Constructing Ni(OH) nanosheets on a nickel foam electrode for efficient electrocatalytic ethanol oxidation.

The main bottleneck faced by traditional hydrogen production technology through water electrolysis lies in the high energy consumption of the anodic oxygen evolution reaction (OER). Combining the thermodynamically favorable ethanol oxidation reaction (EOR) with the hydrogen evolution reaction provides a promising route to reduce the energy consumption of hydrogen production and generate high value-added products. In this study, a facile method was developed for nickel oxyhydroxide (NiOOH) fabrication.

Ultrasound-assisted enzyme extraction, primary structures and bioactivities of Selaginella uncinata polysaccharides.

In this study, polysaccharides (SUP) were extracted from Selaginella uncinata using ultrasonic-assisted enzymatic extraction (UAEE) and decoction method extraction (DME). UAEE was optimized by response surface methodology, with optimal conditions of 40 min extraction time, a 40:1 liquid-to-material ratio, cellulase to pectinase ratio of 2:1, and pH 5.0.

CMA-based adaptive MIMO equalization for MDM systems.

In modern optical communication systems, mode division multiplexing (MDM) faces challenges such as intermodal interference, mode coupling, and differential mode delay. Traditional multiple input multiple output (MIMO) equalization algorithms, including the constant modulus algorithm (CMA), have shown limitations in terms of convergence speed, precision, and robustness. In this work, a CMA-Adam-NAG equalization algorithm is proposed, which integrates the strengths of the adaptive learning capability of the adaptive moment estimation method (Adam) and predictive updates of the Nesterov accelerated gradient method (NAG) into CMA.

Successful management of Still's disease with severe liver injury through the administration of baricitinib: a case report.

Still's disease (SD) is a rare systemic autoinflammatory disorder of unknown etiology, clinically characterized by a triad of high-spiking fevers, an evanescent salmon-colored rash, and arthritis. The disease exhibits considerable heterogeneity, ranging from mild manifestations to severe, life-threatening complications such as macrophage activation syndrome (MAS). Management strategies are tailored according to disease severity, with glucocorticoids remaining the mainstay of treatment for moderate to severe cases.

Genetic Evidence for Causal Effects of Lipid-Lowering Drug Targets on Primary Sjögren's Syndrome Risk: A Mendelian Randomization Study.

Introduction: Primary Sjögren's Syndrome (pSS) is a chronic autoimmune condition affecting lacrimal and salivary glands. While previous studies suggest potential associations between dyslipidemia and autoimmune diseases, the causal relationship between lipid-lowering medications and pSS remains unclear.

Methods: This study employed drug-targeted Mendelian randomization (MR) analysis to assess the impact of lipid-lowering drugs on pSS risk, focusing on genetic targets including HMGCR, PCSK9, NPC1L1, APOB, CETP, and LDLR.

Disorder of phospholipid metabolism in the renal cortex and medulla contributes to acute tubular necrosis in mice after cantharidin exposure using integrative lipidomics and spatial metabolomics.

Cantharidin (CTD), a natural compound used to treat multiple tumors in the clinic setting, has been limited due to acute kidney injury (AKI). However, the major cause of AKI and its underlying mechanism remain to be elucidated. Serum creatinine (SCr) and blood urea nitrogen (BUN) were detected through pathological evaluation after CTD (1.

Case Report: A rare case of tuberculous otitis media mimicking chronic suppurative otitis media - an ongoing challenge.

Ear tuberculosis, a rare form of extrapulmonary tuberculosis caused by , predominantly affects the middle ear. The common symptoms of ear tuberculosis include otorrhea, hearing loss, and facial nerve paralysis, and if left untreated, it can lead to complete deafness. Diagnosing ear tuberculosis can be challenging, as its symptoms often overlap with those of otitis media, leading to potential misdiagnosis.

Case Report: Coadministration of TNF-α blockade as an effective adjunctive strategy in the treatment of ANCA-negative EGPA with refractory peripheral neuropathy.

Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by abnormal eosinophilia and extravascular eosinophilic granuloma formation. Conventional treatments combining glucocorticoids and immunosuppressants can alleviate the condition in most patients with EGPA. However, the efficacy of blocking tumor necrosis factor (TNF)-α-mediated inflammatory reactions in managing EGPA remains controversial.

