A novel comprehensive strategy for research on wine-processed mechanism of corni fructus guided by variation in the chemical components and network analysis.

Background: Corni Fructus, a plant with both medicinal and edible properties, is renowned for its aromatic flavor and hepatoprotective and renoprotective effects, offering significant nutritional value and broad application potential. Wine-processed Corni Fructus (WCF) is a primary processed form of Corni Fructus, widely utilized in food supplements. Traditional Chinese medicine suggests that wine-processing enhances its hepatoprotective and renoprotective properties, yet the underlying mechanisms remain unclear.

Real-time monitoring of secretory protein traffic for investigating trafficking regulators of ACE2 in living cells.

The cellular secretory pathway is a fundamental physiological process; yet a precise, efficient, and quantitative method for monitoring this process remains seldom explored. In this study, we achieved real-time monitoring of the secretion of angiotensin-converting enzyme 2 and programmed death-ligand 1 by integrating the HiBiT tag with the classic Retention Using Selective Hooks system. Through this strategy, we identified and validated Niemann-Pick complex 1 as a lysosomal adaptor involved in the angiotensin-converting enzyme 2 trafficking process.

SMILES Token Additivity Model with Interpretability and Generalizability for Fuel Property Predictions.

Deep learning models for the quantitative structure-property relationship (QSPR) have traditionally encountered challenges related to limited interpretability and generalizability. In this study, we present the simplified molecular input line entry system (SMILES) token additivity (STA) model for accurately predicting fuel properties, which takes SMILES as input and employs stacked multihead self-attention encoders to extract molecular structural information. This model provides insights into the structure-property relationships by quantifying the contributions of individual tokens to target properties.

Molecular insights into the anti-asthma potential of Zhimu-Chuanbeimu drug pair based on serum pharmacochemistry, network pharmacology and immune infiltration analysis.

In traditional Chinese Medicine, Zhimu-Chuanbeimu (ZC) is one of the most classical herb pairs used in the treatment of lung diseases such as asthma. This study aimed to elucidate its specific components and potential mechanisms involved in treating asthma by altering the immune microenvironment. A systematic analysis of the chemical substance and absorbent components were conducted using UHPLC-Q-TOF-MS.

CBH-BDC Enhanced Δ-ML for Predicting the Accurate Standard Enthalpy of Formation.

The standard enthalpy of formation (Δ°) is a fundamental thermodynamic property that is essential for understanding various physicochemical processes. Our group recently developed the connectivity-based hierarchy with the bond difference correction (CBH-BDC) method for calculating the accurate Δ°. However, it encounters challenges in high-accuracy electron energy calculations and is restricted by BDC parameters that are limited to specific elements.

A Gut Microbial Transformation-Integrated Network Pharmacology Approach to Elucidate the Therapeutic Mechanisms of Timosaponin AIII in Diabetes.

Objective: Timosaponin AIII, with poorly soluble characteristics, has a potential antidiabetic effect evaluated in vitro and in vivo. The major problem associated with poorly soluble drugs is very low bioavailability. This study aimed to investigate the metabolic profiles and antidiabetic mechanism of Timosaponin AIII.

Bunge- Bulbus Herb Pair Alleviates Ovalbumin-Induced Asthma by Regulating Arachidonic Acid Pathway.

Background: In traditional Chinese Medicine (TCM), Zhimu ( Bunge, ZM) - Chuanbeimu ( Bulbus, CBM) (ZC) is one of the most classical herb pairs used in the treatment of lung diseases such as asthma. This study aimed to investigate how ZC affects asthma and its mechanism.

Methods: Asthma model rats were sensitized by ovalbumin.

Identification of druggable genetic targets for prostate cancer risk based on mendelian randomization and single-cell RNA sequencing.

Purpose: This study aimed to identify genetic targets linked to prostate cancer risk using advanced genetic analysis techniques.

Objective: The goal was to conduct a comprehensive analysis using Mendelian Randomization (MR), colocalization, and single-cell RNA sequencing to identify druggable genes as potential therapeutic targets or diagnostic markers.

Methods: The study involved selecting 2608 druggable genes by intersecting expression Quantitative Trait Loci (eQTLs) with druggable genome databases.

Traditional Chinese medicine as a promising choice for future control of PEDV.

Porcine epidemic diarrhea virus (PEDV) is the major agent of the recent outbreaks of diarrhea in piglets, which has caused huge economic losses to the global swine industry. Since traditional vaccine strategies cannot provide complete protection for piglets, the development of safe, effective, and economical antiviral drugs is urgently needed. For many years, traditional Chinese medicines (TCMs) have been broadly applied for viral infectious diseases, exhibiting advantages such as abundant resources, lower toxicity, and minimal drug resistance.

Soluble ST2 as a Predictive Biomarker for Acute Graft-Versus-Host Disease Post -Allogeneic Stem Cell Transplantation.

Background: Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Identifying reliable biomarkers for early prediction of aGVHD could enable timely interventions and improve patient outcomes.

Objective: This study aims to assess whether levels of specific cytokines can serve as predictive markers for the onset and severity of aGVHD.

Towards more equitable cooling services of urban parks: Linking cooling effect, accessibility and attractiveness.

Global warming and rapid urbanization have caused frequent occurrences of heat waves and urban heat island effect, presenting a significant threat to health of urban residents. Researches have indicated that cooling services provided by parks are essential in alleviating impact of heat wave events and urban heat island effect. However, previous researches on park cooling services center around cooling effect, with a lack of exploration regarding the fairness of such services.

