Novel surveillance protocol for gastric cancer based on CEA: a high-volume multi-center study.

Tumor markers are commonly used in gastric cancer patients, but their effectiveness in monitoring recurrences is not optimal. This study aims to evaluate the recurrence predictive performance of carcinoembryonic antigen (CEA) across different baseline groups and establish a new surveillance protocol. We analyzed data from 1708 patients at Sun Yat-Sen University Cancer Center with stage I-III gastric adenocarcinoma.

Optimized small object detection in low resolution infrared images using super resolution and attention based feature fusion.

Infrared (IR) imaging is extensively applied in domains such as object detection, industrial monitoring, medical diagnostics, intelligent transportation due to its robustness in low-light, adverse weather, and complex environments. However, challenges such as low resolution, high noise, limited texture details, and restricted dynamic range hinder the performance of traditional object detection models. To address these limitations, this study proposes an optimized approach for small object detection in low-resolution IR images by integrating super-resolution reconstruction with an enhanced YOLOv8 model.

Causal relationship between infection and gastrointestinal cancers: a multivariable Mendelian randomization study.

Background: The association between infection and gastrointestinal cancers (GICs) were indicated by pervious studies, but the direct causal link between infection and GIC remains largely unknown. We performed multivariable mendelian randomization (MR) analyses in order to investigate the causal relationship between genetically predicted infection and the GIC risk.

Methods: Instrumental variables (IVs) for several common pathogens including Helicobacter pylori (H.

Plumbagin ameliorates ferroptosis of ovarian granulosa cells in polycystic ovary syndrome by down-regulating SLC7A5 m6A methylation modification through inhibition of YTHDF1.

Background And Objective: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disease in women of reproductive age. One of its core pathologies is ovarian granulosa cell (GC) dysfunction, and ferroptosis, as a novel cell death mode dependent on iron ions and lipid peroxidation, may be involved in the PCOS process, but the exact mechanism is unknown. Plumbagin (PLB) shows potential in PCOS treatment due to its antioxidant properties.

LUNETR: Language-Infused UNETR for precise pancreatic tumor segmentation in 3D medical image.

The identification of early micro-lesions and adjacent blood vessels in CT scans plays a pivotal role in the clinical diagnosis of pancreatic cancer, considering its aggressive nature and high fatality rate. Despite the widespread application of deep learning methods for this task, several challenges persist: (1) the complex background environment in abdominal CT scans complicates the accurate localization of potential micro-tumors; (2) the subtle contrast between micro-lesions within pancreatic tissue and the surrounding tissues makes it challenging for models to capture these features accurately; and (3) tumors that invade adjacent blood vessels pose significant barriers to surgical procedures. To address these challenges, we propose LUNETR (Language-Infused UNETR), an advanced multimodal encoder model that combines textual and image information for precise medical image segmentation.

π-π Stacking in Kerogen and Its Mechanical Impact.

Kerogen is a key source of hydrocarbon production through hydraulic fracturing. However, the direct correlation between the molecular structure and mechanical properties remains unclear. Here, we employ four-dimensional scanning transmission electron microscopy (4D-STEM) to reveal heterogeneities defined by the orientation of π-π stacking domains and amorphous regions in kerogen.

ALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner.

The N6-methyladenosine (m6A) modification serves as an essential epigenetic regulator in eukaryotic cells, playing a significant role in tumorigenesis and cancer progression. However, the detailed biological functions and underlying mechanisms of m6A regulation in gastric cancer (GC) are poorly understood. Our research revealed that the m6A demethylase ALKBH5 was markedly downregulated in GC tissues, which was associated with poor patient prognosis.

Development and validation of a programmed cell death index to predict the prognosis and drug sensitivity of gastric cancer.

Aim: Programmed cell death (PCD) critically influences the tumor microenvironment (TME) and is intricately linked to tumor progression and patient prognosis. This study aimed to develop a novel prognostic indicator and marker of drug sensitivity in patients with gastric cancer (GC) based on PCD.

Methods: We analyzed genes associated with 14 distinct PCD patterns using bulk transcriptome data and clinical information from TCGA-STAD for model construction with univariate Cox regression and LASSO regression analyses.

Transcriptional landscape and predictive potential of long noncoding RNAs in peritoneal recurrence of gastric cancer.

Background: Long noncoding RNAs (lncRNAs) play a critical role in gastric cancer (GC) progression and metastasis. However, research comprehensively exploring tissue-derived lncRNAs for predicting peritoneal recurrence in patients with GC remains limited. This study aims to investigate the transcriptional landscape of lncRNAs in GC with peritoneal metastasis (PM) and to develop an integrated lncRNA-based score to predict peritoneal recurrence in patients with GC after radical gastrectomy.

Multi-omics analysis of the prognostic and biological role of cuproptosis-related gene in gastric cancer.

Background: A considerable number of gastric cancer (GC) patients cannot receive benefits from current treatments. We aimed to identify possible biomarkers of cuproptosis-related genes (CRGs) in GC patients, which may help guide precision medicine-based decision-making.

Methods: RNA sequencing data, copy number variations (CNVs) data, and single nucleotide variant (SNV) data were obtained from The Cancer Genome Atlas (TCGA) database and Gene Set Cancer Analysis (GSCA) database.

Acrosin activity negatively influences the cumulative live birth rate in patients undergoing IVF treatment.

Research Question: Is acrosin activity related to cumulative live birth rate (CLBR) over 1 year after IVF, intracytoplasmic sperm injection (ICSI) treatment or both?

