TGF-β1 Promotes Angiogenesis via Endothelial-to-Mesenchymal Transition in Infantile Hemangioma.

Background: Infantile hemangioma (IH) is the most common benign tumor in infancy and severely affects aesthetics and function. Hemangioma-derived endothelial cells (HemECs) are the main cellular component of IH and contribute to angiogenesis in IH. TGF-β1 (transforming growth factor β1) can induce endothelial-to-mesenchymal transition (EndoMT).

An injectable hydroxyapatite microsphere filler loaded with GHK-Cu tripeptide for anti-Inflammatory and antioxidant.

With the wide application of soft tissue fillers, implant material-induced inflammatory reactions have become a key factor affecting the therapeutic efficacy. This study developed an injectable filler with enhanced anti-inflammatory and antioxidant effects by adsorbing glycyl-L-histidyl-L-lysine copper complex (GHK-Cu) onto hydroxyapatite microspheres (HAPs), marking the first combination of HAPs and GHK-Cu to address inflammation caused by soft tissue fillers. GHK-Cu was successfully loaded onto HAPs by electrostatic adsorption.

Comparison of Infantile Hemangiomas in Male and Female Infants: A Prospective Study.

Infantile hemangioma (IH) predominantly occurs in females, yet few studies have compared the clinical characteristics of IH between girls and boys. This study compared the clinical characteristics of females and males with IH. This prospective study included 1016 patients with IHs for whom complete clinical data were available.

PHACE syndrome: looking backward and forward.

PHACE syndrome rarely occurs in patients with infantile hemangioma (IH) but is common in patients with segmental IH involving the head and face. PHACE syndrome involves at least one system abnormality, including arterial abnormalities, structural brain abnormalities, cardiovascular abnormalities, eye abnormalities, and ventral or midline abnormalities. The pathogenesis of PHACE syndrome remains unclear, and it affects various systems in diverse ways.

Gradient pH Hydrogel Promotes Infected Wound Healing through pH Regulation of Microenvironment.

A healthy skin surface has an acidic environment with an average pH below 5, which helps to protect against bacterial infection. A weakly acidic environment of the dermis not only reduces bacterial infection but also affects fibroblasts' activity, vascular endothelial cell activity, and the immune response. The natural pH gradient helps to ensure the integrity of the skin and accelerates the repair process, following skin damage.

Concurrent spread through air spaces in dominant tumours impacts prognosis in synchronous multiple primary lung adenocarcinoma.

Objectives: The impact of tumour spread through air spaces (STAS) on the prognosis of synchronous multiple primary lung adenocarcinoma (sMPLA) remains unclear. This study evaluates the prognostic significance of STAS in early-stage sMPLA and its combined effect with surgical strategies.

Methods: Patients with cT1-3N0M0 sMPLA (2012-2018) were selected based on multidisciplinary team evaluation, surgical confirmation of invasive adenocarcinoma and exclusion of metastases or minimally invasive disease.

Long-term outcomes of oral propranolol for facial infantile hemangioma.

Background: Oral propranolol is the first-line treatment for problematic infantile hemangiomas (IHs) requiring systematic therapy. Several retrospective studies have reported the successful treatment of facial IHs with propranolol. In this study, we conducted a prospective trial to evaluate the long-term outcomes of oral propranolol use in patients with facial IHs.

Dexmedetomidine alleviates lung ischemia-reperfusion injury by inhibiting cuproptosis: an study.

Lung ischemia-reperfusion (I/R) injury represents an inevitable complication in lung transplantation, characterized by the excessive production of oxygen free radicals and toxic substances. Dexmedetomidine (DEX), a widely used anesthetic agent, has been shown to significantly elevate glutathione (GSH) levels, thereby conferring protection against copper influx. This study investigates the protective mechanisms of DEX in lung I/R injury, with a particular focus on cuproptosis.

CXCL1 and CXCL8: Reliable and feasible biomarkers differentiating intrapulmonary metastasis from multiple primary neoplasms in non-small cell lung cancers.

ObjectiveIn NSCLC, the main approach to differentiate between intrapulmonary metastases (IPM) and multiple primary lung cancer (MPLC) is to integrate histopathological and genomic information. Here, we identified viable biomarkers that can distinguish IPM from MPLC by integrating comprehensive genomic profiling (CGP) and targeted RNA sequencing.MethodsWe retrospectively collected tissues from at least two lesions in 34 patients.

Nanoparticles co-loaded with sorafenib and emodin: preparation and efficacy against liver cancer and .

Liver cancer is common worldwide and associated with relatively high mortality. Sorafenib is a first-line treatment for advanced liver cancer, but its efficacy is limited by its high toxicity, wide distribution in the body and low water solubility. Combination therapy with multiple drugs can lead to greater therapeutic efficacy, and nano-delivery systems can facilitate such therapy by solubilizing drugs and thereby increasing their bioavailability.

Preparation of TEMPO-partially oxidized sodium alginate/SF scaffolds with degradation compatibility for skin defect repair.

This study aimed to curtail the secondary damage caused by traditional dressings by cross-linking TEMPO-mediated oxidized sodium alginate (TOSA) with silk fibroin (SF) through the EDC system and preparing the scaffolds through freeze-drying and anhydrous ethanol immersion. The good adsorption, mechanical properties, high porosity, and good in vitro and in vivo biocompatibility of the scaffold can improve the healing efficiency of the wound. Additionally, sodium alginate was oxidized by the TEMPO system to lower its molecular weight and hence increase the degradation rate of the scaffold.

Efficacy and safety of high-vs low-dose sirolimus in patients with kaposiform hemangioendothelioma: A randomized clinical trial.

