A study of criteria-based online adaptive radiotherapy with radiomics and dosimetry for postoperative prostate cancer.

Background: Online adaptive radiotherapy (OART) can address the reduction in radiation therapy precision caused by changes such as tumor shrinkage, rectal gas filling, and bladder distension. Currently, the determination of OART triggers during the fractions of radiotherapy requires clinicians to spend considerable effort and time on-site for assessments.

Objective: To reduce the clinical workload while maintaining the precision of radiotherapy, this study aims to explore the feasibility of developing a triggered OART prediction model for postoperative prostate cancer by combining radiomics and dosimetric features using machine learning.

prevents NRF2 nuclear translocation to drive hypoperfusion-related cognitive deficits by targeting .

-based therapeutics represent a promising approach for treating multiple diseases, yet the key regulatory in chronic cerebral hypoperfusion (CCH)-related cognitive impairment remains unclear. Here, we identify as consistently upregulated in both male and female mild cognitive impairment (MCI) and late-stage of Alzheimer's disease (AD) patients, as well as in the basal forebrain of both male and female postmortem AD specimens and male CCH rats. Knockdown of in the basal forebrain alleviated CCH-induced cognitive deficits.

Mapping QTLs for adult-plant resistance to yellow rust in a hard winter wheat population Heyne × Lakin.

Adult-plant resistance to yellow rust, caused by Puccinia striiformis f. sp. tritici, is a durable type of resistance in wheat (Triticum aestivum L.

A nomogram model to predict grade ≥2 acute radiation enteritis in older adult patients with cervical cancer.

Introduction: Acute Radiation Enteritis (ARE) is a common complication of pelvic radiotherapy, with incidence rates exceeding 60% in older adult populations. Especially, grade ≥2 ARE can lead to treatment interruptions, malnutrition, and even septic shock, thereby impairing patients' quality of life and survival outcomes. However, existing risk prediction models are predominantly developed based on younger populations or mixed cohorts, lacking sophisticated evaluation tools tailored to older adult patients.

The gene influences the multiple stresses tolerance by affecting cytochrome c in N8.

, an internationally recognized safe species of Gram-positive bacteria, produces a variety of antimicrobial peptides. In this study, we examined the gene of N8 and its influence on the bacterial stress response. We used the Cre-loxP system to knock out the gene from the N8Δ genome.

Traditional Chinese medicine therapies for insomnia: An umbrella review and evidence map.

Background: An increasing number of systematic reviews and meta-analyses (SR/MAs) suggests traditional Chinese medicine therapies are effective for insomnia. We aimed to synthesize and evaluate the methodological quality of these studies through an umbrella review with an evidence map for improving evidence quality.

Methods: We searched 10 databases from inception to March 20, 2025, that investigated the effects of TCM therapies on sleep-related subjective or objective outcomes for insomnia.

Comparative analysis of chloroplast genomes within Saxifraga sect. Ciliatae: insights into their adaptation to the alpine environment.

Saxifraga sect. Ciliatae, comprising about 200 species, primarily concentrated in the Qinghai-Tibet Plateau (QTP), exhibits high species richness in alpine regions, showing variations in habitat, morphology, physiology, and life cycles. Its adaptation to alpine environments renders it ideal for understanding the genetic basis of how species cope with cold climates.

Predictive biomarkers in the gut microbiome and metabolome for severe acute radiation enteritis in cervical cancer radiotherapy.

Introduction: Radiation enteritis (RE), a common side effect, is a growing health concern, particularly the severe acute form of RE (SARE), among cervical cancer patients undergoing radiation therapy. Currently, there is no noninvasive diagnostic method for SARE. This study aimed to identify gut microbiomics- and metabolomics-based signatures, and assess their predictive value for SARE.

Protective effects of AER-271 in acute-phase radiation-induced brain injury in rats: reduction of brain edema, inflammation, apoptosis and maintenance of blood-brain barrier integrity.

Objective: The expression changes of aquaporin-4 (AQP4) in radiation-induced brain jinjury (RIBI) and whether it is involved in the pathologic development of RIBI are currently unknown. In this study, we constructed a RIBI model by whole-brain radiation of Sprague-Dawley (SD) rats and tried to reveal the role of AQP4 in RIBI. The specific inhibitor AER-271 was used to inhibit the expression of AQP4 in RIBI to explore its neuro-protective effect.

