Solvent-controlled silver catalyzed radical transformation of α-imino-oxy acids with cyclic aldimines.

Chem Commun (Camb)

Lunan Institute of Intelligent Biomedical Engineering, College of Food Science and Pharmaceutical Engineering, Zaozhuang University, Zaozhuang, 277160, P. R. China.

Published: February 2025


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Article Abstract

A silver-catalyzed cross coupling of cyclic aldimines and α-imino-oxy acids has been developed. The solvent-dependent reaction could selectively deliver either cyclic imine moiety retained nitriles or ring-opened oxonitriles in moderate yields. The mechanistic studies show that the reaction undergoes a radical pathway.

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http://dx.doi.org/10.1039/d4cc05675bDOI Listing

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