Investment feasibility and optimization strategies of RFID technology in logistics field.

The rapid growth of logistics demand has made improving operational efficiency and service level an important development goal for logistics enterprises. Radio frequency identification technology has great potential in logistics processes such as cargo tracking and path optimization due to its real-time and efficient nature. However, existing research mostly focuses on the theoretical application of technology, lacking support for investment feasibility analysis and system optimization strategies based on practical scenarios.

High-strength chitosan-sericin cryogel with synergistically reinforced networks for hemostasis.

Developing chitosan-based hemostatic cryogels with simultaneously excellent mechanical properties and good biocompatibilities is still a challenge yet crucial for hemostasis of deep tissue bleeding. Typical approaches to enhancing the mechanical properties sacrifice biocompatibility of chitosan cryogels, thereby increasing the potential application risk. In this study, we develop a chitosan-sericin-ε-polylysine (CS-Ser-EPL) cryogel with synergistically reinforced networks achieved by physical and chemical crosslinking to address the limitations.

Metallo-Polyampholyte Hydrogel Based on a Y-Shaped Amphoteric Monomer with Robust Antibacterial and Antifouling Performance.

A Y-shaped metallo-amphoteric monomer with cobaltocenium as the cation and sulfonyl as the anion was synthesized and used to prepare the corresponding metallo-polyampholyte hydrogel (PAH). The cobaltocenium in the amphoteric system and its Y-shape may introduce tunable supramolecular interactions, providing regulation of hydration properties and biomedical performance. Such metallo-PAH showed a higher water swelling ratio and comparable mechanical performance in comparison with its organic counterpart, polysulfobetaine methacrylate hydrogel (SBMA-PAH).

Artificial Intelligence in Lymphoma Histopathology: Systematic Review.

Background: Artificial intelligence (AI) shows considerable promise in the areas of lymphoma diagnosis, prognosis, and gene prediction. However, a comprehensive assessment of potential biases and the clinical utility of AI models is still needed.

Objective: Our goal was to evaluate the biases of published studies using AI models for lymphoma histopathology and assess the clinical utility of comprehensive AI models for diagnosis or prognosis.

Super Stable Coating Based on Ovalbumin and Tannic Acid for Hydrophilic and Antibacterial Functionalization of Polymer Materials.

Surface modification of polymer materials is crucial in the biomedical field, as it can endow materials with new properties, including high efficacy and durability and a low risk of infection. Here, we propose a simple, green, and reliable surface modification strategy using ovalbumin (OVA) and tannic acid (TA). The hydrogen bonds and hydrophobic interactions revealed between the OVA and TA molecules make the OVA/TA composite tenacious and stable.

A Discrete Brain Storm Optimization Algorithm for Hybrid Flowshop Scheduling Problems with Batch Production at Last Stage in the Steelmaking-Refining-Continuous Casting Process.

The iron and steel industry is energy-intensive due to the large volume of steel produced and its high-temperature and high-weight characteristics, sensors such as high-temperature application sensors can be utilized to collect production data and support the process control and optimization. Steelmaking-refining-continuous casting (SRCC) is a bottleneck in the iron and steel production process. SRCC scheduling problems are worldwide problems and NP-hard.

Manganese-modified biochar for sediment remediation: Effect, microbial community response, and mechanism.

Heavy metal sediment pollution has become an increasingly serious problem associated with industrial development, so extensive studies have been conducted concerning their removal. Biochar has recently shown good potential for in-situ remediation of heavy metal-contaminated sediments. The heavy metal adsorption capacity of inexpensive biochar can be improved by loading it with metal oxides.

Polyvinylamine and Its Derivative as Effective Carrier for Targeted Delivery of Small RNAs.

Polymeric delivery systems could enable the fast- and low-side-effect transport of various RNA classes. Previously, we demonstrated that polyvinylamine (PVAm), a cationic polymer, transfects many kinds of RNAs with high efficiency and low toxicity both in vitro and in vivo. The modification of poly lactic-co-glycolic acid (PLGA) with cartilage-targeting peptide (CAP) enhances its stiffness and tissue-specific delivery of RNA to overcome the avascular nature of articular cartilage.

