Modulating Interfacial Solvent Aggregation Chemistry to Enable Low-Temperature Sodium-Ion Battery.

The capability of sodium-ion batteries (SIBs) to operate under extreme temperatures is highly desirable; however, achieving stable performance remains challenging due to limitations in interfacial dynamics. Here, it is revealed that at low temperatures, linear solvents tend to aggregate within the inner Helmholtz plane (IHP), leading to the formation of a solvent-derived solid-electrolyte interphase (SEI) with sluggish Na diffusion kinetics. To address this issue, it is proposed to leverage the polarization interaction induced by the orbital overlap between the solvent molecules and free radicals as an effective approach to breaking solvent aggregation.

A serum TNFR2-based model effectively predicates preoperative microvascular invasion and stratifies the tumor recurrence risk in hepatocellular carcinoma.

Aim: Microvascular invasion (MVI) is a key risk factor for hepatocellular carcinoma (HCC) recurrence. There is a lack of methods to diagnose MVI preoperatively. The objective of this study was to develop a model for preoperative prediction of MVI in HCC.

Targeting ATP7A-Dependent Copper Metabolic Homeostasis Induces Cuproptosis and Suppresses the Progression of Mutant KRAS-Driven Lung Cancer.

Despite progress in tumor-targeted therapy, oncogenic KRAS remains a major challenge in treating lung adenocarcinoma (LUAD). In clinical practice, KRASG12C inhibitors have limited response rates and are associated with acquired drug resistance. Cuproptosis is a recently identified form of copper (Cu)-mediated cell death, and previous studies have revealed that Cu metabolism plays an important role in the development of KRAS-driven tumors.

Anion-tethered interface engineering enabling dendrite-free lithium metal anodes.

A functionalized fiber separator with an anion-sieving effect facilitates rapid Li transfer and guides ordered Li deposition. The integration of metal organic frameworks (MOFs) with polyacrylonitrile (PAN) fibers effectively prevents MOF agglomeration, and reduces the high reactivity of -CN groups with Li anodes. Real-time visualization technology confirms uniform Li deposition behavior.

Synergistic Multi-Field Regulation via MOF-Polymer Hybrid Separators Enabling Dendrite-Free and Thermally Stable Lithium Metal Batteries.

Lithium metal batteries (LMBs) offer exceptional energy storage potential but suffer from dendrite growth, SEI instability, and thermal risks. To address these challenges, a multifunctional composite separator (GF@UiO-66-NH + HFP) combining a glass fiber with a metal-organic framework (MOF) layer and polymer coating is constructed to synergistically regulate ion transport, thermal behavior, and interfacial chemistry. The MOF selectively adsorbs PF anions and solvent species, disrupting Li solvation to generate weakly solvated ions for uniform deposition, while poly(vinylidene difluoride)-HFP aligns polymer chains to homogenize Li flux, overcoming inherent limitations of porous substrates.

Programmable DNA Nanocages Enable Adaptive Spatiotemporal Organization of Biomimetic Organelle Networks.

Synthetic organelles have emerged to simulate the multicompartmental organization and communication within cells. However, current synthetic organelles (e.g.

Association between computed tomography-based adipose tissue parameters and liver transplant outcomes in patients with hepatocellular carcinoma.

Background & Aims: The prognostic value of skeletal muscle in liver transplant recipients with hepatocellular carcinoma (HCC) has been documented; however, the role of adipose tissue remains ambiguous. This study aimed to evaluate the association between adipose tissue and transplant outcomes in patients with HCC.

Methods: A total of 765 patients with HCC who underwent liver transplantation (LT) at 3 transplant centers were included in this retrospective study.

Remodelling of corticostriatal axonal boutons during motor learning.

Motor skill learning induces long-lasting synaptic plasticity at dendritic spines and at the outputs of motor cortical neurons to the striatum. However, little is known about corticostriatal axon activity and structural plasticity during learning in the adult brain. Here, using longitudinal in vivo two-photon imaging, we tracked thousands of corticostriatal axonal boutons in the dorsolateral striatum of awake mice.

IPSC-induced podocytes from a BORS patient with EYA1 gene mutation showed glucocorticoid-resistant and cytoskeletal rearrangement.

The primary cause of branchio-oto-renal syndrome (BORS) is mutations in the EYA1 gene. The aim of this study was to investigate the clinical characteristics associated with induced podocyte reappearance in children with BORS and EYA1 mutations. We collected clinical and genetic data from a 4-year-old girl diagnosed with BORS and her family.

