Integrin factor (FAM27E3), as a metastatic marker of papillary thyroid carcinoma, through the p53 signaling pathway promoting lymph node metastasis.

Background: Papillary thyroid carcinoma (PTC) has a lymph node metastasis rate of 20%-90%. This study aims to explore the role and regulatory mechanism of the FAM27E3 in PTC lymph node metastasis.

Method: The seven thyroid cancer (THCA) datasets from the Gene Expression Omnibus (GEO) were combined as the training group, while the PTC dataset served as the testing group.

Analysis of preoperative influential factors and construction of a predictive nomogram of difficult thyroidectomy.

Objective: To explore the preoperative influential factors of difficult thyroidectomy and establish a preoperative nomogram for predicting the difficulty of thyroidectomy.

Methods: A total of 753 patients who underwent total thyroidectomy with central lymph node dissection between January 2018 and December 2021 were retrospectively enrolled in this study and randomly divided into training and validation groups at a ratio of 8:2. In both subgroups, the patients were divided into difficult thyroidectomy and nondifficult thyroidectomy groups based on the operation time.