SMURF2 Inhibits Autophagy and Growth in Ovarian Cancer by Regulating the RACK1/AKT/mTOR Pathway.

Background: Ovarian cancer (OC) is a common malignancy characterized by disseminated peritoneal metastases. Smad ubiquitin regulatory factor 2 (SMURF2) is involved in OC progression by stabilizing receptor for activated C kinase 1 (RACK1). However, the functions and mechanisms of action of SMURF2 in OC remain unclear.

Global, Regional, and National Burden of Atopic Dermatitis: Insights From the Global Burden of Disease Study 2021.

The 2017 Global Burden of Disease (GBD) report identified atopic dermatitis (AD) as the skin disease with the highest disease burden, assessed in terms of disability-adjusted life-years (DALYs), and a modest increase in the number of AD-associated DALYs was observed in 2019 compared to 2017. This study aims to provide updated insights from the GBD 2021 database. Data on the prevalence and DALYs of AD in 2021 were extracted from the GBD database.

Design of a 3D-printing fluorescence detector for HPLC separation: a prototype device.

Herein, we developed a three-dimensional (3D)-printing fluorescence detector that could be connected to the HPLC system, and distinguished by its ease of assembly, cost-effectiveness, and high adaptability. The detector comprises a laser diode, a 3D-printing flow cell, quartz glass, a long-pass filter, a silicon phototube, and a voltmeter. Technically, the flow cell we designed here has a very compact structure, and it is convenient to embed the optical filter and the phototube, which is also a highlight of our detector to ensure the miniaturization of the whole device.

Exploring dual-view graph structures: Contrastive learning with graph and hypergraph for multivariate time series classification.

Multivariate time series classification involves not only extracting temporal information but also uncovering the relationships between multiple variables. Graph-based methods have gained attention for their ability to extract temporal information and directly model relationships between variables. However,these methods primarily focus on low-order pairwise relationships between variables, neglecting high-order multivariate non-pairwise relationships, which results in an incomplete capture of inter-variable dependencies.

The combination of linkage mapping, genome-wide association study, and dynamic transcriptome analysis reveals conserved candidate genes for salt tolerance in maize.

Six candidate genes for salt tolerance were identified through a accumulation of QTL mapping, GWAS, and transcriptome analysis. Additionally, the accumulation of favorable alleles significantly improved salt tolerance. Salinization in China is primarily concentrated in the northeast, northwest, and north regions, which overlap heavily with maize-growing areas, severely affecting maize production.

Glucan-based biomaterials and their applications in the biomedical field.

Glucan is a class of natural polysaccharide formed by multiple glucose units connected by glucoside bonds. In recent years, it has attracted much attention in the biomedical field because of its biodegradability, biocompatibility, bioactivity, and ease of chemical modification, among other properties. The development of various glucan-based biomaterials such as prodrugs, hydrogels, micelles, microspheres, and nanoparticles have great potential for applications in drug delivery, tissue engineering, wound healing, etc.

The preparation of silk fibroin-based hydrogels and their applications in cartilage repair.

With the social development, the number of patients with osteoarthritis (OA) is increasing year by year, making it crucial to explore novel therapies and treatments to facilitate cartilage repair. Among these, hydrogels have become a center of conversation as potential cartilage substitutes in view of their swelling capacity, mechanical properties, lubricating performance, and other characteristics similar with that of extracellular matrix of articular cartilage. Therefore, it is of important values to generate multi-functional hydrogels with various bioactive materials for cartilage repair.

Emerging Contaminants: An Important But Ignored Risk Factor for Psoriasis.

Industrialization and modernization have changed the environment. A group of emerging contaminants (ECs) has been defined recently. Psoriasis, whose incidence has increased in recent years, is a relapsing immune-mediated disease carrying a heavy disease burden.

Temporomandibular disorder prevalence in malocclusion patients: a meta-analysis.

Objectives: This study investigated the prevalence of temporomandibular disorders (TMD) in patients with malocclusion through a systematic review and meta-analysis.

