Economic evaluation of antibody-drug conjugates (ADCs) in patients with breast cancer: systematic review.

Introduction: Metastatic breast cancer (mBC) is a major global health challenge. Antibody-drug conjugates (ADCs), including trastuzumab emtansine (T-DM1), trastuzumab deruxtecan (T-DXd), and sacituzumab govitecan (SG), offer clinical benefits but are associated with high costs, making cost-effectiveness assessments essential for policy decisions.

Methods: This systematic review analyzed economic evaluations comparing T-DM1, T-DXd, and SG with conventional treatments in breast cancer.

D1-like dopamine receptors in the dentate gyrus mediate cannabidiol's facilitation of extinction and prevention of reinstatement in methamphetamine-induced conditioned place preference.

Methamphetamine (METH) is a highly addictive psychostimulant, and despite its widespread abuse, there are no FDA-approved treatments for METH use disorder (MUD). Cannabidiol (CBD), a non-psychoactive cannabinoid, has shown promise in reducing behaviors linked to psychostimulant use, including METH. However, the underlying neurobiological mechanisms remain unclear.

Optimal Chirality Enhances Long-Range Fluctuation-Induced Interactions in Active Fluids.

Understanding interactions between chiral active particles- self-propelling and self-rotating entities- is crucial for uncovering how chiral active matter self-organizes into dynamic structures. Although fluctuation-induced forces in nonequilibrium active systems can drive structure formation, the role of chirality remains largely unexplored. Effective fluctuation-induced forces between intruders immersed in chiral active fluids are investigated and revealing that the impact of chirality depends sensitively on particle shape.

Neuron-type-specific Contributions to Dynamic Coding during Flexible Sensorimotor Decisions in Frontoparietal Cortex.

Neocortical circuits consist of multiple neuronal cell types, each likely playing distinct roles in flexible behavior. However, studies of decision-making have often overlooked these cell types, limiting our understanding of their specific contributions to local circuit functions. To address this, we simultaneously recorded neuronal activity from the frontal eye field (FEF), lateral PFC, and lateral intraparietal area (LIP) in a macaque monkey performing a visuomotor decision-making task.

Contextual feedback in object recognition: A biologically inspired computational model and human behavioral study.

Scene context is known to significantly influence visual perception, enhancing object recognition particularly under challenging viewing conditions. Behavioral and neuroimaging studies suggest that high-level scene information modulates activity in object-selective brain areas through top-down mechanisms, yet the underlying mechanism of this process remains unclear. Here, we introduce a biologically inspired context-based computational model (CBM) that integrates scene context into object recognition via an explicit feedback mechanism.

Work extraction from coupled qubits in equilibrium and nonequilibrium thermal reservoirs.

This study investigates the thermodynamic behavior of a two-qubit quantum system, where each qubit is coupled to an independent thermal reservoir, either bosonic or fermionic. Using a master equation approach, we analyze both steady-state and time-dependent ergotropy to understand how different reservoir statistics affect work extraction. In bosonic environments, ergotropy consistently declines with increasing temperature due to thermal noise.

Correction: Timing matters! Academic assessment changes throughout the day.

[This corrects the article DOI: 10.3389/fpsyg.2025.

Search for a Neutral Gauge Boson with Nonuniversal Fermion Couplings in Vector Boson Fusion Processes in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for a heavy neutral spin-1 gauge boson (Z^{'}) with nonuniversal fermion couplings produced via vector boson fusion processes and decaying to tau leptons or W bosons is presented. The analysis is performed using LHC data at sqrt[s]=13  TeV, collected from 2016 to 2018 with the CMS experiment and corresponding to an integrated luminosity of 138  fb^{-1}. The data are consistent with the standard model predictions.

Jahn-Teller effect for controlling quantum correlations in hexanuclear Fe[Formula: see text] magnets.

We theoretically investigate the low-temperature magnetic and quantum properties of hexanuclear Fe[Formula: see text] complexes under an external magnetic field. We primarily study the impact of competing exchange interactions and their asymmetries induced by the Jahn-Teller distortion on the quantum properties of the complexes. The inequality in exchange interactions lifts the ground-state degeneracy that gives rise to complex quantum behavior.

Prediction of superconductivity in Haeckelite compounds using first-principles calculations.

Research into the superconducting characteristics of materials has intrigued scientists for an extended period. This study examines the superconductivity of 3D metallic Haeckelite compounds (XY), characterized by square-octagonal structures and symmetry group. Utilizing first-principles calculations, we have performed a thorough examination of the dynamic stability, electronic structures, and electron-phonon coupling (EPC) in Haeckelite structures containing elements and .

Exotic Harmonium model: Exploring correlation effects of attractive Coulomb interaction.

Simple few-body systems often serve as theoretical laboratories across various branches of theoretical physics. A prominent example is the two-electron Harmonium model, which has been widely studied over the past three decades to gain insights into the nature of the electron-electron correlations in many-electron quantum systems. Building on our previous work [Riyahi et al.

Coherent control of anisotropic SPPs in a symmetric double-layer metal/uniaxial dielectric structure.

We investigate the coherent control of anisotropic surface plasmon polaritons (SPPs) in a symmetric double-layer metal/uniaxial dielectric structure. The directional anisotropy introduced by the uniaxial dielectric enables tunable SPP dispersion, absorption, and propagation characteristics through an external control field. We analyze reflection and transmission spectra, dispersion relations, propagation lengths, and the scattering matrix eigenmodes.

