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http://dx.doi.org/10.1186/s12967-025-07002-3 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug De
Proliferative retinopathy is a leading cause of irreversible blindness in humans; however, the molecular mechanisms behind the immune cell-mediated retinal angiogenesis remain poorly elucidated. Here, using single-cell RNA sequencing in an oxygen-induced retinopathy (OIR) model, we identified an enrichment of sorting nexin (SNX)-related pathways, with SNX3, a member of the SNX family that is involved in endosomal sorting and trafficking, being significantly upregulated in the myeloid cell subpopulations of OIR retinas. Immunostaining showed that SNX3 expression is markedly increased in the retinal microglia/macrophages of mice with OIR, which is mainly located within and around the neovascular tufts.
View Article and Find Full Text PDFCurr Protein Pept Sci
September 2025
Department of Pharmaceutics, College of Pharmacy, JSS University, C-20/1, Sector-62, Noida, (U.P)-201301, India.
A complex condition called diabetes mellitus is characterized by insufficient or resistant insulin production. The incidence of diseases is rising quickly, placing a significant economic, social, and health burden on the modern world. Interventions in nutrition and improved physical activity could make a big difference in controlling this disease.
View Article and Find Full Text PDFChem Sci
August 2025
School of Chemistry and Chemical Engineering, Guizhou University Guiyang 550025 Guizhou China
Efficiently activating inert C-H bonds while maintaining control over the selective pathways of complex chemical reactions involving high-energy species remains a highly challenging and as-yet unattained objective. Herein, we propose a novel concept called 'dynamic local free radical confinement-mediated mechanism' to efficiently achieve synergetic selective oxidation of toluene and hydrogen generation for the first time a CdS-CdInS semi-coherent heterojunction (CCS) under two-phase conditions. Surprisingly, the optimized CCS-2 exhibited amazing catalytic efficiency and long-term stability in gram-scale experiments and automatically separated the catalyst from the product.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P.R. China.
Zinc metal, as the mainstream anode material of aqueous batteries, faces severe side reactions and notorious dendrite growth. Surface passivation of Zn anodes with a protective layer is one of the effective strategies to address these issues. The previous reports have focused on applying different components as surface layers while neglecting the impact of their crystallographic orientation on electrochemical performance.
View Article and Find Full Text PDFJ Transl Med
September 2025
Center for Educational Research in Medical Sciences (CERMS), Department of Medical Education, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.