Discordance between knee and hand-wrist bone age in adolescents: implications for skeletal maturity assessment and its association with thyroid-stimulating hormone levels.

Background: Hand-wrist radiographs may not fully reflect skeletal bone age (BA) during mid-to-late puberty. Knee magnetic resonance imaging (MRI), a non-radiative imaging technique, may provide detailed evaluation of the lower limbs.

Objective: To validate the San Diego MRI-based knee BA atlas in a Chinese adolescent cohort presenting with growth deceleration, evaluate the concordance between knee and hand-wrist BA, and explore factors influencing potential discrepancies.

The combination of linkage mapping, genome-wide association study, and dynamic transcriptome analysis reveals conserved candidate genes for salt tolerance in maize.

Six candidate genes for salt tolerance were identified through a accumulation of QTL mapping, GWAS, and transcriptome analysis. Additionally, the accumulation of favorable alleles significantly improved salt tolerance. Salinization in China is primarily concentrated in the northeast, northwest, and north regions, which overlap heavily with maize-growing areas, severely affecting maize production.

Biodegradable Zn-Li-Sr alloy implants with antioxidant properties for improved bone osseointegration under diabetic conditions.

The repair of bone defects under diabetes mellitus remains challenging due to the hyperglycaemic environment that tends to initiate oxidative stress, leading to poor bone healing. Therefore, the biodegradable, antioxidant and pro-osseointegration properties of bone implants are essential for the healing of diabetic bone defects. Addressing this issue requires bone implants with specialized properties, including biodegradability, antioxidant activity, and the ability to enhance pro-osseointegration.

A Starch Phosphorylase, ZmPHOH, Improves Photosynthetic Recovery from Short-Term Cold Exposure in Maize.

The photosynthetic system of maize () leaves is sensitive to low temperatures and suffers from irreversible damage induced by cold exposure, making cold stress a major factor limiting maize yield. Identifying genes that improve the recovery of photosynthesis from low temperatures in maize will help enhance the cold tolerance of this crop and ensure stable yields. Here, we demonstrate the role of () in promoting photosynthetic recovery from cold damage.

Genetic variations in ZmEREB179 are associated with waterlogging tolerance in maize.

Maize (Zea mays) is highly susceptible to waterlogging stress, which reduces both the yield and quality of this important crop. However, the molecular mechanism governing waterlogging tolerance is poorly understood. In this study, we identify a waterlogging- and ethylene-inducible gene ZmEREB179 that encodes an ethylene response factor (ERF) localized in the nucleus.

Potential source and health risks of black carbon based on MERRA-2 reanalysis data in a typical industrial city of North China Plain.

Black carbon (BC) significantly affects climate, environmental quality, and human health. This study utilised Modern-Era Retrospective Analysis for Research and Applications, version 2 (MERRA-2), which can compensate for the shortcomings of ground BC monitoring in spatial-temporal distribution to study the pollution characteristics of BC and potential pollution sources in a typical industrial city (Xinxiang) with serious air pollution in northern China. The results showed that average daily ground observation and MERRA-2 concentration of BC of 7.

Carbonized polymer dots modified ZnInS microspheres for visible-light-driven hydrogen evolution promotion performance.

To effectively separate electron-hole pairs produced by light, a heterojunction arrangement can be employed, thereby improving photocatalytic efficiency. In this study, a simple hydrothermal process is used to manufacture carbonized polymer dots/ZnInS (CPDs/ZIS) heterostructure, which enhances the light absorption and charge carrier lifetime in comparison to bare ZnInS (ZIS). Upon irradiation with visible light, the 3-CPDs/ZIS composite generates hydrogen at a rate of 133 μmol g h, which is 8.

Contribution of gene polymorphisms on 3p25 to salivary gland carcinoma, ameloblastoma, and odontogenic keratocyst in the Chinese Han population.

Objective: This study aimed to investigate the contribution of gene polymorphisms in 3p25 to salivary gland carcinoma (SGC), ameloblastoma (AM), and odontogenic keratocyst (OKC) in the Chinese Han population.

Study Design: Sixteen tag-single nucleotide polymorphisms (SNPs) within 5 genes (SYN2, TIMP4, PPARG, RAF1, and IQSEC1) in 3p25 were genotyped in 411 individuals with or without SGC, AM, and OKC. Genotype, clinical phenotype, and bioinformatics analyses were performed to evaluate the function of candidate SNPs.

Analysis of cytokines in bronchoalveolar lavage fluid in patients with checkpoint inhibitor pneumonitis and pulmonary infection: A case-control study.

Background: The discovery of immune checkpoint inhibitors (ICIs) is a breakthrough in the field of cancer therapy. However, ICIs may cause immune-related adverse reactions, including checkpoint inhibitor-related pneumonitis (CIP). The aim of this study was to investigate cytokines in bronchoalveolar lavage fluid (BALF) of patients with CIP compared with patients with pulmonary infection and patients with cancer.

Acromegaly complicated with fulminant pituitary apoplexy: clinical characteristic analysis and review of literature.

Purpose: To retrospectively summarize the clinical features of acromegaly complicated with fulminant pituitary apoplexy and analyze the prognostic factors to guide early identification and timely treatment of such patients.

Methods: A retrospective analysis was carried out to summarize the clinical manifestations, hormone changes, imaging, treatment and follow-up of ten patients with acromegaly complicated with fulminant pituitary apoplexy admitted to our hospital from February 2013 to September 2021.

Results: The mean age of the ten patients (five males and five females) at the time of pituitary apoplexy was 37.

Fam83h mutation causes mandible underdevelopment via CK1α-mediated Wnt/β-catenin signaling in male C57/BL6J mice.

