Microglial Membrane-Coated Biomimetic Nanoplatform for Enhanced Blood-Brain Barrier Penetration and Targeted Photodynamic Therapy in Orthotopic Glioblastoma.

Glioblastoma multiforme (GBM) continues to pose a significant challenge in the field of neuro-oncology primarily because of the limited penetration of therapeutics across the blood-brain barrier (BBB) and the presence of immunosuppressive tumor microenvironments. To address these challenges, a HD-PEG@BM biomimetic nanoplatform (hereinafter referred to as HD-P@BM) is developed that cloaks the near-infrared II photosensitizer HD-PEG (HD-P) inside microglial membranes to enable enhanced BBB penetration and tumor-targeted delivery. In this study, it is found that the microglia-derived membranes enhanced the uptake of nanoparticles by both the glioma cells and tumor-associated microglia.

Discordance between knee and hand-wrist bone age in adolescents: implications for skeletal maturity assessment and its association with thyroid-stimulating hormone levels.

Background: Hand-wrist radiographs may not fully reflect skeletal bone age (BA) during mid-to-late puberty. Knee magnetic resonance imaging (MRI), a non-radiative imaging technique, may provide detailed evaluation of the lower limbs.

Objective: To validate the San Diego MRI-based knee BA atlas in a Chinese adolescent cohort presenting with growth deceleration, evaluate the concordance between knee and hand-wrist BA, and explore factors influencing potential discrepancies.

Unveiling hepatic Krüppel-like factor 15 as the key regulator of cyclosporine A metabolism and adverse effects.

Cyclosporine A (CsA) is a widely used immunosuppressant for posttransplantation and autoimmune diseases, but its clinical application is limited by severe hepatorenal toxicity. Krüppel-like factor 15 (KLF15), a key regulator of xenobiotic metabolism, has been shown to modulate the metabolism of acetaminophen and rifampicin and play a role in the associated drug-induced liver toxicity. However, its role in CsA metabolism and CsA-induced hepatorenal injury remains unclear.

Interferon-stimulated gene screening identifies CCND3 as a host restriction factor against emerging high-pathogenic bandaviruses.

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a representative high-pathogenic bandavirus (Bandavirus genus, Phenuiviridae family). Inducible expression of interferon-stimulated genes (ISGs) is the foundation of host antiviral defense; however, their roles in bandavirus infection remain elusive. Here, we identify over 200 ISGs potentially inhibiting or promoting bandaviral replication.

Serum levels of leucine-rich α-2 glycoprotein 1 (LRG1), pro-neurotensin (PNT), fatty acid-binding protein 4 (FABP4) and furin in pediatric growth hormone deficiency before and after 1-year growth hormone replacement therapy.

Objective: To investigate serum levels of leucine-rich α-2 glycoprotein 1 (LRG1), pro-neurotensin (PNT), fatty acid-binding protein 4 (FABP4), and furin in children with growth hormone deficiency (GHD) compared to idiopathic short stature (ISS) and healthy children, and to evaluate their changes and clinical relevance after 1-year growth hormone replacement therapy (GHRT).

Methods: The prospective cohort study was conducted in 32 idiopathic GHD, 32 ISS and 32 healthy children. Serum LRG1, PNT, FABP4, furin and clinical parameters were measured at baseline and after 6 and 12 months of GHRT.

Novel surveillance protocol for gastric cancer based on CEA: a high-volume multi-center study.

Tumor markers are commonly used in gastric cancer patients, but their effectiveness in monitoring recurrences is not optimal. This study aims to evaluate the recurrence predictive performance of carcinoembryonic antigen (CEA) across different baseline groups and establish a new surveillance protocol. We analyzed data from 1708 patients at Sun Yat-Sen University Cancer Center with stage I-III gastric adenocarcinoma.

SimID: Wi-Fi-Based Few-Shot Cross-Domain User Recognition with Identity Similarity Learning.

In recent years, indoor user identification via Wi-Fi signals has emerged as a vibrant research area in smart homes and the Internet of Things, thanks to its privacy preservation, immunity to lighting conditions, and ease of large-scale deployment. Conventional deep-learning classifiers, however, suffer from poor generalization and demand extensive pre-collected data for every new scenario. To overcome these limitations, we introduce SimID, a few-shot Wi-Fi user recognition framework based on identity-similarity learning rather than conventional classification.

Presacral tumors: a retrospective analysis of 112 cases with emphasis on diagnostic challenges and surgical outcomes.

