Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Spinal cord injury (SCI) is one of the most devastating diseases worldwide, and its recovery is hindered by damage and loss of nerve endings leading to loss of neurons and formation of glial scars. In this study, an injectable GelMA hydrogel incorporating neural stem cells (NSCs) and fingolimod (FTY720), combined with electrical stimulation (ES), was developed to enhance neural regeneration and suppress glial scar formation in a rat SCI model of complete spinal cord transection. The combined therapy of ES and injectable hydrogel incorporated with FTY720 improved both proliferation and neuronal differentiation and inhibited astrocytic differentiation of NSCs . When applied to a complete transected SCI rat model, the combined therapy significantly enhanced neuronal regeneration and reduced glial scar formation in the lesioned area, thus resulting in better motor function recovery. Taken together, this research demonstrated a promising FTY720 enhanced GelMA hydrogel loaded with NSCs for exogenous NSCs delivery and provided a novel strategy for combination therapy of SCI.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/09205063.2025.2541973 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
C-reactive protein levels at admission among stroke patients - A comparative analysis.
Clin Neurol Neurosurg
September 2025
Neurovascular Research Unit, Department of Neurology, Copenhagen, University Hospital - Herlev and Gentofte, Herlev, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Brain, and Spinal Cord Injury, Copenhagen University Hospital - Rigshospitalet,
Objective: Severity and outcome of stroke may be associated with a concomitant or subsequent inflammatory response. C-reactive protein (CRP) may correlate with length of stay (LOS) in hospital, indicating increased complexity of stroke patients with an ongoing inflammatory reaction upon admission.
Methods: This retrospective cross-sectional study used data from admissions to the non-comprehensive Stroke Unit, which receives patients ineligible for revascularization therapy at Herlev-Gentofte hospital, in 2019 and 2020.
The value of spontaneous electromyographic activity in differentiating ischemic myelopathies from inflammatory demyelinating diseases: A retrospective study.
Mult Scler Relat Disord
September 2025
Department of Neurology, The First Medical Center of PLA General Hospital, Beijing, China. Electronic address:
Background: Differentiating ischemic myelopathies from inflammatory demyelinating diseases is challenging due to overlapping imaging and clinical manifestations. Needle electromyography (EMG) is highly sensitive to spinal anterior horn damage.
Objectives: This study investigates the diagnostic value of spontaneous EMG activity in distinguishing ischemic myelopathies from inflammatory demyelinating diseases.
The molecular mechanisms and therapeutic implications of PANoptosis in ischemic diseases.
Apoptosis
September 2025
Key Laboratory of Emergency and Trauma of the Ministry of Education, Department of Interventional Radiology and Vascular Surgery, First Affiliated Hospital of Hainan Medical University, Hainan Medical University, 31 Longhua Road, Longhua District, Haikou City, Hainan Province, China.
The singular forms of programmed cell death (PCD), including pyroptosis, apoptosis, and necroptosis, are inadequate for comprehensively elucidating the complex pathological mechanisms underlying ischemic diseases. PANoptosis is a unique lytic, innate immune, and inflammatory cell death pathway, initiated by innate immune sensors and driven by caspases and RIPKs through PANoptosome complexes. In diseases like cerebral ischemia, retinal ischemia, myocardial ischemia, renal ischemia, and spinal cord ischemia, targeting key regulatory factors of PANoptosis can help mitigate tissue damage.
View Article and Find Full Text PDFUses of the ICECAP measure of capability in adults with neurological health conditions: a scoping review.
Qual Life Res
September 2025
Department of Physical Therapy, Rady Faculty of Health Sciences, College of Rehabilitation Sciences, University of Manitoba, Winnipeg, MB, Canada.
Purpose: The purpose was to identify how the ICECAP-A and ICECAP-O have been used with adults who have neurological health conditions.
Methods: Following the Joanna Briggs Institute framework, a scoping review was conducted, searching five databases (Scopus, CINAHL, MEDLINE, Embase, and PsycINFO). Studies were included if participants were adults (age 18+ years) with neurological health conditions, and ICECAP-A or ICECAP-O were used in the study.
Stereotactic Body Radiation Therapy for Epidural Spinal Cord Compression: Treat Aggressively Now, Avoid Recurrence Later.
Int J Radiat Oncol Biol Phys
October 2025
Department of Central Nervous System Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.