Exogenous jasmonic acid and salicylic acid enhance selenium uptake and mitigate cadmium accumulation in pak choi ( L.) grown in selenium-rich, high-cadmium soil.

Plant hormones are known to regulate the uptake and distribution of mineral elements, including heavy metals, in crops. This study evaluated the effects of exogenous jasmonic acid (JA) and salicylic acid (SA), applied individually or in combination, on selenium (Se) enrichment and cadmium (Cd) mitigation in pak choi ( L.) cultivated in Se-rich and high-Cd soils.

Impact of high-pressure homogenization on the homogalacturonan and rhamnogalacturonan-I regions of pectin in strawberry pulp and their interaction with anthocyanins.

The effects of high-pressure homogenization (HPH, 100 MPa) on the physicochemical and structural characteristics of homogalacturonan non-de-esterified (HG-ND), homogalacturonan de-esterified (HG-D), and rhamnogalacturonan-I (RG-I)-enriched fractions of pectin in strawberry pulp were investigated. Furthermore, the relationship between these pectin fractions and the binding and digestive stability of anthocyanins (ACNs) was analyzed. Following HPH-100 MPa treatment, the yields of the HG-ND, HG-D, and RG-I-enriched fractions significantly increased, accompanied by a slight decrease in the molecular weight (Mw).

Enhancing yield and nutritional quality of sweet potato through genotype selection and selenium application.

Selenium (Se) is an essential micronutrient for human health, but its widespread deficiency remains a major public health concern worldwide. Biofortification of staple crops, such as sweet potato (Ipomoea batatas), offers a sustainable strategy to improve dietary Se intake. This study systematically evaluated the capacity for natural Se accumulation in 12 major local sweet potato varieties in Guangxi, China.

Preparation, Spectroscopic Characterization, and Reactivity of High-Valent Non-Oxo Co(IV) and Formally Co(V) Complexes.

In the presence of artificial oxidants, high-valent Co-X (X = O and NTs) complexes can be achieved in many different types of ligand structures. This paper reports, for the first time, the synthesis, spectroscopic and theoretical characterization, and reactivity of formally Co-(V) and Co-(IV) intermediates without the axial oxo or imido groups by using a strongly electron-donating ligand, PCAPD (PCAPD = bis-[2-(1H-pyrrol-2-carboxamido)--phenylenediamine). The formally Co-(V) complex was prepared by reacting [EtN][Co(PCAPD)-(Cl)] with iodosylbenzene (PhIO) as an artificial oxidant in acetone at -40 °C.

Kangbo Knife Cryoablation for the Treatment of Functional Adrenal Tumors.

Aldosterone-producing adenomas and cortisol-secreting adenomas are among the most common functional tumors of the adrenal gland. Primary aldosteronism often leads to refractory hypertension and significantly increases the long-term risk of stroke and cardiovascular events. Autonomous cortisol-secreting adenomas are associated with various complications, including hypertension, hyperglycemia, osteoporosis, infections, and thrombosis.

mA-modified EHD1 controls PD-L1 endosomal trafficking to modulate immune evasion and immunotherapy responses in lung adenocarcinoma.

Background: Eps15 homology domain (EHD) proteins, including EHD1 to EHD4, play vital roles in tumor progression. In this study, we aimed to investigate which specific EHD proteins, if any, are implicated in tumor immune evasion and immunotherapy response.

Methods: The immunotherapy responses of lung adenocarcinoma (LUAD) patients were predicted using tumor immune dysfunction and exclusion (TIDE) analysis.

Efficacy and safety of narlumosbart, an anti-RANKL monoclonal antibody, in postmenopausal women with osteoporosis: a multi-center, randomized, double-blind, placebo- and active-controlled, phased II study.

Background: This study aimed to preliminarily explore the efficacy and safety of narlumosbart, an anti-RANKL monoclonal antibody, in treating postmenopausal women with osteoporosis.

Methods: This multi-center, randomized, double -blind, placebo- and active-controlled study was conducted at 23 clinics across China between April 21, 2022 and April 19, 2023. Eligible patients were randomly assigned (1:1:1:1:1) to receive either 45 mg.

Vaccine therapies for glioma: clinical frontiers and potential breakthrough.

