A systematic review and meta-analysis of the comparison between lasers and other therapeutic modalities in skin rejuvenation and resurfacing with a focus on RCTs.

Aims And Objectives: This systematic review and meta-analysis sought to compare the efficacy of lasers with other modalities in skin rejuvenation and resurfacing. Methodology: The database was thoroughly searched, and six articles meeting specific inclusion criteria were selected for meta-analysis. Inclusion criteria comprised studies that compared lasers with other methods, with four studies focusing on laser comparisons and two studies comparing more than two methods.

A systematic review of comparative clinical trials on the efficacy, safety, and patient satisfaction of ablative and non-ablative laser therapies for atrophic, hypertrophic, and keloid scars.

Scar formation is a common outcome of tissue injury, manifesting as atrophic, hypertrophic, and keloid scars, which can significantly impact quality of life. Laser therapy has emerged as a promising treatment modality for scars, encompassing ablative and non-ablative approaches, yet there are gaps in understanding their comparative efficacy, safety, and patient satisfaction. This study aims to comprehensively review published research comparing the efficacy, safety, and patient satisfaction of various laser therapies for treating atrophic, hypertrophic, and keloid scars.

Systematic review of comparative studies on emerging psoriasis treatments: comparing biologics with biologics, small molecule inhibitors with small molecule inhibitors, and biologics with small molecule inhibitors.

Background: Psoriasis is a chronic inflammatory skin condition driven by immune dysregulation, significantly diminishing patients' quality of life. The advent of targeted biological therapies and small molecule inhibitors has transformed the treatment landscape for moderate-to-severe Psoriasis. Nevertheless, there remains a scarcity of comparative efficacy and safety data between these therapeutic classes, highlighting the need for a systematic review to evaluate their relative performance.

Effect of Topical Timolol on Healing of Immature Breast Scars After Mammoplasty: A Randomized Controlled Trial With Blinded Assessors and Patients.

Introduction: Wound healing is a complex process encompassing four main stages: hemostasis, inflammation, cell proliferation, maturation, and differentiation. Timolol (TM) may influence these stages, particularly re-epithelialization. This study aims to evaluate the 1-month effects of timolol on acute surgical wounds in post-mammoplasty patients.

Successful and Sustained Treatment of Cutaneous Tumoral Lesions in Brooke-Spiegler Syndrome (BSS) Using Ablative CO Laser: A Case Series and Literature Review.

Continuous-wave CO laser therapy is an effective and safe treatment for trichoepitheliomas in Brooke-Spiegler syndrome, improving lesion color, texture, and overall appearance. This non-invasive approach offers high patient satisfaction and demonstrated no recurrence during a 2-year follow-up, making it a promising alternative to surgical excision.

Investigating the Relationship Between Androgenetic Alopecia and Hair Shape, Color, and Thickness: A Case-Control Study.

Background And Aims: Androgenetic alopecia is the most common cause of hair loss in both men and women. The aim of this case-control study was to investigate the role of phenotype (hair shape, thickness, and color) and demographic characteristics, including smoking history, in the development of androgenetic alopecia.

Methods: In this case-control study, participants were divided into two groups: patients diagnosed with androgenetic alopecia (case group) and individuals without hair loss (control group).

Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review.

Introduction: Mesenchymal stem cell (MSC)-derived conditioned media is emerging as a promising alternative to stem cell therapy, owing to its abundant content of growth factors and cytokines.

Objective: This review evaluates the clinical applications of MSC-conditioned media in improving scars, promoting wound healing, stimulating hair growth, and rejuvenating the skin.

Materials And Methods: A thorough search of relevant databases was performed to identify studies meeting the inclusion criteria.

Impact of pentoxifylline on efficacy, safety, tolerability, and treatment satisfaction of fractional carbon dioxide laser in patients with burn scars: a pilot blinded randomized controlled trial.

