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Background: Delirium is an acute condition marked by disturbances in cognition, awareness, and attention, commonly observed in hospitalized patients due to factors such as illness severity and medication. It is particularly prevalent in intensive care unit settings, affecting up to 80% of ventilated patients. This study investigates whether coronavirus disease 2019 (COVID-19) delirium aligns with expectations of non-COVID-19 delirium incidence in other hospitalized patients and identifies unique or common factors contributing to delirium in these groups.
Methods: An observational cross-sectional study was conducted on 107 hospitalized patients diagnosed with delirium, comprising 56 COVID-19 patients and 51 non-COVID-19 patients. Data were collected through detailed medical record reviews and structured interviews with patients and their caregivers to evaluate factors associated with delirium.
Results: The findings revealed a higher prevalence of medication-related stressors in COVID-19 delirium compared to non-COVID-19 delirium. This suggests that overmedication may play a critical role in the development of delirium, regardless of the underlying critical illness condition.
Conclusions: This study highlights the significant association between medication stressors and COVID-19 delirium. These findings emphasize the importance of minimizing unnecessary medications and closely monitoring pharmacological treatments to reduce delirium incidence and improve outcomes in hospitalized populations.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408460 | PMC |
http://dx.doi.org/10.4266/acc.004944 | DOI Listing |
Acute Crit Care
August 2025
National Brain Center, Iran University of Medical Sciences, Tehran, Iran.
Background: Delirium is an acute condition marked by disturbances in cognition, awareness, and attention, commonly observed in hospitalized patients due to factors such as illness severity and medication. It is particularly prevalent in intensive care unit settings, affecting up to 80% of ventilated patients. This study investigates whether coronavirus disease 2019 (COVID-19) delirium aligns with expectations of non-COVID-19 delirium incidence in other hospitalized patients and identifies unique or common factors contributing to delirium in these groups.
View Article and Find Full Text PDFAcute Crit Care
August 2025
Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Background: Delirium is a common but serious complication in critically ill patients. Family visitation has been shown to reduce delirium; however, during the coronavirus disease 2019 (COVID-19) pandemic, intensive care units (ICUs) restricted regular visitation to prevent the spread of infection. This study aimed to evaluate the association between visitation policies and incidence of delirium in the ICUs.
View Article and Find Full Text PDFIr J Med Sci
September 2025
Acute and General Medicine Department, St James's Hospital, Dublin 8, Ireland.
Background/aims: Subacute complex discharge units (CDUs) offer intermediary person-centred care between acute hospital and community services by providing specialised care for patients with complex medical and functional needs. However, several elements of clinical practice were affected during the COVID-19 pandemic. We aimed to determine the impact of several case mix factors on length of stay and how this impact changed across three phases: pre-COVID-19 (2019), during COVID-19 (2021) and late-stage COVID-19 (2023) in our Complex Discharge Unit.
View Article and Find Full Text PDFCrit Care Explor
September 2025
Department of Critical Care Medicine, University of Calgary and Alberta Health Services, Calgary, AB, Canada.
Objectives Background: Delirium remains frequently undetected by healthcare providers; partnering with family may be a novel way to identify and manage delirium. This study explores the feasibility of a family-administered intervention for delirium prevention, detection, and management.
Design: Pilot randomized controlled trial.
Alzheimer Dis Assoc Disord
August 2025
Centre for Healthy Brain Ageing, Discipline of Psychiatry, UNSW Medicine and Health, University of New South Wales, Randwick, Sydney.
Background: We assessed the cost-benefit of person-centered care education for direct care staff of an Australian subacute rehabilitation hospital, with respect to clinical outcomes and service costs of persons with dementia.
Methods: In a nonrandomized pre/post/follow-up design, clinical outcomes and service use were evaluated for matched comparison (n=77) and intervention (n=80) groups for delirium incidence, accidents/injuries, injury treatment, psychotropic medicines, length of stay, hospital readmissions and discharge destination. Group-level outcomes were monetized and included in a cost-benefit analysis (present value of benefits/present value of education and service costs).