Intracranial Artery Calcification Relates to Brain Damage and Clinical Outcomes in Patients Receiving Intravenous Thrombolysis.

Aim: Intracranial artery calcification (IAC) in patients with acute ischemic stroke may cause cerebral hemodynamic injury and aggravate ischemia-reperfusion injury. However, its relationship with brain damage and clinical outcomes has not yet been fully explored.

Methods: Patients with acute anterior circulation ischemic stroke who underwent intravenous thrombolysis (IVT) were enrolled.

External validation of N2H3 nomogram to predict outcomes in patients with acute ischemic stroke treated by intravenous thrombolysis.

Background: The N2H3 model was evaluated for forecasting the 3-month outcomes for patients experiencing acute ischemic stroke who received intravenous thrombolysis (IVT), in our previous study. The present study aimed to validate the predictive ability of the N2H3 model and to compare its accuracy to the THRIVE-c and START models (both of which are widely employed for prognostic predictions following IVT).

Methods: Our study prospectively enrolled consecutive stroke patients who received IVT from 16 hospitals.

Risking for Good: A Three-Wave Within-Person Analysis of the Reciprocal Relations Among Prosocial Risk Taking, Positive Risk Taking, and Prosocial Leadership.

Adolescence is a developmental stage characterized by increased engagement in risk taking, which can serve adaptive functions such as identity exploration and social integration. However, most existing research has focused on negative risk taking, with limited attention to how positive and prosocial risk taking contribute to adolescents' leadership development. Moreover, previous studies on adolescent risk taking have predominantly relied on cross-sectional designs, leaving within-person developmental processes underexplored.

prevents NRF2 nuclear translocation to drive hypoperfusion-related cognitive deficits by targeting .

-based therapeutics represent a promising approach for treating multiple diseases, yet the key regulatory in chronic cerebral hypoperfusion (CCH)-related cognitive impairment remains unclear. Here, we identify as consistently upregulated in both male and female mild cognitive impairment (MCI) and late-stage of Alzheimer's disease (AD) patients, as well as in the basal forebrain of both male and female postmortem AD specimens and male CCH rats. Knockdown of in the basal forebrain alleviated CCH-induced cognitive deficits.

Newcastle disease virus exploits the phospholipid flippase ATP11c-CDC50A complex to promote viral infection.

Newcastle disease virus (NDV), a highly contagious avian pathogen, causes significant economic losses in the poultry industry. As an enveloped, negative-sense single-stranded RNA virus, NDV infection and replication are intricately linked to host lipid metabolism, particularly phospholipids like phosphatidylserine (PS). PS asymmetry across the plasma membrane, maintained by phospholipid flippases, such as the ATP11c-CDC50A complex, is crucial for cellular homeostasis but can be exploited by viruses.

Remote ischaemic conditioning improves outcomes of ischaemic stroke treated by endovascular thrombectomy: the SERIC-EVT trial.

Background And Aims: Even after endovascular thrombectomy, more than half of patients with acute large vessel occlusion stroke do not achieve favourable outcomes. This study aimed to assess the efficacy and safety of remote ischaemic conditioning (RIC), a promising neuroprotective treatment, in patients with acute ischaemic stroke who received endovascular thrombectomy.

Methods: This participant-blinded, randomized controlled clinical trial was conducted at 25 hospitals.

Protective Effects of Pectin From Honey-Processed Hawthorn on Acute Myocardial Ischemia.

Previous studies have shown that both hawthorn and honey-processed hawthorn (HH) can prevent heart injury in acute myocardial ischemia (AMI). Hawthorn pectin (HP) and stir-fried hawthorn pectin (FHP) have been identified as protective agents against AMI, with the effects closely related to their structural characteristics. This study aims to investigate the effects of pectin of HH (HHP) in preventing AMI.

ANGWC Nomogram for Predicting Poor 3-month Outcome after Intravenous Thrombolysis in Young and Middle-aged Patients with First-ever Stroke.

The rising prevalence of ischemic stroke among younger individuals is concerning. Despite the significant benefits of intravenous thrombolytic therapy for young and middle-aged patients, the disease burden in this demographic is often overshadowed by that of older patient groups. This study aims to identify the risk factors for poor 3-month outcomes following intravenous thrombolysis in young and middle-aged patients with first-ever stroke and to develop a novel nomogram.

