Miconazole activates MAPK-driven oligodendrogenesis to promote myelin regeneration and neurological recovery after subarachnoid hemorrhage.

Subarachnoid hemorrhage (SAH) induces multifaceted brain injuries, with white matter injury (WMI) exhibiting dual pathological features resembling traumatic brain injury and cerebral ischemia. Inflammatory responses triggered by SAH lead to extensive axonal and myelin disintegration in white matter, resulting in severe neurological dysfunction. Myelin regeneration post-injury primarily relies on promoting the differentiation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OLs).

Serum levels of interleukin-17, -18, -22, and -25 in patients with bullous pemphigoid before and after treatment.

Objective: This study aimed to explore the relationship between serum levels of interleukin-17 (IL-17), interleukin-18 (IL-18), interleukin-22 (IL-22), interleukin-25 (IL-25), anti-BP180 antibodies, anti-BP230 antibodies, and immunoglobulin E (IgE) and the percentage of eosinophils (EOS) in peripheral blood and disease activity and severity in bullous pemphigoid (BP) patients.

Methods: Blood samples from 61 BP inpatients were collected on the first day of admission and again 1 week after systemic corticosteroid treatment. Additionally, blood specimens were collected from 61 healthy controls.

Anthropometric and lipid indices in relation to prediabetes and diabetes: A cross-sectional study in resource-limited areas of northwestern China.

Aims: This cross-sectional study was conducted to assess the association of triglyceridemic-waist phenotype, waist-to-height ratio (WHtR), lipid accumulation product (LAP), visceral adiposity index (VAI), and triglyceride-glucose (TyG) index with prediabetes and diabetes (PAD) using data from the Ningxia Cardiovascular Disorders and Related Risk Factors Survey.

Materials And Methods: This study included 10,803 patients. Logistic regression analysis and restricted cubic splines were applied to identify the association between the PAD and each index.

Application of an obstetric comorbidity index to predict childhood cancer risk: a population based case-control study in Denmark.

Background: Maternal health during pregnancy appears to impact childhood cancer risk, yet comprehensive studies remain scarce. This study investigates associations between childhood cancer and multiple maternal comorbidities.

Methods: A population-based case-control study was conducted using Danish national registers, with maternal health conditions identified from the National Patient Register and Medical Births Registry.

Turbulence-Resilient Object Classification in Remote Sensing Using a Single-Pixel Image-Free Approach.

In remote sensing, object classification often suffers from severe degradation caused by atmospheric turbulence and low-signal conditions. Traditional image reconstruction approaches are computationally expensive and fragile under such conditions. In this work, we propose a novel image-free classification framework using single-pixel imaging (SPI), which directly classifies targets from 1D measurements without reconstructing the image.

Association between ABO Blood Types and the Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study.

Objective: To investigate the association between ABO blood types and gestational diabetes mellitus (GDM) risk.

Methods: A prospective birth cohort study was conducted. ABO blood types were determined using the slide method.

Using easy-to-collect indices to develop and validate models for identifying metabolic syndrome and pre-metabolic syndrome.

Background: This study aimed to develop and validate models for identifying individuals at high risk for metabolic syndrome (MetS) and pre-MetS using easily collectible indices.

Methods: A cross-sectional analysis was conducted using data from the Ningxia Cardiovascular Disorders Survey (NCDS) in China, collected between January 2020 and December 2021. The study population comprised 10,520 participants with complete demographic, anthropometric, and laboratory data.

Glymphatic dysfunction in classical trigeminal neuralgia: DTI-ALPS index stratification from healthy controls to post-MVD.

Background: The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index is a non-invasive marker of glymphatic function. Its relevance in classical trigeminal neuralgia (CTN), postoperative glymphatic changes after microvascular decompression (MVD), and associations with clinical and structural measures remain unclear. This study aimed to evaluate glymphatic dysfunction in CTN, examine postoperative DTI-ALPS alterations, explore correlations with clinical indicators, and assess relationships with hippocampal, amygdala, and ventricular volumes.

COVID-19 hospitalization place of live discharge outcomes for long-term care facility residents with dementia: Mediation by comorbidities index scores and moderation by health insurance status.

Background And Aim: COVID-19 hospitalization place of discharge outcomes for Long Term Care Facility (LTCF) residents with dementia are less well known for preventing excess mortality in this vulnerable population.

Method: This cross-sectional study utilized the Texas Inpatient Public Use Data File (PUDF) data on LTCF residents with dementia (n = 1,413) and without dementia (n = 1,674) to examine variations in their hospitalization outcomes of live place of discharge, comorbidity scores, and health insurance status.

Results: Dementia diagnosis increased risks of hospice care (OR = 1.

Highly Conductive, Adhesive and Biocompatible Hydrogel for Closed-Loop Neuromodulation in Nerve Regeneration.

Developing conductive hydrogels has led to significant advancements in bioelectronics, especially in the realms of neural interfacing and neuromodulation. Despite this progress, the synthesis of hydrogels that simultaneously exhibit superior mechanical stretchability, robust bioadhesion, and high conductivity remains a significant challenge. Traditional approaches often resort to high filler concentrations to achieve adequate electrical conductivity, which detrimentally affects the hydrogel's mechanical integrity and biocompatibility.

Numerical investigation on jet-enhancement effect and interaction of out-of-phase cavitation bubbles excited by thermal nucleation.