Background: Presacral tumors are rare entities with heterogeneous pathology including malignant potential. Due to nonspecific symptoms mimicking common anorectal diseases, misdiagnosis remains a major challenge that may delay treatment and worsen prognosis, particularly for malignant variants. This study analyzes diagnostic pitfalls and surgical outcomes in a large single-center cohort.

Growth plate continuity on knee MRI predicts growth hormone effect in mid-to-late puberty with idiopathic short stature.

Purpose: To evaluate the efficacy and cost-effectiveness of recombinant human growth hormone (rhGH) therapy in adolescents with idiopathic short stature during mid-to-late puberty, using knee MRI to predict therapeutic response.

Methods: This one-year prospective cohort study included 50 idiopathic short stature adolescents and 100 healthy controls. Participants underwent knee MRI to classify growth plates into "continuous" and "discontinuous" subgroups.

EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy.

Osimertinib resistance is a global problem for NSCLC patients mediated by new EGFR mutations or bypass mechanisms. Proteolysis targeting chimeras (PROTACs) have been utilized to overcome drug resistance by degrading mutant EGFR, but most are restricted to their poor cell permeability and insufficient tumor-targeting ability. Meanwhile, these PROTACs has little effect on bypass resistance mechanisms.

Targeting CLK1/SRSF7 axis-dependent alternative splicing sensitizes pancreatic ductal adenocarcinoma to chemotherapy and immunotherapy.

Aim: The persistently high mortality rate of pancreatic ductal adenocarcinoma (PDAC) is largely attributed to the acquired resistance to chemotherapy, particularly gemcitabine. This study aims to elucidate the underlying molecular mechanisms of gemcitabine resistance in PDAC, uncover additional pro-tumorigenic factors contributing to drug resistance, and develop more effective and safer targeted therapeutic strategies against this phenomenon.

Methods: Circular RNA (circRNA) sequencing was employed to identify differentially expressed circRNAs between chemo-sensitive and resistant tumors.

Microenvironment crosstalk and immune evasion of circulating tumor cells: From mechanism to clinical significance.

Circulating tumor cells (CTCs), shed from the primary malignancies, are regarded as the "seeds" of tumor metastasis. They employ sophisticated strategies to evade immune detection during blood circulation by engaging with various blood components, ultimately facilitating their colonization in distant organs. Elucidating the mechanisms underlying CTC immune evasion may unlock novel immunotherapeutic strategies to prevent tumor metastasis.

A multivalent mRNA vaccine elicits robust immune responses and confers protection in a murine model of monkeypox virus infection.

Monkeypox virus (MPXV) has re-emerged globally since May 2022, posing a significant public health threat. To address this, we develop two multivalent mRNA vaccine candidates-AAL, encoding three MPXV antigens, and AALI, which combines AAL with an immune-enhancing IFN-α protein. Both vaccines are delivered via mannose-modified lipid nanoparticles to target dendritic cells.

Government digital governance and urban green economic efficiency in China.

Nowadays, widespread application and continuous advancement of digital technologies have made the digital governance become one of the dominant themes in the transformation of worldwide governments. This paper explores the impact of government digital governance on urban green economic efficiency (GEF), focusing on the "Internet + Government Services" pilot policy as a quasi-natural experiment in China, by panel dataset of China's cities from 2010 to 2022 and employing a difference-in-differences approach. This paper reveals that digital governance significantly enhances urban GEF, validated by parallel trend test, placebo test, instrumental variable method, double machine learning, elimination of alternative factors and disturbing policies.

Feasibility, safety and preliminary effect of exercise prehabilitation in patients with esophageal cancer undergoing surgery: an open-label, randomized, parallel-group pilot and feasibility study.

Background: Increasing evidence underscores the effectiveness of prehabilitation in improving postoperative outcomes in patients with cancer. However, evidence on structured exercise prehabilitation, specifically for functional recovery after esophagectomy, remains limited. Hence, this pilot study aimed to examine the feasibility and safety of a one-week exercise prehabilitation protocol and to explore its preliminary effects on functional capacity in patients with esophageal cancer undergoing surgery.

Zinc-Coordinated Trienzyme Nanogel Cascade Therapy for Accelerated Post-Pancreatectomy Cutaneous Wound Healing.

Orchestration of enzyme cascades in synthetic systems remains a major challenge for catalytic control in complex biological environments. Here, a zinc-coordinated tri-enzyme nanogel system (Zn@nGSC) is reported that mimics natural enzymatic assemblies by confining individual glucose oxidase (GOX), superoxide dismutase (SOD), and catalase (CAT) within an imidazole-functionalized polymeric nanogel matrix. The nanogel is fabricated via mild in situ polymerization combined with Zn⁺-imidazole coordination, yielding structurally stable multi-enzyme assemblies.

