Comprehensive distribution of Se in yellowfin tuna dark meat and characterization of its Se-enriched water-soluble protein.

Yellowfin tuna dark meat is usually discarded as a processing by-product. In this study, dark meat was found to be an excellent animal-derived Se carrier, with its protein fraction exhibiting the highest Se-binding capacity of 15.76 ± 0.

Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression.

Metabolic reprogramming not only reshapes cellular bioenergetics but also profoundly influences RNA metabolism through metabolite signaling and the RNA-binding activities of metabolic enzymes. Emerging evidence highlights that certain metabolic enzymes act as RNA-binding proteins (RBPs) to regulate gene expression and promote tumor progression. However, the non-catalytic post-transcriptional regulatory functions of metabolic enzymes in hepatocellular carcinoma (HCC) remain largely unexplored.

Acute Cu exposure induces neurotoxicity via DAF-16/FoxO and SKN-1/Nrf2 pathway.

Copper (Cu) pollution has raised global environmental concern due to its persistence and toxicity. Numerous studies have shown that the imbalance of Cu metabolism is closely related the neurodegenerative diseases. Previous study exposited that excessive Cu participating in neurotoxic mechanism through oxidative stress, protein misfolding, mitochondrial malfunction, autophagy dysregulation, and apoptosis.

Analysis of the mechanism of starch gelatinization, disintegration and component interaction during roasting processing of Chinese traditional oat food.

Chinese traditional oat food processing involves three times thermal treatment, with the first processing being high-temperature roasting to improve the processing quality. However, the mechanism by which roasting affects the starch structure and processing quality is not clear. Therefore, oat with different roasting time (0-20 min) was collected for in-depth structural analysis.

"Check Ligament Suspension for Severe Congenital Blepharoptosis".

Background: Check ligament suspension has been expected to become an alternative to frontalis technique. However, it has not yet been widely used because of anatomical controversies, concerns regarding its reliability, and the risk of conjunctival prolapse. This article details the authors' experience with the use of check ligament suspension for the treatment of severe congenital ptosis, and evaluates the functional and cosmetic results.

Work performance of middle-aged and elderly employees in hotel industry: the moderating effects of organizational support and age discrimination.

With the acceleration of the process of social aging, the re-employment of middle-aged and elderly people has gradually attracted the attention of society. Due to the relatively low barrier to entry, the hotel industry is favored by middle-aged and elderly people who are re-employed. This study analyzes the impacts of the three-dimensional capital on the job performance of middle-aged and elderly employees and investigates how organizational support and age discrimination moderate the effect of job satisfaction on job performance.

Pyrotinib and Nab-Paclitaxel in HER2-Positive Breast Cancer (PANHER Trial): A Prospective, Single-Arm, Phase II Trial.

Trastuzumab and pertuzumab combined with chemotherapy represent the standard therapy for first-line treatment of HER2-positive metastatic breast cancer (BC). Due to challenges related to availability and cost in China, it is necessary to explore treatments involving tyrosine kinase inhibitors (TKIs). In this multicenter, single-arm, open-label phase II trial, patients with HER2-positive BC were enrolled from seven hospitals in China.

Selenium-containing polyurethane nanofibers with MnO nanoparticles and gelsevirine promote diabetic wound healing by modulation of ROS and inflammation.

Reactive oxygen species (ROS) and subsequent inflammatory cascades hinder the healing of diabetic wounds, which should be tackled simultaneously when designing wound dressings. In this study, ROS-responsive di‑selenium-containing polyurethane nanofibers (PUF) loaded with manganese dioxide nanoparticles (MnO NPs) and gelsevirine (GSV) with an average diameter of 0.6 ± 10 μm, were prepared to specifically target ROS and inflammation control, thereby enhancing healing in diabetic wounds.

Adaptive decoupling-fusion in Siamese network for image classification.

Convolutional neural networks (CNNs) are highly regarded for their ability to extract semantic information from visual inputs. However, this capability often leads to the inadvertent loss of important visual details. In this paper, we introduce an Adaptive Decoupling Fusion (ADF) designed to preserve these valuable visual details and integrate seamlessly with existing hierarchical models.

Achieving Higher-Order Exceptional Points in a Terahertz Metasurface.

