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Exceptional points (EPs) are unique features of non-Hermitian systems, where eigenvalues and eigenvectors coalesce, enabling functionalities such as ultrasensitive sensing and topological energy transfer. While higher-order EPs have been studied in microdisk cavities and circuits, their realization in metasurfaces has been challenging. In this work, we demonstrate the first realization of a third-order EP (EP3) in terahertz metasurfaces by tuning the near-field interaction between three gold split-ring resonators. This transition from second-order EP (EP2) to EP3 is validated by the simultaneous collapse of three eigenvalues and eigenfunctions. Using a global optimization algorithm combined with neural networks, we optimized the condition for EP3 in a high-dimensional parameter space. Our terahertz metasurface is suitable for ultrasensitive biosensing applications, offering a novel mechanism for EP3 realization and paving the way for advanced optical communication and sensing systems.
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http://dx.doi.org/10.1021/acs.nanolett.4c05599 | DOI Listing |
Mikrochim Acta
September 2025
Department of Surgical Oncology, Shaanxi Provincial People's Hospital, 256 Friendship West Road, Beilin District, Xi'an, 710068, Shaanxi, China.
Mycoplasma pneumonia, a primary aetiological agent of atypical pneumonia, necessitates the implementation of rapid point-of-care diagnostics. Lateral flow immunoassays (LFIAs) hold promise for point-of-care testing (POCT), yet their sensitivity levels are frequently constrained by probe affinity and matrix interference. We introduce an orientational labelling strategy that employs magnetic nanoparticles (MNPs) functionalized with staphylococcal protein A (SPA) to simultaneously enhance antibody orientation and facilitate magnetic enrichment.
View Article and Find Full Text PDFMicrobiol Spectr
September 2025
Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Efficient DNA delivery is essential for genetic manipulation of mycobacteria and for dissecting their physiology, pathogenesis, and drug resistance. Although electroporation enables transformation efficiencies exceeding 10⁵ CFU per µg DNA in and , it remains highly inefficient in many nontuberculous mycobacteria (NTM), including . Here, we discovered that NTM such as exhibit exceptional tolerance to ultra-high electric field strengths and that hypertonic preconditioning partially protects cells from electroporation-induced damage.
View Article and Find Full Text PDFFront Psychol
August 2025
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China.
Background: Under high-pressure situations, such as crucial games, some athletes often underperform. This is the case even for exceptional athletes in critical moments of competition. Athletes often experience performance anxiety, which creates attentional errors and underperformance.
View Article and Find Full Text PDFBiosens Bioelectron
September 2025
Department of Biological Sciences, Faculty of Science, National University of Singapore, 117543, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore; Precision Medicine Translational Research Programme (TRP), Yong Loo Lin School
DNAzymes possessing kinase-like activities have long held theoretical promise, yet their practical implementation has remained significantly limited. Notably, DNAzyme kinase 1 (DK1), discovered over two decades ago, exhibits a unique self-phosphorylation capability upon encountering specific substrates like ATP, but its broad-based and programmable applications have not yet been fully realized. In this study, we innovatively couple DK1's autophosphorylation mechanism with the PfAgo to establish a novel programmable cascade sensing platform named RASTEN (Robust pfAgo-based Strategy for POC Testing Non-nucleic Acid and Nucleic Acid).
View Article and Find Full Text PDFAnal Biochem
September 2025
Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-Cho Minami, Tottori, 680-8552, Japan.
The duplex-forming behavior of an inchworm-type PNA-PEG conjugate (i-PPc), engineered for the selective recognition of point mutations in DNA, was assessed through thermodynamic analysis employing UV melting curves and circular dichroism spectroscopy. The i-PPc demonstrated the ability to form stable duplexes exclusively with fully complementary DNA sequences, while no hybridization with single-base mismatched sequences. This binary on/off hybridization behavior was maintained even under physiologically relevant conditions (37 °C), thereby illustrating the exceptional point mutation discrimination capability of i-PPc.
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