Combining transcriptomics and network pharmacology to reveal the mechanisms of QuZhuoHuaYu decoction ameliorating gouty arthritis.

QuZhuoHuaYu decoction (QZHY), a traditional Chinese medicine, has demonstrated a potential effect in gouty arthritis (GA) treatment, but its underlying mechanisms have yet to be fully elucidated. In this study, a strategy of UHPLC-Q-Orbitrap-MS/MS, transcriptomics, and network pharmacology combined with experimental verification was conducted to explore the constituents and the potential mechanisms of QZHY. A total of 26 compounds were identified from QZHY.

Solvation Chemistry of Nonaqueous Electrolytes for Rechargeable Magnesium Batteries.

Rechargeable magnesium batteries (RMBs) have emerged as a promising candidate for next-generation energy storage due to their intrinsic safety and abundant resource availability. However, the development of ideal electrolytes that enable reversible Mg plating/stripping and ensure electrode compatibility remains a significant bottleneck. Over the past decades, considerable efforts have been devoted to addressing this challenge, highlighting the need for a comprehensive and fundamental understanding of the complex nature of Mg electrolytes.

Building S-Scheme p-n Junction by the In Situ Sulfidation of Cu-TCPP Toward Boosted Photocatalytic Activity for CO Photoreduction and Sterilization.

In this work, an S-type p-n junction is designed and fabricated by in situ interfacial sulfidation of Cu-TCPP. Due to the combination of in situ derived CuS, the light absorption expanded to the full-solar-light spectrum, with expected thermal effect and exponentially increased electrical conductivity. The co-shared Cu atoms inspired intimate atomic-level contact and strong electron cooperation to formulate the high-speed electron/heat transfer channel.

Low-strain spherical NaFe(SO) cathode enabled by morphology control for long-cycle sodium-ion batteries.

Alluaudite-type NaFe(SO), characterized by its cost-effectiveness and high operating voltage, has emerged as a prospective cathode material for sodium-ion batteries (SIBs). However, poor electronic conductivity and sluggish reaction kinetics hinder its practical application. In this study, we developed a low-strain spherical NaFe(SO)@C@KB (NFS@C@KB) cathode, enclosed within highly conductive Ketjen Black (KB) using a scalable spray-drying method.

Right Trisegmentectomy and Caudate Lobectomy with Portal Vein (PV) and Inferior Vena Cava (IVC) Reconstruction for Intrahepatic Cholangiocarcinoma (ICC): More Preoperation 3D-Simulated Details and More Safety.

Background: Extended hepatectomy combined with complex vascular reconstruction for huge intrahepatic cholangiocarcinoma (ICC) invading the first hilum, and even inferior vena cava (IVC), is an extreme surgical procedure. High-quality three-dimensional (3D) simulations can offer a clear understanding of intraoperative anatomical structures, allowing for increases in resectability rates and reductions in postoperative complications. In this video, we present a case of precise surgical resection based on 3D simulation: right trisegmentectomy and caudate lobectomy with portal vein (PV) and IVC reconstruction.

Simultaneous medullary thyroid carcinoma and primary non-small cell lung cancer: case report and literature review.

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor, accounting for 1-2% of all thyroid cancers. MTC originates from the C cells or parafollicular cells, which produce and release two critical hormones called calcitonin (CT) and carcinoembryonic antigen (CEA), both serving as key tumor markers. Elevated basal serum calcitonin is critical for diagnosing lateral neck lymph node metastasis, with levels exceeding 500 pg/mL indicating distant metastasis.

An interferometric fiber optic vibration sensor based on random phase modulation.

A stable homodyne interferometric fiber optic vibration sensor is proposed and demonstrated by using a probe pulse, which is generated based on random phase modulation. The first half of the probe pulse is divided into three time slots. Each time slot is subjected to random and different phase modulation.

Glucocorticoid Discontinuation in Patients with Rheumatoid Arthritis under Background of Chinese Medicine: Challenges and Potentials Coexist.

Objective: To evaluate the dynamic changes of glucocorticoid (GC) dose and the feasibility of GC discontinuation in rheumatoid arthritis (RA) patients under the background of Chinese medicine (CM).

