Recent advances in magnetic sodium alginate-based composites as the emerging adsorbents for wastewater treatment: A review.

Researchers are actively pursuing the development of novel adsorbents that are uncomplicated, efficient, and cost-effective for water contaminant removal. Recently, magnetic sodium alginate-based adsorbents (MSABAs), comprising sodium alginate (SA) and magnetic nanoparticles (MNPs), have attracted great attention in wastewater treatment. MSABAs possess superior mechanical properties, a loose porous structure, biodegradability, accessibility, and abundant active sites.

Association between retinal vascular fractal dimension and hearing loss: a cross-sectional study.

Hearing loss (HL) is a prevalent health issue, and identifying noninvasive biomarkers for early detection is crucial. This study investigates the association between retinal vascular fractal dimension (FD) and HL in a health checkup population. A retrospective cross-sectional study was conducted with 575 participants who underwent ophthalmological and audiological assessments at Shanghai Health and Medical Center CN between October 2014 and January 2024.

Identification and Genetic Analysis of Downy Mildew Resistance in Intraspecific Hybrids of L.

Downy mildew caused by is an important disease in grape production, particularly in the highly susceptible, widely cultivated L. Breeding for disease resistance is an effective solution, and intraspecific crosses can yield progeny with both disease resistance and high quality. To assess the potential of intraspecific recurrent selection in (IRSV) in improving grapevine resistance to downy mildew and to analyze the pattern of disease resistance inheritance, the disease-resistant variety Ecolly was selected as one of the parents and crossed with Cabernet Sauvignon, Marselan, and Dunkelfelder, respectively, creating three reciprocal combinations, resulting in 1657 hybrid F1 progenies.

Insights into the molecular mechanisms underlying the function of lysyl oxidase like 1 in cancers.

Cancer is one of the primary causes of human mortality and a significant barrier to increasing human life expectancy. The effective screening, early diagnosis, and treatment of cancer have long been clinical challenges, and thus new biomarkers or molecular targets must be identified to improve the diagnosis and treatment of cancer patients. Lysyl oxidase like 1 (LOXL1), a secreted copper-dependent amine oxidase, is commonly expressed in a variety of cell types.

Heterogeneity of serum metabolism in patients with myeloproliferative neoplasms and acute myeloid leukemia: A Raman spectroscopy study.

In recent years, Raman spectroscopy analysis of hematological diseases is increasingly applied in research, but its application in serum analysis of myeloid neoplastic diseases represented by myeloproliferative neoplasms (MPN), myelodysplastic/myeloproliferative neoplasms (MDS/MPN), and acute myeloid leukemia (AML) has not been fully tested. To establish an oversimplified non-invasive serum test approach for MPN, MDS/MPN and AML, we systematically examined peripheral blood serum samples from 8 patients diagnosed with MPN, 4 patients with MDS/MPN, 3 patients with AML, and 9 control participants. A laser Raman spectroscopy was utilized together with orthogonal partial least squares discriminant analysis (OPLS-DA).

Research Progress on Traditional Uses, Chemical Composition, Pharmacological Actions, and Clinical Applications of Ginseng-Containing Sijunzi Decoction.

Sijunzi Decoction (SJZD), a classic traditional Chinese medicine formula, is primarily composed of , , , and . This review aimed to provide a comprehensive overview of SJZD's traditional uses, chemical composition, pharmacological actions, and clinical applications, with a particular emphasis on its potential role in cancer therapy. The review also aims to identify the gaps in current knowledge and suggest directions for future research on SJZD.

pH/NIR light-responsive carboxymethyl starch/sodium alginate/MXene hydrogel beads for doxorubicin delivery.

The evolution of responsive drug delivery systems capable of responding to external stimuli is the core driving force behind the development of customized biomaterials for medical oncology. Herein, we prepared the novel carboxymethyl starch/sodium alginate/MXene (CMS-SA-MXene@DOX) hydrogel beads by mixing two-dimensional MXene nanosheets, carboxymethyl starch (CMS), and sodium alginate (SA), which could be efficiently loaded with the anticancer drug doxorubicin (DOX), and responded to pH/near-infrared light (NIR). With the incorporation of MXene, the drug loading capacity reached 31.

End-to-End One-Pot Preclinical Immunoaffinity-Liquid Chromatography-Tandem Mass Spectrometry Workflow for Simultaneous Quantitation of Total and Conjugated Antibody Levels of Antibody-Drug Conjugates with Protease-Cleavable Linkers.

