Factors associated with early response to efgartigimod in patients with generalized myasthenia gravis: a multicenter retrospective observational study.

Background And Purpose: Efgartigimod has demonstrated efficacy in generalized myasthenia gravis (gMG) in both clinical trials and real-world studies. However, factors influencing early response have been less reported. This study aimed to evaluate the efficacy of efgartigimod in a multicenter gMG cohort and to identify the clinical factors associated with early therapeutic response.

Special Regulation of in Ovules Increases the Size of Cotton Seeds.

Background: L. is one of the main economic crops worldwide, and increasing the size/weight of its seeds is a potential strategy to improve its seed-related yield. AINTEGUMENTA (ANT) is an organogenesis transcription factor mediating cell proliferation and expansion in , but little is known about its candidate function in upland cotton seed.

Applying the Communication Bill of Rights to Enact Principles of Diversity, Equity, Inclusion, and Accessibility.

Purpose: This article situates the revised Communication Bill of Rights (National Joint Committee for the Communication Needs of Persons with Severe Disabilities, 2024) within a Diversity, Equity, Inclusion, and Accessibility (DEIA) framework. With an emphasis that diversity should be inclusive of disability, this work postulates the interconnectedness of DEIA and the communication rights of individuals with severe disabilities. The full set of communication rights is presented, followed by a deeper discussion of four rights that address dignity and respect in interactions, meaningful conversations that are culturally and linguistically appropriate, services across the lifespan, and access to functioning augmentative and alternative communication and other assistive technology to support communication.

A novel comprehensive strategy for research on wine-processed mechanism of corni fructus guided by variation in the chemical components and network analysis.

Background: Corni Fructus, a plant with both medicinal and edible properties, is renowned for its aromatic flavor and hepatoprotective and renoprotective effects, offering significant nutritional value and broad application potential. Wine-processed Corni Fructus (WCF) is a primary processed form of Corni Fructus, widely utilized in food supplements. Traditional Chinese medicine suggests that wine-processing enhances its hepatoprotective and renoprotective properties, yet the underlying mechanisms remain unclear.

Liquid-liquid phase separation: A dynamic driver of hepatocellular carcinoma.

Liquid-liquid phase separation (LLPS) is a physicochemical phenomenon prevalent in eukaryotic cells, mediating the compartmentalization of discrete subcellular regions through the formation of membrane-less organelles and biomolecular condensates and thereby enabling precise spatiotemporal regulation of cellular physiological processes. LLPS dysregulation constitutes a pathogenic mechanism underlying various diseases, with accumulating evidence demonstrating its critical involvement in hepatocellular carcinoma (HCC) progression. Here, we summarize the biophysical principles governing LLPS and the biological characteristics of intracellular phase separation, and primarily discuss the mechanistic contributions of aberrant LLPS to HCC pathogenesis, including disrupted gene expression, signal transduction, stress adaptation, etc.

Oral natural extracellular vesicles for biomedical applications: Advances and clinical perspectives.

Background: Natural extracellular vesicles (EVs) are nanoscale vesicles derived from diverse biological sources, recognized for their roles in intercellular communication and therapeutic cargo delivery. Due to their intrinsic biocompatibility, low immunogenicity, and ability to traverse biological barriers, EVs have garnered increasing interest as oral drug delivery vehicles. However, despite growing preclinical research, there is currently no comprehensive review that systematically focuses on EVs specifically for oral delivery applications-a critical gap in the literature.

Enhanced recovery after surgery-guided strategies in single-incision laparoscopic totally extraperitoneal hernioplasty for inguinal hernia: a narrative review.

Objective: To investigate the clinical efficacy and implementation challenges of single-port laparoscopic total extraperitoneal hernia repair (SIL-TEP) combined with enhanced recovery after surgery (ERAS) in the treatment of inguinal hernia.

Methods: This review summarized the technical advantages of SIL-TEP in reducing postoperative pain, accelerating functional recovery and improving cosmetic results compared with traditional three-port TEP. The perioperative strategies under eras concept were further discussed, including preoperative nutrition optimization, laryngeal mask airway (LMA) use, early oral feeding, multimodal analgesia and timely removal of urinary catheter.

Application of Problem-Oriented Nursing Model Combined with Early Enteral Nutrition Support in the Perioperative Period of Stage II/III Gastric Cancer Patients.