Timing matters! Academic assessment changes throughout the day.

The influence of timing on decision-making processes has garnered significant attention across various domains, yet its impact on academic assessment remains under investigated. While previous research has suggested time-of-day effects on judicial decisions, methodological limitations have restricted the generalizability of these findings. Here, we present a comprehensive analysis of 104.

Tuning Fermi liquids with polaritonic cavities.

The question of whether or not passive subwavelength cavities can alter the properties of quantum materials is currently attracting a great deal of attention. In this article, we show that the Fermi liquid parameters of a two-dimensional metal are modified by cavity polariton modes, and that these changes can be monitored by measuring a paradigmatic magneto-transport phenomenon, Shubnikov-de Haas oscillations in a weak perpendicular magnetic field. This effect is intrinsic, and totally unrelated to disorder.

Impaired Interference Control in Individuals With Internet Addiction: Evidence From Event-Related Potentials and Brain Oscillations.

Individuals with Internet addiction disorder (IAD) exhibit deficits in cognitive control, particularly in interference control; however, the behavioural and neural mechanisms underlying these impairments remain unclear. In this study, classic and modified Stroop tasks were administered to individuals with IAD and healthy control (HC) participants, whereas electroencephalography (EEG) was recorded. We hypothesized that individuals with IAD would demonstrate impaired interference control, as evidenced by longer reaction times (RTs) on incongruent trials and that these behavioural deficits would be accompanied by reduced ERP activity in both early and late medial frontal negativity (MFN) components, as well as diminished conflict slow potential (SP).

Differential cognitive and clinical improvements in Schizophrenia and bipolar disorder following hospitalization: A comparative analysis based on the Clock Drawing Test.

Background: Schizophrenia (SCZ) and bipolar disorder with psychotic features (BDP) are psychiatric disorders with significant impact on affected individuals. However, research comparing cognitive impairments between these groups is limited. This study aimed to evaluate the changes in cognitive function based on the Clock Drawing Test (CDT) among hospitalized SCZ and BDP patients and its association with positive and negative symptoms.

Distinct neural patterns for various information in working memory: A brain connectivity study.

Working memory (WM) relies on brain networks including the prefrontal cortex (PFC) and medial temporal lobe (MTL) as key nodes. Graph theory analysis has recently played an important role in uncovering brain connectivity architectures due to its ability to characterize complex brain networks. Yet, it remains unclear whether the PFC and MTL exhibit distinct effective connectivity patterns during information processing in WM.

Altered fronto-parietal alpha synchronization and coherence in paranormal believers.

Recent research has revealed a correlation between paranormal beliefs and distinct neural activity patterns. However, the neural mechanisms underlying these beliefs remain unclear. To address this issue, we recorded EEG resting state data from both paranormal believers and skeptics.

Protocol for phase-amplitude coupling analysis in local field potentials from macaque monkeys to investigate neural oscillation dynamics.

Phase-amplitude coupling (PAC) is a critical neural mechanism that reflects the coordination between oscillatory brain activity across different frequency bands. Here, we present a protocol for analyzing PAC in macaque monkeys. We describe steps for preprocessing local field potential (LFP), performing time-frequency decomposition, and computing PAC between distinct frequency bands.

Driven polymer translocation through a nanopore from a confining channel.

We consider the dynamics of pore-driven polymer translocation through a nanopore to a two-dimensional semi-infinite space when the chain is initially confined and equilibrated in a narrow channel. To this end, we use Langevin dynamics (LD) simulations and iso-flux tension propagation (IFTP) theory to characterize local and global dynamics of the translocating chain. The dynamics of the process can be described by the IFTP theory in very good agreement with the LD simulations for all values of confinement in the channel.

Specialized response of default mode subnetworks and multiple-demand regions to changes in social content, place and time.

This study used functional MRI data from the StudyForrest dataset to investigate the role of subnetworks of the default mode network (DMN) during naturalistic stimulus transitions of different types and magnitudes. We found distinct activation profiles within the DMN: the dmPFC subnetwork was specifically associated with social and location transitions, the MTL subnetwork preferred location and temporal transitions, while the Core DMN subnetwork responded to all three transition types. The multiple-demand network instead responded selectively to temporal transitions.

Spatio-temporal independent component classification for localization of seizure onset zone.

Localization of the epileptic seizure onset zone (SOZ) as a step in presurgical planning leads to higher efficiency in surgical and stimulation treatments. However, the clinical localization procedure is a difficult, long procedure with increasing challenges in patients with complex epileptic foci. The interictal methods have been proposed to assist in presurgical planning with simpler procedures for data acquisition and higher speeds.

Magnetoelectric Decoupling in Bismuth Ferrite.

It is still an open question if magnetoelectric coupling occurs at the atomic scale in multiferroic BiFeO_{3}. Nuclear solid-state techniques monitor local fields at the atomic scale. Using such an approach, we show that, contrary to our own expectation, ferroelectric and magnetic ordering in bismuth ferrite (BiFeO_{3} or BFO) decouple at the unit-cell level.

Cannabidiol mechanism of action on modulating extinction and reinstatement of methamphetamine-seeking behavior: Targeting D2-like dopamine receptors in the hippocampus.

Methamphetamine (METH) use disorder is a significant public health problem lacking effective and approved pharmacological treatments. Cannabidiol, a non-addictive compound derived from cannabis, has garnered attention as a potential therapeutic agent. However, the mechanisms underlying its effects on improving drug-related behaviors remain unclear.