Integrated network pharmacology and GC-MS-based metabolomics to investigate the chemical profile and efficacy of Anemarrhenae Rhizoma and its processed products.

Rationale: Anemarrhenae Rhizoma (AR) has been a frequently utilized traditional Chinese medicine (TCM) for an extended period, with its salt-processed variant being a prevalent application form. Contemporary pharmacological investigations have demonstrated that the salt-processed iteration exhibits a multitude of markedly augmented pharmacological properties. However, whether the pharmacodynamic material basis of this change is related to volatile substances remains unclear.

Application of CD25 and CTLA4 gene transcription levels in early prediction of acute graft-versus-host disease.

Introduction: Our study investigated the potential of peripheral blood T cell CD25, CD28, and CTLA-4 gene transcription levels as predictive biomarkers for acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Methods: Real-time reverse transcription fluorescent quantitative PCR (RT-qPCR) analysis was conducted on day +7, +14, and +21 post-transplantation in patients undergoing allo-HSCT.

Results: Elevated levels of CD25 and CTLA-4 mRNA were found to be associated with the occurrence of aGVHD, as well as severe and gastrointestinal aGVHD.

High sensitivity humidity sensor based on the U-shaped tapered no-core fiber coated with MXene.

TiCT MXene is an emerging two-dimensional material that has good potential in relative humidity (RH) measurement because of its unique layer structure, strong hydrophilic nature, and large specific surface area. Here, a high-performance RH sensor integrating TiCT MXene nanosheets and U-shaped tapered no-core fiber (UTNCF) is proposed. The sensing principle is based on mode interference.

Superconductivity of cubic MB6 (M = Na, K, Rb, Cs).

Previous studies have shown that NaB6, KB6, and RbB6 adopting Pm3̄m are superconductors with a relatively high Tc under ambient conditions. In this paper, we conducted systematic structural and related properties research on CsB6 through a genetic evolution algorithm and total energy calculations based on density functional theory between 0 and 20 GPa. Our results reveal a cubic Pm3̄m CsB6, which is dynamically stable under the pressures we studied.

Role of solute carrier transporters in regulating dendritic cell maturation and function.

Dendritic cells (DCs) are specialized antigen-presenting cells that initiate and regulate innate and adaptive immune responses. Solute carrier (SLC) transporters mediate diverse physiological functions and maintain cellular metabolite homeostasis. Recent studies have highlighted the significance of SLCs in immune processes.

The therapeutic effect of wine-processed Corni Fructus on chronic renal failure in rats through the interference with the LPS/IL-1-mediated inhibition of RXR function.

Ethnopharmacological Relevance: Corni Fructus, derived from the fruit of Cornus officinalis Sieb. et Zucc, is a widely utilized traditional Chinese medicine (TCM) with established efficacy in the treatment of diverse chronic kidney diseases. Crude Corni Fructus (CCF) and wine-processed Corni Fructus (WCF) are the main processed forms of Corni Fructus.

Research on the clinical factors of cardiac iron deposition in children with beta-thalassemia major.

Magnetic resonance imaging (MRI) T2* is the gold standard for detecting iron deposition in cardiac tissue, but the technique has limitations and cannot be fully performed in paediatric thalassemia patients. The aim of this study was to analyse clinical data to identify other predictors of cardiac iron deposition. A retrospective analysis was performed on 370 children with β-TM.

The bioavailability enhancement and insight into the action mechanism of poorly soluble natural compounds from co-crystals preparation: Oridonin as an example.

Background: Natural bioactive molecules are important sources for the development of new drugs. However, most of them were limited in clinical applications due to their low aqueous solubility and bioavailability. Oridonin (ORI) is a powerful anticancer compound with above characteristics.

The role of ROS-pyroptosis in PM induced air-blood barrier destruction.

Fine particulate matter (PM) has attracted increasing attention due to its health-threatening effects. Although numerous studies have investigated the impact of PM on lung injuries, the specific mechanisms underlying the damage to the air-blood barrier after exposure to PM remain unclear. In this study, we established an in vitro co-culture system using lung epithelial cells and capillary endothelial cells.

Knitting from Nature: Self-Sensing Soft Robotics Enabled by All-in-One Knit Architectures.

Self-sensing soft robotics that mimic the proprioception and exteroception abilities of natural biological systems have shown great potential in challenging applications. However, current add-on strategies that simply combine sensors with actuators by post processing generally suffer from poor compatibility in mechanical properties, interfacing problems, complex manufacturing, and high cost. Herein, we present knitted soft robotics with build-in textile-integrated multimodal sensors, where the knit structure is used not only as a physical actuating layer but also as a sensing functional component.

Systematically uncovering the absorbed effective substances of Radix Scutellaria-licorice drug pair in rat plasma against COVID-19 using a combined UHPLC-Q-TOF-MS analysis and target network pharmacology.

Radix Scutellaria-Licorice drug pair (RSLDP), a frequently used herbal pair with the effect of clearing heat and detoxifying, is the commonly employed drug pair in TCM prescriptions for the treatment of COVID-19. Until now, the metabolism feature and anti-COVID-19 mechanism of RSLDP have not been fully elucidated. In this study, a sensitive and rapid method was developed for the separation and identification of the absorbed constituents of RSLDP in the rat plasma by UHPLC-QTOF-MS.

Integrated metabolomics, network pharmacology, and molecular docking to reveal the mechanisms of Isodon excisoides against drug-induced liver injury.

Isodon excisoides (Y.Z.Sun ex C.