Feature fusion based on global-local weighted attention model for automatic epileptic seizure detection.

Objective: Epilepsy is a neurological disorder characterized by recurrent seizures, which present significant challenges in both diagnosis and treatment. Despite advances in seizure detection, existing methods often struggle with accurately capturing the complex and dynamic interactions between temporal, spatial, and spectral features of EEG signals. This leads to limitations in the detection accuracy and generalization across different datasets.

ALDH1A3 promotes aggressive basal-like pancreatic cancer through an AP-1/RUNX2 enhancer network.

The basal-like transcriptional subtype of pancreatic ductal adenocarcinoma (PDAC) is linked to therapy resistance and poor prognosis. The cancer stem cell marker aldehyde dehydrogenase 1A3 (ALDH1A3) is a critical enzyme in acetaldehyde metabolism, but the interconnection to the basal-like subtype is poorly understood. Here, we identified ALDH1A3 as a key gene, which correlates with reduced survival and increased tumor growth.

P300-dependent acetylation of the FOXQ1 complex activates super-enhancers to promote colorectal cancer proliferation and metastasis.

The FOX transcription factor family plays a pivotal role in the malignant progression of tumors. We propose a hypothesis that FOXQ1 recruits p300 and BRD4 to super-enhancer regions. Our findings indicate that p300 acetylates Lys190 of FOXQ1, resulting in its recognition and binding by BRD4.

HrpW Modulates Paracidovorax citrulli Virulence and Plant Immunity via ClRAR1 Interaction in Watermelon.

Bacterial fruit blotch (BFB), caused by Paracidovorax citrulli, severely threatens watermelon production. This study investigates the role of HrpW, an atypical harpin in P. citrulli AAC00-1, in bacterial virulence and host immune modulation.

Comparison of short- and long-term outcomes between robotic and laparoscopic operation in hilar cholangiocarcinoma patients: a case control study.

Background: Robotic surgery (RS) has gained increasing acceptance due to its ability to overcome certain limitations associated with laparoscopic surgery (LS). However, the performance of RS in hilar cholangiocarcinoma (HCCA) patients compared with LS remain unclear. This study aimed to compare the short- and long-term outcomes of RS versus LS in patients with HCCA.

Ralstonia solanacearum injected protein RipH1 targets transcription factor B-box (BBX)-containing protein 31 in Arabidopsis thaliana to manipulate plant immunity.

The type III effector RipH1, a conserved virulence factor in Ralstonia solanacearum, manipulates plant immunity by targeting the transcription factor B-box (BBX)-containing protein 31, AtBBX31 in Arabidopsis thaliana. Here, we demonstrate that RipH1 suppresses reactive oxygen species (ROS) production and triggers programmed cell death (PCD) in multiple plant species, including Nicotiana benthamiana, tomato, and Arabidopsis thaliana. Notably, RipH1 negatively regulates the pathogenicity of R.

MOF-derived Pt-ZnO nanotubes: toward advanced chemical sensors with high sensitivity and selectivity.

The detection of volatile organic compounds (VOCs), particularly acetone, is critical for applications in environmental monitoring and medical diagnostics, including diabetes detection. Conventional metal oxide semiconductor sensors face challenges such as poor selectivity, high operating temperatures, and limited stability. This study addresses these limitations by developing Pt-doped ZnO nanotubes (Pt-ZnO NTs) using a coaxial electrospinning andgrowth method.

[Comparison of anti-inflammatory, antibacterial and analgesic activities of formulated granules traditional decoction of Powder].

Objectives: To compare the anti-inflammatory, antibacterial and analgesic effects of Powder (YQS) formulated granules and decoction.

Methods: We first evaluated the anti-inflammatory effects of the two dosage forms of YQS in a LPS-induced RAW 264.7 cell model using RT-qPCR and Western blotting.

GPX4 Inhibition Contributes to NLRP3-Mediated Pyroptosis and Cognitive Impairment in Ketamine-Exposed Neonatal Rats.

Increasing evidence reveals that multiple or prolonged exposure to ketamine causes hippocampal damage and cognitive dysfunction. However, the critical mechanisms underlying ketamine-induced neurotoxicity in the developing brain remain elusive. The present study was designed to investigate the role of GPX4 in ketamine-induced pyroptosis and cognitive dysfunction in the developing rat hippocampus.

Research on the financial early warning models based on ensemble learning algorithms: Introducing MD&A and stock forum comments textual indicators.

This study analyzes 284 publicly listed companies first designated as ST or *ST between 2015 and 2023. It utilizes two types of textual indicators: Management's Discussion and Analysis (MD&A) and stock forum comments. PCA and MLP are employed for dimensionality reduction.

Examining the burden of major depressive disorder with moderate-to-severe insomnia symptoms in five European countries.

Background: Insomnia is a core and prevalent symptom of major depressive disorder (MDD). However, the impact of insomnia on health-related outcomes among patients with MDD remains inadequately understood. This study evaluated the clinical, humanistic, and economic burden of adults with MDD with moderate-to-severe insomnia symptoms (MDDIS) compared to adults with MDD and no-or-mild insomnia symptoms (other-MDD) and adults in the general population without MDD (non-MDD).

Comprehensive analysis of UPK3B as a marker for prognosis and immunity in pancreatic adenocarcinoma.

The low immunogenicity of pancreatic cancer inhibits effective antitumor immune responses, primarily due to the immune evasion mediated by low expression of the major histocompatibility complex (MHC). Through comprehensive analysis, our study identifies UPK3B as a gene closely associated with low MHC expression and low immunogenicity in pancreatic cancer. UPK3B has been reported as a marker of primary mesothelial cells, mature epicardium and promotes extracellular matrix signaling.