The share of the oncology drug pipeline represented by antibody-drug conjugates (ADCs) continues to grow at a remarkable pace. To support the preclinical screening and characterization of early ADC candidates at scale, innovative bioanalytical approaches that improve turnaround times and data quality are sorely needed. This article presents a novel, streamlined one-pot immunoaffinity-liquid chromatography-tandem mass spectrometry (LC-MS/MS) workflow employing proteinase K for the simultaneous quantitation of total and conjugated antibody levels in human IgG1-based ADCs with protease-cleavable linkers by generating both surrogate analytes in a single digestion.

Cell Shock Absorption via Stress Relaxation Hydrogel Microspheres for Alleviating Endoplasmic Reticulum Stress in Chondrocytes.

Chronic mechanical vibrations and endoplasmic reticulum (ER) stress are major contributors to osteoarthritis (OA) progression. This study proposes a novel "cellular shock absorption" approach by developing viscoelastic hydrogel microspheres with tunable stress relaxation properties. By modulating the chemical bonds in the hydrogel network through oxidation and hydrazine coupling reaction, hydrogel microspheres capable of absorbing shock and reducing mechanical stimulus-induced ER stress in chondrocytes are created.

A Multi-Context Emotional EEG Dataset for Cross-Context Emotion Decoding.

EEG-based emotion decoding is essential for unveiling neural mechanisms of emotion and has applications in mental health and human-machine interaction. However, existing datasets for EEG-based emotion decoding are limited to a single context of emotion elicitation. The ability of emotion decoding methods to generalize across different contexts remains underexplored.

IGF2BP3 promotes autophagy-mediated TNBC metastasis via m6A-dependent, cap-independent c-Met translation.

Background: Metastatic tumors pose clinical treatment challenges due to their high adaptability to diverse environments. The cooperation of epigenetic modifications and metabolic adaptations enables tumor cells to dynamically adjust for survival in variable environments, which is crucial for tumor metastasis and worth exploring in depth.

Methods: RNA immunoprecipitation sequencing, transmission electron microscopy photograph and GFP-mCherry-LC3 fluorescence imaging were employed to reveal the role of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) in triple-negative breast cancer (TNBC) cells.

Deletion of p18 enhances both osteogenesis and hematopoietic supportive capacity of bone marrow mesenchymal stromal cells.

Background: p18 (CDKN2C, encoded by p18 or Cdkn2c) is an early G1-phase cyclin-dependent kinase inhibitor protein. Previous studies demonstrated enhanced self-renewal capacity of hematopoietic stem cells (HSCs) in p18 mice compared to wild-type (WT) mice. Given the critical role of bone marrow niche cells-particularly mesenchymal stromal cells (MSCs)-in hematopoiesis, this study investigated the functional alterations of p18 MSCs and their impact on hematopoietic support.

Engineering Sanghuangporus sanghuang for enhanced (-)-aristolone production via metabolic pathway optimization and terpene synthase engineering.

(-)-Aristolone, a sesquiterpene with promising therapeutic properties such as antidiabetic and vasorelaxant effects, currently suffers from limited availability due to inefficient chemical synthesis and lack of viable extraction methods. This study presents a novel strategy for high-yield microbial (-)-aristolone production using Sanghuangporus sanghuang DM989 as a fungal chassis. Genome mining identified nine sesquiterpene synthases, among which TPS2152 was functionally linked to (-)-aristolone biosynthesis.

Near infrared light-enhanced peroxidase-like catalytic activity of copper tannic acid nanosheets for ultrasensitive detection of volatile sulfur compounds.

Monitoring the concentration of volatile sulfur compounds (VSCs) including HS in the oral cavity allows the assessment of severity for various periodontal disease. Rational design of dual-functional copper tannic acid nanosheets with tunable peroxidase-like catalytic activity and efficient photothermal property has enabled the development of a novel near infrared (NIR) light-enhanced colorimetric platform for the ultrasensitive detection of disease-related VSCs. The system achieves NIR light-enhanced sensing performance with a broad linear range (0.

Meta-analysis of the Effect of Semaglutide on Blood Pressure in Obese Populations.

Objective: The aim was to systematically evaluate the effect of semaglutide on blood pressure in obese populations using meta-analysis methods.

Methods: Randomized controlled trials on the effect of semaglutide on blood pressure regulation published from the inception of the databases to October 2024 were searched for in PubMed, Embase, the Cochrane Library, and Web of Science. Stata software was used for statistical analysis of the outcome measures in all included studies.

Evaluating the impact of Carbon Emission Trading Policy on pan-cancer incidence among middle-aged and elderly populations: a quasi-natural experiment.

