Protective effect of astragalus polysaccharides against sodium fluoride-induced liver injury: A comprehensive study based on network pharmacology, metabolomics, and transcriptomics.

Fluoride, a water-soluble environmental contaminant, poses significant risks to hepatic health due to long-term excessive intake, yet effective interventions for NaF-induced liver injury remain limited. Astragalus polysaccharides (APS), the principal bioactive component of Astragalus membranaceus, exhibit immunomodulatory, anti-inflammatory, and antioxidant properties, and have been shown to protect against alcohol- and chemical-induced liver injury. This study employed animal experiments and integrative multi-omics (network pharmacology, transcriptomics, metabolomics) to investigate the protective mechanisms of APS against NaF toxicity in rats.

Rare Case Report of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma.

Bronchial mucosa-associated lymphoid tissue is the site of the uncommon malignancy known as mucosa-associated lymphoid tissue (MALT) lymphoma. Due to its lack of distinct clinical signs and imaging characteristics, it is frequently misdiagnosed and underdiagnosed. After receiving unsuccessful treatment for a lung infection or tuberculosis in multiple tertiary care hospitals, we report a male patient who had a solid lesion in his left upper lung for 18 years.

Cantharidin-induced enterotoxicity: A molecular insight into intestinal barrier breakdown.

Ethnophamacological Relevance: Cantharidin (CTD), a terpenoid from Mylabris beetles, has been used in traditional Chinese medicine for cancer treatment ("using toxicity to combat toxicity"), but its clinical use is limited by unclear enterotoxicity mechanisms. This study integrates omics and traditional toxicology to decode its intestinal injury mechanisms in the context of traditional applications.

Aim Of The Study: This study aimed to study the damage of CTD to the intestine and preliminarily explore its potential.

Pharmacovigilance of five commonly used antibiotics in acute exacerbations of COPD (AECOPD): Analysis of the FDA adverse event reporting system database.

Objective: Antibiotics are commonly administered during acute exacerbations of chronic obstructive pulmonary disease (AECOPD) to manage infections and alleviate their symptoms. However, their use may result in adverse drug events (ADEs), potentially compromising patient safety and treatment effectiveness. The U.

Bupleuri Radix polysaccharides enhance the efficacy and intestinal absorption of baicalin via regulating intestinal β-glucuronidase activity in MASH mice.

Background: Bupleuri Radix polysaccharides (BRP) and baicalin (BAI) are key coexisting constituents in the traditional Chinese medicine (TCM) pair Bupleuri Radix-Scutellariae Radix, a classical herbal pair widely used in TCM formulations for treating liver diseases. However, the influence of BRP on BAI's intestinal metabolism, absorption, and therapeutic efficacy remains insufficiently explored.

Purpose: This study investigated BRP's effects on the oral pharmacokinetics and therapeutic efficacy of BAI in mice with metabolic dysfunction-associated steatohepatitis (MASH) to elucidate underlying mechanisms.

Orthokeratology, 0.04% Atropine, and 0.01% Atropine for Myopia Control: A Randomized Clinical Trial.

Importance: Investigating the antimyopia efficacy and safety of orthokeratology and varying atropine doses in specific age groups could optimize personalized treatment choices.

Objective: To evaluate the efficacy and safety of orthokeratology, 0.04% atropine, and 0.

Gut microbiota dysbiosis in inflammatory bowel disease: interaction with intestinal barriers and microbiota-targeted treatment options.

Recent studies have deepened our understanding on gut microbiota alterations and the interaction with intestinal barrier impairments, which play a crucial role in the etiology and pathophysiology of Inflammatory bowel disease (IBD). The intestinal microbiota dysbiosis in IBD including the altered microbiota composition, decreased beneficial species and increased harmful species. The disturbed gut microbiota results in the aggravation of intestinal barrier dysfunction through regulation of antimicrobial substances in mucus layer, tight junction protein in mechanical layer and inflammatory response in immune layer.

