Impact of meteorological factors on influenza incidence in Wuxi from 2014 to 2019: a time series and comprehensive analysis.

Background: Although the association between meteorological factors and influenza was numerously documented, the results are inconsistent, requiring a meta-analysis for synthesis. A recent analysis of the association between influenza and meteorological factors was conducted in Wuxi, China.

Methods: Meteorological data and laboratory-confirmed influenza cases from 2014 to 2019 were collected in Wuxi.

Out-of-Plane Polarization in a 2D Ruddlesden-Popper Hybrid Lead Halide Perovskite Ferroelectric Semiconductor.

Lead halide hybrid perovskite ferroelectric semiconductor materials with out-of-plane polarization show great advantages in ultrathin photoelectric devices, especially vertical sandwich-type ferroelectric devices. However, out-of-plane polarization in lead halide hybrid perovskite ferroelectrics is extremely rare, even for the Ruddlesden-Popper (RP) type. Here, we report an RP lead-based hybrid perovskite ferroelectric semiconductor [3,3-difluoropyrrolidium]PbBr (DPB) with = 1.

Familial spinocerebellar ataxia type 3: A case report of multi-generational presentation.

Rationale: Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease, a rare autosomal dominant neurodegenerative disorder caused by cytosine-adenine-guanine repeat expansions in ATXN3, lacks effective therapies. This case report highlights the clinical and genetic features of a family with 5 affected members to emphasize the challenges in diagnosis, management, and the need for targeted therapies.

Patient Concerns: A 33-year-old male proband presented with progressive gait instability, limb incoordination, and dysarthria for more than 2 years.

Integrative bulk RNA analysis unveils immune evasion mechanisms and predictive biomarkers of osimertinib resistance in non-small cell lung cancer.

Non-small cell lung cancer (NSCLC) is one of the most prevalent and deadliest cancers worldwide, accounting for a significant global health burden. Targeted therapies such as osimertinib, a third-generation EGFR inhibitor, have transformed the treatment landscape for EGFR-mutant NSCLC by offering improved progression-free survival. However, the inevitable development of resistance remains a formidable challenge, necessitating deeper insights into its molecular underpinnings.

Efficacy of Low-Intensity Transcranial Ultrasound Stimulation in Enhancing Motor Recovery via Modulation of Microglial Polarization, Angiogenesis and Neurogenesis in MCAO Rats.

Objective: Low-intensity transcranial ultrasound stimulation (LITUS) is a novel neuromodulation technology characterized by its non-invasive nature, strong penetration, and high spatial resolution, which has been applied in the treatment of neurological diseases. LITUS has demonstrated effectiveness in promoting motor function recovery following stroke; however, the underlying mechanisms remain unclear.

Methods: A rat model of middle cerebral artery occlusion (MCAO) was established using the suture method, followed by a 6-day LITUS intervention initiated 24 h postmodel creation.

Anthropometric and lipid indices in relation to prediabetes and diabetes: A cross-sectional study in resource-limited areas of northwestern China.

Aims: This cross-sectional study was conducted to assess the association of triglyceridemic-waist phenotype, waist-to-height ratio (WHtR), lipid accumulation product (LAP), visceral adiposity index (VAI), and triglyceride-glucose (TyG) index with prediabetes and diabetes (PAD) using data from the Ningxia Cardiovascular Disorders and Related Risk Factors Survey.

Materials And Methods: This study included 10,803 patients. Logistic regression analysis and restricted cubic splines were applied to identify the association between the PAD and each index.

[Retracted] MicroRNA‑181a regulates epithelial‑mesenchymal transition by targeting PTEN in drug‑resistant lung adenocarcinoma cells.

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the scratch wound and cell migration and invasion assay experiments shown in Fig. 2A and B and Fig. 5A‑C, a large number of data panels showed evidence of overlapping data, both within the same figure parts and comparing between figures.

Integrated microfluidic cartridge for rapid and colorimetric detection of Mycoplasma pneumoniae.

Mycoplasma pneumoniae is a major cause of community-acquired pneumonia, yet its diagnosis remains challenging due to overlapping symptoms with other respiratory pathogens. In this study, an integrated microfluidic cartridge platform has been developed that combines three synergistic advancements: a chemical lysis reagent (GuHCl/EDTA) enabling direct genomic DNA release from M. pneumoniae collected by nasal swabs within 2 min without extraction steps, a novel dual-dye system (hydroxy naphthol blue/SYBR Green I) that leverages complementary fluorescence transitions from red to green for enhanced visual discrimination of loop-mediated isothermal amplification (LAMP) results, and a smartphone-based RGB quantification algorithm to standardize interpretation by analyzing colorimetric changes.

