Publications by authors named "Chengzhi Wei"
Tumor markers are commonly used in gastric cancer patients, but their effectiveness in monitoring recurrences is not optimal. This study aims to evaluate the recurrence predictive performance of carcinoembryonic antigen (CEA) across different baseline groups and establish a new surveillance protocol. We analyzed data from 1708 patients at Sun Yat-Sen University Cancer Center with stage I-III gastric adenocarcinoma.
View Article and Find Full Text PDFThe N6-methyladenosine (m6A) modification serves as an essential epigenetic regulator in eukaryotic cells, playing a significant role in tumorigenesis and cancer progression. However, the detailed biological functions and underlying mechanisms of m6A regulation in gastric cancer (GC) are poorly understood. Our research revealed that the m6A demethylase ALKBH5 was markedly downregulated in GC tissues, which was associated with poor patient prognosis.
View Article and Find Full Text PDFAim: Programmed cell death (PCD) critically influences the tumor microenvironment (TME) and is intricately linked to tumor progression and patient prognosis. This study aimed to develop a novel prognostic indicator and marker of drug sensitivity in patients with gastric cancer (GC) based on PCD.
Methods: We analyzed genes associated with 14 distinct PCD patterns using bulk transcriptome data and clinical information from TCGA-STAD for model construction with univariate Cox regression and LASSO regression analyses.
Background: Long noncoding RNAs (lncRNAs) play a critical role in gastric cancer (GC) progression and metastasis. However, research comprehensively exploring tissue-derived lncRNAs for predicting peritoneal recurrence in patients with GC remains limited. This study aims to investigate the transcriptional landscape of lncRNAs in GC with peritoneal metastasis (PM) and to develop an integrated lncRNA-based score to predict peritoneal recurrence in patients with GC after radical gastrectomy.
View Article and Find Full Text PDFMultiple cell-death patterns predict the prognosis and drug sensitivity of melanoma patients.
Front Pharmacol
October 2024
Article Synopsis
- - The study focuses on melanoma treatment challenges, highlighting the need for a model that can predict prognosis and assess drug sensitivity using programmed cell death (PCD) modes.
- - Researchers analyzed 13 PCD modes to create a Cell Death Index (CDI) based on gene signatures, which was validated with various data sources and showed distinct differences in patient outcomes.
- - The CDI model effectively predicts melanoma prognosis and drug resistance, indicating that patients with higher CDI values have poorer postoperative outcomes.
Article Synopsis
- Chronic exposure to interferon-γ (IFN-γ) in cancers leads to tryptophan shortage via the IDO-kynurenine pathway, which results in abnormal peptides being produced through ribosomal frameshifting and codon reassignment.
- In EBV-positive gastric cancer (GC), infiltrating lymphocytes secrete IFN-γ, increasing IDO1 expression and depleting tryptophan, which promotes the production of tryptophan-to-phenylalanine (W>F) substitutants.
- The mTOR/eIF4E signaling pathway plays a crucial role in this process, as inhibiting it can reduce W>F substitutant production and improve antigen presentation,
Anti-Helicobacter pylori Treatment in Patients With Gastric Cancer After Radical Gastrectomy.
JAMA Netw Open
March 2024
Importance: Whether anti-Helicobacter pylori treatment can provide survival benefits for patients with gastric cancer who are diagnosed with H pylori infection is an area with limited research.
Objective: To explore the potential survival benefits of anti-H pylori treatment after radical gastrectomy in patients with gastric cancer and presurgical confirmation of H pylori infection.
Design, Setting, And Participants: This retrospective cohort study was conducted using data from patients with gastric cancer treated between January 1, 2010, and December 31, 2018, and followed up for outcome ascertainment until May 19, 2021.
Objective: To compare the computed tomography (CT) images of patients with locally advanced gastric cancer (GC) before and after neoadjuvant chemotherapy (NAC) in order to identify CT features that could predict pathological response to NAC.
Methods: We included patients with locally advanced GC who underwent gastrectomy after NAC from September 2016 to September 2021. We retrieved and collected the patients' clinicopathological characteristics and CT images before and after NAC.
Article Synopsis
- Recent studies on PD-L1 expression in gastric cancer show mixed outcomes, especially regarding patients with peritoneal metastasis.
- Immunohistochemistry was conducted on 147 gastric cancer patients to evaluate PD-L1 expression using a combined positive score (CPS) and analyze its impact on survival.
- Results indicated that higher PD-L1 expression (CPS ≥ 10) was linked to significantly better overall survival compared to lower expression levels, highlighting its potential as a favorable prognostic factor alongside palliative chemotherapy.
Evaluating relapse-free survival as an endpoint for overall survival in adjuvant immunotherapy trials.
J Natl Cancer Inst
September 2023
Background: Relapse-free survival (RFS) has been considered a primary endpoint to assess the effects of immunotherapy in the adjuvant setting among patients with early-stage disease. However, it is not clear whether RFS is a valid surrogate endpoint for overall survival (OS) in this clinical context.
Methods: Phase II or III clinical trials of adjuvant immunotherapy that reported hazard ratios on OS and RFS were identified.
Background: The prognosis of patients with gastric cancer (GC) with gastric outlet obstruction (GOO) after gastrectomy is highly variable. In this study, we aimed to develop a nomogram to predict the prognosis of these patients.
Patients And Methods: Data from 218 GC patients with GOO who underwent gastrectomy at Sun Yat-sen University Cancer Center were retrospectively collected as a training cohort.
Effects of Laparoscopic Radical Gastrectomy on Peritoneal Micrometastases of Gastric Cancer.
Surg Laparosc Endosc Percutan Tech
March 2021
Background: Some reports asserted that the stimulation of ultrasonic scalpel and the persistent state of carbon dioxide (CO2) pneumoperitoneum in laparoscopic surgery may affect the adhesion and invasion of gastric cancer (GC) cells. This study aimed to reveal the effects of laparoscopic radical gastrectomy on peritoneal micrometastases (PM) of GC.
Materials And Methods: Fifty-three patients who underwent laparoscopic radical gastrectomy for GC were enrolled in the study.
Background: In recent five years, reports regarding albumin-to-globulin ratio (AGR) and the survival of gastric cancer (GC) have emerged rapidly, yet their association remains controversial. This meta-analysis was aimed to provide an insight into the prognostic significance of pretreatment AGR in GC.
Methods: PubMed, Embase, Cochrane library, Web of Science, WanFang, China National Knowledge Infrastructure (CNKI) and VIP databases were searched for relevant studies, from inception to September 30, 2020.
Background And Objectives: The relative effectiveness of tracers in guiding para-aortic lymph node dissection (PAND) in advanced gastric cancer is undefined. In this single-center, prospective study, we aimed to discuss the effectiveness of such tracers.
Materials And Methods: Between January 2015 and January 2016, 90 consecutive patients with stage T4a gastric cancer were evenly assigned to receive 0.