Dyadic coping experience of persons with young-onset dementia and their spousal caregivers: A review of qualitative studies and meta-synthesis.

BackgroundPersons with young-onset dementia (PwYOD) often face issues with social role conflicts, financial crises, and family relationship breakdowns. Spousal caregivers (SCGs) balance numerous family responsibilities while facing a significant burden of care and emotional strain. Currently, an increasing number of qualitative studies focus on the experience of illness from the perspective of the YOD couple's dyadic experience.

The Efficacy of Sodium Bicarbonate Ringer's Solution and Lactate Ringer's Solution in Patients Undergoing Long-Term Abdominal Open Surgery: A Multicenter Prospective Randomized Controlled Study.

Purpose: Sodium bicarbonate Ringer's solution (BRS) is an intravenous fluid that does not rely on hepatic or renal metabolism. It contains bicarbonate ions (HCO ) and lacks lactate ions. This study hypothesizes that BRS is more effective in maintaining acid-base balance during prolonged open abdominal surgeries.

Mediating role of emotional intelligence in the relationship between dual work stress and reflective ability among junior nurses.

Background: Junior nurses constitute the backbone of the nursing workforce, and their reflective ability is essential for clinical decision-making, as well as for driving innovation and improvement in nursing practices. Although numerous studies emphasize the importance of enhancing reflective ability in junior nurses, the specific relationships among emotional intelligence, dual work stress, and reflective ability remain unclear.

Objective: To explore the mediating effect of emotional intelligence on the relationship between dual work stress and reflective ability among junior nurses, with the aim of providing evidence-based guidance for nursing managers to improve reflective ability in clinical settings.

Pattern of cortical thickness in depression among early-stage Parkinson's disease: A potential neuroimaging indicator for early recognition.

Purpose: This study aims to investigate the early change in cortical thickness and surface area in early-stage depressed PD (dPD) patients, and its associations with severity of depression.

Methods: 59 patients with dPD, 27 patients with non-depressed PD (ndPD), and 43 healthy controls (HC) were recruited. The dPD patients were subclassified into mild-depressed PD (mi-dPD, n = 24), moderate-depressed PD (mo-dPD, n = 21) and severe-depressed PD (se-dPD, n = 14) subgroups.

Identification of Cuproptosis-Related Genes and Their Potential Role in COPD Pathogenesis: A Bioinformatics Analysis.

Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, and its pathogenesis and potentially relevant biomarkers require further study. Imbalance in copper (Cu) metabolism is related to a series of diseases, but its role in COPD has not been specified.

Methods: A dataset relevant to COPD was downloaded from Gene Expression Omnibus database, among which a total of 18 cuproptosis-related genes (CRGs) were screened.

Exploring the tissue distribution propensity of active alkaloids in normal and stomach heat syndrome rats following oral administration of Zuojin Pill based on pharmacokinetics and mass spectrometry imaging.

Ethnopharmacological Relevance: Zuojin Pill (ZJP) is a traditional Chinese medicine (TCM) formula composed of Coptidis Rhizoma and Euodiae Fructus in a ratio of 6:1 (w/w), which has been widely used for treating gastrointestinal disorders, especially stomach heat syndrome (SHS). However, the active alkaloids in ZJP showed low plasma exposure in rats following oral administration, which failed to explain their potent pharmacological effects, thereby limiting further mechanism studies.

Aim Of The Study: This study aimed to investigate the in vivo exposure and tissue distribution propensities of the active alkaloids in normal and SHS rats following oral administration of ZJP.

Rosuvastatin mitigates blood-brain barrier disruption in sepsis-associated encephalopathy by restoring occludin levels.

Background: Blood-brain barrier (BBB) disruption is a key pathological feature of sepsis-associated encephalopathy (SAE). Rosuvastatin, a third-generation statin, exhibits diverse pharmacological functions beyond its lipid-lowering capacity. However, its potential neuroprotective role in SAE remains unclear.