Successive over-relaxation based Markov chain Monte Carlo symbol detection for multiple-input multiple-output underwater acoustic communications.

Markov chain Monte Carlo (MCMC) technique has been employed for symbol detection in underwater acoustic (UWA) communications. Existing MCMC detectors, however, may even be inferior to a conventional linear minimum mean square error detector in case of nonideal factors. Moreover, they suffer high complexity, limiting their practical applications.

N-Acetylcysteine Mitigates Ketamine Neurotoxicity in Young Rats by Modulating ROS-Mediated Pyroptosis and Ferroptosis.

Ketamine, an N-methyl-D-aspartate receptor antagonist with anesthetic and analgesic properties, is extensively utilized for the induction and maintenance of pediatric perioperative anesthesia. Increasing evidence suggests that prolonged exposure to ketamine may induce neurotoxicity in developing animals, adversely affecting their long-term cognitive function. N-acetylcysteine (NAC) is an organic sulfur compound in the Allium genus; however, the mechanisms through which it alleviates ketamine-induced neurotoxicity during developmental stages remain inadequately understood.

Metabolic phenotypes and fatty acid profiles associated with histopathology of primary aldosteronism.

Primary aldosteronism (PA) caused by aldosterone hypersecretion is treated by adrenalectomy or medications. Histopathologic examination of resected adrenals reveals diverse histopathologic features. This study aimed to investigate the potential association of peripheral and adrenal tissue metabolic profiles with the histopathologic features of PA.

Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy.

Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive and characterized by pronounced desmoplasia. PDAC cells communicate with cancer-associated fibroblasts (CAFs) in a paracrine/reciprocal manner, substantially promoting tumor growth and desmoplastic responses. This study highlights the critical role of anterior gradient 2 (AGR2), an endoplasmic reticulum protein disulfide isomerase, secreted by PDAC cells to activate CAFs via the Wnt signaling pathway.

Effects of different polysaccharides on the formation, stability, and rheological properties of oleogels structured by octenyl succinic anhydride starch.

The stability and mechanical strength of oleogels formed from emulsion templates can be enhanced by incorporating polysaccharides in the aqueous phase. In this paper, the effects of three different polysaccharides, including xanthan gum, guar gum and chitosan, on the structure, stability, and rheological properties of oleogels stabilized by octenyl succinic anhydride starch (OS) were investigated. As the concentration of these polysaccharides increased from 0.

Large screen size transparent display using spectrum expanded light field holograms.

Holographic displays have the potential to reconstruct natural light field information, making them highly promising for applications in augmented reality (AR), head-up displays (HUD), and new types of transparent three-dimensional (3D) displays. However, current spatial light modulators (SLMs) are constrained by pixel size and resolution, limiting display size. Additionally, existing holographic displays have narrow viewing angles due to device diffraction limits, algorithms, and optical configurations.

Recent Advances in Two-Dimensional Ferromagnetic Materials-Based van der Waals Heterostructures.

Two-dimensional (2D) ferromagnetic materials are subjects of intense research owing to their intriguing physicochemical properties, which hold great potential for fundamental research and spintronic applications. Specifically, 2D van der Waals (vdW) ferromagnetic materials retain both structural integrity and chemical stability even at the monolayer level. Moreover, due to their atomic thickness, these materials can be easily manipulated by stacking them with other 2D vdW ferroic and nonferroic materials, enabling precise control over their physical properties and expanding their functional applications.

Enhancement of soy protein functionality by conjugation or complexation with polysaccharides or polyphenols: A review.

Soy proteins have good nutritional quality and exhibit a range of useful functional attributes, making them a viable option for replacing animal proteins in the development of more sustainable and eco-friendly plant-based food products. Nevertheless, soy proteins are prone to denaturation and/or aggregation under conditions they encounter in some food and beverage products (including certain pH, ionic, and thermal conditions), which adversely impact their functional performance. This problem can often be overcome by covalently (conjugation) or noncovalently (complexation) linking the soy proteins to polysaccharides or polyphenols, thereby expanding their application scope.

Carbon emission quantification analysis of excavation engineering under road transport conditions.

Current research on building carbon emissions primarily focuses on various carbon emission assessment models and the use of life cycle analysis to evaluate overall building carbon emissions, with limited attention given to excavation engineering. Based on the life cycle method and process analysis, this study analyzes carbon emissions in excavation engineering by optimizing the evaluation model for fuel consumption standards of freight vehicles during the transportation phase in China. To account for the difference between actual and rated fuel consumption of transport vehicles, factors such as road conditions, traffic congestion, and temperature are introduced to adjust the carbon emission calculation model for the transportation phase.

Tryptanthrins as multi-bioactive agents: discovery, diversity distribution and synthesis.

Tryptanthrin and its derivatives, representing a type of alkaloids with indoloquinazoline structures, were first obtained from blue plants and indigo, and then extracted from fungi, marine bacteria and a number of many other natural sources. Various strategies for their chemical synthesis have been reported while tryptanthrin biosynthesis has been less investigated. Tryptanthrin and its derivative products have a broad range of pharmacological and biological functions.

Single-incision laparoscopic cholecystectomy reduced postoperative pain than three-incision laparoscopic cholecystectomy in patients with large gallstone, a retrospective study.

Aim: To compare the short-term outcomes between SILC and TILC depending on gallstone size.

Material And Methods: Data from 114 patients with gallstones who underwent cholecystectomy hospitalized in Nanjing Drum Tower Hospital between June 2022 and October 2023 were collected. The gallstone diameter, the operation time, estimated blood loss, post-operative pain, complications post-operation, and length of hospital stay were all collected and examined.