Exploring the Complexities of Liver Transplantation for Secondary Hemophagocytic Lymphohistiocytosis-Associated Acute Liver Failure.

Background: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by the aberrant activation of macrophages. Liver dysfunction is often observed in patients with HLH and has the potential to advance to acute liver failure (ALF). However, limited data exist regarding the application of liver transplantation (LTx) for the management of HLH-associated acute liver failure (HLH-ALF).

Mechanistic insights into SUMOylation and its role in cancer pathogenesis: bridging oncogenesis, immunity, and therapeutic opportunities.

SUMOylation is a post-translational modification mediated by SUMO proteins, a family of small ubiquitin-like biological macromolecules that covalently attach to specific lysine residues in target proteins. This modification regulates various macromolecular functions, including transcriptional control, subcellular localization, DNA repair, and cell cycle progression. Recent advances have unveiled the multifaceted roles of SUMOylation in cancer pathogenesis, encompassing oncogenesis, immune modulation, and therapeutic resistance.

Performance-enhanced lateral flow immunoassay for rapid and ultrasensitive detection of aflatoxin M in dairy products using in-situ gold deposition-mediated signal amplification strategy.

Aflatoxin M (AFM) is a common mycotoxin in dairy products, leading to both acute and chronic poisoning and the detection requirement is much higher than that of AFB1. In this study, we proposed a performance-enhanced lateral flow immunoassay (PE-LFIA) using in-situ gold deposition-mediated signal amplification strategy for effectively monitoring AFM. Of significance, this sensing signal on both T line and C line of lateral flow strip is improved by simultaneous and direct growth and deposition of gold shells on the surface of AuNPs.

The computational fluid dynamics analysis of "left-at-right" liver transplantation: The research from the perspective of biomechanics.

Hyperperfusion injury is a major contributor to small-for-size syndrome (SFSS) following liver transplantation, particularly in left-liver transplantation (LLT). Given donor preservation constraints, "left-at-right" liver transplantation (LAR-LT) has emerged as a potential strategy to mitigate this complication. This study employed computational fluid dynamics (CFD) to investigate the mechanical mechanisms underlying SFSS in five patients who underwent LLT at Beijing Friendship Hospital.

Arthroscopic capsular suture benefits the clinical prognosis of distal radius fracture with DRUJ instability.

Background: This study investigated the effectiveness of capsular suture repair for triangular fibrocartilage complex (TFCC) in restoring distal radioulnar joint (DRUJ) stability after plate fixation for distal radius fracture (DRF) combined with acute DRUJ instability, comparing the results of arthroscopic capsular suture with those of conservative treatment of TFCC injury.

Methods: Cases of DRF combined with DRUJ instability treated from January 2019 to December 2022 were reviewed retrospectively. After plate fixation of the distal radius fracture, patients with acute DRUJ instability were divided into two groups.

Development and validation of a novel prognostic model to predict 1-year post-transplant mortality for acute-on-chronic hepatitis B liver failure: a nationwide, multicentre, cohort study.

Background: Liver transplantation (LT) provides a potential cure for hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). We aimed to develop and externally validate a prognostic model to predict 1-year post-LT mortality in patients with HBV-ACLF.

Methods: This retrospective, nationwide, observational cohort study was conducted at ten high-volume LT centres in China.

From bench to bedside: Synthetic strategies and clinical application of PARP inhibitors.

PARP inhibitors have revolutionized the treatment paradigm for BRCA1/2-mutated cancers by exploiting synthetic lethality-a therapeutic strategy that capitalizes on tumor-specific defects in homologous recombination repair. These agents induce dual cytotoxic effects through catalytic inhibition of poly(ADP-ribose) synthesis and "PARP trapping," irreversibly stabilizing PARP-DNA complexes to disrupt DNA repair and promote replication catastrophe. Clinically approved inhibitors (olaparib, niraparib, rucaparib) demonstrate unprecedented efficacy, with olaparib extending median progression-free survival to 19.

A mechanism-driven failure causality modeling approach for mechanical systems combining causal ordering theory and Ishikawa diagram.

Failure causality modeling plays a critical role in mechanical system diagnostics. Current methods primarily rely on empirical knowledge and historical datasets, resulting in constrained applicability and inconsistent predictive accuracy. To address these limitations, this study proposes a novel mechanism-driven causality modeling framework that systematically integrates causal ordering theory with Ishikawa diagram analysis.