Exceptional points (EPs) are unique features of non-Hermitian systems, where eigenvalues and eigenvectors coalesce, enabling functionalities such as ultrasensitive sensing and topological energy transfer. While higher-order EPs have been studied in microdisk cavities and circuits, their realization in metasurfaces has been challenging. In this work, we demonstrate the first realization of a third-order EP (EP3) in terahertz metasurfaces by tuning the near-field interaction between three gold split-ring resonators.

A self-sacrificing anti-inflammatory coating promotes simultaneous cardiovascular repair and reendothelialization of implanted devices.

During interventional surgeries of implantable cardiovascular devices in addressing cardiovascular diseases (CVD), the inevitable tissue damage will trigger host inflammation and vascular lumen injury, leading to delayed re-endothelization and intimal hyperplasia. Endowing cardiovascular implants with anti-inflammatory and endothelialization functions is conducive to the target site, offering significant tissue repair and regeneration benefits. Herein, inspired by the snake's molting process, a ShedWise device was developed by using the poly(propylene fumarate) polyurethane (PPFU) as the foundational material, which was clicked with hyperbranched polylysine (HBPL) and followed by conjugation with pro-endothelial functional Arg-Glu-Asp-Val peptide (REDV), and finally coated with a "self-sacrificing" layer having reactive oxygen species (ROS)-scavenging ability and degradability.

Sarcopenia, Depressive Symptoms, and Fall Risk: Insights from a National Cohort Study in the Chinese Population.

Background: Previous investigations have indicated that both sarcopenia and depressive symptoms are linked to a heightened risk of falls. However, the potential synergistic effect of these conditions on fall risk remains unclear. This study aims to assess the combined influence of sarcopenia and depressive symptoms on the occurrence of falls in the Chinese population.

Lignin-Based Functional Materials in Agricultural Application: A Review.

The demand for biodegradable, sustainable, and eco-friendly alternatives is growing in crop production and protection, which forces an urgent need for society to shift toward more sustainable agricultural development. In recent years, the development and research of lignin-based functional materials have gained increasing attention and impetus, and their use has become more widespread in sustainable agriculture. This review covers the latest research on the potential applications of lignin-based functional materials in plant protectants, sensors for pollutant detection, toxic element removal in soil and water, enzyme immobilization, plant growth regulators/biostimulants, hydrogels, and mulching films.

Preparation of Acetylcholinesterase Inhibitory Peptides from Yellowfin Tuna Pancreas Using Moderate Ultrasound-Assisted Enzymatic Hydrolysis.

Bioactive peptides represent a promising therapeutic approach for Alzheimer's disease (AD) by maintaining cholinergic system homeostasis through the inhibition of acetylcholinesterase (AChE) activity. This study focused on extracting AChE inhibitory peptides from yellowfin tuna pancreas using moderate ultrasound-assisted enzymatic hydrolysis (MUE). Firstly, papain and MUE stood out from five enzymes and four enzymatic hydrolysis methods, respectively, by comparing the degree of hydrolysis and AChE inhibitory activity of different pancreatic protein hydrolysates.

Identification and Verification of the Driver Genes for the Formation and Development of Intracranial Aneurysms.

Background: Research on driver genes that can be used to diagnose and control the formation and development of intracranial aneurysms (IAs) is still limited, and bioinformatics and machine learning approaches are implemented in the study in an aim to identify and validate them.

Methods: By applying datasets from the Gene Expression Omnibus database for human cerebrovascular tissue, 47 cases of ruptured IA, 71 cases of ruptured IA, and 64 cases of normal control intracranial vessels were analyzed. Apply bioinformatics and machine learning methods to screen for the driver genes that contribute to the occurrence and development of IAs.

The Quality and Starch Digestibility of Multi-Grain Noodles Are Regulated by the Additive Amount of Dendrobium Officinale.

Dendrobium officinale (DO) is a well-known medicinal and edible plant, yet its impact on the quality of noodles has been infrequently reported. In this study, DO was incorporated into multi-grain flour in varying proportions (0, 2, 4, 6, 8%) to prepare noodles, and their quality was assessed. The percentage increase in DO decreased the cooking loss, whiteness, appearance, and taste of the noodles while simultaneously enhancing their water absorption, adhesiveness, smoothness, and starch digestion resistance.

