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Article Abstract
Background: The safety of blood transfusion can be significantly affected by complex blood group antigens, especially the polymorphic Rh blood group system. This case study is to alert clinicians and laboratory personnel to accurately identify and manage RhD blood groups.
Methods: A Chinese female patient with cervical squamous cell carcinoma underwent surgical treatment; her blood typing identified that she had serological type A and different RhD titers to the anti-D reagent. RHD genetic testing was performed.
Results: After RHD gene sequencing, the patient was confirmed as RhDV Type 1; 1.5 units of type A RhD-negative suspended red blood cells were transfused to the patient, and the hemoglobin level increased from 66 to 73 g/L. No adverse reaction occurred, and the patient recovered well after surgery.
Conclusions: RhD antibody reagents from different manufacturers are required to identify the RhD subtypes and ensure transfusion safety.
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Background: The safety of blood transfusion can be significantly affected by complex blood group antigens, especially the polymorphic Rh blood group system. This case study is to alert clinicians and laboratory personnel to accurately identify and manage RhD blood groups.
Methods: A Chinese female patient with cervical squamous cell carcinoma underwent surgical treatment; her blood typing identified that she had serological type A and different RhD titers to the anti-D reagent.
Chimeric virus-like particles replacing the loop on the surface of VP60 from rabbit hemorrhagic disease virus (RHDV) provide protection against two serotypes of RHDV.
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August 2025
State Key Laboratory of Veterinary Public Health and Safety, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People's Republic of China. Electronic address:
In recent years, the rabbit hemorrhagic disease virus 2(RHDV GI.2) has rapidly spread worldwide due to its broad natural host range, strong pathogenicity, and significant antigenic differences from the traditional RHDV1 (GI.1).
View Article and Find Full Text PDFNeglected Spleen Transcriptional Profile Reveals Inflammatory Disorder Conferred by Rabbit Hemorrhagic Disease Virus 2 Infection.
Viruses
March 2024
Sichuan Provincial Key Laboratory of Animal Breeding and Genetics, Sichuan Animal Science Academy, Chengdu 610066, China.
Rabbit hemorrhagic disease (RHD) is an acute fatal disease caused by the rabbit hemorrhagic disease virus (RHDV). Since the first outbreaks of type 2 RHDV (RHDV2) in April 2020 in China, the persistence of this virus in the rabbit population has caused substantial economic losses in rabbit husbandry. Previous failures in preventing RHDV2 prompted us to further investigate the immune mechanisms underlying the virus's pathogenicity, particularly concerning the spleen, a vital component of the mononuclear phagocyte system (MPS).
View Article and Find Full Text PDFSerological characterisation of virus-like particles originating from native and mutated VP60 of rabbit haemorrhagic disease virus 2 and European brown hare syndrome virus.
J Vet Res
March 2024
Department of Foot and Mouth Disease, National Veterinary Research Institute, 24-100 Puławy, Poland.
Introduction: Since lagoviruses cannot be cultivated , using expression systems is an alternative and promising way of producing diagnostic viral antigens. It opens up their use as active immunogens for vaccine production.
Material And Methods: Virus-like particles (VLPs) were produced in a baculovirus expression system in 9 (Sf9) insect cells based on wild-type and mutated variants of the virus capsid VP60 protein from a Polish strain of European brown hare syndrome virus (EBHSV) and wild-type and mutated versions of this protein from a Polish strain of rabbit haemorrhagic disease virus 2 (RHDV2).
Recombination between non-structural and structural genes as a mechanism of selection in lagoviruses: The evolutionary dead-end of an RHDV2 isolated from European hare.
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January 2024
Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna Via Bianchi 9, 25124 Brescia, Italy.
Article Synopsis
- The genus Lagovirus, part of the Caliciviridae family, includes both lethal viruses like rabbit hemorrhagic disease virus (RHDV) and European brown hare syndrome virus (EBHSV) and non-lethal ones such as rabbit calicivirus (RCV) and hare calicivirus (HaCV).
- Lagoviruses have two main genetic lineages: GI in rabbits (including RHDV and RCV) and GII in hares (including EBHSV and HaCV), with significant genetic recombination occurring at specific genomic junctions.
- A new strain known as RHDV type 2 (RHDV2) emerged in 2010 due to