterial stiffness and the result of treadmill exercise test in patients with suspected coronary artery disease.

The effectiveness of diagnostic tools can be enhanced by their combination. This study aimed to investigate whether total arterial stiffness data, obtained by brachial-ankle pulse wave velocity (baPWV) measurement, could improve prognostic value to exercise treadmill test (ETT) to predict future cardiovascular events. A total of 1 610 consecutive subjects (mean age 56.

Improve Lung Function Through Boys' Natural Learning Course Singing Program (NLCSP) as a Singing Skill Habilitation.

The purpose of this study was to evaluate the effects of Natural Learning Course Singing Program (NLCSP) as an alternative habilitation approach on adolescents' pulmonary function. The program demonstrated significant improvements in lung function indicators, including forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1), even after adjusting for demographic covariates such as age, gender, height, and weight. A total of 48 subjects participated, divided into a Program group (P group) (n = 23, age 12-13 years) and a Control group (C group) (n = 18, age 12-13 years).

Correction: Posttreatment pulse rate reduction and not baseline pulse rate as an indicator of blood pressure response to nebivolol: a subanalysis from the real-world BENEFIT-KOREA study.

[This corrects the article e8 in vol. 31, PMID: 40083595.].

Effectiveness of a Facet Joint Block Versus a Medial Branch Block in Spinal Pain Management: A Systematic Review and Meta-Analysis.

Objective: Facet joint injections (FJIs) and medial branch blocks (MBBs) are commonly used interventions for chronic spinal pain, but their comparative effectiveness remains unclear. This meta-analysis aimed to compare the pain relief, functional improvement, complications, and patient satisfaction associated with FJI and MBB.

Methods: A systematic review and meta-analysis of randomized controlled trials and observational studies were conducted.

A cadaveric study of ultrasound guided nonincisional trigger finger release with newly developed threads.

This study investigated the effectiveness and safety of ultrasound-guided non-incisional thread trigger finger release on cadavers using a newly developed domestic thread (Smartwire-01). Ultrasound-guided non-incisional thread trigger finger release was performed on 12 fresh cadaveric hands, including 12 thumbs and 48 long fingers. Two experts, experienced in an ultrasound-guided thread transecting technique, performed the procedures independently.

Exploring the Clinical Implication of S100A9 in Ulcerative Colitis and Its Progression to Cancer: A Journey from Inflammation to Cancer.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal inflammation and debilitating symptoms that considerably impair life quality. UC is particularly prevalent in younger populations, where early diagnosis remains challenging owing to nonspecific symptoms and the potential progression to colitis-associated cancer (CAC). The GSE177044 dataset, consisting of whole blood samples, was analyzed to identify differentially expressed genes, perform gene annotation, analyze key signaling pathways, and detect key hub genes in UC using protein-protein interaction networks.

Global research trends on exercise and circadian rhythm: A bibliometric analysis.

Recent advancements in the field of exercise and circadian rhythms have brought attention to the potential for tailored exercise strategies based on individual biological rhythms, aiming to optimize both health and performance, yet there is a lack of bibliometric analysis within this specific area of research. This study seeks to provide an extensive insight into the knowledge structure and primary research focuses on the correlation between exercise and circadian rhythms using bibliometric analysis. Publications pertinent to exercise and circadian rhythms were sourced from the Web of Science Core Collection (WoSCC) database.

Prognostic Significance of , , and in Colon Adenocarcinoma: A Multi-Omics and Single-Cell Approach.

: Colon adenocarcinoma (COAD), the most prevalent form of colorectal cancer, remains a leading cause of cancer-related mortality. Advances in various treatments for COAD have significantly improved treatment outcomes. However, therapeutic limitations persist, highlighting the need for personalized strategies driven by novel biomarkers.

Deescalation From Ticagrelor to Clopidogrel for Myocardial Infarction With Chronic Kidney Disease: A Secondary Analysis of a Randomized Clinical Trial.

Importance: Chronic kidney disease (CKD) is a significant risk factor for both ischemic and bleeding complications following percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). Optimizing dual antiplatelet therapy (DAPT) is essential for improving clinical outcomes.

Objective: To evaluate whether an 11-month, unguided deescalation strategy from ticagrelor to clopidogrel was associated with reduced bleeding without an increase in ischemic events in stabilized patients with CKD after AMI.

Concurrent pancreatic exocrine hyperplasia and adenomas in a Eurasian otter with pleuropneumonia and urolithiasis.

The Eurasian otter () is a semi-aquatic mammal classified as near-threatened by the International Union for Conservation of Nature. There have been few reports on their diseases, especially neoplasms. Here we describe exocrine nodular hyperplasia and adenomas in the pancreas, along with suppurative pleuropneumonia and urolithiasis, in an aged captive Eurasian otter.