Combination therapy of fingolimod-GelMA hydrogel loaded with neural stem cells and electrical stimulation promotes recovery of spinal cord injury.

Spinal cord injury (SCI) is one of the most devastating diseases worldwide, and its recovery is hindered by damage and loss of nerve endings leading to loss of neurons and formation of glial scars. In this study, an injectable GelMA hydrogel incorporating neural stem cells (NSCs) and fingolimod (FTY720), combined with electrical stimulation (ES), was developed to enhance neural regeneration and suppress glial scar formation in a rat SCI model of complete spinal cord transection. The combined therapy of ES and injectable hydrogel incorporated with FTY720 improved both proliferation and neuronal differentiation and inhibited astrocytic differentiation of NSCs .

Quantification of brain tissue injury and prediction of prognosis using serum GFAP and UCH-L1: A multicenter prospective cohort study.

Background: It remains unclear whether the serum levels of the brain injury biomarkers (glial fibrillary acidic protein [GFAP] and ubiquitin C-terminal hydrolase-L1 [UCH-L1]) can be used to quantitatively evaluate brain tissue injury and predict prognosis in patients with intravenous thrombolysis (IVT).

Aim: This study investigates the association between serum GFAP and UCH-L1 levels with functional outcomes in patients receiving IVT.

Methods: Patients were prospectively enrolled from 16 hospitals.

Multi-omics reveals the health advantages of minor coarse cereals.

Minor coarse cereals play an essential role in the agricultural industry and in promoting healthy diet, owing to their strong climate adaptability and nutritional purposes. The present study comprehensively analyzed nutritional value of minor coarse cereals, which surpasses that of staple crops, through multi-omics. Minor coarse cereals possessed higher level of dietary fiber, particularly foxtail millet (37.

Multi-omics profiling reveals infectious bursal disease virus-induced alterations in gene expression and metabolism in chicken bursa of fabricius.

Infectious Bursal Disease (IBD) is an acute, highly contagious disease caused by IBDV, characterized by inflammation, atrophy of the Bursa of Fabricius, and immunosuppression. This study infected 21-day-old SPF chickens with three IBDV strains (classical YZ, very virulent AH, and variant SD). On day 7 post-infection, bursa samples were collected for transcriptomic and metabolomic analyses.

SPP1+ Tumor-associated Macrophages Drive Immunotherapy Resistance via CD8+ T-Cell Dysfunction in Clear Cell Renal Cell Carcinoma.

Tumor-associated macrophages (TAMs) are key regulators of tumor immunity. With advances in single-cell analyses, SPP1+ TAMs have been observed across multiple tumor sites. However, their clinical relevance and phenotypic characteristics in clear cell renal cell carcinoma (ccRCC) have not been comprehensively delineated.

Prefrontal activity to negative emotions moderates the longitudinal links between parents and youth's internalizing symptoms.

Parents' internalizing symptoms, such as anxiety and depression, may contribute to similar symptoms in their youth. However, these associations vary, as youth with better emotion regulation may be more protected from negative parental influence. Yet, it remains unclear how youth's neural correlates of emotion regulation, particularly in prefrontal regions-such as dorsolateral prefrontal cortex (dlPFC), lateral orbitofrontal cortex (lOFC), and medial orbitofrontal cortex (mOFC)-play a role in these associations.

Synergistic and Antagonistic Mechanisms of L. Polyphenols on Human Neutrophil Elastase Inhibition: Insights from Molecular Docking and Enzymatic Kinetics.

This study systematically investigated the inhibitory mechanism of L. polyphenols (ALP) against human neutrophil elastase (HNE). Molecular docking techniques were employed to predict the binding patterns and inhibition types between polyphenolic components and HNE, complemented by in vitro enzymatic tests to validate inhibitory efficacy.

Effects of the Maillard Reaction on the Structural and Functional Properties of Camel Whey Protein.

Consumer demand for dairy products like cheese and curds has resulted in a rise in whey production, which has caused significant waste and environmental issues. For this reason, improving the functional characteristics of whey proteins and their usage value are essential. In this study, camel whey protein-galactose conjugates (CWP-Gal) and camel whey protein-glucose conjugates (CWP-Glu) were prepared through the Maillard reaction, and their structural and functional properties were characterized.

Molecular imprinted BiOBr nanosheets for visual ultrasensitive chlorophenols detection by developing a dye-photosensitization sensing system.