Objective: This study aims to evaluate the effects of a problem-oriented nursing model combined with early enteral nutrition (EEN) during the perioperative period in patients with stage II/III gastric cancer (GC).

Methods: One hundred patients with stage II/III GC were randomly divided into a control group (conventional perioperative care and routine nutritional support) and an intervention group (problem-oriented nursing model plus EEN). Clinical outcomes, body mass index (BMI), emotional status, nutritional and inflammatory markers, complication rates, and patient satisfaction were compared.

Lactylation of XLF promotes non-homologous end-joining repair and chemoresistance in cancer.

Metabolic reprogramming and DNA damage repair are essential in tumorigenesis and chemoresistance, yet their link remains elusive. Here, we show that LDHA deficiency impairs NHEJ and class switch recombination. Additionally, glycolysis-derived lactate promotes XLF lactylation at K288 within its Ku-binding motif (X-KBM) to regulate NHEJ.

Vaccine therapies for glioma: clinical frontiers and potential breakthrough.

Glioma, the most common primary malignant brain tumor, is characterized by high recurrence and mortality rates. Its effective treatment remains a therapeutic challenge in clinical neuro-oncology. Despite over twenty years of exploring new therapies for glioma, progress in improving patient survival outcomes has been limited.

Manipulation of Rare-Earth-Ion Emission by Nonlinear-Mode Oscillation in a Lithium Niobate Microcavity.

Optical microcavities provide opportunities to explore nonlinear effects and enable classic and quantum applications. This work investigates the manipulation of rare-earth-ion emission through nonlinear-mode oscillation in an erbium-doped thin-film lithium niobate microdisk cavity and demonstrates the changed laser performance. A pulsed transmission was generated with a detuned laser injected into the cavity.

A neuropsychological examination of the nature of perceived person-environment fit.

This study provides a neuropsychological examination of the conceptualization of perceived person-environment fit in relation to its cognitive and affective components. It addresses key challenges in the current fit literature through empirically clarifying the theoretical "black box" of how individuals cognitively compare themselves to their environment, fundamentally examining affective aspects of fit beyond correlational analysis, and exploring whether psychological and neural perspectives offer different conceptualizations of fit. Two functional magnetic resonance imaging studies, involving 62 and 41 working adults respectively, show that both lateral brain regions (associated with higher order cognition) and medial brain regions (associated with emotion processing) are activated when participants perceive fit.

Tyrosinase Enzyme-Inspired Cu(I)-Porous Organic Polymer for Selective Oxidation of Biomass-Derived 5-HMF.

In biobased PET, terephthalic acid (TPA) can be replaced with biobase alternatives like bioderived 5-diformylfuran (DFF). In this work, we have selectively synthesized DFF from the oxidation of 5-hydroxymethylfurfural (HMF) using our tyrosinase enzyme-inspired catalysts vicinal and nonvicinal , respectively. Motivated by the oxygenated form of tyrosinase, we introduced binuclear copper(I) moieties into a porous organic polymer to create enzyme-inspired heterogeneous catalysts for the selective oxidation of HMF.

Direct Modulation of Host Cells and Gut Microbiota by Orally Delivered Antioxidant Nanocages for Colitis Treatment.

Ulcerative colitis (UC) involves a complex interplay of mucosal inflammation, intestinal barrier dysfunction, and gut dysbiosis, all exacerbated by elevated reactive oxygen species (ROS). Existing therapies often fail to concurrently address these interrelated pathologies. Here we present an orally administrable nanocage system that targets both host cells and gut microbiota and can simultaneously address immune dysregulation, epithelial damage, and microbial imbalances for UC treatment when loaded with antioxidant enzymes.

Leading the way to a safer workplace: What enables supervisors to be servant leaders and enhance subordinates' workplace safety behaviors?

Introduction: Drawing on the Motivation-Ability-Opportunity (MAO) framework and social information processing (SIP) theory, we hypothesized that supervisors demonstrate the highest level of servant leadership when their prosocial motivation (motivation), perspective taking (ability), and perceived collaborative-based HR configuration (opportunity) are all high. Moreover, we also hypothesized that servant leadership plays an important channeling role that links the three-way interaction and subordinates' workplace safety behaviors.

Method: We recruited 167 supervisor-subordinate dyads across high-risk and non-high-risk industries via LinkedIn and authors' professional networks.

Reliability and Validity of the Chinese Version of the Social Skills Improvement System Autism Spectrum Scale.