Glioma, the most common primary malignant brain tumor, is characterized by high recurrence and mortality rates. Its effective treatment remains a therapeutic challenge in clinical neuro-oncology. Despite over twenty years of exploring new therapies for glioma, progress in improving patient survival outcomes has been limited.

[Retracted] PADI4‑mediated epithelial‑mesenchymal transition in lung cancer cells.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the western blot data shown in Fig. 5C on p. 5092 were strikingly similar to data that had already been published in different form in the journal in an article written by different authors.

Prospective Phase 2 Clinical Trial of Carbon Ion Radiation Therapy Combined With Chemotherapy for Locally Advanced Pancreatic Carcinoma.

Purpose: In locally advanced pancreatic carcinoma (LAPC), combining chemotherapy with photon radiation therapy has not demonstrated survival benefits over chemotherapy alone. Conversely, carbon ion radiation therapy (CIRT) has shown encouraging outcomes from Japanese studies. The purpose of this trial was to assess the efficacy and toxicities of CIRT combined with chemotherapy in LAPC through a prospective phase 2 clinical trial.

Efficacy and safety of a biased GLP-1 receptor agonist ecnoglutide in adults with overweight or obesity: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.

Background: Ecnoglutide is a novel cyclic adenosine monophosphate (cAMP)-biased GLP-1 receptor agonist currently in development for weight management. We aimed to assess the efficacy and safety of once weekly ecnoglutide versus placebo for the treatment of overweight or obesity in Chinese adults.

Methods: This randomised, double-blind, placebo-controlled, phase 3 trial was done at 36 medical centres across China.

Objective biomarkers of cognitive performance in older adults with mild cognitive impairment: acoustic features of affective prosody.

Objectives: To explore negative affective prosody production patterns in older adults with mild cognitive impairment (MCI) and identify acoustic features as objective biomarkers for cognitive performances.

Methods: We recruited 42 older adults with MCI and 29 healthy controls (HC). The cognitive performances were assessed with the auditory verbal learning test-HuaShan version, the Trail Making Test A, the Digit Span-Forward, and the Digit Span-Backward.

Development and Validation of Ultrasound Hemodynamic-based Prediction Models for Acute Kidney Injury After Renal Transplantation.

Rationale And Objectives: Acute kidney injury (AKI) post-renal transplantation often has a poor prognosis. This study aimed to identify patients with elevated risks of AKI after kidney transplantation.

Materials And Methods: A retrospective analysis was conducted on 422 patients who underwent kidney transplants from January 2020 to April 2023.

Exploring Pain Empathy Among Doctors, Nurses and Patients: A Scoping Review.

Purpose: This review aims to systematically assess the existing body of research on pain empathy among healthcare workers and patients, with the goal of enhancing both understanding and clinical application.

Methods: Studies were retrieved from seven databases: PubMed, EBSCO, The Cochrane Library, Embase, CBM, CNKI, and Wanfang, with a search date limit from database inception to September 13, 2024. Inclusion and exclusion criteria were established based on the PCCs (Population, Concept, Context, Study design) principle.

Development and Psychometric Properties Evaluation of the Patient-Reported Outcome Measure for People With Schizophrenia in Day Rehabilitation Centres.

Background: Given the paucity of appropriate patient-reported outcome measure (PROM) to assess the multidimensional rehabilitation status of people with schizophrenia in day rehabilitation centres (DRCs) in China, the present study aimed to develop a PROM specifically designed for people with schizophrenia in DRCs (SDRC-PROM) and evaluate its psychometric properties.

Methods: The development process of the SDRC-PROM was in accordance with the guideline established by the US Food and Drug Administration and the guideline outlined in the COnsensus-based Standards for the selection of health status Measurement INstruments (COSMIN) checklist. Participants with schizophrenia were recruited from six DRCs in Nanjing, China.

Mitigating methylmercury in rice through ridge tillage: A sustainable solution for mercury-polluted paddy fields in populated regions.

Mercury (Hg) contamination of rice poses a health risk to consumers. Sustainable use of Hg-contaminated farmland is necessary to meet increasing demand for safe rice caused by rapid population growth. Ridge tillage is a water-saving tillage method that rice is planted on raised ridges, typically with furrows between them.

