[Mechanism of Cyanotis arachnoidea Gel in improving melasma based on network pharmacology and transcriptomics].

Through a comprehensive analysis combining network pharmacology prediction and transcriptomics, this study systematically explained the multi-target mechanism of Cyanotis arachnoidea(CA) Gel in improving melasma. A melasma model was induced in female SD rats by progesterone injection combined with ultraviolet B(UVB) irradiation for 40 consecutive days, while the blank control group was only fed routinely. After successful model establishment, the rats were randomly divided into five groups and administered different doses of CA ethanol extract gel(high, medium, and low doses) or arbutin Gel(positive control), which were applied once daily for 28 consecutive days.

DeepNuParc: A novel deep clustering framework for fine-scale parcellation of brain nuclei using diffusion MRI tractography.

Brain nuclei are clusters of anatomically distinct neurons that serve as important hubs for processing and relaying information in various neural circuits. Fine-scale parcellation of the brain nuclei is vital for a comprehensive understanding of their anatomico-functional correlations. Diffusion MRI tractography is an advanced imaging technique that can estimate the brain's white matter structural connectivity to potentially reveal the topography of the nuclei of interest for studying their subdivisions.

A propensity score matched retrospective study of psychological and behavioral therapy impact on muscle function recovery in Guillain Barré Syndrome.

Guillain-Barré Syndrome (GBS) is an autoimmune disorder that leads to acute flaccid paralysis and often results in long-term sequelae such as muscle weakness and sensory dysfunction. While recovery is possible, current rehabilitation strategies for muscle function and nerve regeneration often show limited effectiveness and require prolonged treatment. Psychological and behavioral therapy has shown promise in enhancing recovery by improving patient compliance and emotional stability.

Co-exposure to bisphenol a and arsenic enhance hepatotoxicity in zebrafish by targeting the hypothalamic-pituitary-thyroid axis and PPAR pathway.

The worldwide production of bisphenol A (BPA) has doubled over the last two decades, reaching around 6.2 million tons in 2020, with a continuing rise. In contrast, arsenic (As) persists as a prevalent geogenic and anthropogenic contaminant in both global drinking water and surface water.

Extensive nrDNA Polymorphism in L. and Its Application.

The internal transcribed spacer (ITS) is one of the most extensively utilized in the taxonomy of the genus due to its generally concerted evolution. Although non-concerted evolution of nuclear ribosomal DNA (nrDNA) has been reported in some species, genome-wide nrDNA characteristics in the genus remain poorly understood. In this study, 158 single-nucleotide polymorphisms (SNPs) and 15 insertions and deletions (InDels) were identified within the nrDNA regions of 542 mulberry accessions representing sixteen species.

International Partnerships in AI-Driven Healthcare: Opportunities and Challenges for Advancing the UN Sustainable Development Goals-A Perspective.

Artificial Intelligence (AI) is reshaping global healthcare systems by offering innovative solutions to improve diagnostic accuracy, optimize treatment planning, and enhance public health management. This article provides a structured perspective on the role of international partnerships in accelerating the adoption of AI-driven healthcare, with a focus on advancing the United Nations Sustainable Development Goals (SDGs), particularly SDG 3 (Good Health and Well-being). Drawing on representative global initiatives, the paper explores best practices in technology transfer, ethical data sharing, and capacity building-key enablers for inclusive and equitable AI healthcare adoption.

Exploring DNA topoisomerase II alpha in adrenocortical carcinoma through multi-omics analysis: a potential biomarker and therapeutic target.

Adrenocortical carcinoma (ACC) is a rare but aggressive cancer. Recent studies identified DNA Topoisomerase II Alpha (TOP2A) as a potential biomarker for ACC, which can provide new avenues for targeted therapy and improve clinical outcomes. This study aims to elucidate the role of TOP2A in ACC by exploring its prognostic value and identifying inhibitors for ACC therapy.

Study on the influencing factors of ecological spatial grouping optimization in the huangshan region based on entropy weight topsis.

This study evaluates and analyzes the influencing factors of ecological spatial configuration optimization in the Greater Huangshan Region. By identifying and assessing these factors, it aims to reveal the mechanisms underlying ecological space optimization in the area. The findings provide a theoretical foundation for promoting high-quality development and optimizing ecological spatial governance policies in the Greater Huangshan Region.

In Situ Cation-Switched Organometallic Cage Reconfiguration Enables Highly Selective Li Recognition and Extraction.