Design: Retrospective monocentric cohort study of 5704 couples who started IVF/ICSI treatments between 2016 and 2021. Acrosin activity was determined by a modified Kennedy method using a commercial kit. Patients were divided into two groups according to their acrosin activity: below 25 μIU/10 spermatozoa; and an acrosin activity 25 μIU/10 spermatozoa or above.

The dual role of LOXL4 in the pathogenesis and development of human malignant tumors: a narrative review.

Background And Objective: Lysyl oxidase-like protein 4 (LOXL4) is a secreted copper-dependent amine oxidase involved in the assembly and maintenance of extracellular matrix (ECM), playing a critical role in ECM formation and repair. Tumor-stroma interactions and ECM dysregulation are closely associated with the mechanisms underlying tumor initiation and progression. LOXL4 is the latest identified member of the lysyl oxidase (LOX) protein family.

Anti-Helicobacter pylori Treatment in Patients With Gastric Cancer After Radical Gastrectomy.

Importance: Whether anti-Helicobacter pylori treatment can provide survival benefits for patients with gastric cancer who are diagnosed with H pylori infection is an area with limited research.

Objective: To explore the potential survival benefits of anti-H pylori treatment after radical gastrectomy in patients with gastric cancer and presurgical confirmation of H pylori infection.

Design, Setting, And Participants: This retrospective cohort study was conducted using data from patients with gastric cancer treated between January 1, 2010, and December 31, 2018, and followed up for outcome ascertainment until May 19, 2021.

Rejuvenation as the origin of planar defects in the CrCoNi medium entropy alloy.

High or medium- entropy alloys (HEAs/MEAs) are multi-principal element alloys with equal atomic elemental composition, some of which have shown record-breaking mechanical performance. However, the link between short-range order (SRO) and the exceptional mechanical properties of these alloys has remained elusive. The local destruction of SRO by dislocation glide has been predicted to lead to a rejuvenated state with increased entropy and free energy, creating softer zones within the matrix and planar fault boundaries that enhance the ductility, but this has not been verified.

Construction of hub transcription factor-microRNAs-messenger RNA regulatory network in recurrent implantation failure.

Purpose: Recurrent implantation failure (RIF) affects up to 10% of in vitro fertilization (IVF) patients worldwide. However, the pathogenesis of RIF remains unclear. This study was aimed at identifying hub transcription factors (TFs) of RIF in bioinformatics approaches.

Combined Use of Tumor Markers in Gastric Cancer: A Novel Method with Promising Prognostic Accuracy and Practicality.

Background: The effect of a single tumor marker on the prognosis of gastric cancer patients is not ideal. This study explored a novel prognostic assessment method for gastric cancer (GC) patients using a combination of three important tumor markers (CEA, CA72-4, and CA19-9).

Method: Data from 1966 GC patients who underwent curative gastrectomy at Sun Yat-Sen University Cancer Center (Guangzhou, China) were included.

Fabrication of Specimens for Atom Probe Tomography Using a Combined Gallium and Neon Focused Ion Beam Milling Approach.

We demonstrate a new focused ion beam sample preparation method for atom probe tomography. The key aspect of the new method is that we use a neon ion beam for the final tip-shaping after conventional annulus milling using gallium ions. This dual-ion approach combines the benefits of the faster milling capability of the higher current gallium ion beam with the chemically inert and higher precision milling capability of the noble gas neon ion beam.

Evaluating relapse-free survival as an endpoint for overall survival in adjuvant immunotherapy trials.

Background: Relapse-free survival (RFS) has been considered a primary endpoint to assess the effects of immunotherapy in the adjuvant setting among patients with early-stage disease. However, it is not clear whether RFS is a valid surrogate endpoint for overall survival (OS) in this clinical context.

Methods: Phase II or III clinical trials of adjuvant immunotherapy that reported hazard ratios on OS and RFS were identified.

Transcriptome-wide profile of 1α,25 dihydroxyvitamin D in HTR-8/SVneo cells.

Aim: Vitamin D has been implicated in multiple reproductive events, whereas the effect of its bioactive metabolite 1α, 25 dihydroxyvitamin D3 (1,25(OH) D ) on transcriptome profile of the placenta is unclear. The aim of this article is to determine transcriptome-wide profile caused by 1,25(OH) D in human placental trophoblast cells.

Methods: We performed RNA sequencing after stimulation of HTR-8/SVneo cells with 0.

Deformation and failure of the CrCoNi medium-entropy alloy subjected to extreme shock loading.

The extraordinary work hardening ability and fracture toughness of the face-centered cubic (fcc) high-entropy alloys render them ideal candidates for many structural applications. Here, the deformation and failure mechanisms of an equiatomic CrCoNi medium-entropyalloy (MEA) were investigated by powerful laser-driven shock experiments. Multiscale characterization demonstrates that profuse planar defects including stacking faults, nanotwins, and hexagonal nanolamella were generated during shock compression, forming a three-dimensional network.

Grain refinement in titanium prevents low temperature oxygen embrittlement.

Interstitial oxygen embrittles titanium, particularly at cryogenic temperatures, which necessitates a stringent control of oxygen content in fabricating titanium and its alloys. Here, we propose a structural strategy, via grain refinement, to alleviate this problem. Compared to a coarse-grained counterpart that is extremely brittle at 77 K, the uniform elongation of an ultrafine-grained (UFG) microstructure (grain size ~ 2.