Effect of risk-based screening for upper gastrointestinal cancers: a multi-center real-world study.

Background: To evaluate the feasibility, effectiveness, and cost-effectiveness of risk-based sequential screening for upper gastrointestinal (UGI) cancer via questionnaire-based quantitative models.

Methods: We applied the risk-based screening strategy to the ongoing government-administered screening project in two areas (Longde and Litong) of Ningxia Hui Autonomous Region, China. Through epidemiological investigation, participants assessed as high-risk were invited for endoscopic screening.

Alkaline Earth Metal-Based Hybrid Organic-Inorganic Perovskite-Like Ferroelectrics.

Hybrid organic-inorganic perovskites (HOIPs) with the ABX formula have garnered significant scientific interest owing to their substantial technological promise in photovoltaics, optoelectronics and ferroelectrics. Their structural diversity and molecular-scale chemical programmability provide an exceptional platform for engineering diverse functional HOIP architectures through targeted compositional design. However, the strategic potential of alkaline earth metals (e.

Serum moesin is associated with cognitive impairment and glucose fluctuations in patients with type 2 diabetes.

Background: Cognitive impairment is a common complication of type 2 diabetes mellitus (T2DM); however, its underlying mechanisms are unclear. This study investigated the association between serum moesin levels, cognitive impairment, and glucose fluctuations in T2DM patients.

Methods: A total of 229 T2DM patients and 150 healthy controls were enrolled, and patients with T2DM were further categorized into those with mild cognitive impairment (MCI, n = 71) and without MCI (non-MCI, n = 158).

Pharmacological targeting of large tumor suppressor kinases (LATS) 1 and 2 augments tissue repair and regeneration.

Background And Purpose: Large tumor suppressor kinases (LATS1 and 2) are core kinases of the Hippo signalling pathway, directly phosphorylate and inactivate the transcriptional coactivator Yes-associated protein 1 (YAP), playing a pivotal role in cell self-renewal and tissue regeneration. Hippo signalling inhibitors are urgently needed, both as tools for pharmacological studies of the Hippo pathway and as leads for developing novel, molecularly targeted drugs for the treatment of tissue injury and regeneration.

Experimental Approach: An enzyme linked immunosorbent assay (ELISA)-based in vitro high-throughput biochemical assay was used to the identification of a potent and reversible LATS1/2 inhibitor, N-(2-chloro-6-fluorobenzyl)-5-(1H-pyrrolo[2,3-b] pyridin-3-yl) furan-3-carboxamide (named as LPi-1).

Daily validation using a metabolic simulator after regular calibration increases the quality of cardiopulmonary exercise testing.

Background: Gas exchange measurements, such as oxygen uptake ( ) and carbon dioxide output ( ), of cardiopulmonary exercise testing (CPET), are the key and gold standard for human cardiopulmonary functional evaluation. However, in terms of quality control, they are unstable and inaccurate. We used a metabolic simulator (MS) to detect measurement errors and enhance quality control.

Holistic integrative interpretation for similarities and differences of cardiopulmonary exercise testing (CPET) pathophysiological characteristics in patients with left and right heart failure.

Background: This study is based on the theory of Holistic Integrative Physiology and Medicine (HIPM), which emphasizes a comprehensive understanding of the interplay of respiratory-circulatory-metabolic integration regulation. Within this theory, we recognize that left heart failure (LHF) and right heart failure (RHF) present distinct pathophysiological profiles, especially when assessed through cardiopulmonary exercise testing (CPET). We seek to elucidate the similarities and differences in CPET responses between LHF and RHF, thereby enhancing our understanding of their unique exercise pathophysiology.

Impact of personalized accurate intensity exercise on radial artery pulse wave in patients with multi-chronic diseases: a holistic functional assessment approach.

Background: The prevalence of chronic diseases continues to rise. Personalized accurate intensity exercise based on an overall functional evaluation is a useful supplement to medication therapy. The aim of this study is to provide a simple method for detecting human function and evaluating the role of individualized exercise.

SOX4 promotes triple-negative breast cancer progression by promoting SRPX2 transcription to regulate AKR1C1.

Triple-negative breast cancer (TNBC) is a specific subtype of breast cancer that poses a serious threat to women's health. The aldo-keto reductase type 1 C (AKR1C) family serves as a crucial ferroptosis defense system, catalyzing the conversion of aldehydes and ketones into their corresponding alcohols. SRY-Box4 (SOX4), a transcription factor of the SOX (sry-related HMG-box) family, is important in regulating tumor progression.