Molecular interactions and binding mechanisms of the homogalacturonan and rhamnogalacturonan-I fractions of pectin and different anthocyanins.

This study investigated the interactions between different structural regional fractions of pectin, specifically homogalacturonan (HG) and rhamnogalacturonan-I (RG-I) fractions, and three anthocyanin monomers: cyanidin-3-O-glucoside (C3G), peonidin-3-O-glucoside (P3G), and pelargonidin-3-O-malonylglucoside (P3M). The binding ratios, physicochemical and structural characteristics of these pectin-anthocyanin complexes, and their binding mechanisms were analyzed. The HG fraction exhibited the highest binding ratio with C3G.

Ameliorating effect of the aldose reductase inhibitor 1-Acetyl-5-phenyl-1 H-pyrrol-3-ylacetate on galactose-induced cataract.

Diabetes mellitus, as a common chronic disease, easily leads to significant changes in the structure of the eye, among which diabetic cataract is particularly common. Although surgery is the main treatment for this complication, it may be accompanied by postoperative complications. Therefore, it is particularly important to develop specific drugs for diabetic cataract, aiming to fundamentally reduce its incidence and reduce the need for surgery.

Statins and the risk of dementia: a meta-analysis.

Clarify the relationship between the use of statins and the risk of dementia, and further guide the clinical application of statins. This paper uses computer search Chinese and foreign language databases Pubmed, Medline, Cochrane, Embase, Web of Science, Weipu, CBM, Wanfang, CNKI, etc., to include the literature that meets the standards from the establishment of the library to December 2020, and uses Revman 5.

Trophic Plasticity of the Invasive Redbelly Tilapia () in China Inferred From DNA Metabarcoding Analysis.

The redbelly tilapia () is one of the most dangerous invasive alien fishes in the world. In order to better understand the feeding patterns of invasive populations in different habitats and seasons, and to reveal the possible force of differences in dietary composition among populations, we used DNA metabarcoding technology to analyze the dietary composition of 23 specimens from five different water bodies (two rivers and three reservoirs) in southern China, and 60 specimens from Shuikou Reservoir in four seasons (spring, summer, fall, and winter). The results showed that samples from five different water bodies and four seasons in Shuikou Reservoir were annotated to a total of 22 and 37 phyla of food categories, respectively.

The symptom network of oral health conditions in older populations with oral frailty: a cross-sectional study.

Background: Population aging is increasing globally, with oral frailty affecting 24% of the older population. Previous studies have demonstrated the relationship between oral frailty and poor oral health symptoms but the interactions and core symptoms among these oral symptoms remain vague.

Objective: To clarify the relationship between oral frailty and oral symptoms, explore the intrinsic connections between these symptoms, and identify core symptoms to provide more effective management and treatment strategies for oral frailty and related health issues.

Constraint-Induced Movement Therapy Promotes Contralesional Red Nucleus Plasticity and Increases Bilateral Motor Cortex-to-Red Nucleus Projections After a Large-Area Stroke.

For decades, scientists have explored the patterns of neural network remodeling that occur after a stroke. Several studies have shown that both motor cortexes (MCs) undergo crucial remodeling after cerebral ischemia. However, the mechanism by which corticofugal fibers are remodeled is not well understood.

Digital Health Literacy Questionnaire for Older Adults: Instrument Development and Validation Study.

Background: The integration of digital technology into older adult health and care has enhanced the intelligence of health and older adult care products and services while also transforming how seniors acquire and share health information. Assessing older adults' digital health literacy (DHL) is crucial for developing targeted interventions.

Objective: This study aims to develop and validate a DHL assessment questionnaire for older adults.

Triglyceride-glucose related indices as predictors for major adverse cardiovascular events and overall mortality in type-2 diabetes mellitus patients.

Background: Recent studies have indicated that triglyceride glucose (TyG)-waist height ratio (WHtR) and TyG-waist circumference (TyG-WC) are effective indicators for evaluating insulin resistance. However, research on the association in TyG-WHtR, TyG-WC, and the risk and prognosis of major adverse cardiovascular events (MACEs) in type 2 diabetes mellitus (T2DM) cases are limited.

Aim: To clarify the relation in TyG-WHtR, TyG-WC, and the risk of MACEs and overall mortality in T2DM patients.