Methods: This multicenter retrospective cohort study included 1,196 RA patients enrolled in the China Rheumatoid Arthritis Registry of Patients with Chinese Medicine (CERTAIN) from September 1, 2019 to December 4, 2023, who initiated GC therapy. Participants were divided into the Western medicine (WM) and integrative medicine (IM, combination of CM and WM) groups based on medication regimen.

Determination of potential α-glucosidase inhibitors in Jinxuan black tea based on bioaffinity ultrafiltration combined with UHPLC-Q-Exactive-MS.

The search for natural α-glucosidase (α-Glu) inhibitors has gained significant attention in developing novel antidiabetic agents or functional foods. Low-temperature fermented Jinxuan black tea represents a promising source of such bioactive compounds. Sixteen potential α-Glu inhibitors were identified from the tea using 10 kDa affinity ultrafiltration.

Study on the Association Network of Tuberculosis Lesions in Adult Extrapulmonary Tuberculosis in China: A Large-Scale Multicenter Observational Study.

Extrapulmonary tuberculosis (EPTB) is a significant health problem which can lead to severe morbidity and mortality. In clinical practice, EPTB can have a variety of nonspecific clinical manifestations and can be concurrent with other types of EPTB. As information pertaining to concurrent EPTB is scarce, research efforts are needed to find concurrent EPTB types and to explore the association networks and rules of concurrent EPTB.

Sinomenine alleviates gouty inflammation by inhibiting macrophage M1 polarization and neutrophil extracellular trap formation.

Gout is a common inflammatory arthropathy characterized by the deposition of monosodium urate (MSU) crystals, leading to severe pain and swelling. Sinomenine (SIN) is the major active component of Sinomenium acutum. SIN has been demonstrated to exert preventive and therapeutic effects on arthritis in cell-based, animal, and clinical studies.

Treatment of hepatocellular carcinoma with gluteus medius metastasis: a case report and a literature review.

Hepatocellular carcinoma (HCC) accounts for 85%-90% of all primary liver cancers (PLCs). Owing to the occult nature of HCC, most patients present at an advanced stage at the time of initial diagnosis and have a poor prognosis. With regard to systemic therapy, targeted therapy and immunotherapy are currently the centers of clinical research.

The effect of Kuiyuan chewing tablet on hyperuricemia: protocol for a randomized, double-blind, multicenter, parallel-controlled trial.

Background: Hyperuricemia (HUA) is a metabolic disorder characterized by elevated serum uric acid levels resulting from dysfunction in purine metabolism and/or inadequate uric acid excretion. It is an independent risk factor for many chronic diseases and is associated with a poor long-term prognosis. Existing uric acid-lowering drugs often lead to numerous adverse reactions, resulting in poor patient compliance and limited clinical application.

The degree of esterification influences the bioactivity of pectic polysaccharides isolated from .

Pectic polysaccharides are the mainly bioactive components in (sweet tea) leaves. Nevertheless, owing to their diverse and complex chemical structures, the detailed structure-function relationships (SFR) of pectic polysaccharides from sweet tea (STP) are still unclear. Herein, the influence of STP's esterified degree on its diverse biological functions was uncovered.

Fecal metabonomics combined with 16S rRNA gene sequencing to study the mechanisms of cantharidin-induced hepatotoxicity.

Cantharidin (CTD) serves as the principal bioactive compound in traditional Chinese medicine Mylabris, commonly employed in cancer treatment. Nevertheless, the clinical application of CTD is partly restricted by hepatotoxicity, and the toxicology mechanism is not fully elucidated. This study aims to explore the potential mechanism of CTD-induced hepatoxicity by targeted metabolomics-based UPLC-QTOF-MS/MS analysis and 16S rRNA sequencing.

Prospects of Ganoderma polysaccharides: Structural features, structure-function relationships, and quality evaluation.

Polysaccharides, the primary bioactive compounds found in Ganoderma, are responsible for a multitude of biological activities. The bioactivity of Ganoderma polysaccharides (GPs) closely correlates to their physicochemical properties. Consequently, the accurate characterization and quantification of GPs are essential for the quality control of these compounds.

Case report: Gouty renal abscess and gouty sacroiliitis associated with genetic variants of a young woman.

Gout is a form of inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints, resulting from a disorder in purine metabolism. It occurs more frequently in men than in women prior to menopause and is rare in young women. Gout can lead to various health complications, with many patients experiencing a significant burden of chronic kidney disease (CKD) and joint deformities.