Bioinspired pullulan-tannic acid hydrogels with high toughness, stretchability, adhesion and self-healing properties.

Inspired by the high-density hydrogen bonds in spider silk and the mussel adhesive mechanism, pullulan-tannic acid (TA) hydrogels with high stretchability, toughness, adhesiveness, and rapid self-healing capabilities were successfully fabricated via a hydrogen-bond-driven co-assembly strategy combined with controlled evaporation. Infrared spectroscopy confirmed the presence of hydrogen bonds between pullulan and TA, while scanning electron microscopy revealed the porous network structure of the hydrogels. The tensile strength (TS), Young's modulus (YM), and toughness values of PulTA5 hydrogels were 0.

Multi-beam interference metasurface generating 3D vector optical field arrays for chiral sensing.

Chiral substances are widely present in nature, from macroscopic cosmic stars to microscopic biomolecules. The detection and preparation of chiral substances have always been a hot research topic. At present, there is an urgent need to develop a production method for chiral materials with a simple preparation process and low cost.

A bi-specific CAR-T cell therapy targeting CD19 and CD22 in relapsed or refractory B-ALL.

CAR-T therapies targeting either CD19 or CD22 have shown significant promise for treating relapsed or refractory B-lineage acute lymphoblastic leukemia (r/r B-ALL). However, a common limitation is the high frequency of antigen loss, which leads to r/r B-ALL progression. To overcome progression caused by antigen loss, bi-specific CAR-T immunotherapies targeting both CD19 and CD22 may offer enhanced efficacy in eliminating r/r B-ALL and preventing relapse by hindering leukemia cell proliferation.

Phage-encoded depolymerases and endolysins as prospective strategies to combat multidrug-resistant Klebsiella pneumoniae.

Hypervirulent Klebsiella pneumoniae (hvKP), classified as ESKAPE pathogens, represent substantial global public health threats owing to their antibiotic resistance and virulence factors. Infections caused by hvKP are often associated with high mortality rates and healthcare costs, and the pathogen tends to form biofilms, which further complicates treatment. Thus, novel therapeutic strategies are urgently needed for K.

PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.

Objective: This study aimed to investigate the role of poly(A) binding protein nuclear 1 (PABPN1) as a potential pan-cancer biomarker for prognosis and immunotherapy.

Methods: The original datasets were acquired from TCGA and GEO databases. PABPN1 expression analysis was conducted utilizing the Oncomine, TIMER, GEPIA, and BioGPS databases.

Glucose Metabolism, Lactate, Lactylation and Alzheimer's Disease.

Alzheimer's disease (AD) is a neurodegenerative disorder primarily characterized by cognitive decline; however, its pathogenesis remains incompletely understood. In recent years, the role of lactate metabolism and its derived lactylation modifications in AD has received increasing attention. As a product of glycolysis, lactate is not only a key molecule in energy metabolism but also regulates gene expression and protein function through lactylation modifications.

Hereditary chronic intestinal pseudo-obstruction caused by a rare mutation: A case report.

Background: Chronic intestinal pseudo-obstruction (CIPO) is a rare and debilitating disorder, characterized by severe impairments in gastrointestinal motility. The affected sites include the enteric/intrinsic autonomic nerves (neuropathy), intestinal smooth muscle cells (myopathy), and interstitial cells of Cajal (mesenchymopathy). The etiology can be genetic, idiopathic, or acquired.

Embedding oxygen heterocycles into BODIPY to enhance intersystem crossing for photodynamic therapy.

By incorporating an oxygen heterocycle into a BODIPY core, near-infrared (NIR) absorbing dyes were successfully prepared. The solid-state structures of these systems were confirmed through X-ray crystallographic analysis. The extended BODIPY compounds exhibited absorption and emission wavelengths in the NIR region (up to = 772 nm and = 807 nm in DMSO).

Vibrio parahaemolyticus VtrB contributes to bile resistance and regulatory influences extend beyond the pathogenicity island (Vp-PAI).