Solvent-controlled silver catalyzed radical transformation of α-imino-oxy acids with cyclic aldimines.

A silver-catalyzed cross coupling of cyclic aldimines and α-imino-oxy acids has been developed. The solvent-dependent reaction could selectively deliver either cyclic imine moiety retained nitriles or ring-opened oxonitriles in moderate yields. The mechanistic studies show that the reaction undergoes a radical pathway.

The intermediary effect of work stress on the relationship between off-duty professional growth and reflective ability among mid- and senior-level nurses.

Background: Mid- to senior-level nurses play a pivotal role in healthcare. Their reflective ability is crucial for clinical decision-making and the continuous improvement of nursing practices. Although numerous studies have emphasized the importance of enhancing reflective ability among mid- to senior-level nurses, the specific relationship between off-duty professional growth, dual work stress, and reflective ability remains unclear.

Comparison of Jinzhen oral liquid and ambroxol hydrochloride and clenbuterol hydrochloride oral solution in the treatment of acute bronchitis in children: A multicenter, non-inferiority, prospective, randomized controlled trial.

The comparison between traditional Chinese medicine Jinzhen oral liquid (JZOL) and Western medicine in treating children with acute bronchitis (AB) showed encouraging outcomes. This trial evaluated the efficacy and safety of the JZOL for improving cough and expectoration in children with AB. 480 children were randomly assigned to take JZOL or ambroxol hydrochloride and clenbuterol hydrochloride oral solution for 7 days.

Nanomorphogenesis of interlayered polyamide membranes for precise ion sieving in lithium extraction.

Nanofiltration (NF) offers a scalable and energy-efficient method for lithium extraction from salt lakes. However, the selective separation of lithium from magnesium, particularly in brines with high magnesium concentrations, remains a significant challenge due to the close similarity in their hydrated ionic radii. The limited Li/Mgselectivity of current NF membranes is primarily attributed to insufficient control over pore size and surface charge.

Effects of fully immersive virtual reality training on cognitive function in patients with mild cognitive impairment: a systematic review and meta-analysis.

Background: Mild cognitive impairment (MCI) is a prodromal stage of dementia. There is no specific medication to slow the progression of MCI. Recent studies have confirmed the positive effects of virtual reality (VR).

The diagnostic value of peripheral blood lymphocyte testing in children with infectious mononucleosis.

Objective: To investigate the diagnostic value of peripheral blood lymphocyte testing in children with infectious mononucleosis (IM).

Methods: A total of 135 children with IM as the IM group and 100 healthy volunteers as the healthy group were included in this retrospective study. Peripheral blood lymphocyte subsets marked as CD3+, CD4+, CD8+, CD16 + CD56+, and CD19 + in the peripheral blood were quantified using flow cytometry.

Protection against cigarette smoke-induced chronic obstructive pulmonary disease via activation of the SIRT1/FoxO1 axis by targeting microRNA-132.

Objective: To investigate the biological role of miR-132 in a murine model of chronic obstructive pulmonary disease (COPD) via activation of the SIRT1/FoxO1 axis.

Methods: COPD was induced in C57BL/6J male mice by exposing them to cigarette smoke (CS) for 8 weeks. A miR-132 knockout mouse model was used to assess the role of miR-132 in CS-induced COPD.

Cost-effectiveness of dostarlimab plus carboplatin-paclitaxel for primary advanced or recurrent endometrial cancer from a US payer perspective.

Objective: Dostarlimab in combination with carboplatin-paclitaxel (CP) improves progression-free survival in patients with primary advanced or recurrent endometrial cancer (pA/rEC), including in patients whose cancer is mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H). This study examined the cost-effectiveness of dostarlimab plus CP as a first-line treatment in the dMMR/MSI-H and overall populations.

Methods: A partitioned survival model with three mutually exclusive health states (progression-free disease, progressed disease, death) was developed using a US base case and a third-party payer perspective.