HBM Package Interconnection Pseudo All-Channel Signal Integrity Simulation and Implementation Method of the Synchronous Current Load Research.

This paper proposes a pseudo full-channel signal integrity (SI) simulation method tailored for high-bandwidth memory (HBM) interconnects. In this approach, real interconnect models are applied to selected portions of the channel, while the remaining sections are replaced with synchronized current loads that emulate the electrical behavior of actual signal transmission. This technique enables accurate modeling of the HBM interface under full-channel parallel data transfer conditions.

Laparoscopic surgery for lumbar hernia in children.

Objective: To explore the safety, feasibility, and superiority of laparoscopic surgery in the treatment of lumbar hernia in children.

Methods: Retrospective analysis of children with lumbar hernia who underwent surgical treatment at our hospital from March 2010 to March 2024.

Inclusion Criteria: (1) Definite diagnosis of lumbar hernia: symptoms of lumbar hernia, ultrasound or CT diagnosis of lumbar hernia; (2) Clear surgical indication: the child patient with lumbar hernia has shown no significant improvement for over a year; (3) Complete intraoperative and postoperative follow-up data; (4) No contraindications for surgery.

Identification and Pathogenicity Analysis of Qf-1 in Mink ().

Mink () is a commercially farmed animal of global importance. However, disease outbreaks during farming not only cause significant economic losses but also substantially increase the risk of zoonotic infections. The identification and characterization of pathogenic bacteria remain a major bottleneck restricting the development of healthy and sustainable mink farming.

Genetic score omics regression and multitrait meta-analysis detect widespread -regulatory effects shaping bovine complex traits.

To complete the genome-to-phenome map, transcriptome-wide association studies (TWAS) are performed to correlate genetically predicted gene expression with observed phenotypic measurements. However, the relatively small training population assayed with gene expression could limit the accuracy of TWAS. We propose genetic score omics regression (GSOR) correlating observed gene expression with genetically predicted phenotype, i.

Effects of microplastics on bacterial communities in lake wetland sediments: a comparison between drought and flooded conditions.

Under the backdrop of increasingly frequent wetland alternation between dry and wet conditions driven by global climate change, the differential impact mechanisms of microplastics (MPs) on microbial communities under drought and flooding conditions remain insufficiently characterized. This study established a sediment microcosm experimental system for Poyang Lake wetland to systematically analyze the regulatory effects of polyethylene (PE) and polypropylene (PP) microplastics on sediment bacterial community structure, functional genes, and ecological processes over 180 days under simulated drought and flooded conditions. The results demonstrated that microplastics significantly enhanced the richness (Chao1 index +95.

Polarization-Driven Control of Dynamically Tunable Solar-to-Hydrogen Conversion and On-Demand Water Splitting in 2D Janus-Ferroelectric Heterojunctions.

van der Waals heterostructures improve carrier efficiency via band engineering and interfacial design, surpassing traditional photocatalytic material limitations. However, their intrinsic electric fields are limited by work function differences, and carrier accumulation weakens field effects. Two-dimensional ferroelectric heterostructures leverage spontaneous polarization and dynamic tunability to optimize carrier transport and photocatalytic water-splitting kinetics.

Integrating large-scale meta-GWAS and PigGTEx resources to decipher the genetic basis of 232 complex traits in pigs.

Understanding the molecular and cellular mechanisms underlying complex traits in pigs is crucial for enhancing genetic gain via artificial selection and utilizing pigs as models for human disease and biology. Here, we conducted comprehensive genome-wide association studies (GWAS) followed by a cross-breed meta-analysis for 232 complex traits and a within-breed meta-analysis for 12 traits, using 28.3 million imputed sequence variants in 70 328 animals across 14 pig breeds.

[Physiological and Ecological Response Characteristics and Transcriptomic Change Characteristics of Rice （）Under Different Microplastic Stresses].