Self-supply activation Fenton-like system for water purification using polyethyleneimine-driven electron pumps in polymeric carbon nitride.

A hierarchically structured photocatalyst composite bead (CS-PG-Fe) was developed in this study through a synergistic electronic modulation strategy, incorporating porphyrin-tailored polymeric carbon nitride (CNpor), Fe(III) coordination, and polyethylenimine(PEI)-alginate cross-linked matrix to overcome challenges in Fenton-like wastewater treatment. The multi-component architecture was constructed via triple cross-linking treatment, with comprehensive mechanistic analysis employing in-situ characterization, reactive species tracking, and theoretical calculations to reveal the photo-driven HO self-supply and activation processes. PEI acted as an electron pump and proton-relay mediator to enhance CN charge separation, while the cross-linked structure enabled spatially the confined HO activation.

miR-574-3p Regulates Smad/Snail Signaling to Promote Epithelial-Mesenchymal Transition in Nasopharyngeal Carcinoma Cells.

Epithelial-mesenchymal transition (EMT) is pivotal in the progression and metastasis of nasopharyngeal carcinoma (NPC). MicroRNAs (miRNAs), particularly miR-574-3p, are emerging as critical regulators in these processes. This study examines the role of miR-574-3p in NPC and its relationship with the Smad/Snail signaling pathway.

Aggregation-Induced Emission-Integrated Chemiluminescent Probe for Tumor-specific Detection and Treatment.

Near-infrared (NIR) chemiluminescent probes offer significant advantages for cancer imaging due to their high signal-to-noise ratios and deep tissue penetration. However, the integration of chemiluminescence (CL) units and aggregation-induced emission (AIE) components to enhance emission wavelength and combine diagnostics with therapeutics remains underexplored. Here, we present an innovative probe, H-C, formed by conjugating 10-hydroxycamptothecin (HCPT)--a natural product with anticancer activity and AIE properties--with a chemiluminescent unit.

Expression and correlation of SOCS3 and Eotaxin mRNA and proteins levels in nasal mucosal tissue of allergic rhinitis patients.

Objective: This study aims to investigate the expression and interaction mechanisms of Suppressor of Cytokine Signaling 3 (SOCS3) and Eotaxin in the nasal mucosal tissues of patients with Allergic Rhinitis (AR).

Methods: In this retrospective study, we selected nasal mucosa tissues from 35 AR patients as the AR group, and nasal mucosa tissues from 22 patients with isolated nasal septum deviation as the control group. Utilizing reverse transcription polymerase chain reaction (RT-PCR) techniques, we measured the expression levels of SOCS3 mRNA and Eotaxin mRNA in both groups.

Toxicity Challenges and Current Advancement in Metal-Organic Frameworks (MOFs) for Biomedical Applications.

Metal-organic frameworks (MOFs) are highly versatile porous crystalline polymers with diverse structural compositions, high porosity, and biocompatibility, which guarantees their significant potential in various biomedical applications, including drug delivery, magnetic resonance imaging (MRI), and biosensing. However, despite these promising features, MOFs' application is considerably hindered by main challenges such as toxicity and biocompatibility. This review aims to provide a comprehensive understanding of MOF-associated toxicity, and the challenges involved in their biomedical applications.

Topological representation based on wavelet transform as a novel imaging biomarker for tumor diagnosis in ultrasound images: A comprehensive study.

Background And Objective: Topological data analysis (TDA) and topological representation are emerging research directions in medical image analysis, aimed at mining the spatial topological features of diseases such as tumors, exploring biological complex patterns, and constructing predictive tools for clinical diagnosis and treatment. Ultrasound examinations are widely used in the preliminary diagnosis of various tumor diseases due to their convenience, real-time imaging, and non-radiation. However, since ultrasound examinations rely heavily on the subjective experience of doctors and often require pathological gold standards for tumor typing determination, there is an urgent need to develop novel quantitative analysis methods to build the correlation between ultrasound quantitative features and histological information, thereby optimizing clinical decision-making paths.

One Fast and Accurate Model to Assess Ion/Protein Interaction with Antifouling Surfaces .