ABC transporter-mediated MXR mechanism in fish embryos and its potential role in the efflux of nanoparticles.

ATP-binding cassette (ABC) transporters are believed to protect aquatic organisms by pumping xenobiotics out, and recent investigation has suggested their involvement in the detoxification and efflux of nanoparticles (NPs), but their roles in fish embryos are poorly understood. In this regard, this paper summarizes the recent advances in research pertaining to the development of ABC transporter-mediated multi-xenobiotic resistance (MXR) mechanism in fish embryos and the potential interaction between ABC transporters and NPs. The paper focuses on: (1) Expression, function, and modulation mechanism of ABC proteins in fish embryos; (2) Potential interaction between ABC transporters and NPs in cell models and fish embryos.

Design and Optimization of Multi-Stage TMR Sensors for Power Equipment AC/DC Leakage Current Detection.

Tunnel magnetoresistance (TMR) can measure weak magnetic fields and has significant advantages for use in alternating current/direct current (AC/DC) leakage current sensors for power equipment; however, TMR current sensors are easily perturbed by external magnetic fields, and their measurement accuracy and measurement stability are limited in complex engineering application environments. To enhance the TMR sensor measurement performance, this paper proposes a new multi-stage TMR weak AC/DC sensor structure with high measurement sensitivity and anti-magnetic interference capability. The front-end magnetic measurement characteristics and interference immunity of the multi-stage TMR sensor are found to be closely related to the multi-stage ring size design via finite element simulation.

Machine learning links different gene patterns of viral infection to immunosuppression and immune-related biomarkers in severe burns.

Introduction: Viral infection, typically disregarded, has a significant role in burns. However, there is still a lack of biomarkers and immunotherapy targets related to viral infections in burns.

Methods: Virus-related genes (VRGs) that were extracted from Gene Oncology (GO) database were included as hallmarks.

Co-Polymer Carrier with Dual Advantages of Cartilage-Penetrating and Targeting Improves Delivery and Efficacy of MicroRNA Treatment of Osteoarthritis.

Osteoarthritis (OA) is a debilitating joint disease affecting nearly 400 million people with no efficient etiological therapies. OA is primarily identified by cartilage destruction, and gradual degeneration of the whole joint would happen when the OA progresses. Hence, cartilage has been identified as the primary therapeutic target of OA.

Amyloid Protein Cross-Seeding Provides a New Perspective on Multiple Diseases .

Amyloid protein cross-seeding is a peculiar phenomenon of cross-spreading among different diseases. Unlike traditional infectious ones, diseases caused by amyloid protein cross-seeding are spread by misfolded proteins instead of pathogens. As a consequence of the interactions among misfolded heterologous proteins or polypeptides, amyloid protein cross-seeding is considered to be the crucial cause of overlapping pathological transmission between various protein misfolding disorders (PMDs) in multiple tissues and cells.

A lipid-polymer hybrid nanoparticle (LPN)-loaded dissolving microneedle patch for promoting hair regrowth by transdermal miR-218 delivery.

Alopecia is the most common multifactorial hair loss disorder, affecting almost 50% of the population and even having a serious psychological impact on the patients. miR-218 has therapeutic potential for alopecia since it can activate the Wnt/β-catenin channel by down-regulating SFRP2, which is a key channel in hair follicle cycle transformation for hair regrowth. Although miR-218 has the potential to treat this disease, several barrier properties of the skin challenge miRNA's delivery to the target location, such as passing through the corneum and resistant enzymatic degradation.

Tensile Experiments and Numerical Analysis of Textile-Reinforced Lightweight Engineered Cementitious Composites.