Traditional plastics are difficult to degrade in the environment after use and disposal, but they are prone to aging and forming microplastics （MPs）, which are emerging environmental contaminants, posing a serious threat to global ecological security and human health. To mitigate the ecological impact caused by traditional plastic products, the use of biodegradable plastics is gaining widespread attention. However, the ecological risks of biodegradable materials to the soil remain unclear.

Genetic regulation of gene expression across multiple tissues in chickens.

The chicken is a valuable model for understanding fundamental biology and vertebrate evolution and is a major global source of nutrient-dense and lean protein. Despite being the first non-mammalian amniote to have its genome sequenced, a systematic characterization of functional variation on the chicken genome remains lacking. Here, we integrated bulk RNA sequencing (RNA-seq) data from 7,015 samples, single-cell RNA-seq data from 127,598 cells and 2,869 whole-genome sequences to present a pilot atlas of regulatory variants across 28 chicken tissues.

The effect of a new in-hospital trauma care model on the outcomes of severely injured trauma patients in the emergency department: a retrospective observational study in China.

Background: The mortality and disability rates among severely injured trauma patients are very high. This study aimed to investigate whether a new in-hospital trauma care model can improve emergency care efficiency and enhance the prognosis of severely injured trauma patients.

Methods: This retrospective observational study included 366 severely injured trauma patients (ISS ≥ 16) who were admitted to the emergency department of a tertiary hospital between 2023 and 2024.

The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project.

Genetic mutation and drift, coupled with natural and human-mediated selection and migration, have produced a wide variety of genotypes and phenotypes in farmed animals. We here introduce the Farm Animal Genotype-Tissue Expression (FarmGTEx) Project, which aims to elucidate the genetic determinants of gene expression across 16 terrestrial and aquatic domestic species under diverse biological and environmental contexts. For each species, we aim to collect multiomics data, particularly genomics and transcriptomics, from 50 tissues of 1,000 healthy adults and 200 additional animals representing a specific context.

Terrestrial Adaptation in as Revealed Based on Analysis of the Complete Mitochondrial Genome.

Background/objectives: Mitochondrial genomes are widely used in phylogenetics and evolutionary and ecological research.

Methods: In this study, the newest mitochondrial genome of was assembled and annotated. The comparative mitochondrial genome and selection pressure analyses were used to examine the terrestrial adaptive evolution characteristics of and other terrestrial reptiles.

FarmGTEx TWAS-server: An Interactive Web Server for Customized TWAS Analysis.

Transcriptome-wide association study (TWAS) is a powerful approach for investigating the molecular mechanisms linking genetic loci to complex phenotypes. However, the complexity of the TWAS analytical pipeline, including the construction of gene expression reference panels, gene expression prediction, and association analysis using data from genome-wide association studies (GWASs), poses challenges for genetic studies in many species. In this study, we provide the Farm Animal Genotype-Tissue Expression (FarmGTEx) TWAS-server, an interactive and user-friendly multispecies platform designed to streamline the translation of genetic findings across tissues and species.

Heterobifunctional cross-linker with dinitroimidazole and azide modules for protein and oligonucleotide functionalization.

Dinitroimidazole (DNIm) was recently identified as a powerful bioconjugation agent that could selectively modify thiol over amine on biomolecules at an ultrahigh speed in an aqueous buffer. However, its derivative containing a DNIm module and a terminal alkyne module failed to construct functional agents bearing a DNIm warhead the CuAAC reaction. To solve this problem, a heterobifunctional cross-linker was designed and synthesized by linking a DNIm module with an azide module an oxoaliphatic amido bond spacer arm.

Arginine-Rich Peptides Regulate the Pathogenic Galectin-10 Crystallization and Mitigate Crystallopathy-Associated Inflammation.

