Prognostic Value of CRP-Albumin-Lymphocyte (CALLY) Index in Colorectal Cancer Survival: A Multicenter Retrospective Cohort Study.

Background: Colorectal cancer (CRC) has become one of the major health burdens in the world with high mortality rates, especially at the advanced stages. The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel multidimensional biomarker combining systemic inflammation, nutritional status, and immune function. This study evaluated the association between the CALLY index and overall survival (OS) as well as recurrence-free survival (RFS) in colorectal cancer (CRC) patients.

Residual disease in NPM1-mutated acute myeloid leukemia.

Acute myeloid leukemia (AML) represents a genetically heterogeneous malignancy, with mutations in the nucleophosmin-1 (NPM1) gene identified as the most prevalent and clinically significant molecular biomarkers. These mutations play a crucial pivotal role in the realms of diagnosis, prognosis, and therapeutic decision-making. Although an ideal measurable residual disease (MRD) test has yet to be developed, there is increasing acknowledgment of the significance of advanced molecular methodologies for monitoring MRD in NPM1-mutated (NPM1) AML.

Innovative nanosensing methods for lysozyme identification.

Lysozyme (LYZ) is a critical enzyme recognized for its significant antimicrobial properties, playing an integral role in the immune response and being implicated in various diseases, including infections and inflammatory conditions. Traditional detection methods for LYZ, such as enzyme-linked immunosorbent assays (ELISA) and spectrophotometric techniques, often encounter limitations regarding sensitivity, specificity, and time efficiency. In light of these challenges, there has been substantial advancement in the development of novel biosensor technologies over the past two decades, particularly those that incorporate nanomaterials.

Psychological Correlates of Auditory-Motor Integration in Primary Muscle Tension Dysphonia: A Preliminary Study.

Objective: Primary Muscle Tension Dysphonia (pMTD) is a functional voice disorder characterized by excessive laryngeal muscle tension and vocal hyperfunction, often linked to psychological factors and impaired vocal motor control. This preliminary study investigates the relationship between psychological constructs and auditory-motor integration in pMTD, focusing on vocal compensation responses to altered auditory feedback (AAF).

Methods: Twenty-one individuals with pMTD (mean age: 35.

The relation between sensation seeking, aggression and self-confidence with Needle stick and Sharp injuries among nurses.

Background: One of the most important occupational injuries experienced by nurses is needle sticks. The causes and factors of needle sticks are not fully known. This study was conducted with the aim of investigating the relationship between sensation-seeking, aggressiveness, and self-confidence with needle stick and Sharp injuries among nurses in a children's and women's hospital.

A systematic review and meta-analysis of the comparison between lasers and other therapeutic modalities in skin rejuvenation and resurfacing with a focus on RCTs.

Aims And Objectives: This systematic review and meta-analysis sought to compare the efficacy of lasers with other modalities in skin rejuvenation and resurfacing. Methodology: The database was thoroughly searched, and six articles meeting specific inclusion criteria were selected for meta-analysis. Inclusion criteria comprised studies that compared lasers with other methods, with four studies focusing on laser comparisons and two studies comparing more than two methods.

Investigating effective factors on musculoskeletal pain prevention behaviors in the elderly population living in nursing homes, based on the health belief model: structural equation modeling approach.

Background: The world's elderly population is increasing. Due to the increase in musculoskeletal disorders in this group and the multifactorial nature of this disease, this study investigated the effective factors in preventing musculoskeletal pain in the elderly living in nursing homes, based on the Health Belief Model.

Methods: A cross-sectional design was conducted with a random sample of 311 older adult nursing home residents in the Kahrizak nursing home, whose aims were to identify the determinants influencing musculoskeletal pain prevention practices (intake of vitamin D, stress management, and correct body posture).

COVID-19 delirium versus non-COVID-19 delirium in Iran: a computational approach.

Background: Delirium is an acute condition marked by disturbances in cognition, awareness, and attention, commonly observed in hospitalized patients due to factors such as illness severity and medication. It is particularly prevalent in intensive care unit settings, affecting up to 80% of ventilated patients. This study investigates whether coronavirus disease 2019 (COVID-19) delirium aligns with expectations of non-COVID-19 delirium incidence in other hospitalized patients and identifies unique or common factors contributing to delirium in these groups.

Bilirubin biosensors for liver disease management.

Bilirubin is a vital biomarker that plays a significant role in assessing liver function and diagnosing hemolytic disorders. While current detection methods are indeed sufficient for clinical practice, the accurate and timely detection of bilirubin levels remains essential for effective management of liver diseases. Enhanced detection capabilities through sensitive nanoscale biosensors can provide more precise monitoring, which may lead to earlier identification of abnormalities and improved patient outcomes.

Placenta specific 1: A Novel Marker for Detection of Metastasis in Mouse Model of Breast Cancer.

Background: Placental-specific 1 (Plac1), with no expression in normal tissues, is expressed in different cancers. Therefore, the potential application of Plac1 to detect metastasis was investigated in breast cancer model.

Methods: A spontaneous metastasis model was established using 4T1 cells.

Electronic patient-reported outcome systems and capabilities in cancer care: a systematic review.