Despite many cases of textile-reinforced engineered cementitious composites (TR-ECCs) for repairing and strengthening concrete structures in the literature, research on lightweight engineered cementitious composites (LECC) combined with large rupture strain (LRS) textile and the effect of textile arrangement on tensile properties is still lacking. Therefore, this paper develops textile-reinforced lightweight engineered cementitious composites (TR-LECCs) with high strain characteristics through reinforcement ratio, arrangement form, and textile type. The study revealed that, by combining an LRS polypropylene (PP) textile and LECC, TR-LECCs with an ultimate strain of more than 8.

A Versatile Hydrophilic and Antifouling Coating Based on Dopamine Modified Four-Arm Polyethylene Glycol by One-Step Synthesis Method.

A versatile hydrophilic and antifouling coating was designed and prepared based on catechol-modified four-arm polyethylene glycol. The dopamine (DA) molecules were grafted onto the end of the four-arm polyethylene glycol carboxyl (4A-PEG-COOH) through the amidation reaction, which was proven by H NMR and FTIR analysis, assisting the strong adhesion of PEG on the surface of various types of materials, including metallic, inorganic, and polymeric materials. The reduction of the water contact angle and the bacteria-repellent and protein-repellent effects indicated that the coating had good hydrophilicity and antifouling performance.

Vehicle-Assisted UAV Delivery Scheme Considering Energy Consumption for Instant Delivery.

Unmanned aerial vehicles (UAVs) are increasingly used in instant delivery scenarios. The combined delivery of vehicles and UAVs has many advantages compared to their respective separate delivery, which can greatly improve delivery efficiency. Although a few studies in the literature have explored the issue of vehicle-assisted UAV delivery, we did not find any studies on the scenario of an UAV serving several customers.

Polyvinylamine with moderate binding affinity as a highly effective vehicle for RNA delivery.

Polymeric carriers for RNA therapy offer potential advantages in terms of low immunogenicity, promoting modifiability and accelerating intracellular transport. However, balancing high transfection efficacy with low toxicity remains challenging with polymer-based vehicles; indeed, polyethyleneimine (PEI) remains the "gold standard" polymer for this purpose despite its significant toxicity limitations. Herein, we demonstrate the potential of polyvinylamine (PVAm), a commodity high-charge cationic polymer used in the papermaking industry and has similar structure with PEI, as an alternative carrier for RNA delivery.

Formation of β-Lactoglobulin Self-Assemblies via Liquid-Liquid Phase Separation for Applications beyond the Biological Functions.

Proteins are like miracle machines, playing important roles in living organisms. They perform vital biofunctions by further combining together and/or with other biomacromolecules to form assemblies or condensates such as membraneless organelles. Therefore, studying the self-assembly of biomacromolecules is of fundamental importance.

[Self-assembly in the transparent droplets formed during the screening of protein self-assembly conditions].

Protein self-assemblies at the micro- and nano-scale are of great interest because of their morphological diversity and good biocompatibility. High-throughput screening of protein self-assembly at different scales and morphologies using protein crystallization screening conditions is an emerging method. When using this method to screen protein self-assembly conditions, some apparently transparent droplets are often observed, in which it is not clear whether self-assembly occurs.

Database Study on the Expression and Purification of Membrane Proteins.

Membrane proteins are crucial for biological processes, and many of them are important to drug targets. Understanding the three-dimensional structures of membrane proteins are essential to evaluate their bio-function and drug design. High-purity membrane proteins are important for structural determination.

Searching for conditions of protein self-assembly by protein crystallization screening method.

The self-assembly of biomacromolecules is an extremely important process. It is potentially useful in the fields of life science and materials science. To carry out the study on the self-assembly of proteins, it is necessary to find out the suitable self-assembly conditions, which have always been a challenging task in practice.

Optimizing multi-supplier multi-item joint replenishment problem for non-instantaneous deteriorating items with quantity discounts.

This paper deals with a new joint replenishment problem, in which a number of non-instantaneous deteriorating items are replenished from several suppliers under different quantity discounts schemes. Involving both joint replenishment decisions and supplier selection decisions makes the problem to be NP-hard. In particular, the consideration of non-instantaneous deterioration makes it more challenging to handle.