The renoprotective anti-hyperuricemia effect of Cornus officinalis extract in hyperuricemia rats based on network pharmacology and multiple omics.

Ethnopharmacological Relevance: Corus officinalis Siebold & Zucc belongs to the genus Cornus in the Cornaceae family, and was first recorded in the "Shennong Herbal Classic", now has been included in "according to the tradition of both food and Chinese herbal medicines", consist of kidney and liver tonifying, antioxidant substances including cycloid glycosides, flavonoids, polyphenols, organic acids, etc. AIM OF THE STUDY: This study was aimed at discovering the mechanism underlying the anti-hyperemia effect of Cor in rats, particularly its protective effect against liver and kidney dysfunction caused by HUA.

Materials And Methods: In this study, the effect of Cor extract against HUA was verified in rats, subsequently, network pharmacology combined with non-targeted metabolomic were performed to investigate its composition characteristics, and further multi-omics studies and molecular validation were performed to reveal molecular mechanism both in vivo and in vitro.

SOX11 Modulates BCR Signaling Through the PAX5/CD19 Axis for Therapeutic Targeting in BTK Resistant Mantle Cell Lymphoma.

Mantle cell lymphoma (MCL) is an incurable subtype of B-cell non-Hodgkin lymphoma (NHL). Despite multiple approved Bruton tyrosine kinase inhibitors (BTKi), resistance to BTKi continues to pose a major clinical challenge. The transcription factor SOX11 is expressed in most MCL patients and is associated with poor outcomes.

Bioremediation of cadmium-phoxim co-contamination by an autochthonous pollutant-resistant consortium enhances Ligusticum Chuanxiong Hort. resistance.

Prominent cadmium (Cd) pollution and widespread phoxim (pH) use hinder the growth and medicinal value of Ligusticum chuanxiong Hort. (Chuanxiong). While bioremediation by rhizobacteria helps plants counter pollutants, the specific roles of indigenous resistant consortia collected from polluted soils in immobilizing heavy metals, degrading pesticides, and enhancing plant stress tolerance remain insufficiently explored.

Analysis wheat wild relatives Thinopyrum intermedium and Roegneria kamoji genomes reveal different polyploid evolution paths.

Many wild relatives of wheat in the Triticeae tribe provide important genetic resources for crop improvement, but their complex, polyploid genomes shaped by hybridization remain poorly understood. Here, we assemble and analyze the genomes of Thinopyrum intermedium and Roegneria kamoji, two species commonly used in wheat hybridization. We show that Th.

Cu/Zn superoxide dismutase homologs participate in antiviral responses.

Superoxide dismutases (SODs) serve as the first line of defense against reactive oxygen species. Copper-zinc superoxide dismutase () is an enzyme whose activity depends on copper availability. induction is shown to be involved in the antioxidative and antiviral activity of acetylsalicylic acid in hepatitis C virus (HCV)-expressing cells.

Construction of a core collection and SNP fingerprinting database for Chinese chive () through Hyper-seq based population genetic analysis.

Chinese chive ( Rottler ex Sprengel), an autotetraploid vegetable cultivated in Asia for over 3,000 years, possesses apomictic characteristics. However, issues like intricate genetic admixture and unclear phylogenetic relationships pose challenges for effective germplasm preservation and breeding advancements. In this research, we systematically assessed population structure, constructed a core collection, and developed a DNA fingerprinting system utilizing Hyper-seq sequencing data.

Functional analysis of a downregulated guanylate kinase gene associated with the mechanism of action of 6-methylcoumarin against the whitefly Bemisia tabaci.

Background: 6-Methylcoumarin is a botanical compound that displays prominent activity against Bemisia tabaci. The guanylate kinase (GUK) is vital for maintaining intracellular Ca equilibrium. Downregulation of GUK gene expression has been observed in B.

TCA cycle mode switch determines the fate of pirtobrutinib-tolerant persister cells in mantle cell lymphoma.

Bruton's tyrosine kinase inhibitors (BTKi) and cell therapy have successfully been used to treat mantle cell lymphoma (MCL); however, therapy resistance inevitably emerges. Cancer cells can progressively develop stable resistance by traversing through a transient drug-tolerant persister (DTP) state. The mechanisms enabling DTP cells to reversibly adapt to therapies and evolve to acquire heterogeneity remain poorly understood, and characterizing DTP cells in MCL continues to pose a challenge for clinic translation.

The latent mechanism behind binocular advantage in reading.

Most individuals read binocularly, and previous studies have found a binocular advantage in reading speed. However, the underlying mechanism of the binocular advantage in reading remains unclear. In our study, we quantified contributions from basic visual functions, basic oculomotor functions, and reading-specific eye movements to the binocular advantage in Chinese reading speed, using six tasks and 32 metrics.

Anterograde interference in multitask perceptual learning.

Learning to perform multiple tasks robustly is a crucial facet of human intelligence, yet its mechanisms remain elusive. Here, we formulated four hypotheses concerning task interactions and investigated them by analyzing training sequence effects through a continual learning framework. Forty-nine subjects learned seven tasks sequentially, each of the seven groups following a distinct sequence.

