Impact of meteorological factors on influenza incidence in Wuxi from 2014 to 2019: a time series and comprehensive analysis.

Background: Although the association between meteorological factors and influenza was numerously documented, the results are inconsistent, requiring a meta-analysis for synthesis. A recent analysis of the association between influenza and meteorological factors was conducted in Wuxi, China.

Methods: Meteorological data and laboratory-confirmed influenza cases from 2014 to 2019 were collected in Wuxi.

Design, synthesis, and biological evaluation of aminopyrazine-based ATR/HDACs dual inhibitors.

Ataxia telangiectasia mutated and rad3-related kinase (ATR) and histone deacetylases (HDACs) are important therapeutic targets for cancer. In this study, a series of novel ATR/HDACs dual inhibitors containing 2-aminopyrazine motifs were designed and synthesized for the first time. Compounds 18b and 18c not only exhibited good dual inhibition activity against ATR (IC = 6 and 3 nM) and HDAC6 (IC = 6 and 20 nM), but also showed good anti-proliferative activity against four cancer cell lines.

A novel PARP-ATR dual inhibitor exhibits anti-triple-negative breast cancer activity by inducing excessive DNA damage in the mitotic phase.

Triple-negative breast cancer (TNBC), a particularly aggressive breast carcinoma subtype, exhibits poor clinical outcomes and elevated mortality rates. The therapeutic response to PARP inhibitors (PARPi) is significantly improved in TNBC patients harboring breast cancer susceptibility gene 1/2 (BRCA1/2) mutations compared to naïve patients. Preclinical studies suggested that combination therapy using PARPi and ATR inhibitor (ATRi), which synergistically blocks DNA repair and compromises cell cycle progression, showed promising activity in different cancer models, including TNBC.

Poly(ADP-ribose) polymerase-1 (PARP1)-based dual inhibitors targeting cancer synthetic lethality (2022-present): advances and perspectives.

Poly(ADP-ribose) polymerase 1 (PARP1), a critical enzyme in DNA damage repair (DDR) and genome stability maintenance, has emerged as a pivotal therapeutic target in oncology. PARP1 inhibitors (PARPi) exploit synthetic lethality to selectively target homologous recombination repair (HRR)-deficient cancer cells, revolutionizing treatment for patients with breast cancer susceptibility gene 1/2 (BRCA1/2) mutations and other DNA repair defects. However, monotherapy resistance and limited efficacy in broader patient populations necessitate innovative strategies.

SPNS1 variants cause multiorgan disease and implicate lysophospholipid transport as critical for mTOR-regulated lipid homeostasis.

SPNS1 is a lysosomal transporter that mediates the salvage of lysoglycerophospholipids, the degradative products of lysosomal phospholipid catabolism. However, an understanding of the role of lysolipid transport and salvage in regulating cellular lipid homeostasis and in disease is lacking. Here, we identified members of 2 families with biallelic SPNS1 loss-of-function variants, who presented primarily with progressive liver and striated muscle injury.

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple-Negative Breast Cancer Models.

Concomitant inhibition of ataxia telangiectasia and Rad3-related protein (ATR) and poly ADP-ribose Polymerase (PARP) pathways is a promising strategy in cancer therapy, potentially expanding the clinical utility of ATR inhibitor (ATRi) and PARP inhibitor (PARPi). A novel series of ATR/PARP1 dual inhibitors is developed through the pharmacophore fusion of AZD6738 and Olaparib. Among them, B8 emerges as the most promising candidate, exhibiting potent ATR (IC: 17.

Updated patent review for hematopoietic progenitor kinase (HPK1) inhibitors and degraders (2021-present).

Introduction: Hematopoietic progenitor cell kinase (HPK1) is a serine/threonine kinase of MAP4K family. It negatively regulates T cell receptor and B cell signal transduction. The loss of HPK1 kinase function increases the secretion of cytokines and enhances T cell signal transduction, virus clearance and tumor growth inhibition.

Dissecting the relationships between the insect vector with witches' broom phytoplasma.

