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Article Abstract
The 2017 Global Burden of Disease (GBD) report identified atopic dermatitis (AD) as the skin disease with the highest disease burden, assessed in terms of disability-adjusted life-years (DALYs), and a modest increase in the number of AD-associated DALYs was observed in 2019 compared to 2017. This study aims to provide updated insights from the GBD 2021 database. Data on the prevalence and DALYs of AD in 2021 were extracted from the GBD database. Statistical analyses were performed by R software (version 4.4.1). In 2021, AD still represented the highest age-standardized DALY rate (ASDR) among all skin disorders. Globally, the age-standardized prevalence rate (ASPR) and ASDR of AD were 1728.5 (95% UI: 1658.5-1798.6) and 75.5 (95% UI: 38.8-125.6) per 100,000 population, respectively. The ASPR and ASDR were highest in high-income Asia Pacific but lowest in Central Sub-Saharan Africa. The burden of AD was mainly in children, declining with age; however, a modest rise in ASPR and ASDR was noted among the elderly. Women generally experienced a higher burden than men. In 2021, AD remained the leading cause of DALYs among skin diseases, disproportionately affecting children and older adults, especially in urban areas.
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