Understanding the formation and interactions of out-of-phase cavitation bubbles is crucial for comprehensively exploring cavitation processes in both nature and engineering applications. In this study, a numerical model for the interaction of out-of-phase cavitation bubbles is developed using the hybrid thermal lattice Boltzmann method, where cavitation bubbles are solely excited by thermal nucleation. Furthermore, a new temperature distribution function for thermal nucleation is proposed, enabling a more stable generation of cavitation bubbles.

Impact of a Virtual Reality Video ("A Walk-Through Dementia") on YouTube Users: Topic Modeling Analysis.

Background: Emerging research has highlighted the potential of virtual reality (VR) as a tool for training health care students and professionals in care skills for individuals with Alzheimer disease and related dementias (ADRD). However, there is limited research on the use of VR to engage the general public in raising awareness about ADRD.

Objective: This research aimed to examine the impact of the VR video "A Walk-Through Dementia" on YouTube users by analyzing their posts.

Graphitic Carbon Nitride Nanomaterials-Based Electrochemical Sensing Interfaces for Monitoring Heavy Metal Ions in Aqueous Environments.

The persistent threat of heavy metal ions (e.g., Pb, Hg, Cd) in aqueous environments to human health underscores an urgent need for advanced sensing platforms capable of rapid and precise pollutant monitoring.

Skin-Mimicking Soft Strain Sensor with Elastic Resilience, Crack Tolerance, and Amphibious Self-Adhesion.

The intrinsic elastic resilience, fatigue resistance, and self-adhesion of human skin are highly desired merits. However, they are challenging to combine into a single mechanoreceptive electronic skin for healthcare monitoring and humanoid soft robots. We introduce an elastically resilient, crack-tolerant, amphibiously adhesive, and strain-sensitive electronic skin (ERCAS-skin) featuring a hierarchical and gradient design.

Tunable Synthesis of 2D Bismuth Oxyhydroxide and Oxysulfide from Solid-Liquid Interfacial Reaction for High Performance Optoelectronic Gas Sensing.

The self-limiting Cabrera-Mott oxidation reaction on metal surfaces provides an effective pathway for synthesizing atomically thin 2D metal oxide. Inspired by this reaction, it is proposed that solid bismuth metals can react with dissolved oxygen and water molecules in an aqueous environment, forming an ultrathin oxyhydroxide layer on their surfaces. The lattice mismatch between the surface oxyhydroxide layer and the underlying pure metal enables the mechanical exfoliation of detached 2D oxyhydroxide nanosheets.

Cytochrome P450 CYP6EM1 confers resistance to thiamethoxam in the whitefly Bemisia tabaci (Hemiptera: Aleyrodidae) via detoxification metabolism.

The whitefly Bemisia tabaci (Hemiptera: Gennadius) is a notorious and highly polyphagous agricultural pest that is well known for its ability to transmit a wide range of serious plant pathogenic viruses. The field populations of B. tabaci in some areas have developed resistance to thiamethoxam.

Personal and Organizational Factors as Predictors of Life Satisfaction Among Older Adults in Long-Term Care Settings.

Background And Aims: Resident satisfaction is a critical indicator of the quality of care in long-term care facilities (LTCFs). Yet, the relative importance quality of care factors in predicting resident satisfaction remains unclear for guiding resident support initiatives. This study aims to identify the relative contribution of personal and facility care service factors as predictors of satisfaction LTCF residents.

Fluorescent Particles Based on Aggregation-Induced Emission for Optical Diagnostics of the Central Nervous System.

In 2001, Tang's team discovered a unique type of luminogens with substantial enhanced fluorescence upon aggregation and introduced the concept of "aggregation-induced emission (AIE)". Unlike conventional fluorescent materials, AIE luminogens (AIEgens) emit weak or no fluorescence in solution but become highly fluorescent in aggregated or solid states, due to a mechanism known as restriction of intramolecular motions (RIM). Initially considered a purely inorganic chemical phenomenon, AIE was later applied in biomedicine to improve the sensitivity of immunoassays.

Occupational exposures and age-related cataract: A review.

Occupational exposures comprise of a broad range of factors in constant and direct contact with the ocular surface. Cataract, a leading cause of visual impairment globally, has been associated with various occupational exposures. This review critically examines existing literature on the relationship between occupational exposures and cataract development.

The evaluation of Congo red staining combined with fluorescence microscopy in the diagnosis of primary cutaneous amyloidosis.

Primary cutaneous amyloidosis (PCA) is a chronic pruritic skin disease. The apple-green birefringence of Congo red-stained amyloid under a polarized light microscope (CR-PLM) remains the gold standard in the diagnosis of PCA. However, there are some limitations to this approach.

Reflection-type orientation-switchable optical differentiator exemplified by the BK7-MoS interface.

Optical differential operation is an ultra-fast edge information extraction technology that enables identifying the image features, whereas current optical differentiators mainly operate along one or two differential orientations and is incompetent for switching the differential orientation. A reflection-type orientation-switchable optical differentiator is proposed and the BK7-MoS interface is used as an example to analyze the edge detection performance. Theory suggests that there are dual modulation methods, one is tuning the incident polarization angle with a Brewster incident angle, and the other one is altering the incident angle with a nearly vertical incident polarization angle.