Truncation mutations in FAM83H are the major cause of autosomal dominant hypocalcified amelogenesis imperfecta. Some studies also indicated that FAM83H could be involved in osteogenic differentiation; however, the function of FAM83H in bone formation was rarely explored. This study aimed to explore the effect of Fam83h mutation on skeletal development.

Genetic associations between gene polymorphisms on 3p25 and oral squamous cell carcinoma.

Objectives: To evaluate the association of SYN2, PPARG, RAF1, TIMP4, and IQSEC1 polymorphisms in 3p25 with oral squamous cell carcinoma (OSCC) in the Chinese Han population.

Subjects And Methods: Genomic DNA was extracted from 494 subjects with or without OSCC. Basic information on the subjects, clinical data, and prognoses were collected.

A novel DSPP frameshift mutation causing dentin dysplasia type 2 and disease management strategies.

The present study aims to investigate the mutation in a Chinese family with dentin dysplasia type II (DD-II) and to summarize mutation hotspots, clinical manifestations, and disease management strategies. Phenotype analysis, clinical intervention, mutation screening, and cosegregation analysis within the enrolled family were performed. A summary of the reported mutations in the dentin phosphoprotein (DPP) region of dentin sialophosphoprotein (DSPP) was analyzed.

Effects of Fam83h truncation mutation on enamel developmental defects in male C57/BL6J mice.

Truncation mutations in family with sequence similarity, member H (FAM83H) gene are considered the main cause of autosomal dominant hypocalcified amelogenesis imperfecta (ADHCAI); however, its pathogenic mechanism in amelogenesis remains poorly characterized. This study aimed to investigate the effects of truncated FAM83H on developmental defects in enamel. CRISPR/Cas9 technology was used to develop a novel Fam83h c.

Diagnosis, Manifestations, Laboratory Investigations, and Prognosis in Pediatric and Adult Cushing's Disease in a Large Center in China.

Purpose: Cushing's disease (CD) is a rare disease that contributes to 70-80% hypercortisolemia, which presents similarities and differences between pediatric and adult patients, and even between male and female patients. However, the comparative study of CD between different age groups and different genders is still insufficient. The aim of the study is to make a systematic comparison to reveal the gender differences in children and adult patients of CD, helping clinicians to provide optimal treatment for different groups of patients.

Activation of GATA-binding protein 4 regulates monocyte chemoattractant protein-1 and chemotaxis in periodontal ligament cells.

Background And Objectives: Periodontitis is a chronic inflammatory disease of periodontal supporting tissues. The persistent inflammatory reaction depends on the release of chemokines to continuously recruit inflammation cells. GATA-binding protein 4 (GATA4) exerts effects on senescence and inflammation, while its role in periodontitis is far from clear.

PER2-mediated ameloblast differentiation via PPARγ/AKT1/β-catenin axis.

Circadian rhythm is involved in the development and diseases of many tissues. However, as an essential environmental regulating factor, its effect on amelogenesis has not been fully elucidated. The present study aims to investigate the correlation between circadian rhythm and ameloblast differentiation and to explore the mechanism by which circadian genes regulate ameloblast differentiation.

Inactivation of homeodomain-interacting protein kinase 2 promotes oral squamous cell carcinoma metastasis through inhibition of P53-dependent E-cadherin expression.

Homeodomain-interacting protein kinase 2 (HIPK2), a well-known tumor suppressor, shows contradictory expression patterns in different cancers. This study was undertaken to clarify HIPK2 expression in oral squamous cell carcinoma (OSCC) and to reveal the potential mechanism of HIPK2 involvement in OSCC metastasis. Two hundred and four OSCC tissues, together with paired adjacent normal epithelia, dysplastic epithelia, and lymph node metastasis specimens, were collected to profile HIPK2 expression by immunohistochemical staining.

Enhanced thermal stability of inverted perovskite solar cells by interface modification and additive strategy.

Inverted perovskite solar cells (PSCs) have recently gained increasing attention because of the long operation lifetime achieved. However, bathocuproine (BCP): a commonly used buffer layer in inverted PSCs, is experimentally confirmed by us to show fast aggregation at the temperature of 85 °C, which is the protocol temperature required by the International Electrotechnical Commission (IEC) standard. This thermal instability of the BCP interfacial layer makes long-term thermal stability of inverted PSCs questionable.

Apocrine epithelial-myoepithelial carcinoma of the parotid gland with concurrent oncocytic change: a novel variant.

Epithelial-myoepithelial carcinoma (EMCa) is a rare, low-grade, malignant salivary gland tumor. Here, we report an unusual case of an EMCa with extensive apocrine and oncocytic changes. The tumor occurred in the left parotid gland of a 68-year-old male.

MicroRNA-transcription factor network analysis reveals miRNAs cooperatively suppress RORA in oral squamous cell carcinoma.

Oral squamous cell carcinoma (OSCC) represents over 90% of oral cancer incidence, while its mechanisms of tumorigenesis remain poorly characterized. In this study, we applied RNA-seq and microRNA-seq methodologies in four pairs of cancer and adjacent normal tissues to profile the contribution of miRNAs to tumorigenesis-altered functional pathways by constructing a comprehensive miRNA-mediated mRNA regulatory network. There were 213 differentially expressed (DE) miRNAs and 2172 DE mRNAs with the involvement of negative miRNA-mRNA interactions identified by at least two pairs of cancerous tissues.

XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma.

X‑box‑binding protein 1 (XBP1) contributes to various types of cancer including breast, bladder cancer and esophageal squamous cell carcinoma. The aim of the study was to examine the metastatic role of XBP1 in oral squamous cell carcinoma (OSCC), and identify possible downstream molecules. Immunohistochemical staining was conducted on tissue microarrays comprising 96 OSCC cases to determine the expression level of XBP1 and analyze its association with metastasis, clinicopathological characteristics and survival prognosis.