Protein self-assembly into a crystal in vivo triggers acute or chronic organ injury that can lead to intractable diseases lacking specific treatment options. In this study, we report the discovery of ionic arginine-rich peptides to disrupt the pathogenic galectin-10 (gal-10) crystallization, where the aberrant deposition of gal-10 crystals in airways causes the activation of IL-1β-dependent inflammation and the stimulation of epithelial cells to produce TNF-α. Gal-10 crystals show susceptibility to pH changes and charged residue substitutions at the protein packing interfaces, manifesting the role of charge-charge attractions across protein-protein interaction interfaces in governing gal-10 crystallization.

Polysaccharides-Directed Biomineralization of Enzymes in Hierarchical Zeolite Imidazolate Frameworks for Electrochemical Detection of Phenols.

Biomineralization of enzymes inside rigid metal-organic frameworks (MOFs) is appealing due to its biocompatibility and simplicity. However, this strategy has hitherto been limited to microporous MOFs, leading to low apparent enzymatic activity. In this study, polysaccharide sodium alginate is introduced during the biomineralization of enzymes in zeolitic imidazolate frameworks (ZIFs) to competitively coordinate with metal ions, which endows the encapsulated enzyme with a 7-fold higher activity than that in microporous ZIFs.

Theoretical Study of the Magnetic Mechanism of a Pca21 CN Monolayer and the Regulation of Its Magnetism by Gas Adsorption.

For metal-free low-dimensional ferromagnetic materials, a hopeful candidate for next-generation spintronic devices, investigating their magnetic mechanisms and exploring effective ways to regulate their magnetic properties are crucial for advancing their applications. Our work systematically investigated the origin of magnetism of a graphitic carbon nitride (Pca21 CN) monolayer based on the analysis on the partial electronic density of states. The magnetic moment of the Pca21 CN originates from the spin-split of the 2 orbit from special carbon (C) atoms and 2 orbit from N atoms around the Fermi energy, which was caused by the lone pair electrons in nitrogen (N) atoms.

Causal Relationship Between Childhood Obesity and Sleep Apnea Syndrome: Bidirectional Two-Sample Mendelian Randomization Analysis.

Background: Childhood obesity has become a global pandemic, leading to a range of diseases. Childhood obesity appears to be associated with an increased prevalence of sleep apnea syndrome. Sleep apnea is an inestimable risk factor for thrombosis, hypertension, cardiomyopathy and many other diseases.

Porphyromonas gingivalis Promotes Oral Squamous Cell Carcinoma Progression by Modulating Autophagy.

Objectives: Porphyromonas gingivalis (P. gingivalis) is a keystone periodontal pathogen associated with various gastro-intestinal tract cancers. However, whether P.

Insights into trait-association of selection signatures and adaptive eQTL in indigenous African cattle.

Background: African cattle represent a unique resource of genetic diversity in response to adaptation to numerous environmental challenges. Characterising the genetic landscape of indigenous African cattle and identifying genomic regions and genes of functional importance can contribute to targeted breeding and tackle the loss of genetic diversity. However, pinpointing the adaptive variant and determining underlying functional mechanisms of adaptation remains challenging.

Feasibility and mechanism of adsorption and bioreduction of hexavalent chromium using Rhodopseudomonas palustris immobilized on multiple materials.

Rhodopseudomonas palustris immobilized on multiple materials was used to invistigate Cr(VI) adsorption and bioreduction. The highest Cr(VI) removal (97.5%) was achieved at 276h under the opitimed conditions of 2.

Performance, mechanism regulation and resource recycling of bacteria-algae symbiosis system for wastewater treatment: A review.

The bacteria-algae synergistic wastewater treatment process not only efficiently eliminates nutrients and absorbs heavy metals, but also utilizes photosynthesis to convert light energy into chemical energy, generating valuable bioresource. The study systematically explores the formation, algal species, and regulatory strategies of the bacterial-algal symbiosis system. It provides a detailed analysis of various interaction mechanisms, with a particular focus on nutrient exchange, signal transduction, and gene transfer.