Structural characterization and biological functions of echinoderm polysaccharides: A review.

Int J Biol Macromol

Shenyang Pharmaceutical University, Shenyang 110016, China; Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Dalian Institute of Marine Traditional Chinese Medicine, Dalian 116622, China. Electronic address:

Published: July 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Echinoderm polysaccharides are integral to the biology of these organisms and have significant implications for ecological interactions and potential applications in science and medicine. Understanding their structure and function can provide insights into marine biology and contribute to the development of new biomaterials and therapeutic agents. Various echinoderm polysaccharides have been discovered, but the structure and functional rules of echinoderm polysaccharides have not been elucidated. This review focuses on the identified structures of polysaccharides reported in recent years, summarizing their structural patterns (including composition, nuclear magnetic resonance, infrared spectroscopy, etc.) This review summarizes several representative structures of polysaccharides from echinoderms (including fucan sulfate, fucosylated chondroitin sulfate and glucan) and their structure-activity relationships. Meanwhile, this review also focuses on the various biological functional activities of polysaccharides from echinoderms, including their anticoagulant, immune regulatory, anticancer and anti-tumor effects, improvement of glucose and lipid metabolism, and antioxidant effects. This review offers valuable reference for the development of these polysaccharides as functional ingredients in food biotechnology and as therapeutic agents in the pharmaceutical industry. Future research into the mechanisms underlying their bioactivity, as well as the factors affecting their efficacy, will further expand their potential applications.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2025.146200DOI Listing

Publication Analysis

Top Keywords

echinoderm polysaccharides
16
polysaccharides
8
potential applications
8
therapeutic agents
8
review focuses
8
structures polysaccharides
8
polysaccharides echinoderms
8
echinoderms including
8
review
5
structural characterization
4

Similar Publications

Background: Brown algae polysaccharides (BAPs), derived from marine brown algae, represent bioactive macromolecules with potential functional feed applications as novel feed additives for improving the health and nutritional quality of aquatic animals. Previous studies have shown that BAPs possess antioxidant, anti-inflammatory, immunomodulatory, antimicrobial, and antiviral activities. BAPs extracted from (UPS) contain kinds of BAPs such as alginate, mannitol, fucoidan and fucoheterosaccharides but there are few studies on the combined effects of these BAPs.

View Article and Find Full Text PDF

Structural characterization and biological functions of echinoderm polysaccharides: A review.

Int J Biol Macromol

July 2025

Shenyang Pharmaceutical University, Shenyang 110016, China; Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Dalian Institute of Marine Traditional Chinese Medicine, Dalian 116622, China. Electronic address:

Echinoderm polysaccharides are integral to the biology of these organisms and have significant implications for ecological interactions and potential applications in science and medicine. Understanding their structure and function can provide insights into marine biology and contribute to the development of new biomaterials and therapeutic agents. Various echinoderm polysaccharides have been discovered, but the structure and functional rules of echinoderm polysaccharides have not been elucidated.

View Article and Find Full Text PDF

Sulfated fucans are functional polysaccharides derived from marine food, including brown algae and echinoderms, and are widely studied for their nutritional value and bioactive properties. Endo-1,3-fucanases are ideal tools for the research and development of sulfated fucans. However, the current understanding of the subsite specificity of endo-1,3-fucanases from the GH107 family remains limited, which hinders their potential applications of fucanases.

View Article and Find Full Text PDF

The digestive system of sea urchins is well-described, but the biochemical properties of the individual organs are only insufficiently characterized. The digestive tract begins in the buccal cavity, surrounded by a biting apparatus called Aristoteles' lantern. It then forms a tubular structure, which runs two times around the body wall, ending at the aboral side of the animal.

View Article and Find Full Text PDF

Tumor associated macrophages (TAMs) participate in the development of tumor, which was reported to dominantly be alternatively activated M2 subtype. Metabolic reprogramming of TAMs into tumor-inhibiting M1 type has shown to be a promising treatment strategy. In this study, we firstly demonstrated fucosylated chondroitin sulfate isolated from sea cucumber Stichopus chloronotus (fCS-Sc) exerted anti-tumor effects.

View Article and Find Full Text PDF