Background: Cancer care increasingly emphasizes patient-centred approaches, leading to the adoption of electronic patient-reported outcome (ePRO) systems for essential patient data collection. Our systematic review investigates the landscape of electronic patient-reported outcome systems and their capability in cancer care, focusing on their potential to enhance patient-centred solutions.

Methods: We conducted a systematic review, encompassing studies on electronic patient-reported outcomes in cancer.

Dairy-Derived Bioactive Peptides and the Risk of Prostate Cancer among Iranian Men: A Case-Control Study.

This case-control study aimed to assess the association of dairy-derived digestion-resistant bioactive peptides (BPs) with the risk of prostate cancer (PCa) in a cohort of 50 men with PCa and 99 controls. Dietary, demographic, and anthropometric factors of all participants were assessed. Various types of dairy-derived BPs were determined by an method.

Evaluating the effect of chicory on serum ferritin levels in transfusion-dependent Β-thalassemia patients: a randomized clinical trial.

Introduction: Several approved iron chelators exist, but they may cause significant adverse reactions in some patients. It is essential to explore complementary treatments that enhance compliance and minimize side effects.

Objectives: This study aims to evaluate the efficacy of chicory in reducing serum ferritin levels in transfusion-dependent β-thalassemia patients.

Diosgenin enhances the effect of radiation on head and neck cancer cells through apoptosis induction, G2/M cell cycle arrest, and ROS generation.

Radiotherapy is a cornerstone in treating head and neck cancers, yet its effectiveness is often limited by factors such as hypoxia and cancer stem cells. This study evaluated the radiosensitizing potential of diosgenin in KB cancer cells and normal HDF cells exposed to 4 Gy X-rays, with or without diosgenin. Cell viability, apoptosis, cell cycle distribution, ROS production, and expression of intrinsic apoptosis-related genes were assessed using MTT assays, flow cytometry, and RT-qPCR, respectively.

Anatomy and pattern of tibial periosteal circulation: implications for tibial plating : a cadaveric study.

Aims: The significance of periosteal vessels in the healing of tibial shaft fractures is well-established. However, the gross anatomical patterns and differential distribution of these vessels on the medial versus lateral surface of the tibial shaft have not been thoroughly described. This study aimed to illustrate the comparative anatomy of periosteal circulation on the medial versus lateral surface of the tibial shaft, where tibial plates are commonly applied.

Nanobubbles: An emerging therapeutic paradigm for targeted cancer therapy.

Recently, nanobubbles (NBs) have emerged as a groundbreaking platform for drug and gene delivery in the targeted treatment of cancer because of their unique advantages. The nanoscale dimensions, stability, and responsiveness to external triggers-for example, ultrasound-allow for highly selective localization and controlled release of therapeutic agents in tumor tissues. This review highlights the capability of NBs, when combined with ultrasound activation, to significantly improve the intracellular uptake, penetration, and therapeutic efficacy of chemotherapeutic agents, thus diminishing their off-target toxicity.

The Association Between the Levels of Serum Phosphate and Mortality Rates in Pre-Dialysis and Dialysis Patients.

Background: Discovering predictors to reduce morbidity and mortality in chronic kidney disease (CKD) is now a critical global priority. Serum phosphate level is considered to be a potential marker for mortality rate in patients with CKD. Previous studies examined the independent pathogenic role of phosphorus in the development of CKD and dialysis patients but have yielded contradictory findings.

The Effect of Immersion Technology on the Quality of Life in Older Adults: A Systematic Review.

Objectives: In physical reality, mobility limitations often hinder the ability of older individuals to fully interact with the world. Aging increases the likelihood of a decline in social activities. New technologies, including immersion technologies, are increasingly gaining attention as society grapples with the challenges of an aging population.

Modeling airborne transmission of viral genome using computational fluid dynamics simulation: A case study for SARS-CoV-2 virus.

Predicting indoor air quality during infectious disease conditions relies on models simulating particle materials (PM)/bioaerosols distribution. Understanding the thermo-fluid properties of exhaled air is crucial for comprehending disease transmission dynamics. This study employs a computational fluid dynamics (CFD) model to simulate cough-induced particle dispersion in a closed space.

Use of Clinical Decision Support Systems for Diagnosis and Prognosis of Gastric Cancer: A Scoping Review.

Background And Aims: Gastric cancer (GC) has a high prevalence and death rates, threatening global public health. Utilizing clinical decision support systems (CDSSs) is advantageous for improving the quality of clinical decision-making and enhancing the efficiency of patient care delivery within healthcare environments. The present scoping review aims to identify gaps in existing knowledge and provide insights into the applications and characteristics of CDSSs, particularly in the development, evaluation, and interventions related to the GC disease.

Safety and efficacy of Pharmacologic thromboprophylaxis following percutaneous nephrolithotomy: a retrospective cohort study.

Background: Percutaneous nephrolithotomy (PCNL) is the standard treatment for large or complex renal stones; however, it carries risks such as bleeding and venous thromboembolism (VTE). Current guidelines do not recommend routine pharmacologic thromboprophylaxis in these patients due to concerns about bleeding and limited supporting evidence. This study evaluates the safety and efficacy of unfractionated heparin thromboprophylaxis in patients at moderate to high VTE risk undergoing PCNL.