Phytoplasmas are phloem-limited bacteria that are primarily transmitted by hemipteran insects and are emerging threats to Decne plants due to their associations with a witches' broom disease. Despite numerous studies, there has been no report on insect transmission of phytoplasma among . Here, transmission characteristics of the leafhopper, Zhang and Liu, 2008 and the phytoplasma in plant leaves through PCR quantification are described.

Rhenium -Tricarbonyl Bisimine Chalcogenide Complexes: Synthesis, Photophysical Studies, and Confocal and Time-Resolved Cell Microscopy.

We describe the preparation, characterization, and imaging studies of rhenium carbonyl complexes with a pyta (4-(2-pyridyl)-1,2,3-triazole) or tapy (1-(2-pyridyl)-1,2,3-triazole)-based heteroaromatic N∧N ligand and thiolate or selenoate X ligand. The stability and photophysical properties of the selenolate complexes are compared with parent chloride complexes and previously described analogues with benzenethiolate ligands. Two complexes were imaged in A549 cells upon excitation at 405 nm.

Mfsd2a utilizes a flippase mechanism to mediate omega-3 fatty acid lysolipid transport.

Major Facilitator Superfamily Domain containing 2a (Mfsd2a) is a sodium-dependent lysophosphatidylcholine (LPC) transporter expressed at the blood-brain barrier that constitutes the main pathway by which the brain obtains omega-3 fatty acids, such as docosahexanoic acid. Mfsd2a deficiency in humans results in severe microcephaly, underscoring the importance of LPC transport by Mfsd2a for brain development. Biochemical studies and recent cryo-electron microscopy (cryo-EM) structures of Mfsd2a bound to LPC suggest that Mfsd2a transports LPC via an alternating access mechanism between outward-facing and inward-facing conformational states in which the LPC inverts during transport between the outer and inner leaflet of a membrane.

Myticofensin, a novel antimicrobial peptide family identified from Mytilus coruscus.

In this study, seven transcripts representing a novel antimicrobial peptide (AMP) family with structural features similar to those of arthropod defensins were identified from Mytilus coruscus. These novel defensins from the Mytilus AMP family were named myticofensins. To explore the possible immune-related functions of these myticofensins, we examined their expression profiles in different tissues and larval stages, as well as in three immune-related tissues under the threat of different microbes.

Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage.

The lysosome is central to the degradation of proteins, carbohydrates, and lipids and their salvage back to the cytosol for reutilization. Lysosomal transporters for amino acids, sugars, and cholesterol have been identified, and the metabolic fates of these molecules in the cytoplasm have been elucidated. Remarkably, it is not known whether lysosomal salvage exists for glycerophospholipids, the major constituents of cellular membranes.

Dichotomy in the Impact of Elevated Maternal Glucose Levels on Neonatal Epigenome.

Context: Antenatal hyperglycemia is associated with increased risk of future adverse health outcomes in both mother and child. Variations in offspring's epigenome can reflect the impact and response to in utero glycemic exposure, and may have different consequences for the child.

Objective: We examined possible differences in associations of basal glucose status and glucose handling during pregnancy with both clinical covariates and offspring cord tissue DNA methylation.

Unexpected self-assembly of chiral triangles from 90° chiral di-Pt(II) acceptors.

Two unexpected chiral organometallic triangles rather than squares from newly designed 90° chiral di-Pt(II) acceptors were obtained through coordination-driven self-assembly. Their structures were well characterized by multinuclear NMR ((1)H and (31)P) and variable-temperature NMR experiments, ESI-TOF-MS, and elemental analysis. The PM6 semiempirical molecular simulation was employed for the interpretation of the formation and stability of such chiral triangles.

A simple fluorescent probe for Cd2+ in aqueous solution with high selectivity and sensitivity.

A simple quinoline-based fluorescent probe, PBQ, which contained a tweezer-like receptor, was successfully developed via one-step synthesis. PBQ exhibited a 40-fold fluorescence enhancement response to Cd(2+) in aqueous solution. PBQ was found to have excellent selectivity for Cd(2+) over many other metal ions (Ba(2+), Mn(2+), Hg(2+), Ni(2+), Ca(2+), Cu(2+), Co(2+), Pb(2+), Mg(2+), Zn(2+), Fe(2+), Fe(3+), Cr(3+), Ag(+), Li(+), Na(+), K(+)).