Tanshinone IIA@β-cyclodextrin encapsulated with Eucommia ulmoides rubber/acetylated starch film as novel oral delivery system for therapy of orthotopic colon cancer.

Oral drug delivery plays a key role in the treatment of colon cancer. In this study, as a novel oral delivery system, drug tanshinone IIA (Tan IIA) was firstly loaded into β-cyclodextrin (β-CD) to prepare Tan IIA@β-CD, which was subsequently encapsulated by Eucommia ulmoides rubber (EUR)/acetylated starch (AS) film to endow it colon-targeted drug release function. The constructed EUR/AS/Tan IIA@β-CD was characterized using zeta potential, FT-IR, UV-vis, XRD, TG, SEM, and TEM.

Microbial-mediated carbon metabolism in the subtropical marine mangroves affected by shrimp pond discharge.

Mangrove ecosystems exhibit high efficiency in carbon (C) sequestering within the global ecosystem. However, the rapid expansion of the shrimp farming industry poses a significant threat to these delicate ecosystems. The microbial mechanisms driving C metabolism in shrimp-affected sediments remain poorly understood.

Xylan thermoplastics with closed-loop recyclability.

Xylan-derived packaging materials have gained considerable popularity owing to their renewability, non-toxicity, and biodegradability. However, thermoforming is challenging owing to its rigid structure and hydrogen-bonding network of the xylan molecular chain, which limits its large-scale production. Herein, a heat-processable xylan derivative, xylan cinnamate (XC), was synthesized via an esterification reaction in ionic liquids.

Design and fabrication of xylan-graft-poly (methyl methacrylate) thermoplastic via SARA ATRP.

Due to the emphasis on the environmental and health issues caused by petroleum-based plastics, renewable lignocellulosic materials emerge as promising substitutes. However, their practical application remains hindered by unsatisfactory properties such as fragility and sensitivity to water. Dealing with the challenge of non-thermal processing of xylan and addressing the issue of performance degradation resulting from the hygroscopicity of materials.

RUNX2 Phase Separation Mediates Long-Range Regulation Between Osteoporosis-Susceptibility Variant and XCR1 to Promote Osteoblast Differentiation.

GWASs have identified many loci associated with osteoporosis, but the underlying genetic regulatory mechanisms and the potential drug target need to be explored. Here, a new regulatory mechanism is found that a GWAS intergenic SNP (rs4683184) functions as an enhancer to influence the binding affinity of transcription factor RUNX2, whose phase separation can mediate the long-range chromatin interaction between enhancer and target gene XCR1 (a member of the GPCR family), leading to changes of XCR1 expression and osteoblast differentiation. Bone-targeting AAV of Xcr1 can improve bone formation in osteoporosis mice, suggesting that XCR1 can be a new susceptibility gene for osteoporosis.

Ultrasound-assisted modification of oat protein isolates: Structural and functional enhancements.

Escalating global protein demand necessitates the commercialization of protein rich products. Oat is a promising high-quality protein source but it requires structural and functional modifications to diversify its application. The current investigation was focused on the impact of different powers of ultrasonic waves (200, 400, and 600 W) on structural and functional characteristics of oat protein isolates to improve its techno-functional properties.

The triglyceride-glucose index and risk of cognitive impairment: a systematic review and meta-analysis with inclusion of two national databases.

Background: To investigate the relationship between the triglyceride and glucose (TyG) index and cognitive impairment (CI).

Methods: Five authoritative databases were systematically searched for potentially relevant studies on 'TyG index' and 'CI' from inception to 27 April 2024. Two representative databases from the United Kingdom and United States were also included.

Framework Nucleic Acids: Innovative Tools for Cellular Sensing and Therapeutics.

As emerging biomaterials, framework nucleic acids (FNAs) have recently demonstrated great potential in the biomedical field due to their high programmability, biocompatibility, unique structural diversity, and precise molecular design capabilities. This review focuses on the applications of FNAs in cellular sensing and disease treatment. First, we systematically introduce the applications of FNAs in cellular sensing, including their precise recognition and response to the extracellular tumor microenvironment, cell membrane proteins, and intracellular biomarkers.