Materials And Methods: A comprehensive literature search was conducted up to November 15, 2024. Cross-sectional studies providing data on TMD prevalence among malocclusion patients were included.

A Starch Phosphorylase, ZmPHOH, Improves Photosynthetic Recovery from Short-Term Cold Exposure in Maize.

The photosynthetic system of maize () leaves is sensitive to low temperatures and suffers from irreversible damage induced by cold exposure, making cold stress a major factor limiting maize yield. Identifying genes that improve the recovery of photosynthesis from low temperatures in maize will help enhance the cold tolerance of this crop and ensure stable yields. Here, we demonstrate the role of () in promoting photosynthetic recovery from cold damage.

Multifunctional phenylboric acid modified carboxymethyl chitosan based hydrogel crosslinked by tannic acid.

Hydrogels prepared from natural polysaccharide, such as chitosan, have attracted much attention owing to their advantageous physicochemical properties and functions. Therefore, it is of great significance to develop novel crosslinking and preparation methods for hydrogels. Here, a class of multifunctional chitosan-based (CBT) hydrogels were prepared from 3-carboxy-5-nitrophenylboronic acid (PBA) modified carboxymethyl chitosan (CMCS) and tannic acid (TA) by double crosslinking of borate ester and hydrogen bonds.

Tumor microenvironment-responsive hyperbranched polymers for controlled drug delivery.

Hyperbranched polymers (HBPs) have drawn great interest in the biomedical field on account of their special morphology, low viscosity, self-regulation, and facile preparation methods. Moreover, their large intramolecular cavities, high biocompatibility, biodegradability, and targeting properties render them very suitable for anti-tumor drug delivery. Recently, exploiting the specific characteristics of the tumor microenvironment, a range of multifunctional HBPs responsive to the tumor microenvironment have emerged.

[Analysis of non-targeted variants by invasive prenatal diagnosis for pregnant women undergoing preimplantation genetic testing].

Objective: To compare the results of invasive prenatal diagnosis and preimplantation genetic testing (PGT) and explore the underlying mechanism.

Methods: Clinical data of pregnant women undergoing PGT and invasive prenatal diagnosis at the Sixth Affiliated Hospital of Sun Yat-sen University from January 2019 to December 2022 were collected. The results of PGT and invasive prenatal diagnosis were compared, and the outcomes of pregnancies were followed up.

Arsenic redox disequilibrium in geogenic contaminated groundwater: Bioenergetic insights from organic molecular characterization and gene-informed modeling.

Biotransformation of arsenic (As) influences its speciation and mobility, obscuring mechanistic comprehension on spatiotemporal variation of As concentration in geogenic contaminated groundwater. In particular, unresolved processes underlying As redox disequilibrium in comparison to major redox couples discourage practical efforts to rehabilitate the As-contaminated groundwater. Here, quantitative metagenomic sequencing and ultrahigh-resolution mass spectrometry (FT-ICR-MS) were jointly applied to reveal the links between vertical distribution of As metabolic gene assemblages and that of free energy density of dissolved organic matter (DOM) in As-contaminated groundwater of Datong Basin.

Comprehensive applications of the artificial intelligence technology in new drug research and development.

Purpose: Target-based strategy is a prevalent means of drug research and development (R&D), since targets provide effector molecules of drug action and offer the foundation of pharmacological investigation. Recently, the artificial intelligence (AI) technology has been utilized in various stages of drug R&D, where AI-assisted experimental methods show higher efficiency than sole experimental ones. It is a critical need to give a comprehensive review of AI applications in drug R &D for biopharmaceutical field.

Transferability of Machine Learning Models for Geogenic Contaminated Groundwaters.

Machine learning models show promise in identifying geogenic contaminated groundwaters. Modeling in regions with no or limited samples is challenging due to the need for large training sets. One potential solution is transferring existing models to such regions.

IGF2BP3-mediated regulation of and gene expression promotes treg-induced immune escape in human cervical cancer.