Minimally Invasive, Bioadaptive Multimodal Sensor Probe with Safe Deployment for Real-Time Acute Compartment Syndrome Diagnosis.

Acute Compartment Syndrome (ACS) is a serious medical condition that arises from increased pressure within osteofascial compartments, leading to impaired blood flow and potential tissue damage. Early and accurate diagnosis is critical for preventing permanent damage. Current methods rely largely on qualitative assessments with limited accuracy, and those that exploit invasive pressure measurements often prove inadequate.

Randomized, Placebo-Controlled Trial of Peri-Operative Treprostinil in Pediatric Patients Undergoing the Fontan Operation.

The objective of this study is to assess the effect of subcutaneous treprostinil (TRE) administered peri-operatively after Fontan operation on chest tube duration (CTD), hospital length of stay (LOS), and post-operative hemodynamics. This is a single center randomized, blinded, placebo-controlled study of pediatric patients with single ventricle congenital heart disease undergoing Fontan operation between September 2015 and September 2019. Patients were randomized to receive subcutaneous TRE (target dose 10 ng/kg/min) or saline placebo starting intraoperatively through post-operative day 7.

Recent Advances in Multi-Atom Catalysts for Sustainable Energy Applications.

Single-atom catalysts characterized by their novel electronic configurations and exceptional atomic utilization efficiency have emerged as potential alternatives to costly noble metal catalysts, garnering extensive research attention in various electrocatalytic fields. However, the inherent characteristics of single metal centers constrain their further application in catalyzing multi-electron reactions. In contrast, multi-atom catalysts (MACs), particularly dual-atom catalysts (DACs), possess multiple active metal sites that can significantly enhance catalytic performance through synergistic effects.

Antispike IgG antibody decay after immunisation with fractional versus full booster doses of COVID-19 vaccines: a 6-month longitudinal analysis of the FRACT-COV trial in Brazil.

Objectives: To compare antispike IgG levels over a period of 182 days of follow-up in healthy adults who received full or fractional booster doses of BNT162b2 or AZD1222 after completing a primary series of Sinovac, BNT162b2 or AZD1222.

Design: Double-blind, parallel-arm, phase IV randomised trial.

Setting: The study was conducted in Campo Grande, Brazil, and participants were recruited in neighbourhoods with the lowest booster vaccine coverage.

Alkyl-chain engineering of low-dimensional perovskite seeds for high-efficiency perovskite solar cells.

Perovskite solar cells show immense promise for approaching the Shockley-Queisser limit with a theoretical power conversion efficiency (PCE) of more than 30%. However, their practical implementation remains constrained by crystal phase impurities and the suboptimal performance of the perovskite photoactive layer, where uncontrolled crystallization and residual PbI impede charge transport and stability. To address these challenges, we introduce a novel seed-mediated crystallization approach utilizing 1,3-dimethylimidazolium chloride (DMIMCl) and 1-ethyl-3-methylimidazolium chloride (EMIMCl) to convert residual PbI into strain-tolerant low-dimensional (LD) DMIMPbI and LD EMIMPbI, respectively.

Alkaloids from the tubers of Pinellia pedatisecta.

Nine undescribed alkaloids (1, 3, 4, 7, 8 and 10-13) and four undescribed natural products (2, 5, 6 and 9), together with eight known components, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures were elucidated based on spectroscopic data, Rh(OCOCF)-induced ECD spectral analysis, DP4+ analysis, ECD analysis and interpretation of their optical rotation data. The protective effects of all compounds against Aβ-induced PC-12 cell injury were tested by MTT method, and the results indicated that compounds 1, 2, 5-10 and 16-20 exhibited obviously protective effects.

An optimizing lentiviral titer determination assay based on Raji cells.

Objectives: Accurate lentiviral titer determination is crucial for optimizing transduction efficiency in gene therapy. Traditional titration methods based on the human embryonic kidney 293T (HEK293T) cell line often encounter issues with fidelity and reproducibility. This study assessed the potential of suspension cell lines, such as Raji cells, as a more reliable platform for lentiviral titration.

Targeted Lung Premetastasis Niche: Mechanisms, Strategies, and Application.

