Serum levels of leucine-rich α-2 glycoprotein 1 (LRG1), pro-neurotensin (PNT), fatty acid-binding protein 4 (FABP4) and furin in pediatric growth hormone deficiency before and after 1-year growth hormone replacement therapy.

Objective: To investigate serum levels of leucine-rich α-2 glycoprotein 1 (LRG1), pro-neurotensin (PNT), fatty acid-binding protein 4 (FABP4), and furin in children with growth hormone deficiency (GHD) compared to idiopathic short stature (ISS) and healthy children, and to evaluate their changes and clinical relevance after 1-year growth hormone replacement therapy (GHRT).

Methods: The prospective cohort study was conducted in 32 idiopathic GHD, 32 ISS and 32 healthy children. Serum LRG1, PNT, FABP4, furin and clinical parameters were measured at baseline and after 6 and 12 months of GHRT.

Growth plate continuity on knee MRI predicts growth hormone effect in mid-to-late puberty with idiopathic short stature.

Purpose: To evaluate the efficacy and cost-effectiveness of recombinant human growth hormone (rhGH) therapy in adolescents with idiopathic short stature during mid-to-late puberty, using knee MRI to predict therapeutic response.

Methods: This one-year prospective cohort study included 50 idiopathic short stature adolescents and 100 healthy controls. Participants underwent knee MRI to classify growth plates into "continuous" and "discontinuous" subgroups.

Speckle suppression by a hybrid dual solid-state light source in laser projection.

Laser projection has become a new trend in display technology. However, speckle noise due to laser coherence poses a notable hurdle in achieving high image quality. We propose a new, to the best of our knowledge, architecture of a hybrid dual solid-state light source (HDSSL), which consists of RGB lasers and RGB light-emitting diodes (LEDs).

Deep Learning-Based Multi-View Facial Identification as a Screening Tool for Cushing's Syndrome.

Objectives: Cushing's syndrome (CS) could significantly impair lief quality. It is often diagnosed late due to misdiagnosis as simple obesity under current strategies. Given that CS is characterized by distinctive facial features, e.

Innovative Glucagon-like Peptide 1 Receptor Agonists: Exploring the Therapeutic Potential of Specific Modified Monomer, Dimer, and Tetramer in Type 2 Diabetes Treatment.

Modified glucagon-like peptide 1 (GLP-1) plays a crucial role in type 2 diabetes (T2D) treatment. The comparative hypoglycemic effect among fatty-acid-modified GLP-1 monomer G20, dimer 2G21, and tetramer 4G18 was evaluated in T2D mice. The polymers exhibited an opposite solubility with their monomers.

Metabolic profiles of Turner syndrome: A real-world cohort study.

Background And Objective: Turner syndrome (TS), primarily characterized by premature ovarian insufficiency, is a disease resulting from a complete or partial absence of the second X chromosome. This study aims to describe the prevalence of metabolic comorbidities in TS patients of different ages and karyotypes.

Methods: The medical history, diagnosis, physical examination, laboratory examination and imaging examination data of 145 TS patients were obtained from the medical files.

Rifampicin prevents diet-induced obesity through Sirt6-dependent lipolysis, adipocyte browning and lipogenesis inhibition.

Rifampicin (RFP) is a semi-synthetic macrocyclic broad-spectrum antibiotic known for its ability to inhibit bacterial proliferation. However, its potential role of obesity treatment has not been explored. We unveil a novel function of rifampicin using 3T3-L1 adipocytes and high-fat diet (HFD)-fed mice.

Evaluation of an AI facial recognition system for Turner Syndrome screening and facial complexity: a prospective cohort.

Purpose: Artificial intelligence-based facial recognition (AI-FR) is promising in diagnosis of diseases with distinct facial features. Our team has retrospectively constructed an AI-FR system for Turner Syndrome (TS) based on 1295 facial photographs in previous research. This study aims to evaluate this AI-FR system for TS screening in a prospective cohort in real-world clinic setting.

Exercise-induced metabolomics and its association with metabolic health in adolescents.

Background: While exercise training has been shown to improve various aspects of adolescent metabolic health, such as blood pressure, insulin resistance, and dyslipidemia, the underlying metabolic mechanisms remain poorly understood. No study has examined the metabolomic changes to identify potential mechanisms and explore biomarkers that predict exercise benefits in adolescents.

Methods: We used propensity score matching to select 54 pairs of adolescents (ages 12-14 years) with and without long-term exercise training.

Insulin sensitivity index independently predicts serum IGF-1 decreases in adolescents with long-term exercise.

Background: The study aims to investigate associations between insulin sensitivity and insulin-like growth factor-1 (IGF-1) in adolescents engaged in long-term exercise training, and to assess the impact on growth.

Methods: We conducted a prospective cohort study and followed for 1 year from a general high school (non-exercise group, age 13.3 ± 0.

Unveiling triclosan biodegradation: Novel metabolic pathways, genomic insights, and global environmental adaptability of Pseudomonas sp. strain W03.

The polychlorinated aromatic antimicrobial agent triclosan (TCS) is widely used to indiscriminately and rapidly kill microorganisms. The global use of TCS has led to widespread environmental contamination, posing significant threats to ecosystem and human health. Here we reported a newly isolated Pseudomonas sp.