Biomacromolecular selectivity paradigms, epitomized by the "induced-fit" concept, motivate adaptive supramolecular designs; however, cationic guest-directed morphological responses in metal-coordinated hosts remain inadequately developed. We reveal a dynamic Ag-N-heterocyclic carbene (NHC) cage that experiences alkali ion-induced structural metamorphosis triggered by Lewis acid‒base interactions. X-ray crystallographic analysis and independent gradient model (IGM) evidence confirm that these interaction templates have highly ordered architectures exceeding 340 non-H atoms.

The source and thermal driver of young (<3.0 Ga) lunar volcanism.

The thermal mechanism that drives the prolonged volcanism on the Moon, especially after the major pulse of Imbrian-aged eruptions, remains unknown. Here, we present a petrological and geochemical study of two types of young farside mare basalts, the ~2.8-billion year (Ga) low-Ti and ~2.

A plasmonic meta-rotary travelling-wave oscillator with ultrahigh phase accuracy and figure of merit.

High phase accuracy and figure of merit (FOM) of quadrature signals are essential for integrated systems, including quadrature amplitude modulation (QAM) communications and multi-input multi-output (MIMO) radar. However, the traditional quadrature oscillators often struggle to meet the stringent requirements of high FOM and high quadrature phase accuracy simultaneously. To address this challenge, we propose a spoof surface plasmon polariton (SPP) metawaveguide (Meta) to design on-chip rotary traveling-wave oscillator (RTWO).

Effects of exercise modality-dose combinations on cognitive function in Parkinson's Disease: A bayesian dose-response systematic review and meta-analysis.

Objective: This study aimed to identify the most effective exercise modalities and optimal dose ranges for improving cognitive function in individuals with Parkinson's disease (PD).

Methods: We conducted a systematic search of five databases up to June 1, 2025, and included 33 RCTs involving 1,256 PD patients. Exercise doses were standardized using MET·min/week.

Harnessing Stable Electrode-Electrolyte Interface/Interphase Dynamics via Electrolyte Additives: Rationalized Pathways to Practical Aqueous Zinc-Ion Batteries.

The commercialization trajectory of aqueous zinc-ion batteries (AZIBs) faces critical challenges, including zinc dendrites, parasitic side reactions, and inadequate cycling stability. The electrode-electrolyte interface (EEI), serving as the nexus between macroscopic device performance and microscopic electrochemical processes, fundamentally dictates reaction pathways through solvation structure modulation. A comprehensive understanding of both cathode and anode interfacial chemistries is imperative, as expanding and stabilizing reactive interfaces can significantly enhance depth of discharge (DOD).

[Colonoscopy in infants: procedure and disease spectrum analysis of 184 cases].

Objectives: To investigate the underlying causes and clinical manifestations in infants undergoing colonoscopy, and to analyze changes in disease spectrum.

Methods: Clinical data from 180 infants who underwent a total of 184 colonoscopies at the Department of Gastroenterology, Children's Hospital Affiliated to Shandong University from January 2015 to December 2024 were retrospectively analyzed. Patients were grouped by age: ≤6 months (=41) and >6-12 months (=139); and by examination period: 2015-2019 (=83) and 2020-2024 (=97).

Dual positivity for Anti-Ro52 and Anti-Ro60 antibodies is linked to greater organ involvement and disease progression in systemic sclerosis.

Objectives: To investigate the distinct and combined effects of anti-Ro52/TRIM21 and anti-Ro60/SSA antibodies on the clinical features and prognosis of patients with systemic sclerosis (SSc).

Methods: A single-center observational study was conducted using data from the Renji Scleroderma Longitudinal Cohort (Renji-SLOC), including 379 SSc patients with at least 1 year of follow-up. The patients were categorized into four groups based on serological status: double-negative (Ro52/Ro60), isolated anti-Ro52/TRIM21 positive (Ro52), isolated anti-Ro60/SSA positive (Ro60), double-positive (Ro52/Ro60).

Epidemiological Study of Childhood Idiopathic Epilepsy from 1990 to 2021 at Global, Regional, and National Scales.

Objective: To address the long-term impact of childhood idiopathic epilepsy on health and families, and to provide epidemiological evidence for developing effective prevention and treatment strategies, this study aimed to explore the trends in incidence, deaths, and disability-adjusted life years (DALYs) of childhood idiopathic epilepsy globally and across regions from 1990 to 2021.

Patients And Methods: This cross-sectional analysis utilized data from the 2021 Global Burden of Disease database, covering idiopathic epilepsy cases among children aged 0-14 years across 204 countries and regions. The study period was from September 15, 2024, to October 31, 2024.

Chrysophanol promotes M2 polarization and inhibits M1 polarization through the NF-κB signaling pathway to attenuate sepsis-associated acute kidney injury.