Evidence-based evaluation for stroke guidelines mentioning traditional and complementary medicine rehabilitation.

Background: Traditional and complementary medicine (T&CM) is often sought as an significant alternative intervention in stroke prevention and rehabilitation, and is recommended in several guidelines. However, little is known about the quality and consistency of T&CM rehabilitation recommendations for stroke in the guidelines.

Methods: We systematically searched PubMed, Embase, CNKI, WOS, CBM, Duxiu, Wanfang, VIP, GIN, NICE, NGC, SIGN, BGS, NCCN, WHO guidelines, Google Scholar, MedSci, and Medilive from January 1990 to April 2024 for stroke rehabilitation guidelines that include T&CM recommendations.

Amorfrutin A ameliorates cerebral ischemia/reperfsion injury and modulating Nrf2/HO-1 signaling pathway.

Ischemic stroke is a leading cause of death and disability worldwide. Amorfrutin A (AA), a small molecule compound found in L. (bastard indigo), possesses various activities, including blood glucose regulation, antiinflammatory, analgesic, and tumor suppression.

Acid sphingomyelinase recruits palmitoylated CD36 to membrane rafts and enhances lipid uptake.

CD36 palmitoylation increases its membrane localization and is required for CD36-mediated uptake of oxidized low-density lipoprotein (oxLDL). Acid sphingomyelinase (ASMase) is transported to the plasma membrane, where it promotes lipid raft clustering, facilitating membrane protein anchoring for biological functions. We investigated the effects of oxLDL on CD36 palmitoylation and explored the role of ASMase in CD36 membrane translocation.

Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development.

Gut organoids are 3D cellular structures derived from adult or pluripotent stem cells, capable of closely replicating the physiological properties of the gut. These organoids serve as powerful tools for studying gut development and modeling the pathogenesis of intestinal diseases. This review provides an in-depth exploration of technological advancements and applications of gut organoids, with a focus on their construction methods.

Global patterns and burden of soft tissue and extraosseous sarcomas: trends from 1990 to 2021.

Background: Soft tissue sarcomas (STS) are a rare group of malignant tumors originating from soft tissues. The study systematically evaluates the global burden of soft tissue and extraosseous sarcomas from 1990 to 2021 across diverse populations.

Methods: We examined incidence, mortality, and disability-adjusted life years (DALYs) using data from the Global Burden of Disease (GBD) 2021 database.

Regulation of P2/O3 layered-oxide cathode by cation potential and dual-site doping provides excellent electrochemical performance.

Enhancing the cycle stability of sodium-ion battery cathode materials at high current rates remains a critical challenge. Although layered oxides exhibit high capacity, their long-term stability requires improvement. In this study, we present a low-Ni, Co-free P2/O3-NaKCaNiFeMnMgO layered oxide, engineered through dual-site doping and cation potential to create a stable two-phase structure The synergistic effects of K-Ca-Mg co-doping and the P2/O3 hybrid structure effectively suppress detrimental phase transitions and Na/vacancy ordering at high voltage, enhancing both rate capability and cycle stability.

Artemisinin analogues are effective in the treatment of psoriasis by targeting RORγt.

Psoriasis is a chronic inflammatory skin autoimmune disease. Th17 cells, when pathologically activated, significantly contribute to the progression of psoriasis. The symptoms of this skin condition could be notably alleviated by targeting and suppressing the activity of these cells.

Therapeutic and prognostic impact of target volume delineation in postoperative radiotherapy for high-grade glioma patients with subventricular zone involvement.

Objective: This study aimed to analyze the effect of target volumes for radiotherapy and dose on the prognosis of high-grade glioma (HGG) patients when the tumor involves the subventricular zone (SVZ), and to provide a reference for postoperative target volume delineation in HGG patients with SVZ involvement.

