Novel surveillance protocol for gastric cancer based on CEA: a high-volume multi-center study.

Tumor markers are commonly used in gastric cancer patients, but their effectiveness in monitoring recurrences is not optimal. This study aims to evaluate the recurrence predictive performance of carcinoembryonic antigen (CEA) across different baseline groups and establish a new surveillance protocol. We analyzed data from 1708 patients at Sun Yat-Sen University Cancer Center with stage I-III gastric adenocarcinoma.

Safety and efficacy of perioperative dual PD-1 and HER2 blockade in HER2-positive gastric cancer.

The use of trastuzumab and programmed death-1 (PD-1) inhibitor is effective in patients with HER2-positive advanced gastric or gastro-esophageal junction cancer; however, their use has not been investigated in patients with localized disease. This phase 2 trial evaluates the safety and efficacy of dual PD-1 (sintilimab) and HER2 blockade with chemotherapy in patients with resectable HER2-positive gastric and gastro-esophageal junction adenocarcinoma. 22 patients are enrolled, and 20 patients undergo surgery.

Safety and efficacy of indocyanine green-guided laparoscopic lymphadenectomy for locally advanced gastric cancer: The CLASS-11 clinical trials.

We report the short-term results of indocyanine green (ICG)-guided laparoscopic lymphadenectomy for gastric cancer (GC). The primary outcome is 3-year disease-free survival. In this analysis, we present short-term secondary outcomes focused on the number of lymph nodes (LNs) retrieved and the diagnostic value of fluorescent status for metastatic LNs, excluding long-term outcomes.

Statins do not reduce the parasite burden during experimental infection.

Cardiomyopathy is the most common pathology associated with infection. Reports that statins have both cardioprotective and trypanocidal activity have generated interest in their potential as a therapeutic treatment. Using a highly sensitive bioluminescent mouse model, we show that a 5-day treatment with statins has no significant impact on parasite load.

Rice Growth Estimation and Yield Prediction by Combining the DSSAT Model and Remote Sensing Data Using the Monte Carlo Markov Chain Technique.

The integration of crop models and remote sensing data has become a useful method for monitoring crop growth status and crop yield based on data assimilation. The objective of this study was to use leaf area index (LAI) values and plant nitrogen accumulation (PNA) values generated from spectral indices to calibrate the Decision Support System for Agrotechnology Transfer (DSSAT) model using the Monte Carlo Markov Chain (MCMC) technique. The initial management parameters, including sowing date, sowing rate, and nitrogen rate, are recalibrated based on the relationship between the remote sensing state variables and the simulated state variables.

Lactate activates trained immunity by fueling the tricarboxylic acid cycle and regulating histone lactylation.

Trained immunity refers to the long-term memory of the innate immune cells. However, little is known about how environmental nutrient availability influences trained immunity. This study finds that physiologic carbon sources impact glucose contribution to the tricarboxylic acid (TCA) cycle and enhance cytokine production of trained monocytes.

Using network analysis to identify central symptoms of depression and anxiety in different profiles of infertility patients.

Background: Depression and anxiety were not only common but also with serious consequence in infertility patients. The current study endeavors to define distinct depression and anxiety profiles of infertility patients and identify central symptoms within different profiles to facilitate targeted interventions.

Method: The research employed K-means Clustering to delineate the depression and anxiety profiles, followed by a repetition of the analysis using Latent Class Analysis (LCA).

Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial.

This prospective, nonrandomized, open-label phase 2 trial (Chinese Clinical Trial Registry, ChiCTR2200061906) aimed to evaluate the effectiveness of adding the PD-1 antibody tislelizumab to perioperative chemotherapy in patients with locally advanced gastroesophageal junction adenocarcinoma (GEJA). This study enrolled patients with GEJA clinically staged as cT3-4aNanyM0 or cT1-2N+M0 from October 2022 to June 2023. Eligible patients were administered three preoperative and five postoperative 3-week cycles of treatment with PD-1 antibody tislelizumab plus SOX (S-1 and oxaliplatin) regimen.

Network analysis of stress and stigma symptoms and their associations with quality of life among Chinese female infertility patients.

Background: This study has employed network analysis while investigating the interrelationships among stress and stigma symptoms and their associations with quality of life among Chinese female infertility patients.

Methods: In this cross-sectional study, 428 female patients who visited the Department of Reproductive Center of Dalian Women and Children's Medical Group with chief complaints of infertility symptoms were recruited using convenience sampling from November 2022 to December 2023. Fertility-related stress and stigma status were examined by the Fertility Problem Inventory (FPI) and Infertility Stigma Scale (ISS), respectively.

Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted parasiticidal agent to treat paediatric enteric cryptosporidiosis.

Diarrhoeal disease caused by Cryptosporidium is a major cause of morbidity and mortality in young and malnourished children from low- and middle-income countries, with no vaccine or effective treatment. Here we describe the discovery of EDI048, a Cryptosporidium PI(4)K inhibitor, designed to be active at the infection site in the gastrointestinal tract and undergo rapid metabolism in the liver. By using mutational analysis and crystal structure, we show that EDI048 binds to highly conserved amino acid residues in the ATP-binding site.

Origin and Geochemical Characterization of Groundwater from Coal Seam: A Case Study of Balasu Coalfield, Ordos Basin.

