Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Insulin resistance (IR) plays a noticeable role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The triglyceride glucose-waist circumference (TyG-WC) index, a novel measure for assessing IR, may hold significant predictive value for NAFLD. However, the relationship between TyG-WC and the risk of NAFLD remains elusive. To investigate this association, this comprehensive meta-analysis was conducted.
Methods: A systematic electronic search was conducted using the PubMed, Embase, and Web of Science databases from their inception until July 2024 to identify observational studies assessing the relationship between TyG-WC and the risk of NAFLD. Joanna Briggs Institute's critical appraisal checklist was utilized to evaluate the quality of cross-sectional studies, while the Newcastle-Ottawa Scale (NOS) score was used to assess cohort studies. The principal summary outcomes included the mean difference (MD) and the corresponding 95% confidence interval (CI).
Results: In total, 10 studies comprising 38,518 participants were included in this meta-analysis, of whom 37% were diagnosed with NAFLD. The analysis revealed a significant MD between NAFLD and non-NAFLD cases (MD, 137.41; [95% CI, 121.52-153.31]).
Conclusion: A significant MD was identified between NAFLD and non-NAFLD cases. The TyG-WC index was found to be positively correlated with the risk of NAFLD, suggesting that it may serve as a potential indicator for NAFLD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044922 | PMC |
| http://dx.doi.org/10.1186/s12876-025-03888-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Adiponectin as a Predictor of Metabolic Dysfunction-Associated Steatotic Liver Disease and Non-Alcoholic Fatty Liver Disease: A 17-Year Korean Cohort Study.
Diabetes Metab J
September 2025
Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
Background: This study aimed to investigate the association between adiponectin levels and the incidence of metabolic dysfunction- associated steatotic liver disease (MASLD) and nonalcoholic fatty liver disease (NAFLD), and to explore the predictive value of adiponectin in the onset of these conditions.
Methods: A 17-year follow-up of 35,026 individuals from the Korean Cancer Prevention Study-II biobank cohort (2004-2021) was conducted. Adiponectin levels were categorized into quintiles.
Association between Relative Skeletal Muscle Mass and Metabolic Dysfunction-Associated Steatotic Liver Disease Development in a Community-Based Population.
J Obes Metab Syndr
September 2025
Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: This study explores how relative skeletal muscle mass is associated with the development of metabolic dysfunction-associated steatotic liver disease (MASLD) and the remission of baseline MASLD in a community-based population cohort.
Methods: The study included 1,544 participants with an average age of 58 years. All participants underwent baseline and follow-up assessments in 2015 or 2016.
Enantioselective hepatotoxicity of rac- epoxiconazole and epoxiconazole enantiomers in lizards (Eremias argus).
J Hazard Mater
September 2025
Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing RD 18, Beijing 100085, China; University of Chinese Academy of Sciences, Yuquan RD 19 a, Beijing 100049, China. Electronic address:
Epoxiconazole (EPX) is widely applied to control various fungal diseases in crops. However, the toxicological effects of EPX on reptiles remain unknown, especially at the enantiomer level. In this study, lizards were repeatedly exposed to rac-EPX, (+)-EPX, and (-)-EPX at doses of 10 and 100 mg/kg bw for 21 days.
View Article and Find Full Text PDFTHE HIDDEN IMPACT OF INTRAUTERINE GROWTH RESTRICTION IN THE PATHOGENESIS OF METABOLIC SYNDROME: FUNCTIONAL AND STRUCTURAL ALTERATIONS IN RAT VISCERAL ADIPOSE TISSUE.
J Nutr Biochem
September 2025
Department of Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland. Electronic address:
Background: Individuals born after intrauterine growth restriction (IUGR) have a higher risk of developing metabolic syndrome (MetS) in adulthood. In a rat model, male IUGR offspring exhibit MetS features-including elevated systolic blood pressure, glucose intolerance, non-alcoholic fatty liver disease, and increased visceral adipose tissue (VAT)-by 6 months of age. Female offspring, however, do not.
View Article and Find Full Text PDFThe Triadic Relationship Between Nonalcoholic fatty liver disease, Type 2 Diabetes, and cardiovascular disease: From Molecular Mechanisms to Clinical Management.
Curr Probl Cardiol
September 2025
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston.
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) represent interconnected metabolic disorders with multifaceted etiology, demonstrating bidirectional relationships and pronounced associations with cardiovascular diseases (CVDs). Despite extensive research, significant knowledge gaps persist regarding the temporal progression of these comorbidities, optimal screening strategies for high-risk populations, and personalized therapeutic approaches targeting the hepatic-cardiac-metabolic axis simultaneously. Current literature lacks a comprehensive analysis of phenotypic heterogeneity within NAFLD-T2DM-CVD clusters and fails to address sex-specific and ethnic variations in disease progression patterns adequately.
View Article and Find Full Text PDF