Background: It remains unknown whether low-dose sirolimus can replace high-dose sirolimus for the treatment of kaposiform hemangioendothelioma (KHE) without the Kasabach-Merritt phenomenon.

Objective: To evaluate the noninferiority and safety of low-dose versus high-dose sirolimus in KHE patients.

Methods: This randomized, multicenter, open-label, noninferiority trial was conducted from February 2021 to August 2022.

Clinical features and current management experience in Gorham-Stout disease: a systematic review.

Background: Gorham-Stout disease (GSD) is a rare complex lymphatic malformation. Since its initial description in 1838, only approximately 400 patients have been documented. There is currently no consensus on the diagnostic criteria or treatment options for GSD.

An ultra-compact integrated phase shifter electrically tunable meta-waveguides.

Integrated photonics has emerged as a pivotal technology in the advancement of next-generation computing and communication devices. Thermal optical phase shifters (OPSs) have been widely used to realize a tunable Mach-Zehnder interferometer (MZI) and a micro-ring resonator (MRR), which are the building bricks for the LSI/VLSI photonic integrated circuits. Due to the thermal crosstalk and the low modulation efficiency, thermal OPSs have large-scale size and high power consumption.

Similarities and differences in the clinical features and management of primary lymphedema and kaposiform hemangioendothelioma associated with lymphedema in children.

Background: Primary lymphedema (PLE) and kaposiform hemangioendothelioma-related lymphedema (KLE) are rare vascular anomalies (VAs). This study aimed to examine the clinical features, management, and prognosis of PLE and KLE.

Method: The clinical features, imaging, treatments, and outcomes of 12 patients with PLE and 12 patients with KLE were retrospectively reviewed.

An experimental study and prediction of dynamic deformation of wind turbine blade based on DIC.

Wind turbine blade deformation affects the ability of the blade to capture wind energy, and the dynamic deformation law of the actual wind turbine blade is unclear. This study constructs a wind turbine blade dynamic deformation measurement system based on DIC, investigates the blade dynamic deformation regularity, and fits a polynomial to predict the blade dynamic wave deformation. The results show that the modulus of elasticity of the blade determines the time required to calm the fluctuation after deformation, and the length of this time is negatively correlated with the modulus of elasticity of the blade.

Primary pulmonary adenoid cystic carcinoma: A study of clinicopathological features and molecular alterations in twenty-one cases.

Background: Primary pulmonary adenoid cystic carcinoma (PACC) is a rare malignant tumor. Despite the growing sophistication of ACC research, scant studies have delved into the unique molecular alterations of ACC originating from the lung and the clinical features associations.

Method: Paraffin-embedded specimens of primary PACC tissues pathologically confirmed at the Affiliated Hospital of Qingdao University within the past decade were collected.

Large screen size transparent display using spectrum expanded light field holograms.

Holographic displays have the potential to reconstruct natural light field information, making them highly promising for applications in augmented reality (AR), head-up displays (HUD), and new types of transparent three-dimensional (3D) displays. However, current spatial light modulators (SLMs) are constrained by pixel size and resolution, limiting display size. Additionally, existing holographic displays have narrow viewing angles due to device diffraction limits, algorithms, and optical configurations.

Consensus statement for the diagnosis, treatment, and prognosis of kaposiform hemangioendothelioma.

Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor that typically presents in infancy or early childhood. As awareness of KHE increases, it is imperative that the management of KHE be updated to reflect the latest evidence-based guidelines. The aim of this study was to integrate the literature and Chinese expert opinions to provide updated recommendations that will guide the diagnosis, treatment, and prognosis of patients with KHE.

Fiber-based Miniature Strain Sensor with Fast Response and Low Hysteresis.

Flexible and stretchable strain sensors are in high demand in sports performance monitoring, structural health monitoring, and biomedical applications. However, existing stretchable soft sensors, primarily based on soft polymer materials, often suffer from drawbacks, including high hysteresis, low durability, and delayed response. To overcome these limitations, we introduced a stretchable miniature fiber sensor comprised of a stretchable core tightly coiled with parallel conductive wires.

Deep and dynamic metabolic and structural imaging in living tissues.

Label-free imaging through two-photon autofluorescence of NAD(P)H allows for nondestructive, high-resolution visualization of cellular activities in living systems. However, its application to thick tissues has been restricted by its limited penetration depth within 300 μm, largely due to light scattering. Here, we demonstrate that the imaging depth for NAD(P)H can be extended to more than 700 μm in living engineered human multicellular microtissues by adopting multimode fiber-based, low repetition rate, high peak power, three-photon excitation of NAD(P)H at 1100 nm.

Transumbilical single-trocar laparoscopic-assisted cholangiography with a single intraoperative bile duct lavage procedure for inspissated bile syndrome in infants.

Background: To evaluate the feasibility, safety, and efficiency of a novel technique for the diagnosis and treatment of inspissated bile syndrome (IBS) in infants: transumbilical single-trocar laparoscopic-assisted cholangiography with a single intraoperative procedure bile duct lavage (TUSLC).

Methods: This was a prospective cohort study. All infants with IBS admitted to West China Hospital between January 2015 and January 2023 were included in this study.

Dynamic associations between adverse events after lung transplantation and allograft ischaemic time.

Objectives: The effect of allograft ischaemic time (AIT) on postoperative events after lung transplantation remains unclear. This study aims to assess the feasibility of extending the duration of AIT.

Methods: The United Network for Organ Sharing database was queried for adult lung transplantation from 4 May 2005 to 30 June 2020.