Background: Cancer is a major public health concern, particularly among middle-aged and elderly populations, who are disproportionately affected by rising cancer incidence. Environmental pollution has been identified as a significant risk factor for cancer development. China's Carbon Emission Trading Policy (CETP), implemented in pilot regions since 2013, aims to reduce carbon emissions and improve air quality.

Reversing VTN deficiency inhibits the progression of pancreatic cancer and enhances sensitivity to anti-PD1 immunotherapy.

Background: Pancreatic cancer, a highly lethal malignancy with limited therapeutic options, necessitates the identification of novel prognostic biomarkers and therapeutic targets. The extracellular matrix protein vitronectin (VTN) has been implicated in tumor progression, but its specific role in pancreatic cancer progression and immunotherapy response remains unclear.

Methods: This study employed an integrative approach combining single-cell RNA sequencing, analysis of public databases, and functional assays.

Association Between Sleep Duration and Anxiety in US Adults: A Nationally Representative Cross-Sectional Study.

Background: Previous studies on the relationship between sleep duration and anxiety have yielded inconsistent results. This study aimed to explore this association using data from a large, nationally representative sample of US adults.

Methods: Data from 13,476 participants in the National Health and Nutrition Examination Survey (NHANES) 2007-2012 were analyzed.

Recent advancements in magnetic starch-based composites for biomedical applications: A review.

The increasing demand for biomedical materials to address various diseases has highlighted the need for advanced biocompatible materials with improved biofunctionality for smart diagnostics and clinical therapies. Starch, a natural polymer, is an ideal starting material for the development of multifunctional biomedical materials due to its biocompatibility, low toxicity, and biodegradability. However, native starch lacks certain properties, particularly magnetic properties.

Developmental neurotoxicity of anesthetic etomidate in zebrafish larvae: Alterations in motor function, neurotransmitter signaling, and lipid metabolism.

Etomidate (ETO), a widely used anesthetic, has emerged as a concerning environmental contaminant due to its increasing misuse and demonstrated neurotoxicity in aquatic organisms. This study employed an integrated multi-omics strategy to investigate the developmental neurotoxic effects of ETO in zebrafish (Danio rerio). ETO exposure induced dose-dependent toxicity in zebrafish embryos, characterized by decreased hatching rates (10-20 %), elevated mortality (up to 30 %), and morphological abnormalities such as scoliosis and pericardial edema.

Predictive value of fecal sulfatide and neutrophil-to‑lymphocyte ratio in coronary heart disease.

The incidence of coronary atherosclerotic heart disease is on the rise, posing a serious threat to public health. Emerging evidence highlights the interplay between systemic inflammation and cardiovascular pathophysiology, suggesting novel diagnostic avenues. The aim of the present study was to evaluate the predictive value of fecal sulfatide and neutrophil-to-lymphocyte ratio (NLR), both individually and in combination, for coronary heart disease (CHD).

Metabolic disorders in polycystic ovary syndrome: from gut microbiota biodiversity to clinical intervention.

Polycystic ovary syndrome (PCOS) is a prevalent gynecologic endocrine disorder characterized by menstrual irregularities, elevated androgen levels, and ovulatory dysfunction. Its etiology is multifactorial. Emerging evidence indicates that PCOS patients exhibit diminished gut microbiota (GM) diversity and altered microbial ratios, contributing to the metabolic derangements observed in these individuals.

Sex-based long-term outcome for atrial fibrillation patients post catheter ablation.

Background: Previous studies have demonstrated sex-based disparities in atrial fibrillation (AF) recurrence and procedural complications post-catheter ablation among female patients; however, sex-specific long-term outcomes remain insufficiently characterized.

Objectives: This study aimed to evaluate long-term outcomes of AF recurrence and major adverse cardiovascular/cerebrovascular events (MACE) after catheter ablation, with the objectives of identifying sex-specific risk factors and providing evidence for personalized clinical strategies.

Methods: We conducted a retrospective analysis using data from a prospectively observational registry of AF ablation procedures at our institution from 2015 to 2020.

Nerve Types and Classification of Neurons Innervating Oral Cancer.

Purpose: Although the association between neural invasion and poor survival in oral cavity squamous cell carcinoma (OSCC) is known, innervating nerve types have not been definitively established; this has confounded mechanistic and translational studies. Therefore, we investigated innervation in human OSCC and further explored these findings in mice.

Experimental Design: Sensory, sympathetic, and parasympathetic nerves were identified by IHC and linked to neural phenotypes in 71 patients.