Burn scars are significant consequence of thermal burn injuries, causing cosmetic concerns and potentially leading to symptomatic discomfort or functional limitations; therefore, continuous adoption of novel methods is warranted to improve outcomes. This study aims to assess and compare the effectiveness, safety, and satisfaction of fractional CO2 laser treatment alone versus its combination with oral pentoxifylline at a dosage of 400 mg twice daily for four months in patients with hypertrophic/keloid burn scars. In a assessor and analyst blinded randomized controlled trial, patients with hypertrophic/keloidal thermal burn scars were allocated into two intervention groups.

Systematic review of vascular lasers for the treatment of inflammatory active acne vulgaris.

Acne vulgaris is a prevalent skin disorder with significant emotional and psychological impacts. Conventional treatments often have limitations, prompting exploration into alternative therapies like vascular lasers and light treatments. This systematic review evaluates the efficacy and safety of vascular lasers (IPL, PDL, Nd:YAG) on inflammatory acne lesions associated with acne vulgaris.

A Systematic Review of Vascular Injuries: A Review of Petechiae, Purpura, and Ecchymosis in Critical Situations Following COVID-19 Vaccination.

Background And Aims: Vascular injuries characterized by petechiae, purpura, and ecchymosis have been reported as potential adverse effects following COVID-19 vaccination. This study aims to identify the characteristics of patients experiencing vascular injuries postvaccination and to outline key clinical considerations.

Methods: A systematic review was conducted in accordance with PRISMA guidelines.

Evaluating the combination and comparison of ablative fractional lasers (CO2, Erbium-YAG) with pulsed dye laser (PDL) for treating hypertrophic scars: a systematic review.

The aim of this study is to compare pulsed dye laser (PDL) and ablative fractional lasers (CO2, Erbium-YAG) in the treatment of hypertrophic scars in a systematic review. Databases including Web of Science, Science Direct, Google Scholar and PubMed were searched for clinical trials up to December 1, 2022; focusing on the role of ablative fractional lasers and pulsed dye lasers in treating hypertrophic scars, using comprehensive keywords and search syntaxes. Key data extracted included type of scars, the assessment indexes, treatment modalities, side effects and the final conclusion of each article.

Emerging treatments for dermatologic diseases in infants, children, and adolescents: a systematic review of clinical trials on biologics and small molecule inhibitors.

Background: Recent advancements in the treatment of paediatric dermatological conditions have emerged with the introduction of biologics and small molecule inhibitors (SMIs). These therapies target specific inflammatory pathways, which may enhance treatment outcomes for diseases like atopic dermatitis, psoriasis, and alopecia areata.

Objectives: This systematic review seeks to assess the effectiveness and safety of biologics and SMIs for dermatologic conditions in children and adolescents, with an emphasis on randomised clinical trials.

Evaluating the effectiveness and safety of pulsed dye laser alone, the combination of pulsed dye laser and botulinum toxin type A, and the combination of pulsed dye laser and triamcinolone injection in the treatment of hypertrophic and keloid scars: a three-arm randomized controlled clinical trial.

To evaluate the efficacy and safety of pulsed dye laser (PDL) alone, the combination of PDL and botulinum toxin type A (BTA) injection, and the combination of PDL and triamcinolone injection in the treatment of hypertrophic scars and keloids. In this three-arm, single-blind randomized controlled clinical trial, 10 patients over 18 years old with hypertrophic scars or keloids were enrolled. Each patient had at least 3 lesions, each measuring at least 10 × 10 square centimeters or 10 centimeters long.

Evaluating the Effectiveness, Safety, and Satisfaction Rates of Phenol 90%, Trichloroacetic Acid 100%, and Radiofrequency in Lateral Matricectomy for the Treatment of Ingrown Toenails: A Triple-Arm Clinical Trial.

Background And Aims: This study aimed to evaluate the effectiveness, safety, and satisfaction rates of three different lateral matricectomy methods for treating ingrown toenails: 90% phenol, 100% trichloroacetic acid (TCA), and radiofrequency (RF) ablation. Our objective was to identify which method offers superior outcomes regarding postoperative pain, healing time, aesthetic results, and complication rates.