Tumor-expressing PD-L1 regulates NT5E expression through MAPK/ERK pathway in triple-negative breast cancer.

Objectives: While programmed cell death 1 (PD-1) inhibitors have improved cancer treatment, the function and mechanisms of programmed cell death ligand 1 (PD-L1), particularly when expressed by cancer cells, remain unclear. This study aims to explore the role of PD-L1 within breast cancer cells and identify key targets for future immunotherapy.

Methods: RNA-seq was performed on breast cancer cells with silenced PD-L1 to screen for differentially expressed genes, followed by bioinformatics analysis.

Using easy-to-collect indices to develop and validate models for identifying metabolic syndrome and pre-metabolic syndrome.

Background: This study aimed to develop and validate models for identifying individuals at high risk for metabolic syndrome (MetS) and pre-MetS using easily collectible indices.

Methods: A cross-sectional analysis was conducted using data from the Ningxia Cardiovascular Disorders Survey (NCDS) in China, collected between January 2020 and December 2021. The study population comprised 10,520 participants with complete demographic, anthropometric, and laboratory data.

A hybridization chain reaction-based electrochemical sensor for rapid detection of respiratory pathogens.

Respiratory viral infections continue to pose a significant challenge to global public health. Electrochemical nucleic acid sensors, with their high sensitivity and ease of miniaturization, demonstrate great diagnostic potential. However, the development of high-performance sensors requires comprehensive consideration of factors such as capture probe density, steric hindrance effects, and electrostatic repulsion, which pose significant challenges for the direct detection of long-sequence nucleic acids and limit the application of electrochemical sensors in pathogen diagnosis.

Complete mitochondrial genome of Houttuynia cordata sheds light on the evolution of complex structural features in early angiosperms.

Background: Houttuynia cordata is a well-known medicinal and edible plant with important economic value. It belongs to the magnoliid clade, a basal lineage of angiosperms. Currently, the limited number of reported mitochondrial genomes from magnoliids severely restricts our understanding of early mitochondrial genome evolution.

Utilizing curcumin-mediated blue light photodynamic inactivation for Vibrio vulnificus control and quality preservation of Cynoglossus semilaevis.

Vibrio vulnificus (V. vulnificus) poses severe risks in seafood, yet conventional preservation methods compromise quality. This study investigated curcumin-mediated blue light photodynamic inactivation (PDI) for V.

Structural Phase Transition-Associated Ferroelectricity and Piezoelectric Energy Harvesting in 0D Halogenozincate Hybrid via Cation's Terminal Group Lengthening.

Halogenometallate hybrids have garnered significant research interest for their unique structural properties, making them promising candidates for practical applications. However, due to preparation challenges and stability issues, molecular-based materials with ferroelectric properties are needed. Herein, zero-dimensional (0D) ABX-type halogenozincate hybrids, (CHNR)ZnCl (R = H for 1; methyl for 2; ethyl for 3, n-propyl for 4, and n-butyl for 5), are synthesized.

The role of professional identity, psychological resilience, and coping styles in mitigating compassion fatigue among geriatric services and management interns.

Objective: To examine the impact of professional identity, psychological resilience, and coping styles on compassion fatigue among Geriatric Services and Management interns. It further elucidates how these factors interact within the framework of Kumpfer's resilience model and Lazarus and Folkman's psychological stress and coping theory in managing compassion fatigue.

Methods: A multicenter cross-sectional survey of 654 Geriatric Services and Management interns was designed.

Ultra-simple nucleic acid extraction using a polystyrene microplastic particles-thermal lysis system for rapid detection of pathogen in nasal mucus.

Respiratory infections are a leading cause of death and disability globally and have become an important issue of public concern. Nucleic acid amplification test (NAAT) has been recognized as the gold standard for respiratory infection diagnosis, and played a critical role in epidemic control during the COVID-19 pandemic. However, the laborious nucleic acid extraction limits the application of NAAT in the on-site respiratory infection diagnosis, an effective approach for disease control and prevention.

From human hand joints to continuum robot: how articular surface morphology shapes flexibility and stability in template-based designs.

The design of continuum robots often involves a dilemma between flexibility and stiffness, where increased flexibility may reduce stiffness and control precision. The human hand achieves both power grasp and precision grasp by leveraging different joint structures, particularly in the thumb, which plays a key role in balancing dexterity and stability. Inspired by the three distinct joints of the human thumb, we designed three types continuum manipulators featuring uniaxial, ball-and-socket, and saddle joints (SJ).