The effect of hormonal contraceptives combined with vitamin D3 supplements on sexual dysfunction in women with polycystic ovary syndrome: a randomized double-blind placebo-controlled trial.

Background: Polycystic ovary syndrome (PCOS) is characterized by reproductive and endocrine abnormalities.

Objective: The present study aimed to assess the effect of oral contraceptive pills (OCPs) and vitamin D3 on sexual dysfunction in women with PCOS and vitamin D3 deficiency.

Materials And Methods: This randomized double-blind placebo-controlled clinical trial was conducted in Iran between January and April 2019.

Prognostic Value of CRP-Albumin-Lymphocyte (CALLY) Index in Colorectal Cancer Survival: A Multicenter Retrospective Cohort Study.

Background: Colorectal cancer (CRC) has become one of the major health burdens in the world with high mortality rates, especially at the advanced stages. The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel multidimensional biomarker combining systemic inflammation, nutritional status, and immune function. This study evaluated the association between the CALLY index and overall survival (OS) as well as recurrence-free survival (RFS) in colorectal cancer (CRC) patients.

D1-like dopamine receptors in the dentate gyrus mediate cannabidiol's facilitation of extinction and prevention of reinstatement in methamphetamine-induced conditioned place preference.

Methamphetamine (METH) is a highly addictive psychostimulant, and despite its widespread abuse, there are no FDA-approved treatments for METH use disorder (MUD). Cannabidiol (CBD), a non-psychoactive cannabinoid, has shown promise in reducing behaviors linked to psychostimulant use, including METH. However, the underlying neurobiological mechanisms remain unclear.

Extended oral antibiotics fail to reduce surgical site infection in orthopedic surgeries: A comparative study.

Background: Surgical site infection (SSI) is associated with a significant burden in orthopedic surgeries, leading to increased morbidity, prolonged hospital stays, and higher healthcare costs. Despite the widespread use of prophylactic antibiotics to reduce the risk of infection, the optimal duration for antibiotic administration remains controversial. Newer studies reported controversial results compared to existing guidelines; therefore, we aimed to compare the efficacy and post-operative complications of short-term (<24 hours) and extended oral antibiotics in reducing infection rates following orthopedic surgeries.

Essential amino acids in celiac disease: key roles in immunogenicity, pathogenesis, and therapeutic approaches.

Celiac disease (CD) is a chronic autoimmune disorder triggered by gluten ingestion, causing intestinal damage and systemic complications. Essential amino acids (EAAs) play crucial roles in immune function, intestinal integrity, and metabolic regulation; however, their malabsorption in CD contributes to disease progression. Tryptophan dysregulation may influence mood disorders in CD, while phenylalanine and lysine are linked to immune activation and gluten modification.

Topical erythropoietin in the management of scleral necrosis: a narrative review.

Scleral necrosis is a rare but severe complication caused by various etiologies. The main therapeutic approach is topical and systemic medical treatment. Surgical interventions may be indicated in unresponsive cases.

Effectiveness of pelvic floor muscle training in managing urinary incontinence in pregnant women with and without gestational diabetes mellitus.

Objective: Urinary incontinence (UI) is a common issue during pregnancy. Pelvic floor muscle training (PFMT) may offer an effective solution for managing this condition. This study aimed to evaluate the effect of PFMT on reducing UI symptoms in pregnant women.

Lipid Accumulation Product Index as a Marker of Metabolic Syndrome in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.

Background: Lipid accumulation product (LAP) index is a measure of lipid toxicity based on triglyceride and waist circumference. The aim of the current study is to explore the relationship between LAP index and metabolic syndrome (MetS) among women with polycystic ovary syndrome (PCOS) in a systematic review and meta-analysis.

Methods: Web of Science, Embase and PubMed online databases were systematically searched for studies investigating the relationship between LAP index and MetS in PCOS.

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta-Analysis.

Objective: This systematic review and meta-analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD).

Methods: A systematic search of three databases (2000-2024) was conducted, and two reviewers independently screened studies and extracted data following PRISMA and MOOSE guidelines. Pooled proportions were calculated using a random-effects model, and study quality was assessed using modified STARD criteria.

CRISPR-mediated modulation of EGFR signaling in lung cancer.

Lung cancer is among the most common cancers and the leading source of cancer death. Inhibition of EGFR signaling by small-molecule tyrosine kinase inhibitors and monoclonal antibodies has provided new opportunities for treatment of this type of cancer. However, prognosis remained unfavorable due to the incidence of intrinsic or attained resistance.

The effect of gamification on the medication knowledge, performance and satisfaction of nurses in continued medical education: A quasi-experimental study.

Background And Objective: One of the primary challenges within the health system is improving nurses' motivation and attitude toward participation in the continuous education program. This study was conducted aim to investigate the effect of gamification on medication knowledge, performance and satisfaction of nurses in continued medical education (CME).

Methodology: The study was conducted as a quasi-experimental design from November 1, 2022, to February 1, 2024.

Synergistic Enhancement of Cisplatin Anticancer Efficacy by Photobiomodulation Therapy: A Systematic Review.

Cisplatin (Cis), a key cancer chemotherapy drug, faces limitations such as dose-dependent side effects and resistance. Photobiomodulation therapy (PBMT) shows promise as an adjuvant therapy to enhance Cis efficacy and reduce side effects. A systematic review was conducted to evaluate the combined effects of PBMT and Cis on various cancers.

Gut Microbiome and its Impact on Outcomes following Hematopoietic Stem Cell Transplantation: a Comprehensive Review.