VtrB is a novel ToxR-like transcriptional regulatory protein located on the Vibrio parahaemolyticus pathogenicity island (Vp-PAI). It can be induced by bile to activate the Vp-PAI genes, thereby enhancing the cytotoxicity and enterotoxicity of V. parahaemolyticus.

Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract complicated by protein-losing enteropathy: A case report.

Background: Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract (iNKLPD) is a rare and recently defined entity, recognized in the 2022 WHO classification of hematolymphoid tumors. iNKLPD typically exhibits a benign or slowly progressive clinical course, with disease localized to the gastrointestinal tract. Here, we present what we believe to be the first reported case of iNKLPD associated with protein-losing enteropathy (PLE), characterized by a poor response to chemotherapy and rapid clinical deterioration, culminating in death within a few months.

Two novel Vibrio parahaemolyticus phages (vB_VpaS_1601 and vB_VpaP_1701) can serve as potential biocontrol agents against Vibrio parahaemolyticus infection in seafood.

Vibrio parahaemolyticus poses a serious threat to the aquaculture industry and human health. Two novel phages (vB_VpaS_1601 and vB_VpaP_1701) were isolated from oysters. Phage vB_VpaS_1601 and phage vB_VpaP_1701 exhibited short latent periods and high burst sizes.

Comparative effects of oral nutritional supplementation vs. nutritional education on appetite and weight in older adults with anorexia of aging: a 12-week non-randomized controlled trial.

Background: With global aging, diet education and oral nutritional supplements (ONS) are recognized for improving nutrition and appetite in older adults, yet evidence on anorexia of aging (AA) mechanisms and interventions remains limited in China. This study aimed to evaluate diet education and ONS efficacy for AA in Chinese community-dwelling older adults.

Methods: In an open-label, non-randomized controlled trial, 64 eligible participants were allocated to an ONS group (supplementation) or a diet education group.

Bactericidal synergism between phage and antibiotics: A combination strategy to target multidrug-resistant Klebsiella pneumoniae in vitro and in vivo.

Bacteriophages have reemerged to potentially replace or complement the role of antibiotics, as bacterial viruses have the ability to inactivate pathogens. However, certain intrinsic limitations of phages overshadow their clinical application, particularly their narrow host spectrum and rapid development of resistance upon treatment. This study aimed to explore the synergistic antimicrobial effect of phage combined with antibiotics against Klebsiella pneumoniae.

Safety and Efficacy of Tafamidis in Chinese Patients with Transthyretin Amyloid Cardiomyopathy.

Introduction: Tafamidis is approved in many countries for the treatment of patients with transthyretin amyloid cardiomyopathy (ATTR-CM). Approval is largely based on findings from an international phase 3 trial. This post-approval commitment study aimed to evaluate the safety and efficacy of tafamidis in patients with ATTR-CM in China.

To verify the biological characteristics of disulfidptosis associated gene ADORA2B in esophageal cancer.

Esophageal cancer is an aggressive malignant tumor. Statistics show that esophageal cancer has claimed the lives of approximately 300,000 people worldwide. Many patients are diagnosed as stage 3 or 4 when they visit a doctor; however, the prognosis may not be accurate because the disease's early signs are not always evident.

Video-assisted thoracoscopic lobectomy for a patient with rare partial anomalous pulmonary vein connection: Case report.

Rationale: Partial anomalous pulmonary venous connection (PAPVC) is a rare congenital vascular anomaly that often remains undetected in asymptomatic patients. While most cases are hemodynamically insignificant, failure to recognize PAPVC preoperatively may lead to intraoperative misidentification and surgical complications. Coexistence of PAPVC and lung cancer, particularly on the ipsilateral side, is extremely rare and poses challenges for surgical decision-making.

The derivation of seawater quality criteria and ecological risk assessment of Tonalide.

AHTN (Tonalide) is one of the extensively utilized polycyclic musks (PMs), frequently detected in water ecosystem. It has detrimental impacts on aquatic life, posing a potential threat to marine ecosystems. Therefore, establishing water quality criteria (WQC) for AHTN is paramount for effectively controlling AHTN pollution.

A novel finding relates to the involvement of ATF3/DOCK8 in Alzheimer's disease pathogenesis.