Impact Factors of Blood Copeptin Levels in Health and Disease States.

Objective: Copeptin, the C-terminal glycopeptide of provasopressin, is released into the circulation in an equimolar manner with arginine vasopressin (AVP) when fluid homeostasis changes or has somatic stress. Copeptin is considered a potential alternative to AVP due to its advantages in facilitating assays. Although there have been several studies and reviews that have focused on the marker potential of copeptin in diseases involving changes in AVP, studies on its characteristics and factors that may influence its secretion have not been reviewed before.

Approach to the Patient: Diagnosis and Treatment With Growth Hormone of Turner Syndrome and Its Variants.

Context: Turner syndrome (TS) is characterized by a partial or complete absence of the second X chromosome in female individuals. Here, patients with Xp deletion involving SHOX haploinsufficiency caused by unbalanced X-autosome translocations were discussed and considered as TS variants.

Objective: This work aimed to expand the current knowledge of TS and unbalanced X-autosome translocations and to suggest the definition, clinical characteristics, diagnosis workflow, and growth hormone (GH) treatment strategy of TS and its variants.

Rapid assessment of acetophenone using an anti-interfering triple-emission Ln-functionalized HOF@MOF sensor.

The development of high-performance sensors for rapidly detecting acetylacetone (AP) in water samples is necessary because its release into the environment can result in many vital problems for human health and environment. Herein, we first designed a hybrid by integrating HOF with ZIF-8 through a sequential growth strategy. By separately introducing blue-emitting SiQDs and green- and red-emitting Tb and Eu into ZIF-8 and HOF, the resultant ZIF-8@SiQDs@HOF@Eu@Tb comprised three emission peaks at 484, 545 and 620 nm, all of which could be employed as switch-off responsive peaks to low concentrations of AP with a detection limit of 0.

Brachytherapy in craniopharyngiomas: a systematic review and meta-analysis of long-term follow-up.

Objective: Brachytherapy has been indicated as an alternative option for treating cystic craniopharyngiomas (CPs). The potential benefits of brachytherapy for CPs have not yet been clarified. The purpose of this work was to conduct a meta-analysis to analyze the long-term efficacy and adverse reactions profile of brachytherapy for CPs.

Research progress on the generation of NDMA by typical PPCPs in disinfection treatment of water environment in China: A review.

The drugs and personal care products in water sources are potential threats to the ecological environment and drinking water quality. In recent years, the presence of PPCPs has been detected in multiple drinking water sources in China. PPCPs are usually stable and resistant to degradation in aquatic environments.

Role function and job satisfaction of community nurses in China: A cross-sectional study.

Aim: To evaluate role function and job satisfaction, determine their relationship, and explore the factors influencing job satisfaction among community nurses in China.

Design: Cross-sectional study.

Methods: This study was conducted between March and June 2020 on a cluster random sampling of 302 community nurses from 24 community health centres and stations in Xi'an, China.

Blood Lipid Disorders in Post-Operative Craniopharyngioma Children and Adolescents and the Improvement with Recombinant Human Growth Hormone Replacement.

Context: The high prevalence of hypothalamic obesity (HO) and dyslipidemia in individuals with craniopharyngioma (CP) following surgery is a cause for increasing concern. However, few studies have explored the lipid profile in pediatric CP patients, with inconsistent findings. In addition, the role of recombinant human growth hormone (rhGH) replacement remains unclear in these patients.

On-chip Y-junction with adaptive power splitting toward ultrabroad bandwidth.

Growing research interests have been directed to the emerging optical communication band at 2-µm wavelengths. The silicon photonic components are highly desired to operate over a broad bandwidth covering both C-band and the emerging 2-µm wave band. However, the dispersions of the silicon waveguides eventually limit the optical bandwidth of the silicon photonic devices.

Isolation and characterization of Rhodococcus sp. GG1 for metabolic degradation of chloroxylenol.

The coronavirus disease 2019 (COVID-19) pandemic has significantly increased the demand of disinfectant use. Chloroxylenol (para-chloro-meta-xylenol, PCMX) as the major antimicrobial ingredient of disinfectant has been widely detected in water environments, with identified toxicity and potential risk. The assessment of PCMX in domestic wastewater of Macau Special Administrative Region (SAR) showed a positive correlation between PCMX concentration and population density.

Uncovering the metabolic pathway of novel Burkholderia sp. for efficient triclosan degradation and implication: Insight from exogenous bioaugmentation and toxicity pressure.

Triclosan (TCS), a synthetic and broad-spectrum antimicrobial agent, is frequently detected in various environmental matrices. A novel TCS degrading bacterial strain, Burkholderia sp. L303, was isolated from local activated sludge.

MedShift: Automated Identification of Shift Data for Medical Image Dataset Curation.

Automated curation of noisy external data in the medical domain has long been in high demand, as AI technologies need to be validated using various sources with clean, annotated data. Identifying the variance between internal and external sources is a fundamental step in curating a high-quality dataset, as the data distributions from different sources can vary significantly and subsequently affect the performance of AI models. The primary challenges for detecting data shifts are - (1) accessing private data across healthcare institutions for manual detection and (2) the lack of automated approaches to learn efficient shift-data representation without training samples.