Ion and protein adsorption occurs on the implant surface upon contact with tissues. Increasing research efforts focus on modifying or constructing the physical and chemical properties of surfaces to enhance antifouling capabilities. However, conventional evaluation methods, such as artificial urine and protein immersion models, often fail to replicate the complex interfacial interactions occurring .

Mechanistic insights into the anti-rheumatoid arthritis effects of ursolic acid from Periploca forrestii Schltr. via network pharmacology, molecular docking, and experimental Validation.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent synovitis and systemic inflammation. Periploca forrestii Schltr., one of the "three treasures of Miao medicine", is traditionally used for RA treatment due to its reputed effects in relaxing tendons, activating collaterals, and dispelling wind and dampness.

Diagnostic and therapeutic review of a rare gastric inflammatory fibroid polyps case with distinctive features: A case report.

Background: Inflammatory fibroid polyps (IFPs) are generally considered as benign and relatively rare mesenchymal gastrointestinal tract tumors. IFPs can occur in any part of the gastrointestinal tract but are most prevalent in the stomach, particularly in the gastric antrum. With a low incidence in clinical practice and a lack of distinct endoscopic features, the preoperative diagnosis rate of IFP is disappointingly low, often leading to missed diagnoses or misdiagnoses.

The Deteriorated Center-Surround Suppression in Patients With First-Episode and Drug-Naïve Major Depressive Disorder.

Major depressive disorder (MDD) patients are often associated with inhibition deficits in the visual cortex. Most previous research has focused on visual inhibition in MDD patients during acute and remission phases, with little research on first-episode and drug-naïve (FEDN) patients. To fill this gap, we psychophysically investigated the inhibitory process of visual motion in patients with FEDN MDD.

A Novel Matching Pursuit Modeling Strategy Based on Adaptive Fourier Decomposition Theory for Predicting Antigenic Variation of Influenza A (H1N1).

Introduction: Seasonal influenza poses a significant public health burden, causing substantial morbidity and mortality worldwide each year. In this context, timely and accurate vaccine strain selection is critical to mitigating the impact of influenza outbreaks. This article aims to develop an adaptive, universal, and convenient method for predicting antigenic variation in influenza A(H1N1), thereby providing a scientific basis to enhance the biannual influenza vaccine selection process.

Quaternized chitosan/sodium alginate functionalized halloysite for melamine formaldehyde resin impregnated paper: synergistic toughening and antibacterial properties development.

Melamine formaldehyde (MF) resin is a widely used decorated material, but its inherent brittleness limits broader applications. In this study, a novel bio-based nanomaterial (AQ@HNTs) was fabricated via a layer-by-layer self-assembly of quaternized chitosan and sodium alginate onto halloysite nanotubes (HNTs), providing a green and efficient strategy for natural nanotube surface modification. The resulting AQ@HNTs were incorporated into MF resin to synergistically enhance its toughness and antibacterial properties without affecting its curing behavior at 120 °C.

Hearing vocals to recognize schizophrenia: speech discriminant analysis with fusion of emotions and features based on deep learning.

Background And Objective: Accurate detection of schizophrenia poses a grand challenge as a complex and heterogeneous mental disorder. Current diagnostic criteria rely primarily on clinical symptoms, which may not fully capture individual differences and the heterogeneity of the disorder. In this study, a discriminative model of schizophrenic speech based on deep learning is developed, which combines different emotional stimuli and features.

New feature of hMEIOB and hSPATA22 binding to ssDNA from a single-molecule perspective.

MEIOB and SPATA22 are gonad-specific proteins that function in meiosis recombination. Mutations in these two proteins cause oligospermia or azoospermia in human males. It has been reported that the heterodimer composed of MEIOB and SPATA22 recognizes and binds to the single-strand DNA (ssDNA) protected by the replication protein A (RPA) complex to promote DNA damage repair during homologous recombination.

Outcomes of Combined Liver-Kidney Transplantation in Polycystic Liver and Kidney Disease.

BACKGROUND Adult polycystic liver disease (PLD) is a rare disorder frequently associated with polycystic kidney disease (PKD). This study aimed to evaluate the therapeutic outcomes of organ transplantation in patients with PLD. MATERIAL AND METHODS A retrospective analysis was conducted on the clinical data of 9 PLD patients who underwent organ transplantation at our center from May 2015 to Jan 2024.