The purpose of this study was to examine the reliability and validity of the Chinese version of the SSIS Autism Spectrum Scale Teacher Form, a scale of the SSIS-Rating Scales (Social Skills Improvement System Rating Scales) created by Gresham and Elliott. The scale consists of 15 items divided into two subscales: social skills and problem behaviors related to autism. The participants included 541 school-age children aged 4 to 18 years old (266 females, 275 males).

Erbium-doped lithium niobate waveguide amplifier enhanced by an inverse-designed on-chip reflector.

This study presents a 3.6-cm-long erbium-doped lithium niobate waveguide amplifier enhanced by an inverse-designed on-chip reflector. Integrating a reflector to reflect signal light (1531.

DiabetesLiver score: A non-invasive algorithm for advanced liver fibrosis and liver-related outcomes in type 2 diabetes mellitus population.

Background: This study aimed to develop and validate a non-invasive model for screening advanced liver fibrosis and predicting liver-related outcomes in patients with type 2 diabetes mellitus (T2DM).

Methods: This study included patients with T2DM from five tertiary hospitals for the development and internal validation of a non-invasive model. Advanced liver fibrosis was defined as a liver stiffness measurement ≥12 kPa.

Construction of Atomic-Scale Compressive Strain for Oxime Electrosynthesis.

Tuning the surface strain is a powerful strategy to enhance the catalytic activity of metal nanocatalysts, yet an atomically precise catalyst with intramolecular strain to unlock the atomic-level strain-structure-activity relationship is still highly desired. Herein, we report the synthesis, structural anatomy, and catalytic performance toward cyclohexanone oxime electrosynthesis of an atomically precise AgCu(C≡C-CH) (AgCu) nanocluster, which has a Cu ring in the center. The Cu-Cu distance in the Cu ring is only 1.

Temperature-dependent shifts in gut microbiota and metabolome of olive flounder (Paralichthys olivaceus): implications for cold-water aquaculture expansion and probiotic applications.

Background: In recent years, rising temperatures due to climate change have become significant stressors in aquatic environments, impacting disease incidence, growth, and gut microbiota in fish. Cold-water species, such as the olive flounder (Paralichthys olivaceus), are particularly vulnerable to increasing water temperatures. Despite its economic importance as a species farmed in East Asia, research on temperature-dependent shifts in the gut microbiota and metabolome of olive flounder remains limited.

Brillouin super-cooling/heating in a non-Hermitian phononic dimer.

The ability to coherently manipulate phonons through light permits cooling and heating microscale quantum systems for various critical fields in metrology, information processing, and sensing. However, these physical systems often are hard to isolate and open for exchanging energy externally, making themselves non-Hermitian. Here, we experimentally observe a super-cooling/heating state in a non-Hermitian phononic dimer, where the two independent phonon modes of distinct cooling/heating rates become synchronous in cooling/heating.

Electrochemical dechlorination promotes syngas production in N-heterocyclic carbene protected Au nanoclusters.

Surface ligands play an important role in dictating the structure and catalytic properties of metal nanoclusters. Recently, a novel class of Au clusters protected by N-heterocyclic carbenes (NHCs) and halogens has been synthesized; however, the dynamic stability of the Au-NHCs/Au-halogen interface in real electrochemical environments as well as the influence of the ligand layer on the catalytic process remains obscure. Herein, we combined first-principles simulations with experiments to investigate the metal-ligand interface interaction of the classical [Au(NHC)Cl] cluster and its unique potential to promote electrocatalytic CO reduction to syngas.

Effect of virtual reality on improving arm function in individuals with cerebral palsy: an overview of meta-analyses.

This overview was to understand the impact of virtual reality (VR) on upper-extremity function in individuals with cerebral palsy (CP). A systematic literature search was conducted using electronic databases (e.g.

Ambient fine particulate matter induces cardiac fibrosis through triggering ferroptosis by heme degradation induced-iron overload.

Background: Previous studies have shown a significant correlation between exposure to ambient fine particulate matter (PM) and cardiac fibrosis, yet the precise detrimental effects and underlying mechanisms of PM exposure on cardiac fibrosis remain incompletely understood. Cardiac remodeling, a process involving ferroptosis that can be initiated by iron overload, has been implicated in this phenomenon. In this study, we sought to explore the potential mechanism by which ferroptosis contributes to PM-induced cardiac fibrosis.