Age-Specific Association Between Cumulative Blood Pressure Exposure and Atrial Fibrillation Risk in Adults.

Background: The association between cumulative blood pressure (BP) exposure and atrial fibrillation (AF) risk across different age groups remains unclear.

Methods: We analyzed 77 180 participants from the Kailuan Study who were free of AF and had complete BP data from 2006 to 2010. Time-weighted average BP was calculated as the sum of each interval's mean BP multiplied by the corresponding time interval, divided by total exposure duration.

Cu/Zn superoxide dismutase homologs participate in antiviral responses.

Superoxide dismutases (SODs) serve as the first line of defense against reactive oxygen species. Copper-zinc superoxide dismutase () is an enzyme whose activity depends on copper availability. induction is shown to be involved in the antioxidative and antiviral activity of acetylsalicylic acid in hepatitis C virus (HCV)-expressing cells.

Analysis of a Near-Missing RhDV Type 1 Detection.

Background: The safety of blood transfusion can be significantly affected by complex blood group antigens, especially the polymorphic Rh blood group system. This case study is to alert clinicians and laboratory personnel to accurately identify and manage RhD blood groups.

Methods: A Chinese female patient with cervical squamous cell carcinoma underwent surgical treatment; her blood typing identified that she had serological type A and different RhD titers to the anti-D reagent.

Case Analysis of a Repeated Hydrops Fetalis Caused by Irregular Antibodies of Anti-E and Anti-c.

Background: Blood group irregular antibody is a major factor that may cause adverse pregnancy outcomes. We aimed to emphasize the importance of prenatal blood antibody screening and popularize antenatal care knowledge by sharing a case of hydrops fetalis caused by anti-E and anti-c alloimmunization antibodies.

Methods: We retrospectively analyzed the clinical and laboratory data of a pregnant woman with repeated fetal edema caused by anti-E and anti-c irregular antibodies.

OGT-regulated O-GlcNAcylation promotes the malignancy of colorectal cancer by activating STAT2 to induce macrophage M2: OGT protein macromolecule action.

O-GlcNAcylation, as an important glycosylation modification, plays a key role in cancer progression. The purpose of this study was to investigate the role of OGT (O-GlcNAc transferase) in the regulation of O-GlcNAcylation and macrophage M2 polarization, especially in the malignant progression of cancer. The expression of OGT in COAD (colorectal adenocarcinoma) was identified by bioinformatics analysis, and its function was detected by cell culture and stimulation techniques.

Transient Expression of Hen Egg White Lysozyme (EWL) in Influences Plant Pathogen Infection.

Lysozyme is an enzyme that hydrolyzes bacterial cell walls, which is functional for destroying the integrity of bacteria, enhancing the activity of immune cells, participating in immune signal transmission, helping to maintain the micro-ecological balance of the gastrointestinal tract, etc. Egg white lysozyme (EWL), as one of the typical representatives of lysozyme, is the most widely used enzyme in production so far, and is also one of the most complex structures of lysozyme. EWL also helps protect plants from fungal and bacterial diseases.

Resveratrol synthase homologs participate in infection of by pathogenic plant viruses and fungi.

Introduction: Resveratrol synthase (RS) is a key enzyme involved in the synthesis of stilbene and resveratrol. Resveratrol has many biological pharmacological activities that are beneficial to human health including anti-cancer, cardiovascular protection, estrogen regulation, antibacterial, antiviral, and reduction of tissue and organ damage. In plants, RS catalyzes the production of resveratrol, which helps to protect against fungal and bacterial diseases.

Identify a Novel ABO Allele Similar to ABO*AW.41 Allele with Additional c. 467C>T.

Background: Accurate identification of the ABO blood group is of great significance in ensuring the safety of clinical blood transfusions. Using molecular technologies combined with serological testing helps to identify the new ABO variants.

Methods: The traditional serological blood type test was performed for a 4-year-old Chinese boy, and the result showed a weaker agglutination with anti-A reagent (3+ strength by microcolumn gel card method; 2+ strength by saline tube method).

A case report on the implantation of a leadless pacemaker in a patient with eosinophilic fasciitis and third-degree atrioventricular block.

Eosinophilic fasciitis (EF) is a rare connective tissue disorder characterized by the involvement of the dermis, subcutaneous tissue, and fascia. The treatment for EF usually involves long-term use of glucocorticoids and immunosuppressants. Patients with EF are at risk of developing third-degree atrioventricular (AV) block during the course of the disease.

A Rare Case of Intraoperative Transfusion-associated Hypotension in a Chinese Pregnant Patient.

Background: Transfusion-associated hypotension (TAH) is characterized by the abrupt onset of hypotension immediately after the start of transfusion and usually resolves when transfusion ceases. The pathogenesis of TAH is not yet fully understood.

Methods: A 36-year-old woman underwent exploratory laparotomy and cesarean section due to cervical squamous cell carcinoma.

Characterization of the wall-associated kinase (WAK) gene family in Gossypium barbadense reveals the positive role of GbWAK5 in salt tolerance.

We characterized the WAK gene family in Gossypium barbadense and revealed the potential function of GbWAK5 in regulating salt tolerance by modulating ion homeostasis. Soil salinization is one of the main factors restricting cotton production. Although the role of the wall-associated kinases (WAKs) in plants has been extensively studied, its response to salt stress in sea-island cotton (Gossypium barbadense L.

