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http://dx.doi.org/10.1002/lary.70112 | DOI Listing |
Chem Biol Drug Des
September 2025
Laboratory of Biochemistry and Animal Toxins, Institute of Biotechnology, Federal University of Uberlandia, Uberlandia, MG, Brazil.
Leishmaniasis, a disease caused by Leishmania parasites, poses a significant health threat globally, particularly in Latin America and Brazil. Leishmania amazonensis is an important species because it is associated with both cutaneous leishmaniasis and an atypical visceral form. Current treatments are hindered by toxicity, resistance, and high cost, driving the need for new therapeutic targets and drugs.
View Article and Find Full Text PDFExpert Rev Pharmacoecon Outcomes Res
September 2025
Health Economics Unit, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Introduction: The global obesity epidemic is a complex issue influenced by various factors, including the food system and its environment. Increasingly, interventions targeting systemic changes in the food environment are being implemented to address obesity. Cost-benefit analysis (CBA) is gaining recognition as a valuable tool for evaluating these interventions, due to its ability to capture broader societal impacts beyond health outcomes.
View Article and Find Full Text PDFAnal Biochem
September 2025
Vegetable and Fruit Improvement Center and Department of Horticultural Sciences Texas A&M University, College Station, TX 77843, USA; Molecular and Environmental Plant Sciences, Texas A&M University, College Station, TX 77843, USA. Electronic address:
Whole plasmid sequencing (WPS) using Nanopore long read sequencing has emerged as a cost-effective alternative for dideoxy sequencing methods. De novo sequence assembly for large plasmids, however, are not always successful and may produce large assembly gaps. Here we streamlined a reference guided alignment of WPS nanopore reads using galaxy platform.
View Article and Find Full Text PDFPLoS One
September 2025
School of Applied Economics, Guizhou University of Finance and Economics, Guiyang, China.
This study aims to improve the market efficiency of intellectual property pledge financing, based on the perspective of willingness to perform of technology-based SMEs, this paper defined the end-of-period value conversion coefficient of pledged property (EVCC) to measure the comparative relationship between the end-of-period value of the pledged intellectual property and the sum of principal and interest of the loan and introduced it into the game payment matrix; using evolutionary game theory, based on the assumption of bounded rationality, an evolutionary game model of intellectual property pledge financing between technology-based SMEs and banks based on the EVCC was constructed, and a numerical simulation was then conducted. The results of asymptotic stability analysis showed that when a certain condition is met, the strategy combination (performance, loan) is the evolutionary stability strategy (ESS). The numerical simulation showed that the EVCC has a positive impact on the speed of technology-based SMEs choosing the performance strategy, and there is a positive threshold effect (The threshold is 0.
View Article and Find Full Text PDFDrugs
September 2025
Research Unit in Public Health, Epidemiology and Health Economics, University of Liege, Liege, Belgium.
Objectives: Our objective was to systematically synthesize and evaluate the existing evidence from meta-syntheses (systematic reviews and meta-analyses) reporting on the safety of celecoxib in adults with chronic musculoskeletal disorders.
Methods: We conducted a comprehensive literature search in November 2024 across MEDLINE, Cochrane Central, and Scopus databases, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines for umbrella reviews. Only systematic reviews and meta-analyses involving celecoxib safety in osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis were included.