Methods: Conducted between August 2022 and June 2023, the study included 12 eligible patients divided into three groups: Group 1 underwent lateral matricectomy with 90% phenol, Group 2 with 100% TCA, and Group 3 with RF treatment.

Evaluation of the efficacy, safety, and satisfaction rate of topical latanoprost in patients with hypopigmented burn scars treated with fractional CO2 laser: a double-blind randomized controlled clinical trial.

Burn scars present psychological and social challenges for patients, classified into atrophic and hypertrophic types. Treatments like corticosteroid injections, laser therapy, and platelet-rich plasma (PRP) injections are commonly recommended for hypertrophic scars, while regenerative medicine and fractional CO2 lasers are linked to some degree of improvement for atrophic scars. Hypopigmented and depigmented burn scars pose ongoing challenges for healthcare providers and patients, with therapies such as intense pulsed light and fractional CO2 laser showing variable effects in treating these conditions.

A Systematic Review of Case Series and Clinical Trials Investigating Regenerative Medicine for the Treatment of Vitiligo.

Aims And Objectives: The aim of this study is to examine the efficacy and safety of various regenerative medicine treatments, such as cell therapy, platelet-rich plasma (PRP), plasma-poor platelet (PPP), plasma-rich fibrin (PRF), mesenchymal stem cells, stromal vascular fraction (SVF), exosomes, adipose-derived stem cells (ADSC), and stem cell-conditioned media (SC-CM), for treating vitiligo.

Method: We conducted a thorough search of major databases such as PubMed, Scopus, and Web of Science, and selected 48 articles based on specific criteria. We used EndNote X8 and Google Sheets to review and extract data from the articles.

Efficacy and Safety of Laser Therapy and Phototherapy in Cicatricial and NonCicatricial Alopecia: A Systematic Review Study.

Background And Aims: In recent years, the application of various light and laser devices in the treatment of different types of alopecia has been established. This systematic review aims to assess the efficacy and safety of laser therapy and phototherapy in cicatricial and non-cicatricial alopecia.

Methods: A comprehensive search was conducted on PubMed, Scopus, Science Direct, and Google Scholar.

Cyclosporin for the treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN): a systematic review of observational studies and clinical trials focusing on single therapy, combination therapy, and comparative assessments.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, severe, and potentially life-threatening skin and mucous membrane disorders. They are characterized by widespread skin and mucosal detachment and necrosis, and are classified based on the percentage of total body surface area (TBSA) affected. Given the severe and often life-threatening nature of these conditions, the identification and implementation of effective treatments is crucial.

Evaluating the Effectiveness of Probiotic Supplementation in Combination With Doxycycline for the Treatment of Moderate Acne: A Randomized Double-Blind Controlled Clinical Trial.

Background: Acne is a chronic inflammatory skin disease that negatively affects patients' quality of life. Increasing antibiotic resistance is making acne less responsive to treatment. Probiotics are live microorganisms that can provide health benefits by fighting pathogens and maintaining intestinal homeostasis and skin microbiome balance.

A systematic review of procedural treatments for burn scars in children: Evaluating efficacy, safety, standard protocols, average sessions and tolerability based on clinical studies.

Managing burn scars in children presents significant challenges. This study investigates effective treatment methods for burn scars, focusing on efficacy, safety, standard protocols and tolerability. Major databases such as PubMed, Scopus and Web of Science were thoroughly searched up to August 2024, emphasizing procedural treatments for burn scars in children.

Investigating metabolic syndrome markers and body mass index changes in patients with acne vulgaris treated with isotretinoin: A prospective study.

Background: Acne vulgaris is a common inflammatory skin disease that occurs during puberty, affecting approximately 85% of young adults and may persist into adulthood. The pathophysiology of acne is multifactorial, involving hormonal, inflammatory, and immune mechanisms. Isotretinoin is widely used for treating severe cystic acne or recurrent acne.