Deep Learning-Based Multi-View Facial Identification as a Screening Tool for Cushing's Syndrome.

Objectives: Cushing's syndrome (CS) could significantly impair lief quality. It is often diagnosed late due to misdiagnosis as simple obesity under current strategies. Given that CS is characterized by distinctive facial features, e.

Randomized, double-blind phase III trial of a dexamethasone-free regimen for managing highly emetogenic chemotherapy-induced nausea and vomiting.

Chemotherapy-induced nausea and vomiting (CINV) remains a prevalent treatment complication, often significantly impairing patients' quality of life and reducing adherence to chemotherapy regimens. The standard triplet antiemetic regimen, including either a neurokinin-1 (NK1) receptor antagonist (RA) or olanzapine, combined with a 5-hydroxytryptamine type 3 (5-HT3) RA and dexamethasone (DEX), faces challenges primarily due to DEX-related adverse effects and its potential to compromise the efficacy of antitumor agents. This study assessed whether omitting DEX (F-Group: olanzapine + 5-HT3 RA) is non-inferior to the standard D-Group (olanzapine + 5-HT3 RA + DEX).

Flexibility meets rigidity: a self-assembled monolayer materials strategy for perovskite solar cells.

Self-assembled monolayer (SAM) materials have emerged as promising materials for interface engineering in perovskite solar cells. However, achieving an optimal balance between molecular packing density, charge transport efficiency, and defect passivation remains a challenge. In this work, we propose a SAM material design strategy that synergizes flexible head groups with rigid linking groups.

Efficient Inverted Perovskite Solar Cells Utilizing Inorganic Composite Multiple Electron Transport Layers.

Electron transport layers (ETLs) featuring optimal film coverage and favorable electronic properties play a critical role in high-performance perovskite solar cells (PSCs). In contrast to organic ETLs, which have high material costs, inorganic metal oxide ETLs are considered promising alternatives for efficient inverted PSCs because of their low cost, high carrier mobility, and excellent stability. However, fabricating high-quality top inorganic ETLs that preserve the active perovskite layer remains a challenge.

SenExo-cCCT2 Reprograms Senescence Response and Anti-Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma.

Combination chemotherapy and immunotherapy have failed to achieve breakthroughs in pancreatic ductal adenocarcinoma (PDAC). Chemotherapy-induced senescence is a potential solution for this problem. This study integrates clinical samples with single-cell transcriptomic sequencing, proteomics, and RNA sequencing and reveals that FOLFIRINOX (a combination regimen of 5-fluorouracil, oxaliplatin, irinotecan, and leucovorin) treatment induces a higher proportion of senescent tumor cells (senTCs).

Laser-facilitated peroxidase-like hydrogel with simultaneous wound infection monitoring and eliminating.

Clinically, despite tremendous efforts having been devoted to preventing the invasive bacterial infection in acute and chronic wounds, the abuse or excessive use of antibacterial agents still poses great hurdles for wound management, which significantly raises the risk of detrimental side-effects and complications in the wound disinfection. Herein, we develop a hydrogel dressing of MPAH to attain real-time infection monitoring and on-demand antibacterial therapy. In this scenario, we propose a creative strategy of applying laser-facilitated MPAH photodecomposition of HO to trigger the burst release of reactive oxygen species (ROS) and thus eliminate bacteria.

Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression.

Metabolic reprogramming not only reshapes cellular bioenergetics but also profoundly influences RNA metabolism through metabolite signaling and the RNA-binding activities of metabolic enzymes. Emerging evidence highlights that certain metabolic enzymes act as RNA-binding proteins (RBPs) to regulate gene expression and promote tumor progression. However, the non-catalytic post-transcriptional regulatory functions of metabolic enzymes in hepatocellular carcinoma (HCC) remain largely unexplored.

Group-based trajectory modeling for supportive care needs in Chinese cancer survivors: A systematic review.

Objectives: This study aims to systematically synthesize studies that applied group-based trajectory modeling to examine the trajectories of supportive care needs (SCNs) among cancer survivors and to identify associated influencing factors.

Methods: A comprehensive literature search was conducted in the following databases: CINAHL, Cochrane Library, Embase, PubMed, Web of Science, CNKI, SinoMed, VIP, and Wanfang. Studies were screened and assessed independently by two reviewers using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Cohort Studies and the Guidelines for Reporting on Latent Trajectory Studies (GRoLTS) checklist.