Pathogenic germline variants in mismatch repair genes in patients with microsatellite instability-high gastric cancer.

Objective: Lynch syndrome (LS) increases the risk of various cancers, including colorectal cancer, endometrial cancer and gastric cancer (GC). The incidence of LS among microsatellite instability-high (MSI-H) GC and their association in South Korea remains underexplored. This study investigates LS-associated pathogenic germline variants in MSI-H GC patients using whole-exome sequencing (WES) on normal tissues.

Comparison of Laparoscopic Single-Anastomosis Duodenal-Jejunal Bypass With Sleeve Gastrectomy and Laparoscopic Roux-en-Y Gastric Bypass on Short-term Outcomes in Patients With Obesity.

Purpose: The aim of this study was to compare postoperative course of laparoscopic single-anastomosis duodenal-jejunal bypass with sleeve gastrectomy (SADJB-SG) and laparoscopic Roux-en-Y gastric bypass (RYGB) during a 1-year follow-up period.

Materials And Methods: Electronic medical records of all patients who underwent SADJB-SG and RYGB between March 2019 and June 2021 at a single institution were retrospectively reviewed. Surgical outcomes, weight loss, resolution of co-morbidities, episode of dumping syndrome, and marginal ulcer at endoscopy were assessed.

The Korean Society for Metabolic and Bariatric Surgery (KSMBS) Position Statement on Female Candidates of Reproductive Age for Metabolic Bariatric Surgery.

Obesity has emerged as a major global health issue. The ratio of male to female patients undergoing metabolic bariatric surgery (MBS) is 1:3.5.

Recent advances in diagnostic and therapeutic strategies for canine cognitive dysfunction.

Canine cognitive dysfunction (CCD) is a common neurodegenerative disorder among geriatric dogs, characterized by disorientation, interaction changes, sleep-wake cycle disturbances, house soiling, activity level changes, and anxiety. Canine cognitive dysfunction is currently underdiagnosed due to the lack of an objective and reliable diagnostic tool, and treatment options are severely limited. Importantly, CCD shares common pathological hallmarks of human Alzheimer disease, such as β-amyloid accumulation, τ protein phosphorylation, neuronal loss, and neuroinflammation.

Anatomical exploration of the PC8 acupoint through cadaveric Study: Implications for median and ulnar nerve stimulation.

Background And Objectives: This study aimed to elucidate the neuroanatomical characteristics of the PC8 (Laogong) acupoint to enhance understanding of its therapeutic mechanisms.

Materials And Methods: A detailed anatomical dissection of two cadavers conducted at the Chungnam National University College of Medicine examined the spatial relationship of the PC8 acupoint with the surrounding neural structures, muscles, and tendons in the palm.

Results: The palmar digital nerve, a branch of the median nerve, was located in the superficial layer of the PC8 acupoint.

Comparison of posterior approach surgical techniques for cervical spondylotic myelopathy: laminectomy with fusion, laminoplasty, and laminoplasty with fusion.

Background Context: Laminectomy with fusion (LF), laminoplasty (LP), and laminoplasty with fusion (LPF) are three techniques for posterior cervical decompression. LF can provide stability, but postoperative dural membrane adhesion and fusion failure can occur. LP can prevent postoperative dural membrane adhesion, but it can lead to kyphotic change.

Explainable machine learning for arsenic remobilization potential in the vadose zone: Leveraging readily available soil properties.

The vadose zone acts as a natural buffer that prevents contaminants such as arsenic (As) from contaminating groundwater resources. Despite its capability to retain As, our previous studies revealed that a substantial amount of As could be remobilized from soil under repeated wet-dry conditions. Overlooking this might underestimate the potential risk of groundwater contamination.

Comparison of spinal instability and postoperative complications between laminoplasty and laminectomy surgery for spinal cord tumors.

This study aimed to compare kyphotic changes and postoperative complications between laminectomy and laminoplasty for spinal cord tumors. We retrospectively included 110 patients who underwent spinal cord tumor resection at the Ajou University Medical Center, Korea, between January 1994 and March 2022 to compare the complications and postoperative kyphotic changes between laminectomy and laminoplasty. A total of 59 and 51 patients underwent laminectomy and laminoplasty, respectively.

Protectin D1, an omega-3-derived lipid mediator, resolves mast cell-driven allergic inflammation via FcεRⅠ signaling.

Protectin D1 (PD1) derived from docosahexaenoic acid (DHA) has shown promise in resolving inflammation. Mast cells are critical drivers of allergic inflammation, releasing inflammatory mediators such as histamine and pro-inflammatory cytokines. This study assesses the effectiveness of PD1 in counteracting mast cell-mediated allergic inflammation.

Erratum: Korean Gastric Cancer Association-Led Nationwide Survey on Surgically Treated Gastric Cancers in 2023.

This corrects the article on p. 115 in vol. 25, PMID: 39822171.