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Seven monoterpenoids (1-7) and thirteen iridoids (8-20), including one undescribed monoterpenoids (1) and five undescribed iridoids (8, 11, 16, 19, and 20) were isolated from Gardenia jasminoides Ellis. The structures of the compounds were determined by extensive spectroscopic data analysis, DP4+ analysis and comparing the calculated electronic circular dichroism (ECD) spectra with the experimental ECD spectra. All compounds were evaluated for their acetylcholinesterase and α-glucosidase inhibitory effects whose results showed that all compounds exhibited slightly inhibitory activities.
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http://dx.doi.org/10.1016/j.fitote.2025.106632 | DOI Listing |
Phytochemistry
September 2025
State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Natural Products Research Center of Guizhou Province, Guiyang 550014, China. Electronic address:
Seven previously undescribed glycosides, including four iridoid glycosides (1, 2, 4, and 5), three phenolic glucosides (18, 21, and 22), together with nineteen known compounds, were isolated from the ethanol extract of Gentiana rhodantha Franch. Their structures were determined by analysis of 1D and 2D NMR, HRESIMS, X-ray diffraction, NMR calculation, and electronic circular dichroism (ECD) calculation. Among them, compound 21 was a novel highly rearranged endo-phenolic analogue with a unique skeleton.
View Article and Find Full Text PDFFront Cell Dev Biol
August 2025
Department of Medical Imaging, School of Medicine, Shaoxing University, Shaoxing, Zhejiang, China.
Introduction: Parkinson's disease (PD) is the most prevalent age-related neurodegenerative motor disorder. It affects approximately 1% of individuals aged 65 and older, with its prevalence increasing significantly with advancing age. Current therapeutic approaches primarily focus on symptom management and modestly slowing disease progression, while definitive interventions capable of halting or reversing neurodegeneration remain unavailable.
View Article and Find Full Text PDFFitoterapia
August 2025
Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, TR-34755, Kayışdağı, İstanbul, Türkiye. Electronic address:
Two previously unreported anthraquinones, named sintenisiquinones A (1) and B (2), were isolated from the MeOH extract of Asperula sintenisii together with five iridoid glycosides, five flavonoids, as well as three phenolic acid derivatives. Their chemical structures were elucidated on the basis of extensive 1D (H and C) and 2D (COSY, HSQC, and HMBC) NMR spectroscopy and HRESIMS. Compounds 1 and 2 represent rare type of anthraquinone derivatives bearing a prenyl group cyclized to dihydrofuran ring.
View Article and Find Full Text PDFPhytochemistry
August 2025
Chulabhorn Research Institute, Kamphaeng Phet 6, Talat Bang Khen, Lak Si, Bangkok, 10210, Thailand; Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand. Electronic address:
Three rare verbascoside conjugated with iridoid glucosides linked by an ester bond, termed songmaeosides A-C (1-3), in addition to an unreported diacylated iridoid diglycoside, songmaeoside D (8), were isolated from the leaves of Gmelina elliptica. Additionally, premcoryoside (4), 6-α-L-(2"-caffeoyl)-rhamnopyranosylcatalpol (5), saccatoside (6), scorodioside (7), verbascoside (9), syringalide A 3'-α-l-rhamnopyranoside (10), isoverbascoside (11), icariside F (12), and sericoside (13) were also isolated. The isolation of verbascoside conjugated with iridoid glucosides through an ester linkage from this species is an uncommon phenomenon in plant sources.
View Article and Find Full Text PDFMolecules
July 2025
National Key Laboratory of Lead Druggability Research, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
(1) Background: The urate-lowering effects of three iridoid glycosides, which are paederosidic acid, paederosidic acid methyl ester, and paederoside, isolated from and the protection they provide against hyperuricemia-induced kidney injury were investigated in a rat model. (2) Methods: A hyperuricemia (HUA) rat model was established in Sprague-Dawley (SD) rats through intraperitoneal potassium oxonate (PO) and intragastrical adenine for 2 weeks. Subsequently, rats in the pharmaceutical intervention groups received corresponding drug treatments at a concentration of 40 mg/kg/day, maintained consistently for 7 days.
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