BackgroundThe involvement of microglia is likely to be pivotal in the pathogenesis of Alzheimer's disease (AD) by modulating the deposition of amyloid-β (Aβ) plaques. The deletion of Dedicator of cytokinesis 8 (DOCK8) has a protective effect in mouse with neurodegenerative diseases.ObjectiveTo explore the underlying mechanism of DOCK8 in AD.

Insight into the enhanced performance of the 1-phenylethyl segment in an aza-BODIPY system.

Non-aryl substituted aza-BODIPYs exhibit extraordinary optical properties. 1-Phenylethyl-substituted aza-BODIPY PE-BDP was herein successfully prepared. Based on X-ray crystallographic analysis, 1-phenylethyl segments at 1,7-sites in PE-BDP as a stable mesomer were observed for the first time, and the plane of the phenyl group in the 1-phenylethyl segment is orthogonal to the core of PE-BDP.

Development of a multidimensional 1-year mortality prediction model for patients discharged from the geriatric department: a longitudinal cohort study based on comprehensive geriatric assessment and clinical data.

Background: A poor prognosis within 1 year of discharge is important when making decisions affecting postoperative geriatric inpatients. Comprehensive geriatric assessment (CGA) plays an important role in guiding holistic assessment-based interventions. However, current prognostic models derived from CGA and clinical data are limited and have unsatisfactory performance.

Predictive value of different physical performance assessment methods for falls in older adults: a 3-year longitudinal study in China.

Purpose: This study aimed to analyze the predictive value of different physical performances including short physical performance battery (SPPB), time-up and go test (TUGT), gait speed (GS), five times sit-to-stand test (FTSST) and handgrip strength (HGS) on the incidence of falls among community-dwelling older adults and to propose the cut-off values for predicting the incidence of falls.

Methods: This 3-year longitudinal observational study continuously recruited community-dwelling older adults in 2018, assessing baseline physical performances and recording fall incidence (at least one fall) after 3 years.

Results: Of the 215 older adults (mean age, 84.

Saikosaponin A Mediates the Anti-Acute Myeloid Leukemia Effect via the P-JNK Signaling Pathway Induced by Endoplasmic Reticulum Stress.

Objective: This study aims to investigate the antitumor effects of saikosaponin A (SSA) on acute myeloid leukemia (AML) and elucidate its underlying mechanisms, particularly focusing on the endoplasmic reticulum stress (ERS)-mediated MAPK-p-JNK signaling pathway.

Methods: The inhibitory effects of SSA on the proliferation of AML cell lines K562 and HL60 were evaluated using CCK8 and EdU assays. Apoptotic effects induced by SSA were analyzed via flow cytometry.

Application of 3D printing technology in the surgical management of advanced ovarian serous carcinoma: a case report.

Advanced ovarian serous carcinoma presents significant surgical challenges due to tumor size, deep location, and complex anatomical relationships with surrounding structures. This case report highlights the use of 3D printing technology to improve surgical planning and outcomes in such complex scenarios. A 48-year-old female presented with bilateral ovarian tumors, confirmed as serous cystadenocarcinoma.

PPM1D ameliorates Alzheimer's disease by promoting mitophagy.

Mitochondrial autophagy (mitophagy) plays an essential role in the maintenance of mitochondrial homeostasis. Defective mitophagy triggered by amyloid beta (Aβ) is linked to neuronal deterioration and neurodegeneration in Alzheimer's disease (AD). However, the molecular mechanism underlying the defective mitophagy in AD is still not fully illustrated.

Study on the effect of Western medicine caltrate D combined with traditional Chinese medicine eight section brocade practice therapy on preventing postmenopausal osteoporosis.

Caltrate D is a commonly used drug in the treatment of postmenopausal osteoporosis (PMOP), but the effect of single application is not ideal. Therefore, to investigate the eight section brocade therapy combined with caltrate D effect in preventing and treating PMOP. From January 2021 to June 2022, 110 postmenopausal women with decreased bone mass were selected and randomized into group A (n = 54) and group B (n = 56).