The ultrasensitive, visual and intelligent identification of persistent chlorophenols (CPs) in complex drinking and environmental water matrices is highly desirable. In this study, we have established an interesting colorimetric dye eosin Y (EY)-molecular imprinted BiOBr nanosheet photosensitization sensing system for CPs detection, in which the key is the rapid EY photosensitization decolorization to be efficiently inhibited in the presence of CPs. It displays an ultrasensitive detection of CPs, especially for the typical 2,4,6-trichlorophenol (TCP) across from 10 ng·L to 1 mg·L, achieving a limit of detection of 7 ng·L with remarkable selectivity.

[Retracted] PADI4‑mediated epithelial‑mesenchymal transition in lung cancer cells.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the western blot data shown in Fig. 5C on p. 5092 were strikingly similar to data that had already been published in different form in the journal in an article written by different authors.

The CRM1-dependent NES motif in the matrix protein: another factor influencing Newcastle disease virus propagation and virulence.

As an important structural protein of Newcastle disease virus (NDV), the M protein plays a crucial role in the assembly and budding of the virus. In previous reports, we confirmed the existence of a classical nuclear export signal (NES) sequence on the M protein (i.e.

Prediction of the 70-gene signature (MammaPrint) high versus low risk by nomograms among axillary lymph node positive (LN+) and negative (LN-) Chinese breast cancer patients, a retrospective study.

Background: Luminal-type breast cancer (BC) was characterized as hormonal receptor positive human epidermal receptor 2 negative (HR+/HER2-). The 70-gene signature (70-GS, MammaPrint) test is recommended for assessing recurrence risk and guiding adjuvant chemotherapy decisions for Luminal-type BC. This study updates previously established nomogram models to predict binary 70-GS risk for lymph node positive (LN+) and lymph node negative (LN-) luminal-type BC patients.

Regiospecific hydroxylase and O-methyltransferase for the biosynthesis of anticancer alkaloids in Tabernaemontana elegans (toad tree).

Monoterpenoid indole alkaloids (MIAs) are a structurally diverse class natural products with significant medicinal properties. Bis-MIAs, such as chemotherapeutic vinblastine and anti-autophagic conodurine, are synthesized through enzymatic coupling of monomeric MIAs, often requiring specific modifications to activate reactive centers. In this study, we report the identification and characterization of a regiospecific enzyme pair, coronaridine 11-hydroxylase (TeC11H) and 11-hydroxycoronaridine O-methyltransferase (TeHCOMT), from Tabernaemontana elegans (toad tree).

Right Renal Halo Sign in Dogs with Presumed Acute Pancreatitis on Radiographs: A Pilot Study.

Radiographic signs of acute pancreatitis in dogs include widening of the pyloroduodenal angle and a cranial abdominal mass effect/decreased serosal detail. In some dogs with acute pancreatitis, it has been anecdotally noted that the right renal silhouette could be well visualized on the ventrodorsal abdominal radiograph. The purpose of this study was to see whether increased right renal conspicuity (i.

Prediction of outcomes following intravenous thrombolysis in patients with acute ischemic stroke using serum UCH-L1, S100β, and NSE: a multicenter prospective cohort study employing machine learning methods.

Background: Acute ischemic stroke (AIS) is a leading cause of mortality and disability worldwide. Intravenous thrombolysis (IVT) improves recovery, but predicting outcomes remains challenging. Machine learning (ML) and biomarkers like ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), S100 calcium-binding protein β (S100β), and neuron-specific enolase (NSE) may enhance prognostic accuracy.

Plant-based diet and risk of osteoporosis: A systematic review and meta-analysis.

Background & Aims: Plant-based diet is growing in popularity throughout the world for various reasons, yet its effect on bone health, especially osteoporosis, remains controversial. This systematic review and meta-analysis aim to investigate the association between plant-based diet and risk of osteoporosis.

Methods: A systematic literature search of observational studies examining the relationship between plant-based diets and osteoporosis risk was performed across PubMed, Embase, Web of Science, Scopus, and ProQuest from inception to June 1, 2024.

Pexophagy-driven redox imbalance promotes virus-induced ferroptosis.

Peroxisomes are critical organelles that maintain cellular redox homeostasis. Many viruses induce oxidative stress and degrade peroxisomes, but the mechanisms and consequences remain unclear. In this study, we systematically investigate how virus-induced pexophagy regulates peroxisome homeostasis.