Methods: The clinical and pathological data were collected from 50 HGG patients with SVZ involvement were collected in the Department of Neurosurgery of the First Affiliated Hospital of Soochow University during the period from January 1, 2017 to December 31, 2020. The average dose (Dmean) of the whole ipsilateral and contralateral SVZs as well as the V45Gy and V60Gy of the whole ipsilateral SVZs of the tumor were derived from the dose-volume histograms (DVH).

Preparation and characterization of mesoporous core-shell bioactive glass-based cements for direct pulp capping.

Direct pulp capping is crucial for maintaining dental pulp vitality. The materials employed for this purpose should possess properties such as easy-handling, excellent biocompatibility, infection resistance, and the ability to stimulate the formation of reparative dentin. Mineral trioxide aggregate (MTA) is commonly used for pulp capping.

c-di-GMP inhibits rRNA methylation and impairs ribosome assembly in the presence of kanamycin.

Cyclic diguanosine monophosphate (c-di-GMP) is a ubiquitous bacterial secondary messenger with diverse functions. A previous Escherichia coli proteome microarray identified that c-di-GMP binds to the 23S rRNA methyltransferases RlmI and RlmE. Here we show that c-di-GMP inhibits RlmI activity in rRNA methylation assays, and that it modulates ribosome assembly in the presence of kanamycin.

The choice of adjuvant radiotherapy in pancreatic cancer patients after up-front radical surgery.

Background: The role of adjuvant radiotherapy in pancreatic cancer following radical surgery remains a subject of of controversy. This study aimed to more accurately screen pancreatic patients who benefit from adjuvant radiotherapy.

Methods: Clinicopathologic characteristics of patients with resectable pancreatic cancer were collected from the Surveillance, Epidemiology, and End Results (SEER) database (2004-2015).

Nox1/PAK1 is required for angiotensin II-induced vascular inflammation and abdominal aortic aneurysm formation.

NADPH oxidase 1 (Nox1) is a major isoform of Nox in vascular smooth muscle cells (VSMCs). VSMC activation and extracellular matrix (ECM) remodelling induce abdominal aortic aneurysm (AAA). In this study, we aim to determine the role of Nox1 in the progression of AAA and explore the underling mechanism.

Investigation of the Interaction Between Angiotensin-Converting Enzyme (ACE) and ACE-Inhibitory Tripeptide from Casein.

Angiotensin-converting enzyme (ACE) inhibitory peptides exhibit antihypertensive effects by inhibiting ACE activity, and the study of the interaction between ACEs and inhibitory peptides is important for exploring new therapeutic strategies. In this study, the ACE-inhibitory peptide isolated from casein hydrolysate with the amino acid sequence Leu-Leu-Tyr (LLY) exhibited high ACE-inhibitory activity and stability, which holds significant implications for biochemistry and pharmaceutical applications. Furthermore, systematic investigations were conducted on the interaction between ACE and LLY through various approaches.

Mouse Small Intestinal Organoid Cultures.

The intestinal epithelium is a highly dynamic and self-renewing tissue that is crucial for maintaining gut homeostasis. It can be cultured in vitro from isolated crypts to form three-dimensional (3D) intestinal organoids. These organoids have the ability to proliferate and differentiate into various epithelial cell lineages, offering a more physiologically relevant model compared to traditional two-dimensional (2D) culture systems.

Production, Characterization, and Application of Hydrophobin-Based IR780 Nanoparticles for Targeted Photothermal Cancer Therapy and Advanced Near-Infrared Imaging.

As a promising approach for breast cancer treatment, photothermal therapy (PTT) features high spatial selectivity, noninvasiveness, and minimal drug resistance. IR780 (a near-infrared fluorescent dye) serves as an effective photosensitizer in PTT cancer therapy. However, the clinical application of IR780 in PTT has been hindered by its poor water solubility and unstable photostability.

Screening of biomarkers in acute radiation enteritis based on microbiome and clustering methods.

Background: Radiation enteritis (RE) is a common complication of radiotherapy for abdominal and pelvic tumors, adversely affecting treatment outcomes and patients' quality of life. Gut microbiome alterations may contribute to RE development, but the underlying pathogenic factors are not fully understood. This study aimed to characterize the intestinal microbial changes associated with RE and severe acute radiation enteritis (SARE) and to identify predictive biomarkers.