This study aimed to investigate the impact of IGF2BP3, a well-known m6A modification-related protein, on the metabolic and immune microenvironment of human cervical cancer. Bioinformatics analysis was performed to analyze the expression of IGF2BP3 in various databases, and its findings were validated using human cervical cancer tissue microarrays. We conducted a study to investigate the impact of IGF2BP3 on glutamine metabolism in cervical cancer cells through the application of metabolomics and metabolic flow analysis.

Co-occurrence of arsenic and iodine in the middle-deep groundwater of the Datong Basin: From the perspective of optical properties and isotopic characteristics.

Redox processes can induce arsenic (As) and iodine (I) transformation and thus change As and I co-occurrence, yet there is no evidence that Fe-C-S coupled redox processes have such an impact on the co-occurrence of As and I. To fill this gap, middle-deep groundwater from the Datong Basin were samples for the purpose of exploring how dissolved organic matter (DOM) reactivity affects As and I enrichment and how iron reduction and sulfate reduction processes influence As and I co-occurrence. We identified three DOM components: reduced and oxidized quinone compounds (C1 and C3) and a labile DOM from terrestrial inputs (C2).

Smartphone-based hand-held polarized light microscope for on-site pharmaceutical crystallinity characterization.

Polarized light microscopy (PLM) is a common but critical method for pharmaceutical crystallinity characterization, which has been widely introduced for research purposes or drug testing and is recommended by many pharmacopeias around the world. To date, crystallinity characterization of pharmaceutical solids is restricted to laboratories due to the relatively bulky design of the conventional PLM system, while little attention has been paid to on-site, portable, and low-cost applications. Herein, we developed a smartphone-based polarized microscope with an ultra-miniaturization design ("hand-held" scale) for these purposes.

TENT5D disruption causes oligoasthenoteratozoospermia and male infertility.

Background: Oligoasthenoteratozoospermia (OAT) is one of the most complex aggregators of male gametic problems. However, the genetic etiology of OAT is still largely unknown.

Objectives: To reveal the new genetic factors responsible for male infertility owning to OAT and reveal the outcomes of the affected patients from intracytoplasmic sperm injection (ICSI).

Homozygous mutation in leads to asthenoteratozoospermia by affecting the inner dynein arms.

Asthenozoospermia is the most common cause of male infertility. Dynein protein arms play a crucial role in the motility of sperm flagella and defects in these proteins generally impair the axoneme structure and affect sperm flagella function. In this study, we performed whole exome sequencing for a cohort of 126 infertile patients with asthenozoospermia and identified homozygous mutation in one patient from a consanguineous family.

Synthesis of bimetal MOFs for rapid removal of doxorubicin in water by advanced oxidation method.

Doxorubicin (DOX) has been an emerging environmental pollutant due to its significant genotoxicity to mankind. Advanced oxidation processes are a potential strategy to remove DOX in water solution. To develop a highly efficient catalytic agent to remove DOX, bimetal MOFs were synthesized, with Cu and Co as the central ions and adenine as the organic ligand.

Starch phosphorylase 2 is essential for cellular carbohydrate partitioning in maize.

Carbohydrate partitioning is essential for plant growth and development, and its hindrance will result in excess accumulation of carbohydrates in source tissues. Most of the related mutants in maize (Zea mays L.) display impaired whole-plant sucrose transport, but other mechanisms affecting carbohydrate partitioning have seldom been reported.

The SNP rs516946 Interacted in the Association of MetS with Dietary Iron among Chinese Males but Not Females.

This study aimed to explore the role of the single nucleotide polymorphism (SNP) rs516946 of the Ankyrin 1 (ANK1) gene in the relationship between dietary iron and metabolic syndrome (MetS) in the Chinese population. A total of 2766 Chinese adults (1284 males and 1482 females) were recruited. A 3-day 24-h dietary recall and weighing of household condiments were used to assess dietary intake.

PHDMF: A Flexible and Scalable Personal Health Data Management Framework Based on Blockchain Technology.

Currently, most of the personal health data (PHD) are managed and stored separately by individual medical institutions. When these data need to be shared, they must be transferred to a trusted management center and approved by data owners through the third-party endorsement technology. Therefore, it is difficult for personal health data to be shared and circulated over multiple medical institutions.