[Protective effect of Codonopsis Radix fermented with Lactobacillus plantarum on gastric mucosa in rat model of acute gastric ulcer].

This study aims to decipher the mechanism of the broth of Codonopsis Radix fermented with Lactobacillus plantarum(FCR) on the gastric mucosa in the rat model of acute gastric ulcer. A total of 64 SD rats were randomized into 8 groups: control, model, positive control(omeprazole), probiotic, unfermented Codonopsis Radix, and low-, medium-and high-dose FCR, with 8 rats in each group. The rat model of acute gastric ulcer was established by gavage with anhydrous ethanol.

Versatile roles for neutrophil proteinase 3 in hematopoiesis and inflammation.

Neutrophil proteinase 3 (PR3), cathepsin G, elastase, and neutrophil serine protease 4 constitute the neutrophil serine protease family. These four members share varying sequence homology and functional similarities with each other. However, PR3 stands out as a unique autoantigen, serving as a primary autoantigen in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

LZU-J-Q21 enhanced the functional metabolic profile and bioactivity of .

Microbial fermentation is an effective method to enhance the bioavailability of herbs. This study utilized LZU-J-Q21 to ferment and evaluated its metabolic properties and biological activity. Results showed that the contents of total acid and flavone, and the clearance rates of DPPH, ABTS and OH in fermented (FCD) were increased by 142.

Identification of a Novel Mutation in B Allele in a Chinese Individual.

Background: There are 49 B alleles in the ISBT ABO blood group list. This study will describe a new missense mutation, c.784G>T, in exon 7 of the ABO in a Chinese individual.

3'UTR of tobacco vein mottling virus regulates downstream GFP expression and changes in host gene expression.

Introduction: Tobacco vein mottling virus (TVMV) is a member of the family . The 3' untranslated region (3'UTR) of viral genomic RNA has been reported to significantly impact viral infection. Nevertheless, the role of the TVMV 3'UTR during viral infection remains unknown.

syn-tasiRnas targeting the coat protein of potato virus Y confer antiviral resistance in .

Trans-acting small interfering RNAs (tasiRNAs) are 21-nt phased (phased siRNAs) resulting from successive DCL-catalyzed processing from the end of a double-stranded RNA substrate originating from the RDR of an AGO-catalyzed cleaved RNA at a micro RNA target site. Plant tasiRNAs have been synthesized to produce synthetic tasiRNAs (syn-tasiRNAs) targeting viral RNAs that confer viral resistance. In this study, we engineered syn-tasiRNAs to target potato virus Y (PVY) infection by replacing five native siRNAs of TAS1c with 210-bp fragments from the coat protein (CP) region of the PVY genome.

The homeodomain transcription factor CEH-37 regulates PMK-1/p38 MAPK pathway to protect against intestinal infection via the phosphatase VHP-1.

Increasing evidence indicate that the expression of defense genes at the right place and the right time are regulated by host-defense transcription factors. However, the precise mechanisms of this regulation are not well understood. Homeodomain transcription factors, encoded by homeobox genes, play crucial role for the development of multicellular eukaryotes.

Strategies for Engineering Virus Resistance in Potato.

Potato () is an important vegetable crop that plays a pivotal role in the world, especially given its potential to feed the world population and to act as the major staple food in many developing countries. Every year, significant crop loss is caused by viral diseases due to a lack of effective agrochemical treatments, since only transmission by insect vectors can be combated with the use of insecticides, and this has been an important factor hindering potato production. With the rapid development of molecular biology and plant genetic engineering technology, transgenic approaches and non-transgenic techniques (RNA interference and CRISPR-cas9) have been effectively employed to improve potato protection against devastating viruses.

Baixiangdan capsule and Shuyu capsule regulate anger-out and anger-in, respectively: GB1-mediated GABA can regulate 5-HT levels in multiple brain regions.

The identity of the mechanism by which the Baixiangdan capsule (BXD) and the Shuyu capsule (SY) control anger-out (AO) and anger-in (AI) in rodents is unclear. The current study clarified the intervention role of BXD and SY on AO and AI male rats. We further explored the differences between BXD and SY in the treatment of AO and AI rats.

Dioscin integrates regulation of monosaturated fatty acid metabolism to extend the life span through XBP-1/SBP-1 dependent manner.

Delay aging, especially in healthy life extension, brought the most interest to the medical field. Searching for anti-aging drugs with relative safety profiles bring natural products in hotspot. In this study, we find that dioscin promotes the health span extension in wild-type .

Xiangshao Granules reduce the aggressive behavior and hippocampal injury of premenstrual irritability in rats by regulating JIK/JNK/p38 signal pathway.

Ethnopharmacological Relevance: As a typical prescription for soothing the liver, Xiangshao granule has a good effect on the symptoms of irritability and anxiety. Clinical evidence suggests that it has significant efficacy in the treatment of Premenstrual dysphoria disorder (PMDD). However, the underlying mechanism remains unclear.

A Rare Case of Hemolytic Transfusion Reaction in a Premature Infant Caused by a Passive Anti-Jka Antibody.

Hemolytic transfusion reaction (HTR) is an important type of transfusion-associated reaction and usually occurs after alloimmunization to red blood cell antigens. The HTRs caused by passively transferred Kidd blood group antibodies are not well documented. Here, we report about a premature infant who developed HTR owing to a passive anti-Jka antibody transfer following fresh frozen plasma transfusion.