Gradient pH Hydrogel Promotes Infected Wound Healing through pH Regulation of Microenvironment.

A healthy skin surface has an acidic environment with an average pH below 5, which helps to protect against bacterial infection. A weakly acidic environment of the dermis not only reduces bacterial infection but also affects fibroblasts' activity, vascular endothelial cell activity, and the immune response. The natural pH gradient helps to ensure the integrity of the skin and accelerates the repair process, following skin damage.

X-ray-driven multi-bit quantum random number generator.

Random numbers are vital in cryptography, simulation modeling, and gambling. This study presents a scheme for a multi-bit quantum random number generator utilizing X-ray radiation. Using a homemade multi-pixel single-photon detector array, we extract randomness from three modes of X-ray radiation: arrival time, spatial position, and polarization direction.

Does tourism development contribute to the green water-use efficiency of the Yellow River Basin in China?

The coordination between economic development as well as water resources conservation in ecologically fragile areas is the basis for achieving sustainable development in developing countries. Nonetheless, the existing literature pays little attention to such an issue. The purpose of this quantitative study is to explore the causal relationship between tourism development and green water-use efficiency in the Yellow River Basin (YRB) of China.

A Case of Curative Treatment with Apatinib and Camrelizumab Following Liver Resection for Advanced Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC), a highly malignant digestive system tumor, poses substantial challenges due to its intricate underlying causes and pronounced post-surgery recurrence. Consequently, the prognosis for HCC remains notably unfavorable. The endorsement of sorafenib and PD-L1 inhibitors for HCC signifies the onset of a new era embracing immunotherapy and targeted treatment approaches for this condition.

Recent advances in the intracellular delivery of macromolecule therapeutics.

Intracellular delivery of macromolecules is a critical procedure for biological research and drug discovery, including proteins, peptides, vaccines, antibodies and genes. The penetration of macromolecule therapeutics through the cell membrane to intracellular targets is a prerequisite for their biological activity, but most delivery systems rely on the endocytic pathway to enter the cell and confront an inability to escape from the lysosome. A profound understanding of the cellular internalization of transporting carriers can (i) optimize the design of drug delivery systems, (ii) maintain the biological activity of biomolecular drugs, (iii) improve the efficiency of intracellular macromolecule transport and release, (iv) bring new opportunities for the discovery of macromolecule therapeutics and treatment of refractory disease.