The hydrochemical characteristics of groundwater are of great significance for studying the source, development, and utilization of groundwater. This study investigated the characteristics of anions and cations, total dissolved solids (TDS), hydrochemical types, and hydrogen and oxygen isotopes of surface water and groundwater in the Balasu coalfield. By conducting experiments using inductively coupled plasma emission electron spectrometry, ion chromatography, acid-base titration, and gravimetric analysis, the characteristics of ion concentration and TDS in different aquifers were analyzed to determine the possible source of groundwater in C2 (number 2 coal seam in Yan'an Formation).

Anti-Helicobacter pylori Treatment in Patients With Gastric Cancer After Radical Gastrectomy.

Importance: Whether anti-Helicobacter pylori treatment can provide survival benefits for patients with gastric cancer who are diagnosed with H pylori infection is an area with limited research.

Objective: To explore the potential survival benefits of anti-H pylori treatment after radical gastrectomy in patients with gastric cancer and presurgical confirmation of H pylori infection.

Design, Setting, And Participants: This retrospective cohort study was conducted using data from patients with gastric cancer treated between January 1, 2010, and December 31, 2018, and followed up for outcome ascertainment until May 19, 2021.

Adaptive river flow measurement method based on spatiotemporal image velocimetry and optical flow.

This paper proposes an adaptive river discharge measurement method based on spatiotemporal image velocimetry (STIV) and optical flow to solve the problem of blurred texture features and limited measurement accuracy under complex natural environmental conditions. Optical flow tracking generates spatiotemporal images by following the flow mainstream direction of rivers with both regular and irregular natural banks. A texture similarity function filtering method effectively enhances spatiotemporal texture features.

Detection of pesticide residues on flexible and transparent fluorinated polyimide film based on surface-enhanced Raman spectroscopy technology.

Background: Excessive pesticide residues will seriously endanger human health. The complexity and lag of the current popular analytical methods hinder the timeliness of food safety analysis. Surface-enhanced Raman scattering (SERS) was an ultra-sensitive vibration spectroscopy technology with the advantages of less time cost, non-destructive and semi-quantitative detection, which has attracted much attention in the rapid field detection of pesticide residue.

Flexible, foldable and transparent SERS film with high sensitivity and signal homogeneity via silver ion exchange and in-situ reduction.

The adhesion between metal plasma and substrate was the key of surface-enhanced Raman scattering (SERS) technology. The preparation of ideal SERS substrate with multiple advantages such as high sensitivity and good signal reproducibility was still the focus of research. A flexible foldable and transparent fluorinated polyimide/silver NPs (FPI@Ag) SERS film was fabricated by the ion exchange and in-situ reduction method in this work.

Combined Use of Tumor Markers in Gastric Cancer: A Novel Method with Promising Prognostic Accuracy and Practicality.

Background: The effect of a single tumor marker on the prognosis of gastric cancer patients is not ideal. This study explored a novel prognostic assessment method for gastric cancer (GC) patients using a combination of three important tumor markers (CEA, CA72-4, and CA19-9).

Method: Data from 1966 GC patients who underwent curative gastrectomy at Sun Yat-Sen University Cancer Center (Guangzhou, China) were included.

Selective removal of Cr(VI) by tannic acid and polyethyleneimine modified zero-valent iron particles with air stability.

In this study, a new composite adsorbent for Cr(VI) removal was developed by immobilizing polyethyleneimine (PEI) on the surface of zero-valent iron (ZVI) particles with tannic acid (TA) as a stabilizer. The adsorbent (denoted as Fe-TA-PEI-10) was easy to prepare and regenerate, requiring no conditions for storage. It was found to be particularly effective for Cr(VI) removal from wastewater via reduction and adsorption.

Evaluating relapse-free survival as an endpoint for overall survival in adjuvant immunotherapy trials.

Background: Relapse-free survival (RFS) has been considered a primary endpoint to assess the effects of immunotherapy in the adjuvant setting among patients with early-stage disease. However, it is not clear whether RFS is a valid surrogate endpoint for overall survival (OS) in this clinical context.

Methods: Phase II or III clinical trials of adjuvant immunotherapy that reported hazard ratios on OS and RFS were identified.

Prognostic factors and the necessity of chemotherapy for stage II gastric cancer: a model based on multicenter retrospective study.

Background: This study aimed to construct a prognostic model for prognosis prediction and assess the response to adjuvant chemotherapy (ACT) of stage II gastric cancer (GC) patients on high and low survival risk stratifications.

Methods: We retrospectively reviewed 547 stage II gastric cancer patients who underwent D2 radical gastrectomy from January 2009 to May 2017 in Sixth Affiliated Hospital of Sun Yat-Sen University (SAH-SYSU), the Fujian Medical University Union Hospital (FJUUH), and the Sun Yat-Sen University Cancer Center (SYSUCC).The propensity score matching (PSM) of all variables was performed to balance selective bias between ACT and surgery alone (SA) groups.

Adjuvant Chemotherapy for Patients with Adenocarcinoma of the Esophagogastric Junction: A Retrospective, Multicenter, Observational Study.

Background: Although the incidence of adenocarcinoma of the esophagogastric junction (AEG) has been increasing since the past decade, the proportion of AEG cases in two previous clinical trials (ACTS-GC and CLASSIC) that investigated the efficacy of adjuvant chemotherapy was relatively small. Therefore, whether AEG patients can benefit from adjuvant chemotherapy remains unclear.

Methods: Patients who were diagnosed with pathological stage II/III, Siewert II/III AEG, and underwent curative surgery at three high-volume institutions were assessed.