Objective: Sepsis-associated acute kidney injury (SA-AKI) is a frequent and severe complication in septic patients. This study combines network pharmacology with and experiments to preliminarily investigate the protective effect of chrysophanol (CHR) on SA-AKI and its mechanism, aiming to find new therapeutic targets and strategies for SA-AKI treatment.

Methods: HK-2 cells were used to investigate CHR's inhibitory effects on SA-AKI using CCK-8 assay, Hoechst33258 staining, ELISA, Western blot.

Precision Delivery of CRISPR/Cas Systems via DNA Nanostructures for Gene Therapy and Intracellular Detection.

The CRISPR/Cas system represents a transformative breakthrough in genome editing technology, featuring three principal effector proteins with distinct functionalities: Cas9, which induces site-specific double-strand breaks guided by a single guide RNA, enabling precise gene knockout and knock-in modifications; Cas12, which mediates targeted DNA cleavage through cis-activity while exhibiting nonspecific trans-cleavage of single-stranded DNA, a property exploited for ultrasensitive nucleic acid detection in molecular diagnostics; and Cas13, an RNA-guided RNase that specifically degrades complementary RNA transcripts, demonstrating significant potential for antiviral therapies and transcriptome regulation. Despite these advances, the clinical translation of CRISPR/Cas systems faces substantial challenges, particularly in achieving efficient and controllable delivery. This reviewsystematically examines current delivery modalities for CRISPR/Cas systems, with particular emphasis on the implementation of DNA-based functional materials as advanced delivery vehicles.

Purine Nucleoside Phosphorylase (PNP) as a Biomarker and Therapeutic Target in Muscle-Invasive Bladder Cancer.

Background: This study investigates the potential of purine nucleoside phosphorylase (PNP) as a biomarker and therapeutic target in muscle-invasive bladder cancer (MIBC). We aimed to explore PNP's expression, prognostic value, and role in metabolic pathways, along with its association with gene mutations.

Methods: We conducted multi-omics analyses using data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and other public databases to evaluate PNP expression across MIBC samples and its prognostic impact through Kaplan-Meier and Cox regression analyses.

Sampling bandwidth expansion in channel-interleaved photonic analog-to-digital converters based on optical spectral convolution.

Optical sampling pulses generated by cascade modulators have been widely studied for broadband signal acquisition in photonic analog-to-digital converters (PADCs). In this paper, we establish a comprehensive theoretical optical sampling model that incorporates the photodetection-induced optical spectral convolution, which in turn affects PADCs' bandwidth. Under sufficient bandwidth conditions of the sampling Mach-Zehnder modulators (MZMs), the bandwidth of the PADC is determined by the electrical spectrum, i.

Bisphenol A and its analogs perturb primitive myelopoiesis and inhibit innate immune cell formation during early developmental stages of zebrafish.

Perinatal exposure to bisphenol A (BPA) promotes the development of inflammatory and immune diseases. Nevertheless, the potential mechanisms of this effect and the developmental immunotoxicity of BPA analogs are unclear. Here, embryonic zebrafish were exposed to a range of concentrations of BPA and its analogs.

Theoretical analysis of atomic electronegativity effects on excited state behaviors for HBT-PhCz derivatives.

Context: The excited-state intramolecular proton transfer (ESIPT) reaction of 9-phenyl-9H-carbazole substituted 2-hydroxyphenyl benzothiazole (HBT-PhCz) derivatives is studied based on TDDFT/B3LYP/TZVP theoretical level. To provide direct information on the effect of atomic electronegativity on the ESIPT reactions, the geometric parameters, infrared (IR) vibrational spectra, core-valence bifurcation (CVB) index coupling with predicting the hydrogen bonding energy (E), vertical excitation behaviors, frontier molecular orbitals (MOs), and potential energy curves have been calculated for chalcogen-substituted HBT-PhCz derivatives (HBT-PhCz-O, HBT-PhCz-S, and HBT-PhCz-Se). The charge recombination caused by photoexcitation and energy gap between HOMO and LUMO orbitals further reveal the ESIPT trend.

Effectiveness of Disease-Modifying Therapies in Patients With Late-Onset Relapsing-Remitting Multiple Sclerosis.

Background And Objectives: The benefit of disease-modifying therapies (DMTs) in relapsing-remitting multiple sclerosis (RRMS) is believed to decrease with age. We aimed to compare disease outcomes with DMTs between patients with late-onset RRMS (LO-RRMS) and adult-onset RRMS (AO-RRMS).

Methods: This was a single-center, longitudinal, prospective analysis of patients who fulfilled the following criteria: (1) a diagnosis of RRMS and (2) initiation of a new DMT (dimethyl fumarate, fingolimod, glatiramer acetate, natalizumab, and ocrelizumab) within 3 months.