Transdermal administration of herbal essential oil alleviates high-fat diet-induced obesity by regulating metabolism and gut microbiota.

Introduction: Obesity, a global health challenge, is characterized by excessive fat accumulation and associated metabolic disorders. The ZhiZhu decoction, a traditional Chinese herbal formula consisting of L. (ZS, ZhiShi in Chinese) and (BZ, Baizhu in Chinese), is widely recognized in clinics for its gastrointestinal regulatory effects.

3'UTR of tobacco vein mottling virus regulates downstream GFP expression and changes in host gene expression.

Introduction: Tobacco vein mottling virus (TVMV) is a member of the family . The 3' untranslated region (3'UTR) of viral genomic RNA has been reported to significantly impact viral infection. Nevertheless, the role of the TVMV 3'UTR during viral infection remains unknown.

The coexistence of low muscle mass and obesity evaluated by dual energy X-ray absorptiometry, rather than low muscle mass or obesity alone, is associated with macrovascular but not microvascular complications in patients with type 2 diabetes mellitus.

Aim: The prevalence of the coexistence of low muscle mass and obesity is increasing, particularly with a rising trend observed in patients diagnosed with type 2 diabetes mellitus (T2DM). However, the association between the coexistence of low muscle mass and obesity and diabetic complications remains unclear. This study aimed to investigate these associations in patients with T2D.

Targeting ferroptosis in autoimmune diseases: Mechanisms and therapeutic prospects.

Ferroptosis is a form of regulated cell death that relies on iron and exhibits unique characteristics, including disrupted iron balance, reduced antioxidant defenses, and abnormal lipid peroxidation. Recent research suggests that ferroptosis is associated with the onset and progression of autoimmune disorders such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). However, the precise effects and molecular mechanisms remain incompletely understood.

Biostimulation accelerates landfill stabilization and resource utilization efficiency, providing feasible technical support for the overall lifecycle management of landfills.

Although sanitary landfill is one of the principal municipal solid waste (MSW) treatment and disposal methods, its limitations, such as insufficient use of resources, long stability time, and high risk of environmental pollution, must be urgently resolved. The effect of multifunctional microbial community (MMC) inoculation on MSW landfill process was investigated using simulated anaerobic bioreactor landfill (ABL), and composition and microbial community structure of waste, leachate water quality, and gas production were monitored. MMC inoculation significantly accelerated lignocellulose degradation, and the (Hemicellulose content + Cellulose content)/Lignin content ((C + H)/L) of MMC inoculation treatment was 0.

Relation between blood pressure time in range and composite cardiovascular outcomes in patients with primary aldosteronism: a retrospective case study.

Purpose: To investigate the association between blood pressure (BP) time in range (TIR) and composite cardiovascular outcomes in patients with primary aldosteronism (PA).

Methods: Between January 2019 and December 2021, 47 patients with PA were recruited from the First Affiliated Hospital of Xiamen University. Twenty-four-hour ambulatory BP monitoring (ABPM) and cardiovascular outcomes were assessed in all patients during the first diagnosis of PA.

Identification and experimental validation of immune-related gene PPARG is involved in ulcerative colitis.

Background: The pathophysiology of ulcerative colitis (UC) is believed to be heavily influenced by immunology, which presents challenges for both diagnosis and treatment. The main aims of this study are to deepen our understanding of the immunological characteristics associated with the disease and to identify valuable biomarkers for diagnosis and treatment.

Methods: The UC datasets were sourced from the GEO database and were analyzed using unsupervised clustering to identify different subtypes of UC.

A novel strategy for detoxification of deoxynivalenol via modification of both toxic groups.

Deoxynivalenol (DON) is the most abundant mycotoxin in cereal crops and derived foods and is of great concern in agriculture. Bioremediation strategies have long been sought to minimize the impact of mycotoxin contamination, but few direct and effective enzyme-catalyzed detoxification methods are currently available. In this study, we established a multi-enzymatic cascade reaction and successfully achieved detoxification at double sites: glutathionylation for the C-12,13 epoxide group and epimerization for the C-3 hydroxyl group.

Synergistic action and mechanism of scoparone, a key bioactive component of Artemisia capillaris, and spirodiclofen against spider mites.

Background: Plants have numerous defensive secondary metabolites to withstand insect attacks. Scoparone, which is extracted from the medicinal plant Artemisia capillaris, has potent acaricidal effects on Tetranychus cinnabarinus. Spirodiclofen, derived from a tetronic acid derivative, is a potent commercial acaricide that is extensively used globally.

Feasibility and limitations of combined treatment for lateral pelvic lymph node metastases in rectal cancer.

Colorectal cancer ranks among the most commonly diagnosed cancers globally, and is associated with a high rate of pelvic recurrence after surgery. In efforts to mitigate recurrence, pelvic lymph node dissection (PLND) is commonly advocated as an adjunct to radical surgery. Neoadjuvant chemoradiotherapy (NACRT) is a therapeutic approach employed in managing locally advanced rectal cancer, and has been found to increase the survival rates.