Hematopoietic stem cell transplantation is an important treatment for hematological malignancy and disorders, but is fraught with high risks, including graft-versus-host disease, infection, and relapse. Recent evidence now identifies that the microbiome plays a significant role in influencing transplant outcomes, in which microbial dysbiosis-defined by reduced diversity and pathogen overgrowth-is linked to greater complications and death. Microbiome manipulation with approaches including beneficial microbial species, fiber, fecal transplants, and diet has the potential to mitigate these risks.

Effect of Span and MRD Configurations on Small Animal PET Image Quality and Quantitative Accuracy.

Background: Employing 2D rebinned sinograms in PET scanners has the potential to accelerate the overall reconstruction speed. Among the available rebinning techniques, Single-Slice Rebinning (SSRB) offers a computationally efficient approach.

Objective: This study aimed to evaluate the influence of varying span and Maximum Ring Difference (MRD) parameters in SSRB on the image quality of the Xtrim PET scanner.

Current status and new horizons in stem cell therapy in cardiovascular regenerative medicine (CaVaReM): an update.

Cardiovascular diseases (CVDs) and, consequently, heart failure are life-threatening diseases, and they should be considered a worldwide health primacy. Conventional medical treatments have been unable to tackle the burden of disease thoroughly, and the limited availability of organ donors continues to pose a significant hurdle. This pressing need has prompted researchers to explore innovative regenerative techniques and expedite their progression into clinical trials, instilling fresh hope in patients who do not respond adequately to traditional therapies.

Epigenetic mechanisms and next-gen editing platforms in hematology: From molecular basis to therapeutic frontiers.

Epigenetic regulation is fundamental to hematopoiesis, influencing stem cell fate, lineage commitment, and the development of hematologic diseases. Recent technological innovations have transitioned from traditional genetic editing towards programmable, reversible epigenetic modulation without altering the DNA sequence. This review explores the evolution of epigenetic editing platforms, from zinc finger proteins and TALEs to the transformative CRISPR-dCas9 system, and introduces next-generation technologies leveraging dCas12, dCas13, and modular RNA-guided systems.

Limited Efficacy of Pharmacological Interventions for Improving Postoperative Sleep Quality in Primary Total Joint Arthroplasty Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Sleep disturbances are common after total joint arthroplasty (TJA) and are associated with impaired recovery, increased complications, and prolonged hospital stays. Although various pharmacological interventions have been evaluated to improve postoperative sleep quality among TJA patients, consensus on their efficacy and safety remains elusive.

Methods: We conducted a systematic review and meta-analysis following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered the protocol in the International Prospective Register of Systematic Reviews (PROSPERO).

Evaluation of anti- effects of lipid nanoparticles carrying tea tree oil on tachyzoites in Vero cells.

is a protozoan parasite that infects more than a third of the world's population. The drugs used today to treat toxoplasmosis cause severe side effects in many people and have poor success in treating chronic infections. In the current study, oil extracted from tea leaf was loaded into solid lipid nanoparticles (SLNs) and its anti- properties were analyzed.

Dairy-Derived Bioactive Peptides and the Risk of Prostate Cancer among Iranian Men: A Case-Control Study.

This case-control study aimed to assess the association of dairy-derived digestion-resistant bioactive peptides (BPs) with the risk of prostate cancer (PCa) in a cohort of 50 men with PCa and 99 controls. Dietary, demographic, and anthropometric factors of all participants were assessed. Various types of dairy-derived BPs were determined by an method.

Disseminated Infection With in the Setting of HIV Infection Misdiagnosed as Sarcoidosis.

was first identified in a patient with HIV. Here, we describe a 40-year-old man with prolonged fever and mediastinal and abdominal lymphadenopathy, who was initially misdiagnosed with sarcoidosis. A molecular study was conducted after mycobacterium was isolated from a lymph node biopsy, leading to the identification of .

Diosgenin enhances the effect of radiation on head and neck cancer cells through apoptosis induction, G2/M cell cycle arrest, and ROS generation.

Radiotherapy is a cornerstone in treating head and neck cancers, yet its effectiveness is often limited by factors such as hypoxia and cancer stem cells. This study evaluated the radiosensitizing potential of diosgenin in KB cancer cells and normal HDF cells exposed to 4 Gy X-rays, with or without diosgenin. Cell viability, apoptosis, cell cycle distribution, ROS production, and expression of intrinsic apoptosis-related genes were assessed using MTT assays, flow cytometry, and RT-qPCR, respectively.

Automatic Lugano staging for risk stratification in lymphoma: a multicenter PET radiomics and machine learning study with survival analysis.

Background: Lymphoma staging plays a pivotal role in treatment planning and prognosis. Yet, it still relies on manual interpretation of PET/computed tomography (CT) images, which is time-consuming, subjective, and prone to variability. This study introduces a novel radiomics-based machine learning model for automated lymphoma staging to improve diagnostic accuracy and streamline clinical workflow.

Investigating the Psychometric Properties of the Persian Version of the Revised Illness Perception Questionnaire in a Sample of Patients With Multiple Sclerosis.

Introduction: Illness perception significantly influences treatment adherence and quality of life among patients with multiple sclerosis (MS). Despite the widespread use of the Revised Illness Perception Questionnaire (IPQ-R) in different languages, a validated Persian version tailored for MS patients was lacking.

Methods: A cross-sectional study was conducted with 400 Persian-speaking MS patients recruited from the MS Society of Iran between December 2023 and April 2024.