Lung metastasis remains a leading cause of cancer mortality, driven not only by primary tumors but crucially by dynamic interactions within the premetastatic niche (PMN). Emerging evidence reveals that organ-specific PMN formation precedes tumor cell arrival, creating an immunosuppressive microenvironment conducive to metastatic colonization. Primary tumor-derived factors interact with lung resident cells, promoting the recruitment of bone marrow-derived cells and creating a favorable microenvironment for the migrating tumor cells.

Mesenchymal circulating tumor cells as prognostic markers in HCC Post-Transplantation: Sirolimus as a potential therapeutic Modulator.

Background: The prognostic value of CTCs for post-LT tumor recurrence remains insufficiently studied, and the associations between CTCs and immunosuppressants remain unclear.

Methods: This study analyzed 277 HCC patients undergoing liver transplantation. MCTC and ECTC levels were measured from the day of surgery to one month postoperatively.

Bifunctional 4,5-Diiodoimidazole Interfacial Engineering Enables Simultaneous Defect Passivation and Crystallization Control for High-Efficiency Inverted Perovskite Solar Cells.

Despite the rapid efficiency advancement of perovskite solar cells (PSCs), non-radiative recombination at the buried interface between self-assembled monolayers (SAMs) and perovskite remains a critical bottleneck, primarily due to interfacial defects and energy level mismatch. In this study, we demonstrate a bifunctional interlayer engineering strategy by introducing 4,5-diiodoimidazole (4,5-Di-I) at the Me-4PACz/perovskite interface. This approach uniquely addresses two fundamental limitations of SAM-based interfaces: the insufficient defect passivation capability of conventional Me-4PACz due to steric hindrance effects and the poor perovskite wettability on hydrophobic SAM surfaces that exacerbates interfacial voids.

Targeting LIF With Cyclovirobuxine D to Suppress Tumor Progression via LIF/p38MAPK/p62-Modulated Mitophagy in Hepatocellular Carcinoma.

Leukemia inhibitory factor (LIF) exerts an oncogenic function in several types of cancer, including hepatocellular carcinoma (HCC). However, small-molecule inhibitors of LIF haven't been established. Here, we identified that LIF was remarkably overexpressed in HCC by multi-omics approaches, indicating that inhibition of LIF would be a promising therapeutic strategy.

Monoterpenoids and iridoids isolated from Gardenia jasminoides.

Seven monoterpenoids (1-7) and thirteen iridoids (8-20), including one undescribed monoterpenoids (1) and five undescribed iridoids (8, 11, 16, 19, and 20) were isolated from Gardenia jasminoides Ellis. The structures of the compounds were determined by extensive spectroscopic data analysis, DP4+ analysis and comparing the calculated electronic circular dichroism (ECD) spectra with the experimental ECD spectra. All compounds were evaluated for their acetylcholinesterase and α-glucosidase inhibitory effects whose results showed that all compounds exhibited slightly inhibitory activities.

A novel mouse model for X-linked Alport syndrome induced by splicing mutation in the Col4a5 gene.

Alport syndrome is a hereditary kidney disease with significant variations in onset and prognosis. While 80-85% of cases are due to pathogenic variants in the COL4A5 gene, there is a notable lack of mouse models with Col4a5 mutations for basic research. Our research presents an 8-year-old child with Alport syndrome, exhibiting facial edema and abnormal urine.

Multiomic Underpinnings of Drug Targets for Intracranial Aneurysm: Evidence From Diversified Mendelian Randomization.

Aims: The absence of pharmaceutics poses challenges in preventing intracranial aneurysm (IA) progression and rupture. This research emphasized identifying drug targets for IA through a druggable genome-wide Mendelian randomization (MR) analysis.

Methods: A two-sample MR analysis was performed leveraging cis-expression quantitative trait loci in the blood (n = 31,684) and arteries (n = 584) aligned with 5883 druggable genes as exposure and the largest IA summary statistics (n = 7495) as outcome.

Influence of Altered Immune-Inflammatory Axis on the Risk of Osteomyelitis and Its Network Interaction Effect in European Population.

Osteomyelitis (OM) is a severe bone infection with rising incidence rates, particularly among elderly and diabetic patients. The immune-inflammatory axis is implicated in OM pathogenesis, but its complex interplay remains poorly defined. This study aims to explore the causal relationships between immunophenotypes, plasma inflammatory proteins, and OM using Mendelian randomization (MR) and bioinformatics.